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Madeline Kavanagh

@mads-chem.bsky.social
248 followers 169 following 26 posts

Assistant Professor at Leiden University. Developing chemical probes to better understand & modulate immunology. #chemoproteomics #medchem #drugdiscovery #immunometabolism #antibiotics #scicomm. She/Her/Hers. Hiker & wildlife fanatic. miniurl.com/Mads

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Madeline Kavanagh @mads-chem.bsky.social · 12/06/2026
Big thanks to talented #PhD candidates Jakob van der Wall and Georgia Andriopoulou for representing our lab @led3hub.bsky.social Early #DrugDiscovery symposium yesterday, sharing how #chemoproteomics and new #chemistry can tackle traditional challenging #cancer & #immune targets! #chembiol
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Madeline Kavanagh @mads-chem.bsky.social · 21/05/2026
It was a pleasure to co-host the 12th Life Science Symposium today, organized by @leidenscience.bsky.social LST study association. A stellar lineup of speakers showing how #genetics, #cryoEM, #omics, #organoids, #AI, and #clinical data can advance solutions to #neurodegenerative diseases
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Madeline Kavanagh @mads-chem.bsky.social · 02/03/2026
Save the date! 15th Activity Based Protein Profiling meeting #ABPP2027 is in Leiden, 2-4th June 2027. Join the mailing list for program updates and rego: www.universiteitleiden.nl/en/science/led3/abpp2027 #chembiol #proteomics #ABPs #Chemicalprobes @led3hub.bsky.social @leidenscience.bsky.social
universiteitleiden.nl
ABPP2027
The 15th International Activity-Based Protein Profiling Meeting will be held in Naturalis, Leiden, The Netherlands from June 2nd to 4th, 2027. This meeting will discuss the latest advancements in prot...
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Leiden Early Drug Discovery & Development (LED3) @led3hub.bsky.social · 19/12/2025
Congratulations to the LED3 members that received NWO XS grants: @mads-chem.bsky.social - Inhibiting the growth of brain tumours Margo Dona - Rapid personalised treatment for anaplastic thyroid cancer Sandra Irmisch - Producing rare substances for medicines www.universiteitleiden.nl/en/news/2025...
universiteitleiden.nl
Eleven Open Competition Domain Science XS grants for Leiden researchers
Eleven researchers from Leiden University have been awarded an Open Competition Domain Science ENW XS grant by the Dutch Research Council for their research projects. They are researching how to make ...
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Madeline Kavanagh @mads-chem.bsky.social · 01/10/2025
Awesome talk from @ox.ac.uk Prof. Alex Bullock @leidenscience.bsky.social today. Neat examples of #neomorphic gain-of-function mutations driving disease by acting as #molecularglues and using #FBDD to expand the #druggability of E3ligases with thesgc.bsky.social‬ and #EUbOPEN @led3hub.bsky.social
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Virtual ChemBioTalks @chembiotalks.bsky.social · 24/09/2025
The first Flash Talk at the 5th Virtual ChemBioTalks will be given by Jingzhi Fan. He will present on “Metabolomics-Inspired Biomaterials: Calcium Phosphate with Targeted Metabolic Enhancement for Bone Repair”. Register for free: web.cvent.com/event/60e9f3... #ChemBio #ChemSky #DrugDiscovery
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Stephan Hacker @stephanhacker2.bsky.social · 21/09/2025
Looking forward to a great @led3hub.bsky.social Lecture by Willem Velema on Thursday. Excited to learn, how his group is targeting RNA to develop novel #antibiotics. #ChemSky #ChemBio @leidenscience.bsky.social
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Madeline Kavanagh @mads-chem.bsky.social · 03/09/2025
Looking for a #PhD in #medicinal #chemistry and #chemical #proteomics focused on #drugdevelopment for #infectiousdiseases? We have a vacancy!! Come join our interdisciplinary team @leidenscience.bsky.social & and help develop new approaches to treat mycobacterial infections 😀 tinyurl.com/3srxfr55
universiteitleiden.nl
PhD Candidate in Chemistry, Proteomics, and Immunology
PhD Candidate in Chemistry, Proteomics, and ImmunologyThe Leiden Institute of Chemistry is looking for a PhD candidate to pursue research on the development of immune-modulatory drugs to treat infecti...
