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Synthesis Workshop @synthesisworkshop.bsky.social · 11/09/2026

Tune in this week as Mauro Mato shares his work on a photoredox strategy for unmasking C-H bonds! Link: youtu.be/VW2X6KeLiFY Key paper: @jacs.acspublications.org 2026, 148, 5946–5952 doi.org/10.1021/jacs... Thanks to Kathleen for editing and hosting!

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Synthesis Workshop @synthesisworkshop.bsky.social · 29/08/2026

Today we are joined by Dr. Alexander Düfert, who discusses with us his new book, Methods of Organic Synthesis in a talk followed by a Q&A session with our editorial board! Link: youtu.be/ctVRA18Wwcc @springernature.com: link.springer.com/book/10.1007... Thanks to Alicia for hosting!

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Synthesis Workshop @synthesisworkshop.bsky.social · 01/08/2026

This week we are excited to present our August ChemDev poster, focusing on the development of a manufacturing process for the COVID-19 antiviral ensitrelvir! This poster is brought to you by our Associate Editor of ChemDev Posters, Violet YJ Chen! Key reference: doi.org/10.1021/acsc...

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Synthesis Workshop @synthesisworkshop.bsky.social · 05/07/2026

This week Violet YJ Chen highlights the development of a manufacturing process for a key intermediate of orforglipron (a non-peptide GLP-1 receptor agonist) by the team at Lilly! Key papers: doi.org/10.1021/acs.... doi.org/10.1021/acs.... doi.org/10.1021/acs....

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Synthesis Workshop @synthesisworkshop.bsky.social · 06/06/2026

In this month's ChemDev poster by Augustin "Gus" Péneau, we explore the process development behind a campaign to establish a manufacturing route for a topical pan-Trk inhibitor by Neil Stevenson with the BenevolentAI team! Key paper: doi.org/10.1021/acs....

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Synthesis Workshop @synthesisworkshop.bsky.social · 30/05/2026

Tune in today as Henrik Wilke joins us to share his work on the total synthesis of (±)-Dhilirolide U! Thanks to Alicia Wagner for hosting and editing! Link: youtu.be/-pBrDNQZ_hU @jacs.acspublications.org 2026, 148, 5916–5922. doi.org/10.1021/jacs...

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Total Synthesis of (±)-Dhilirolide U with Henrik Wilke

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Synthesis Workshop @synthesisworkshop.bsky.social · 09/05/2026

Today Augustin "Gus" Péneau presents our ChemDev poster for May, featuring a convergent synthesis of GNE-6893 by the small molecule process team at Genentech! For more details check out the papers here: doi.org/10.1021/acs.... doi.org/10.1021/acsm... @acs.org

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Synthesis Workshop @synthesisworkshop.bsky.social · 02/05/2026

Tune in this week as Dr. Charis Amber @sarponggroup.bsky.social shares his work on the development of an "inside-out" strategy. for the synthesis of hispidospermidin! Link: youtu.be/Rtjb79JtvIE JACS Au 2026, 6, 600–606. doi.org/10.1021/jacs...

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An ”Inside-out” Strategy Enables a 14-Step Total Synthesis of Hispidospermidin with Dr. Charis Amber

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Synthesis Workshop @synthesisworkshop.bsky.social · 11/04/2026

Tune in this week as Xieyang Zhang shares his work on catalytic stereospecific construction of aminocyclopropanes from the Morken group at Boston College! Link: youtu.be/UE-S8R3zd60 Key paper: @jacs.acspublications.org 2026, 148, 3944-3948. doi.org/10.1021/jacs...

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Synthesis Workshop @synthesisworkshop.bsky.social · 04/04/2026

This month's ChemDev poster by Augustin "Gus" Péneau is out now!! Check out how chemists from AbbVie scaled the synthesis of ABBV-105, a Bruton’s tyrosine kinase (BTK)-inhibitor! Key paper: Org. Process Res. Dev. 2024, 28, 8, 3229–3247 doi.org/10.1021/acs....

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Synthesis Workshop @synthesisworkshop.bsky.social · 14/03/2026

Join us this week on Synthesis Workshop as Stanislav Melnikov shares his work on the role of quantum tunneling in metal-ligand proton tautomerism! Link: youtu.be/4hnNuJDdI8Q Key paper: @jacs.acspublications.org 2026, 147, 50, 46324–46335. doi.org/10.1021/jacs...

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The Role of Quantum Tunneling in Metal-ligand Proton Tautomerism with Stanislav Melnikov

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Synthesis Workshop @synthesisworkshop.bsky.social · 07/03/2026

Check out the first poster by Augustin "Gus" Péneau in our new monthly ChemDev virtual poster series, showing how syntheses evolve from Med Chem to Process Development. This poster highlights developments in the synthesis of the oral ERα degrader camizestrant!

