Background Alternative splicing expands the coding capacity of single genes into diverse protein families, and its dysregulation is a recognized hallmark of cancer. Despite this, the characterization ...

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Intracellular pathogens remodel host cells by redirecting cellular machinery to the host-pathogen interface. The protozoan parasite Toxoplasma gondii co-opts host ESCRT proteins at the parasitophorous...

 By pairing two neural networks in an iterative optimization algorithm, small-molecule binding proteins can be designed from scratch with high accuracy, affinity and success rates, showing p...

Protein structure modeling can generate hypotheses about sequence-structure-function relationships. Here, the authors used modern computational methods and experimental characterization to explore the...

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Accurately measuring compound binding affinities is key to driving the pharmaceutical development process. Rigorous physics-based in silico approaches, particularly alchemical free energy methods, hav...

As part of a collaboration with Open Targets on the development of a Side Effect Resource to guide target selection, we have two positions a...

By Adeoye Johnson, Published on 01/01/16

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A central tenet of biology is that protein structure mediates the sequence-function relationship. Recently, there has been excitement about the promise of advances in protein structure modeling to gen...

The Blue Ridge Institute for Medical Research publishes rankings of institutions, departments, and investigators based on the funding they receive from the NIH.

The drastic reduction in indirect costs is not a path to innovation or cost savings — it’s a threat to U.S.’s position as global leader in medical research.

Select a state on the map to see the impact of NIH funding across America.

FOR IMMEDIATE RELEASE January 13, 2025 Healthcare, Public Health, and Scientific Experts Call on the Senate to Reject RFK Jr. Nomination to Lead HHS CONTACT: Julie Scofield, 301-455-2558, jscofie...

The Molecular ML Reading Group aims to explore foundational and recent applications of machine learning models to modeling molecular system.

Proteins power a vast array of functional processes in living cells. The capability to create new proteins with designed structures and functions would thus enable the engineering of cellular...

Molecular ML Reading Group

The computational design of novel protein structures has the potential to impact numerous scientific disciplines greatly. Toward this goal, we introduce $\text{FoldFlow}$ a series of novel...