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Stephan Hacker @stephanhacker2.bsky.social · 16/07/2025
Looking forward to hearing about the potential of machine learning for #Biology and #DrugDiscovery from an industry perspective. Register for the Virtual @chembiotalks.bsky.social to hear the perspective of Chris Dallago (@machine.learning.bio) from Nvidia. #ChemBio #Chemsky #ML #MachineLearning
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Virtual ChemBioTalks @chembiotalks.bsky.social · 06/06/2025
Free registration is now open for the 5th Virtual ChemBioTalks on September 30th, 2025. We are looking forward to a full program including keynote lectures by Sarah O'Connor and @craigmcrews.bsky.social as well as five additional exciting lectures. (1/2) cvent.me/G1geWW #ChemBio #Chemsky
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Stephan Hacker @stephanhacker2.bsky.social · 07/05/2025
Very excited that Ed Tate will visit us for a @led3hub.bsky.social Lecture on May 22nd and talk about cutting-edge #ChemBio and #chemoproteomics research in the field of #DrugDiscovery. If you are interested, feel free to come by! #ChemSky
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Madeline Kavanagh @mads-chem.bsky.social · 01/05/2025
Great opportunity for #PhD #postdoc to showcase their #chemistry #chemicalprobe #proteomics #chembiol research at the next @chembiotalks.bsky.social Looking forward to keynotes from @craigmcrews.bsky.social and @oconnorlab.bsky.social and exciting #earlycareer Flashtalks!! #chemsky
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Madeline Kavanagh @mads-chem.bsky.social · 30/04/2025
Had a great time today discussing the power of #chemoproteomics to help develop #drugs with novel mechanisms of action today for @flgenomics.bsky.social webinar series. Great to see the #chemistry, #AI #proteomics, and #genomics communities coming together to drive change drug development!
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Matt Bogyo @mbogyo.bsky.social · 19/04/2025
If you are interested in lipids in bacteria, check out this awesome new review written by my talented student Alyssa Carter, super postdoc Emily Woods and me. #chembio www.sciencedirect.com/science/arti...
sciencedirect.com
Chemical strategies for targeting lipid pathways in bacterial pathogens
Microbial pathogens continue to plague human health and develop resistance to our current frontline treatments. Over the last few decades, there has b…
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Madeline Kavanagh @mads-chem.bsky.social · 16/04/2025
Exciting Day 3 RACI #MCCB2025 ! Starting with showstopping stories from GateBioscience's Pat Sharp on the development of Sec61 #inhibitors for Prion disease, & Prof. Avril Robertson from UQ on targeting NLRP3 #inflammasomes. Impressive preclinical efficacy fromin both stories!
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HHMI @hhmi-science.bsky.social · 06/04/2025
Congrats to HHMI Investigator David R. Liu on receiving the 2025 Breakthrough Prize in Life Sciences! He is recognized for developing base editing & prime editing: 2 breakthrough gene-editing technologies that enable the correction or replacement of virtually any genetic mutation. hhmi.news/3RA6shj
HHMI Investigator David R. Liu, smiling, with a graphic of a DNA helix in the background. Text overlay announces his award of the 2025 Breakthrough Prize in Life Sciences.
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Stephan Hacker @stephanhacker2.bsky.social · 03/04/2025
Very excited that I will have the chance to work together with @mads-chem.bsky.social, @martola.bsky.social, Daan van der Es, Martijn Verdoes and Paul Geurink on this exciting event. (2/2)
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Madeline Kavanagh @mads-chem.bsky.social · 01/04/2025
Had an amazing time at #abpp2025 over the last couple of days. Incredible lineup of speakers showcasing why #ABPP and #proteomics have transformational for #drugdiscovery and #chembiol Already looking forward for #abpp2027 in @LeidenScience
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Leiden Early Drug Discovery & Development (LED3) @led3hub.bsky.social · 01/04/2025
We are very excited that three of our researchers, @mads-chem.bsky.social, @kimmb1.bsky.social and Sander van Kasteren, were successful in obtaining funding through the ZonMw open competition. Learn more about the three projects here: www.universiteitleiden.nl/en/news/2025...
universiteitleiden.nl
Chemistry as the key to medical innovation
Is it a coincidence that three chemists from the same department have each independently received a ZonMw grant? 'No,' the researchers agree in unison. 'The role of chemistry in medical biology is bec...
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Madeline Kavanagh @mads-chem.bsky.social · 27/03/2025
Really enjoyed hosting @jpoverington.bsky.social from @drughunter.com today for @led3hub.bsky.social lecture @leidenscience.bsky.social Some great insights into how #genetics informs #drug target selection and how we can leverage #chemoinformatics to reduce attrition in #drugdevelopment.