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Synthesis Workshop @synthesisworkshop.bsky.social · 14/02/2026

Tune in this week on Synthesis Workshop as Bryan Parnitzke shares his work on Z-selective semihydrogenation reactions proceeding via multisite proton-coupled electron transfer!! Link: youtu.be/S2NS3sL6_g0 Key paper: ACS Catal. 2026, 16, 1, 203–210. doi.org/10.1021/acsc...

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Synthesis Workshop @synthesisworkshop.bsky.social · 31/01/2026

Join us this week on Synthesis Workshop as Dr. Lucia Anghileri shares her work on ligand design for light-driven nickel catalysis!! Link: youtu.be/-4ggoK4ACUk Key paper: J. Am. Chem. Soc. 2025, 147, 13169. doi.org/10.1021/jacs... Thanks to Dr. Alicia Wagner for hosting!

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Ligand Design for Light-driven Nickel Catalysis with Dr. Lucia Anghileri

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Synthesis Workshop @synthesisworkshop.bsky.social · 24/01/2026

Tune in this week as Dr. Terrence-Thang Nguyen shares his work on asymmetric C-H functionalization and the synthesis of (-)-dragocin D!! Link: youtu.be/Gh1qxy7Z7K0 @jacs.acspublications.org 2025, 147, 31, 28098–28106. doi.org/10.1021/jacs... Thanks to Kathleen for hosting!

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Synthesis Workshop @synthesisworkshop.bsky.social · 17/01/2026

Tune in this week as Joan Pereira shares his work on a bio-inspired total synthesis of daphnepapytone A!! Link: youtu.be/rhhpewmsRBc Big thanks to Reem for hosting and editing!

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Bio-inspired Total Synthesis of Daphnepapytone A with Joan Pereira

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Synthesis Workshop @synthesisworkshop.bsky.social · 03/01/2026

Tune in for our first Research Spotlight of 2026, where Dr. Ruocheng Sang shares his work on a radical approach to the boron-to-copper transmetalation problem!! Link: youtu.be/EVtEZwUSrbU @jacs.acspublications.org doi.org/10.1021/jacs...

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Synthesis Workshop @synthesisworkshop.bsky.social · 21/12/2025

Join us this week as Jordan Berreur shares his work on redox-powered autonomous directional C–C bond rotation under enzyme control, published this year in @nature.com!! Thanks to Xingfeng for hosting! Link: youtu.be/2InU6iFBYFQ Nature 2025, 644, 96–101. doi.org/10.1038/s415...

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Redox-powered Autonomous Directional C–C Bond Rotation Under Enzyme Control with Jordan Berreur

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Synthesis Workshop @synthesisworkshop.bsky.social · 13/12/2025

Tune in today as Dr. Benji Thoma returns for the second installment in our mini-course on prebiotic chemistry, this time focusing on prebiotic peptide synthesis!! Link: youtu.be/BDuyOmrTsqI Also check out the first installment on nucleic acid synthesis! youtu.be/Mi6ybPFtt7w

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Introduction to Prebiotic Chemistry: Prebiotic Peptide Synthesis with Dr. Benji Thoma

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Synthesis Workshop @synthesisworkshop.bsky.social · 29/11/2025

Join us today as Dr. Mikus Purins shares his work recently published in @science.org on bridging the pyridine-pyridazine synthesis gap using skeletal editing! Link: youtu.be/k2nOfYnNk6U Key paper: Science 2025, 389(6757), 295-298. www.science.org/doi/10.1126/... Thanks to Karim for hosting!!

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Rohit Bhatia @rohitbhatia10.bsky.social · 25/11/2025

🔬 You know a young innovator in #organicsynthesis? Great! Nominate them for the Thieme–IUPAC Prize 2026! 🎖️ €5,000 prize 📩 Deadline: Dec 12, 2025 📤 Send to: marcus.white@thieme.de More: thieme.de/en/thieme-ch... @synlettjournal.bsky.social @synthesisworkshop.bsky.social @orgsynth.bsky.social

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Chemical Science @chemicalscience.rsc.org · 20/10/2025

Do make sure to check out this Synthesis Workshop video to discover how aluminyl anions can have enhanced reactivity which enables selective C-H activation! 🧪 #ChemSky

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Synthesis Workshop @synthesisworkshop.bsky.social · 08/11/2025

Is it possible to form a stereogenic carbon with four heteroatom substituents? Would it be configurationally stable? Tune in today to find out in a brand new episode with Olivier Viudes, hosted by Alicia Wagner! Link: youtu.be/-pyvGu56Suo @jacs.acspublications.org 2025, 147, 21121.

