iiinova — where your digital self keeps evolving

Reposted by Luke Jostins-Dean

Yang Luo @y-luo.bsky.social · 01/10/2026

Excited to share our new preprint: “Rank-based integration identifies convergent disease mechanisms across omics” 🧬🧫🧪 Have RNA, protein or other omics from different studies/platforms and want to identify signals they consistently support? *ORBIT* 🪐 might be useful! www.biorxiv.org/content/10.6...

122

Reposted by Luke Jostins-Dean

medRxivpreprint @medrxivpreprint.bsky.social · 10/09/2026

Multi-ancestry MHC-pQTL mapping reveals disease-linked HLA protein networks and shared genetic architecture www.medrxiv.org/content/10.64898/20…

053

Luke Jostins-Dean @lukejostins.bsky.social · 01/08/2026

My 3-year old just handed me my phone, pointed to it and said "I want to see something die". Good times.

110

Luke Jostins-Dean @lukejostins.bsky.social · 14/06/2026

This might be the first time I have seen a pre-pre-print QR code. From @eliseneedham.bsky.social 's lovely talk on phosQTLs at #ESHG26

150

Luke Jostins-Dean @lukejostins.bsky.social · 29/04/2026

Coconut dropped from the roof of a house coconut dropped from the roof of a house

021

Reposted by Luke Jostins-Dean

Aleksejs Sazonovs @sazonovs.bsky.social · 01/04/2026

I believe we can drive biomedicine forward by giving the right tools to the right people. That idea is what led me to build CRAM2Excel, a new HTSlib/SAMtools plugin that exports CRAM alignments directly into native Excel workbooks. github.com/asazonov/cra...

121

Reposted by Luke Jostins-Dean

Konsta Happonen @konsta.happonen.eu · 22/02/2026

style(vintage(of(connoisseur(a(have(we(see(i()))))))))

1392

Reposted by Luke Jostins-Dean

Nightingale Health @nightingalehealth.com · 14/01/2026

Join UK Biobank for a webinar on Nightingale Health metabolomic data from all half a million participants. Our Principal Scientist, @lukejostins.bsky.social, will co-host the webinar. 🗓️ 21 January 2026, 3:00PM - 4:00PM GMT 🔔 Register: events.ringcentral.com/events/webin...

012

Luke Jostins-Dean @lukejostins.bsky.social · 14/01/2026

We have a webinar next week with @ukbiobank.bsky.social on the Nightingale metabolomics data. We did a table read today, and it is shaping up really nicely. Please do come! 300 people have registered already and there are only np.inf spaces left! www.ukbiobank.ac.uk/use-our-data...

A photo of me that is about 10 years old, and details on the webinar: "Inside the world's largest metabolomics study: Insights from UK Biobank, 21st January 2026, 3pm (GMP), Register now".

062

Reposted by Luke Jostins-Dean

Nightingale Health @nightingalehealth.com · 02/12/2025

Our webinar “Multiomic insights into human disease” by @lukejostins.bsky.social is tomorrow! Join us on 3 December at 3 p.m. CET for an exploration of how integrating proteomics and metabolomics can deepen our understanding of human health and disease. Sign up: www.lyyti.fi/reg/webinar-...

001

Reposted by Luke Jostins-Dean

Yang Luo @y-luo.bsky.social · 28/11/2025

🚨 New preprint from the lab! We’re excited to share “Improving population-scale disease prediction through multi-omics integration” by Ng et al. www.medrxiv.org/content/10.1...

2157

Reposted by Luke Jostins-Dean

Jonn Elledge @jonnelledge.bsky.social · 22/10/2025

"The idea of deporting people with settled status is disgusting, and anyone proposing it should be immediately drummed out of polite society. Breaking promises made in good faith to our friends and neighbours is racist, extremist and immoral." I'm basically shouting at the sky here, but still.

jonn.substack.com

It’s racist, it’s extremist and it’s immoral

The right is still calling for deportations, and the government is still being cowardly about it. Also: London’s first green belt; some notes on a shark; and some news, on my next book.

301256456

Reposted by Luke Jostins-Dean

Yang Luo @y-luo.bsky.social · 01/09/2025

This project is in close collaboration with the amazing @lukejostins.bsky.social, and the student will benefit from a multi-disciplinary team! 🌟🧬🧠

011

Reposted by Luke Jostins-Dean

Kaur Alasoo @kauralasoo.bsky.social · 03/09/2025

Parquet works really well with R as well. I use it all the time to work with GWAS summary statistics that won't fit into memory (our latest metabolite GWAS tested 95M+ variants in UKBB). Here's a minimal example of how to filter data on the fly while reading into R: gist.github.com/kauralasoo/f...

gist.github.com

Filtering parquet files with dplyr

GitHub Gist: instantly share code, notes, and snippets.

