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Mario Peña-Hernández

@marioph13.bsky.social
128 followers 187 following 2 posts

Ph.D. in Iwasaki and Wilen Labs studying zoonotic coronaviruses. Incoming postdoc in Tsang Lab to decode/recode immunity to respiratory viruses.Isaiah 40:31 🦅. scholar.google.com/citations?user=l…

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Reposted by Mario Peña-Hernández
Prof. Shane Crotty @profshanecrotty.bsky.social · 14/04/2026
My new comprehensive review of Immune Memory to Vaccines is out! It has an emphasis on human vaccines. It is also accompanied by a full video lecture. Enjoy! @lji.org @cp-immunity.bsky.social authors.elsevier.com/sd/article/S...
authors.elsevier.com
ScienceDirect.com | Science, health and medical journals, full text articles and books.
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Mario Peña-Hernández @marioph13.bsky.social · 03/10/2025
Beyond grateful and excited to be invited to speak in one of the JSV meeting symposiums in Japan later this month! Thank you to @shigeru0701.bsky.social and other meeting organizers. 😁🙏
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Reposted by Mario Peña-Hernández
Laboratory of Functional Viromics (LETKO) @fviromics.bsky.social · 04/09/2025
New preprint! If some merbecoviruses use DPP4 and others use ACE2, what do those hedgehog merbecoviruses use?! As it turns out, neither! In our latest study, we uncover the "missing" receptor for the MERS-related viruses in hedgehogs. [These findings were first shared at ASV this year] (1/6)
tinyurl.com
Aminopeptidase N is a receptor for hedgehog merbecoviruses
Merbecoviruses, closely related to the highly pathogenetic Middle East Respiratory Syndrome Coronavirus (MERS-CoV), circulate in hedgehogs throughout Europe and Asia, raising concerns about zoonotic t...
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Reposted by Mario Peña-Hernández
David R. Martinez @davidmartinez.bsky.social · 07/08/2025
Beaming with pride that Jordan Polster, a student in my lab at Yale, was selected for the #Gilliam #Fellowship from @hhmi.org I look forward to mentoring Jordan and participating in the various mentorship workshops. Jordan - congrats! And I can’t wait to see your research advance!
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Reposted by Mario Peña-Hernández
Jen Christiansen @jenchristiansen.com · 25/06/2025
Vaccination schedules on the CDC website have already started changing under RFK Jr. So we published a guide to the evidence-based vaccine recommendations in place *before* all 17 members of the advisory panel were abruptly dismissed by the new admin. www.scientificamerican.com/article/see-... 🧪
scientificamerican.com
Here’s Your Cheat Sheet for Vaccine Recommendations Backed by Science
These graphics will guide you through science-based vaccine guidelines for children and adults
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Reposted by Mario Peña-Hernández
Spyros Lytras @spyroslytras.bsky.social · 10/05/2025
Sooo happy to finally have this one published!! (3 years in the making… 👀) A comprehensive investigation into the recency and geographical origins of both SARS-CoVs that spilled to humans in the past few decades, now in @cp-cell.bsky.social www.cell.com/cell/fulltex...
cell.com
The recency and geographical origins of the bat viruses ancestral to SARS-CoV and SARS-CoV-2
Recombination-aware evolutionary analyses of the entire genomes of SARS-CoV-1-like and SARS-CoV-2-like viruses indicate that SARS-CoV-1 and SARS-CoV-2 descend from bat coronaviruses that circulated as...
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Reposted by Mario Peña-Hernández
lukelukeluke @lukelukeluke.bsky.social · 10/05/2025
How could you not be impressed by a bird in your yard? This dude can fly anywhere and it came here to hang out with you
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Reposted by Mario Peña-Hernández
Jon Cohen @cohenjon.bsky.social · 25/03/2025
...a “pointless, ill-advised move that will hurt U.S. science and pandemic readiness,” says Charles Rice, a Nobel Prize–winning virologist at Rockefeller University www.science.org/content/arti...
science.org
Saying ‘pandemic is over,’ NIH institute starts cutting COVID-19 research
Grant terminations halt research on improving vaccinations and preventing future pandemics
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Reposted by Mario Peña-Hernández
Thelonevirologist @thelonevirologist.bsky.social · 27/01/2025
Human naïve B cells recognize prepandemic influenza virus hemagglutinins www.science.org/doi/10.1126/...
science.org
Human naïve B cells recognize prepandemic influenza virus hemagglutinins
Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.
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Reposted by Mario Peña-Hernández
Thelonevirologist @thelonevirologist.bsky.social · 10/01/2025
The rising threat of deadly diseases jumping from animals to humans www.ft.com/content/a714...
ft.com
The rising threat of deadly diseases jumping from animals to humans
Zoonotic pathogens very likely caused the last pandemic. Can we get better at halting them before the next one?
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Reposted by Mario Peña-Hernández
Flo Débarre @flodebarre.eurosky.social · 05/01/2025
Five years ago (Sunday 5 Jan 2020), scientists in Zhang YongZhen's group in Shanghai obtained their first sequence of the new virus, from samples obtained outside of the official national protocol. They submitted it to GenBank with an embargo. ▫️1/ www.ncbi.nlm.nih.gov/nuccore/MN90...
screenshot of linked website, with submission date highlighted (05-JAN-2020)