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Synthesis Workshop @synthesisworkshop.bsky.social · 01/11/2025

We have a brand new Research Spotlight episode, as well as a Problem Set and Solution set dropping today!! Tune in to learn about diastereoselective umpolung cyclization reactions with Dr. Giulia Iannelli! Link: youtu.be/uyKZgUbB5Fk Link to our problem sets: synthesis-workshop.com/problem-sets.

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Synthesis Workshop @synthesisworkshop.bsky.social · 18/10/2025

Tune in today for a brand new Research Spotlight episode with Charlotte O’Donnell, focusing on her recent total synthesis of aspidospermidine! Link: youtu.be/lzDv8cJRTyQ

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Synthesis Workshop @synthesisworkshop.bsky.social · 11/10/2025

Tune in today to hear Dr. Fabian Kallmeier explain how to enhance the nucleophilicity of aluminum anions, which he recently published in @chemicalscience.rsc.org, in a brand new Research Spotlight episode! Link: youtu.be/6XBF6Iqi3vE Key paper: doi.org/10.1039/D5SC...

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Synthesis Workshop @synthesisworkshop.bsky.social · 06/09/2025

Join us today to learn about controlled anionic polymerizations with Paige Jacky, focusing on her recently published work in Nature Chemistry!! Link: youtu.be/6XD7dBUByyQ Nat Chem. 2025, 17, 1076-1082. doi.org/10.1038/s415...

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Synthesis Workshop @synthesisworkshop.bsky.social · 23/08/2025

Join. us today as we kick off a brand new course, "Cheminformatics and Computational Chemistry", with an excellent introductory talk on cheminformatics by Dr. Fu Kit Sheong!! If you're interested in contributing to this course, reach out! Link: youtu.be/Hx8kVIsRlO4

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A Crash Course on Cheminformatics with Dr. Fu Kit (Frederick) Sheong

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Synthesis Workshop @synthesisworkshop.bsky.social · 15/08/2025

Today after years of work and a tight collaboration between >40 chemists in academia and industry, we are thrilled to share the story of how our Advanced Organic Chemistry course and other courses were created in the Journal of Chemical Education! Link: doi.org/10.1021/acs....

doi.org

Reimagining Advanced Chemistry Education: A Community-based Approach to Course Design for Modern Learners

Chemistry education at the graduate level and beyond faces the formidable challenge of a boundless and constantly expanding frontier of knowledge on many fronts. While modern learners have an increasi...

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Reposted by Synthesis Workshop

Chemical Science @chemicalscience.rsc.org · 11/08/2025

The @synthesisworkshop.bsky.social channel covers a whole host of publications and cutting edge research in the area of organic chemistry. Highly recommended if you are in this area and would like to keep up to date with the field: www.youtube.com/@SynthesisWo...

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Synthesis Workshop Videos

Synthesis Workshop is a channel dedicated to presenting advances in synthetic organic chemistry in an open-access format with concise explanations and clear visuals. Created by Matthew Horwitz, Ph.D.

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Synthesis Workshop @synthesisworkshop.bsky.social · 09/08/2025

Join us today to hear from Ann-Sophie Paschke and Stefanie Schiele from the @morandilab.bsky.social about their work on C-to-N atom swapping reactions!! Thanks to Karim for hosting and editing! Link: youtu.be/D513hX1gOTg @chemicalscience.rsc.org doi.org/10.1039/D5SC...

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Synthesis Workshop @synthesisworkshop.bsky.social · 19/07/2025

Join us this week on Synthesis Workshop as Immanuel Plangger shares his work on the development of a non-enzymatic methylcyclization reaction!! Thanks to Fabrizio Politano for hosting and editing! Link: youtu.be/fnFfw9T5DTM Key paper: Nat. Chem. 2025, 17, 904–910. doi.org/10.1038/s415...

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Non-enzymatic Methylcyclization of Alkenes with Immanuel Plangger

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Synthesis Workshop @synthesisworkshop.bsky.social · 18/07/2025

Very excited to announce that our recent review has been featured on the cover of Synthesis!! If you haven't had a chance to check it out yet, here is a link to the review: doi.org/10.1055/a-26...

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Synthesis Workshop @synthesisworkshop.bsky.social · 12/07/2025

Join us this week as Jonathan Gruhin @alexanian-lab.bsky.social shares his work on the homologation of carboxylic acids! Thanks to Alicia Wagner for hosting and editing!! Link: youtu.be/hbrrRyy0zfU Key paper: J. Am. Chem. Soc. 2024, 146, 48, 32919–32924 doi.org/10.1021/jacs...