061

Reposted by Luke Jostins-Dean

Yang Luo @y-luo.bsky.social · 01/09/2025

🎓 New PhD opportunity in our lab @kiroxford.bsky.social @oxforduni.bsky.social We're exploring host–microbiome genetic interactions in IBD using population-scale data 🧬🦠 🔗 kennedy.ox.ac.uk/.../deciphering-host2013microbiome-genetic-interactions-in-inflammatory-bowel-disease #PhD #Genetics

kennedy.ox.ac.uk

053

Reposted by Luke Jostins-Dean

Pearl Freier @pearlf.bsky.social · 25/08/2025

Novartis & Roche collaborated w/ Oxford researchers at the Big Data Institute 2 develop AI model using largest collection of clinical trial data (Novartis-Oxford MS dataset) from >8000 ppl living w/ multiple sclerosis (MS) to reclassify the progression of MS www.ndm.ox.ac.uk/news/using-a... #biosky

062

Reposted by Luke Jostins-Dean

Nightingale Health @nightingalehealth.com · 14/08/2025

Welcome to our webinar “Multi-omic insights into human disease” by @jeffbarrett.eu on 4 September at 3 p.m. CEST! Join us for an exploration of how integrating proteomics and metabolomics can deepen our understanding of human health and disease. Learn more and sign up: www.lyyti.fi/reg/multiomi...

042

Reposted by Luke Jostins-Dean

Yang Luo @y-luo.bsky.social · 16/07/2025

Amazing news! Excited to be part of this new direction of research.

041

Reposted by Luke Jostins-Dean

Tobi Alegbe @tobioinformatics.bsky.social · 08/07/2025

🚨New preprint just dropped 🚨 medrxiv.org/content/10.1101/2025.06.24.25330216 The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!

13814

Reposted by Luke Jostins-Dean

Bradley Harris @bradleyomics.bsky.social · 08/07/2025

To see which of these underpin susceptibility, we colocalised these with IBD GWAS. Remarkably, we nominate effector genes at an enormous 74 (❗) loci where one has not previously been nominated in @OpenTargets. This therefore SUBSTANTIALLY improves on previous efforts. 10/

101

Reposted by Luke Jostins-Dean

Helena Kilpinen @hkilpinen.bsky.social · 25/06/2025

Job alert ‼️ @thomasdwkim.bsky.social and I are recruiting a postdoc in single-cell genomics via the NORPOD program of the @nordicembl.bsky.social. Collaboration between @fimm-uh.bsky.social and @dandrite.bsky.social on multimodal data integration in neurodevelopment. jobs.helsinki.fi/job/Helsinki...

jobs.helsinki.fi

Postdoctoral Researcher in Single-Cell Genomics through the NORPOD program

089

Luke Jostins-Dean @lukejostins.bsky.social · 22/06/2025

My 7-year-old just made a knife out of Lego, and did this: "I have a knife!" *Does a few slashes, then poses in a fighting stance" "and I am going to a gun fight" Is this from something, or did he make it up himself?

011

Reposted by Luke Jostins-Dean

James Lee @dr-james-lee.bsky.social · 09/06/2025

📢 📢Job alert!📢📢 We have an exciting opportunity for a 4 year post-doc in my lab at @crick.ac.uk‬. This project will take a similar approach to our recent ETS2 paper, published in Nature, to better understand the mechanisms that contribute to IBD tinyurl.com/yx43upnk

tinyurl.com

Postdoctoral Fellow - Lee Lab

Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Lee Lab Reports to: James Lee [C] Closing Date: 23.59 GMT Job Description: Job titl...

242

Luke Jostins-Dean @lukejostins.bsky.social · 02/06/2025

If you are interested to know why I have been weighing out 15 grams of butter for my bread, and what it has to do with the metabolomics of aging, sign up to this webinar tomorrow

110

Reposted by Luke Jostins-Dean

Nightingale Health @nightingalehealth.com · 02/06/2025

📣 Our webinar “Measuring the effects of aging with metabolomic profiling” by @lukejostins.bsky.social is tomorrow! Remember to sign up and join us tomorrow at 3 p.m. CEST. Sign up: www.lyyti.fi/reg/aging_we...

013

Reposted by Luke Jostins-Dean

Andrea Ganna @andganna.bsky.social · 01/06/2025

We have 2-3 group leader positions opening @fimm-uh.bsky.social !! We are looking for outstanding candidates in human genetics and precision medicine. This time we have a focus on population health data science. E.g. AI for EHR/health data Generous starting package 💰 shorturl.at/FAk6n

jobs.helsinki.fi

FIMM-EMBL Group Leaders in Molecular Medicine

03845

Reposted by Luke Jostins-Dean

Mike Inouye @mikeinouye.bsky.social · 29/05/2025

NB: The Polygenic Score Catalog has just lost its NIH funding. It was substantial. We are now on auxillary funding sources. If anyone has a spare £1m plz DM

21410

Reposted by Luke Jostins-Dean

ilesla.bsky.social @ilesla.bsky.social · 19/05/2025

Considering a return to study in the life/environmental sciences at Masters/PhD level after time away? Working and wondering if full/part-time study is the next step for your career? Our RePOWER workshop on 13th June in Oxford/online will provide advice and support. iles.web.ox.ac.uk/repower-retu...

iles.web.ox.ac.uk

RePOWER: Returning to Postgraduate Study in the Life and Environmental Sciences

036

Luke Jostins-Dean @lukejostins.bsky.social · 27/05/2025

Goodbye #ESHG2025 and goodbye Milano! A great conference and a lovely city.