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Stephan Hacker @stephanhacker2.bsky.social · 25/03/2025
Impressive talk by Georgia Andriopoulou from the group of @mads-chem.bsky.social of the @led3hub.bsky.social at #Lunteren. She talked about her research into new libraries of covalent compounds with tailored properties for #chemoproteomics identification of new therapeutic targets. #chemsky #chembio
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Madeline Kavanagh @mads-chem.bsky.social · 24/03/2025
On #WorldTBday @leidenscience.bsky.social "Dutch Perspective on Mycobacterial Infections" provided insights on #hostpathogen interactions #drugdevelopment & #immunology from global leaders. Unfortunatley, #MDR #infections continue to rise, urgently requiring new #drugs with new #targets
universiteitleiden.nl
Symposium: A Dutch Perspective on Mycobacterial Infections
On the 24th of March 2025, World TB day, we organize a symposium to connect the Dutch scientific community working on mycobacterial infections. We will cover all aspects of tuberculous or non-tubercul...
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Madeline Kavanagh @mads-chem.bsky.social · 13/03/2025
Huge congratulations to the first MSc #graduate from the Kavanagh lab (and future #PhD ) @leidenscience.bsky.social @led3hub.bsky.social Could not be more proud of Jakob and his hard work pushing forward the development of #chemicalprobes to modulate #immunology #chembio #STEMed
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Madeline Kavanagh @mads-chem.bsky.social · 13/03/2025
Excited to be joining an great line up of speakers at RACI #MCCB2025 in Darwin just a couple of weeks. Looking forward to exciting science with the #ozchem community #chembio #proteomics #drugdiscovery #NT bit.ly/3PNkUl6
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Stephan Hacker @stephanhacker2.bsky.social · 12/03/2025
Two amazing @led3hub.bsky.social Lectures are coming up: On March 17th, Jeff Kelly will talk about tackling neurodegenerative diseases. On March 27th, John Overington will talk about the power of data in Drug Discovery. Come by, if you are interested! www.universiteitleiden.nl/en/science/l...
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Stephan Hacker @stephanhacker2.bsky.social · 10/03/2025
Join us in Leiden on March 17th for the @led3hub.bsky.social Lecture of Jeffery W. Kelly of @scripps.edu.
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Madeline Kavanagh @mads-chem.bsky.social · 08/03/2025
Happy #IWD2025 ! Special shout out to all those #STEMwomen today (including my mum!) keep being amazing #mentorsmatter #DEI #standupforscience
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Virtual ChemBioTalks @chembiotalks.bsky.social · 24/02/2025
Whom would you like to hear at our next event? The planning for the 5th Virtual ChemBioTalks is starting. We are excited for talks by @oconnorlab.bsky.social, @craigmcrews.bsky.social and Kelly Chibale. Let us know in reply to this post, whom you would additionally like to hear!
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Madeline Kavanagh @mads-chem.bsky.social · 09/02/2025
Anyone looking to brush up on #ochem should check out this awesome #free resource from @synthesisworkshop.bsky.social Lecture notes, videos, problem sets & more ! #StemEd #chemnerd #medchem #synthesis Also check out their #podcast (The SW Pod) and #youtube lectures! youtu.be/Yn7o9z_93WY?...
youtu.be
Advanced Organic Chemistry: Hammetts and KIEs
YouTube video by Synthesis Workshop Videos
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Stephan Hacker @stephanhacker2.bsky.social · 06/02/2025
Malaria is one of the most devastating diseases especially on the African continent. In his keynote lecture at the #LED3LUCID Symposium, Kelly Chibale talked about his group's amazing contributions to finding new drugs to fight malaria. (1/4)
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Madeline Kavanagh @mads-chem.bsky.social · 06/02/2025
Fantastic start to the #LED3LUCID symposium today with @mvdstelt.bsky.social from @led3hub.bsky.social sharing their discovery of #stereoselctive DNA gyrase inhibitor #antibiotics A collaborative #drugdiscovery program leveraging #medchem #chembiol #microbiology www.nature.com/articles/s41...
nature.com
Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria - Nature Chemistry
Global antibiotic scarcity looms owing to bacterial resistance. Now the discovery of a class of allosteric inhibitors targeting DNA gyrase—essential for bacteria—yields a compound LEI-800 that exhibit...