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Synthesis Journal @synthesis1969.bsky.social · 02/07/2025

Dive into chiral #DrugDevelopment 💊 This review by Álvarez-Calero & Horwitz @synthesisworkshop.bsky.social highlights efficient, scalable #API synthesis for new drug substances. Discover how asymmetric synthesis drives #pharma innovation via diverse case studies 🧬 👉 buff.ly/ganycgH

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Synthesis Workshop @synthesisworkshop.bsky.social · 21/06/2025

Join us today as Michael Zott and Daniel Zuschlag share their work with Prof. Dirk Trauner on the synthesis of isosteroidal alkaloids!! youtu.be/Be-vVFLuGzE Key reference: J. Am. Chem. Soc. 2025, 147, 3010-3016. doi.org/10.1021/jacs...

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Concise Synthesis of Isosteroidal Alkaloids with Michael Zott and Daniel Zuschlag

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Synthesis Workshop @synthesisworkshop.bsky.social · 04/06/2025

Today Ömer Taşpınar joins us to share his work from the Clayden group on asymmetric intramolecular arylation reactions in a virtual research poster!! Check out the full paper, published under a month ago in Angewandte Chemie here: doi.org/10.1002/anie...

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Synthesis Workshop @synthesisworkshop.bsky.social · 26/04/2025

This is just one example of the problems you'll find in our latest problem set on covalent and noncovalent organocatalysis!! Check out the full set at synthesis-workshop.com in the Problem Sets or Courses section (see the Asymmetric Organocatalysis course).

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Synthesis Workshop @synthesisworkshop.bsky.social · 26/04/2025

Check out the latest installment in our Asymmetric Organocatalysis course!! Link: youtu.be/pwtS9YWxldI Once you're done, head over to synthesis-workshop.com and check out the corresponding problem and solution set! You can find it either in the Problem Sets or Courses section.

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Introduction to Asymmetric Organocatalysis: Non-covalent Organocatalysis

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Synthesis Workshop @synthesisworkshop.bsky.social · 28/03/2025

Join us this week as Rahul Giri shares his work on dual-functional group transfer reagents for the dihalogenation of hydrocarbons!! Thanks to Andy for hosting! Link: youtu.be/eL7dFssUHcA

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Synthesis Workshop @synthesisworkshop.bsky.social · 22/03/2025

Join us this week to hear from Dr. Feba Pulikkottil about her recently published work on eFluorination!! Link: youtu.be/U6V6rYhMu1A Key paper: Org. Lett. 2024, 26, 29, 6103–6108 doi.org/10.1021/acs....

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eFluorination for the Rapid Synthesis of Carbamoyl Fluorides from Oxamic Acids

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Synthesis Workshop @synthesisworkshop.bsky.social · 15/03/2025

Join us today on Synthesis Workshop as Prahallad Meher shares his work on site-selective alkylation and acylation reactions on glycines and peptides!! Thanks to Matteo Balletti for hosting! Link: youtu.be/D7GsRePvxSs Key paper: ACS Catal. 2024, 14, 18896-18906. doi.org/10.1021/acsc...

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Site-selective Arylation and Alkylation of Glycines and Peptides with Prahallad Meher

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Synthesis Workshop @synthesisworkshop.bsky.social · 08/03/2025

Join us today as Nicolò Tampellini shares his recently published work on asymmetric cyclization reactions!! Link: youtu.be/9e4Hxt5FjH4 J. Am. Chem. Soc. 2025, 147, 4624-4630. doi.org/10.1021/jacs...

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Synthesis Workshop @synthesisworkshop.bsky.social · 05/03/2025

Also check out our new problem and solution set on synthetic electrochemistry, created by Dr. Peter Bellotti! Available for download for free on our project homepage in the Courses or Problem Set section (www.synthesis-workshop.com)!

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Synthesis Workshop @synthesisworkshop.bsky.social · 05/03/2025

Tune in for an ⚡⚡⚡ELECTRIFYING⚡⚡⚡ talk! Today we release our introductory mini-course on synthetic electrochemistry, led by Dr. Max Palkowitz and hosted by Alicia Wagner!! Link: youtu.be/pBW4xHF2bBw

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Synthesis Workshop @synthesisworkshop.bsky.social · 14/02/2025

Join us this week to hear from Enric Adillon about his work on a carborane-derived proton-coupled electron-transfer reagent!! Thanks to Matteo Balletti for hosting! Link: youtu.be/PDAUl-I8e3g Key reference: J. Am. Chem. Soc. 2024, 146, 30204-30211. doi.org/10.1021/jacs...

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Synthesis Workshop @synthesisworkshop.bsky.social · 08/02/2025

Did you like our Advanced Organic Chemistry course Good news! You can now download all the PDFs on our project homepage: synthesis-workshop.com#downloads Haven't seen the course yet? Check it out! www.youtube.com/playlist?lis...

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