LOCUS       MN908947               30473 bp ss-RNA     linear   VRL 12-JAN-2020
DEFINITION  Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete
            genome.
ACCESSION   MN908947
VERSION     MN908947.1
KEYWORDS    .
SOURCE      Wuhan seafood market pneumonia virus
  ORGANISM  Wuhan seafood market pneumonia virus
            Viruses; Riboviria; Nidovirales; Cornidovirineae; Coronaviridae;
            Orthocoronavirinae; Betacoronavirus; unclassified Betacoronavirus.
REFERENCE   1  (bases 1 to 30473)
  AUTHORS   Zhang,Y.-Z., Wu,F., Chen,Y.-M., Pei,Y.-Y., Xu,L., Wang,W., Zhao,S.,
            Yu,B., Hu,Y., Tao,Z.-W., Song,Z.-G., Tian,J.-H., Zhang,Y.-L.,
            Liu,Y., Zheng,J.-J., Dai,F.-H., Wang,Q.-M., She,J.-L. and Zhu,T.-Y.
  TITLE     A novel coronavirus associated with a respiratory disease in Wuhan
            of Hubei province, China
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 30473)
  AUTHORS   Zhang,Y.-Z., Wu,F., Chen,Y.-M., Pei,Y.-Y., Xu,L., Wang,W., Zhao,S.,
            Yu,B., Hu,Y., Tao,Z.-W., Song,Z.-G., Tian,J.-H., Zhang,Y.-L.,
            Liu,Y., Zheng,J.-J., Dai,F.-H., Wang,Q.-M., She,J.-L. and Zhu,T.-Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JAN-2020) Department of Zoonoses, National Institute
            of Communicable Disease Control and Prevention, Chinese Center for
            Disease Control and Prevention, Changping Liuzi 5, Beijing 102206,
            China
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Mario Peña-Hernández @marioph13.bsky.social · 04/01/2025
Really cool work that shows how different spikes from 27 SARS-2 variants behave in the same ancestral backbone. It also really nicely illustrates how other mutations in the CoV backbone might affect replication and other viral properties! 👇
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Reposted by Mario Peña-Hernández
David R. Martinez @davidmartinez.bsky.social · 06/12/2024
Our article is now out in Nature Biotechnology. Here we outline challenges for developing broad-based mucosal vaccines for respiratory viruses. Check it out! Congrats to Junghwa and Jordan from my lab and to other co-authors! www.nature.com/articles/s41...
nature.com
Challenges for developing broad-based mucosal vaccines for respiratory viruses - Nature Biotechnology
Nature Biotechnology - Challenges for developing broad-based mucosal vaccines for respiratory viruses
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