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Yu Heng Lau @yuhenglau.bsky.social · 05/02/2025
We have PhD scholarships @sydneyuni.bsky.social School of Chemistry available to work on a range of drug discovery and chemical biology projects in my lab, applications close Feb 21 Please let any potentially interested candidates know! www.sydney.edu.au/scholarships...
sydney.edu.au
Postgraduate Research Scholarship in Medicinal Chemistry
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Madeline Kavanagh @mads-chem.bsky.social · 31/01/2025
Topping off #EFMCISCB25 we had an exciting talk on #molecularglue #TPD from @monterosatx.bsky.social Nice to see how rapidly the rational discovery and of #smallmolecule degraders is developing and the insight these platforms are providing into #biology @euromedchem.bsky.social
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Madeline Kavanagh @mads-chem.bsky.social · 31/01/2025
Lovely talk on #fragment based #covalent strategy to drug Leishmania #bromodomain at #EFMCISCB25 this morning from Claudine Greenwood @glaxosmithkline.bsky.social . Great to see this strategy being used for neglected #infectiousdisease
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gsbardella.bsky.social @gsbardella.bsky.social · 31/01/2025
An amazing KL by Akane Kawamura (@kawamuragroup.bsky.social) opened the session on “Chemical Biology of Chromatin and the Epitranscriptome” at #EFMCISCB25, chaired by Paola Arimondo. Akane thrilled the audience with her work on 2OG Oxygenases in Epigenetic Regulation. @euromedchem.bsky.social
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Madeline Kavanagh @mads-chem.bsky.social · 30/01/2025
Up next at #EFMCISCB25 @kjohnsson.bsky.social sharing #fluorescent tools for cell imaging and @mvdstelt.bsky.social from @unileiden.bsky.social showcasing #chembiol and #proteomics to understand #lipid signaling in the diseased brain.
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Madeline Kavanagh @mads-chem.bsky.social · 30/01/2025
First up on day 2 of @euromedchem.bsky.social #EFMCISCB25 is Ben Davis from @ox.ac.uk talking about awesome #chemistry to edit #proteins eg. chemical #mutagenesis, such as Cys>Dha>Xxx transitions #chembiol #chemsky
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Madeline Kavanagh @mads-chem.bsky.social · 29/01/2025
The 2nd talk at #EFMCISCB was from @berndwollscheid.bsky.social from @ethzurich.bsky.social who shared his labs work on #cellsurface capture technology using #chemoproteomics. insight into cell type-specific proteins, monitoring ligand-receptor affinity, spatial distribution of complexes! #chembiol
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Madeline Kavanagh @mads-chem.bsky.social · 29/01/2025
Fantastic kickoff to @euromedchem.bsky.social #EFMCISCB 2025 Peng Chen from Peking University sharing the diverse applications of #bioorthogonal de-caging reactions to #chembiol and #drugdiscovery
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Madeline Kavanagh @mads-chem.bsky.social · 25/01/2025
Can't wait for 4 days of #chembiol #medchem #chemicalprobes #drugdiscovery and #chemoproteomics @RACInational #MCCB2025 Great line of #science and catching up with old friends in #NT bit.ly/3PNkUl6
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Madeline Kavanagh @mads-chem.bsky.social · 20/01/2025
Last chance to register for #ABPP2025 ! Don't miss an incredible line up of talks on #proteomics #chemicalprobes #drugdiscovery #immunology #cancer plus an #earlycareer research. 30th March - 2nd April in London. Registration www.eventcreate.com/e/abpp2025/
eventcreate.com
ABPP2025: The 14th International Activity Based Protein Profiling Meeting | March 30, 2025 - April 02, 2025
Join us on March 30
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Stephan Hacker @stephanhacker2.bsky.social · 17/01/2025
Great to also see him highlight two of the most recent studies of his group: A highly potent monoacylglycerol lipase inhibitor: www.nature.com/articles/s41... A platform to study target engagement of kinases in cells: www.biorxiv.org/content/10.1... #chemsky #ChemBio
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Lars Jeuken @larsjeuken.bsky.social · 16/01/2025
Very happy to present our latest work by Tijn van der Velden and co-workers. Cytochrome bd from Mycobacterium tuberculosis has been studied for a while, but nobody was able to show catalytic activity of the purified enzyme: Find out why here in our JBC paper: www.sciencedirect.com/science/arti...
sciencedirect.com
Menaquinone-specific turnover by Mycobacterium tuberculosis cytochrome bd is redox regulated by the Q-loop disulfide bond
Cytochrome bd from Mycobacterium tuberculosis (Mtbd) is a menaquinol oxidase that has gained interest as an antibiotic target because of its importanc…
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