iiinova — where your digital self keeps evolving

Reposted by Yewon Han

Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 01/08/2026

Riboseek is a fast RNA/DNA search. More sensitive than nhmmer at 250x speed. Structure-aware realignment produces MSAs approaching rMSA quality. Plus 1.7M precomputed RNA MSAs, and an API to search your own 📄 www.biorxiv.org/content/10.6... 💾 github.com/steineggerla... 🌐 search.foldseek.com/riboseek

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Reposted by Yewon Han

hbkgenomics.bsky.social @hbkgenomics.bsky.social · 06/06/2026

Does your designed active site already exist in nature? Is an uncharacterized protein hiding a catalytic site or a pocket? Folddisco answers both, searching millions of structures for a 3D motif in seconds. @natbiotech.nature.com 🧬 📄 www.nature.com/articles/s41... 🧵1/7👇

nature.com

Structural motif search across the protein universe with Folddisco - Nature Biotechnology

Folddisco enables protein structural motif search in million scale databases.

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Reposted by Yewon Han

Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 29/04/2025

Today @yewonhan.bsky.social will give a flash talk about our metagenomic large-scale protein structure clustering and analysis at #RECOMB2025. Today (April 29) 1 p.m. at Global Lounge in “The Commons”

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Reposted by Yewon Han

Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 27/04/2025

AFESM: a metagenomic guide through the protein structure universe! We clustered 821M structures (AFDB&ESMatlas) into 5.12M groups; revealing biome-specific groups, only 1 new fold even after AlphaFold2 re-prediction & many novel domain combos. 🧵 🌐 afesm.foldseek.com 📄 www.biorxiv.org/content/10.1...

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