080

Reposted by Luke Jostins-Dean

Annique Claringbould @anniquec.bsky.social · 27/05/2025

Justified standing ovation for Nobel laureate Katalin Karikó at #ESHG2025 She shared her adventurous scientific life and life lessons like "If you want to do something, you find a way. If not, you find excuses", and reminded us scientists to thank our near and dear because "they suffer a little bit"

0438

Luke Jostins-Dean @lukejostins.bsky.social · 27/05/2025

Daniel MacArthur @dgmacarthur.bsky.social, practically twitching with imposter syndrome, is giving the ESHG Award Lecture #eshg2025

2110

Reposted by Luke Jostins-Dean

Yang Luo @y-luo.bsky.social · 27/05/2025

Ciao #eshg2025! We had a good time!

081

Luke Jostins-Dean @lukejostins.bsky.social · 26/05/2025

Annique Claringbould @anniquec.bsky.social is talking about CRISPR interference in primary CD4 T cells for ~1000 GWAS-implicated enhancers, reading out ~2000 genes. Interfering with some key enhancers (CD28, IL2RA) impact basically every CD4-expressed gene. #eshg2025

122

Reposted by Luke Jostins-Dean

Eric Fauman (he/him) @ericfauman.bsky.social · 25/05/2025

From Adam Butterworth: worth getting embroidered:

151

Luke Jostins-Dean @lukejostins.bsky.social · 25/05/2025

A very pleasant poster session, lots of friendly people came to talk about our work. I took @jeffbarrett.eu's advice to ask everyone who visited my poster what they work on, to get some actual convos rather than spending an hour repeating my spiel over and over #ESHG2025

0111

Luke Jostins-Dean @lukejostins.bsky.social · 25/05/2025

More circadian phenotypes from Clara Albiñana. Gold standard for circadian dysfunction requires 24 hour saliva melatonin assay. Can you do it using a cross-sectional blood assay in UKB? #eshg2025

101

Luke Jostins-Dean @lukejostins.bsky.social · 25/05/2025

Lea Urpa is giving a talk on the interaction between genetics and circadian rhythm on blood glucose. Satisfyingly relevant top hits: CRY2 (blue light sensor) and MTNR1B (melatonin receptor). Leads to higher glucose in the morning and lower in the evening. #eshg2025

100

Reposted by Luke Jostins-Dean

Yang Luo @y-luo.bsky.social · 25/05/2025

We are #eshg2025! Here's where you can find us.

131

Luke Jostins-Dean @lukejostins.bsky.social · 25/05/2025

It is 10.30am in Finland, but nonetheless Helena Kilpinen @hkilpinen.bsky.social has also fallen asleep at the podium. She is talking about looking beyond gene expression to downstream cell phenotypes, such as cell morphology. #ESHG2025

120

Reposted by Luke Jostins-Dean

Yang Luo @y-luo.bsky.social · 25/05/2025

Amazing population-level single cell RNAseq showcases at #eshg2025 -TenK10K (Powell, Australia) and 6.5K donors (Soranzo,UK). lots of interesting findings:cell-type specific eQTLs, disease-associated cell compositions, eGenes enrichment for drug developments, etc. Crucially - they're *open source*!

0114

Luke Jostins-Dean @lukejostins.bsky.social · 25/05/2025

Nicole Soranzo lives in Milan, but it is still first thing in the morning on a Sunday so she has also fallen asleep at the podium. She is talking about the Cardinal study, single cell RNA-seq 6.5k UK participants with genetics and EHR (UKB and Genes and Health) #ESHG2025

220

Luke Jostins-Dean @lukejostins.bsky.social · 25/05/2025

Early morning session on single cell genetics at #ESHG2025. Joseph Powell just flew in from Australia, and may be the first person to fall asleep at the podium.

210

Luke Jostins-Dean @lukejostins.bsky.social · 24/05/2025

Aitzkoa Lopez de Lapuente Portilla (called Aitzkoa Lopez de Lapuente Portilla by her friends) has run high resolution flow cytometry in 12k Swedes. Genetics explains more variance in immune cells traits than does age or sex in this study. #eshg2025

030

Luke Jostins-Dean @lukejostins.bsky.social · 24/05/2025

Austin Argentieri (@austinargen.bsky.social) has built a proteomic aging score in UKB. They have also built a polygenic risk score for having a younger proteomic than chronological age, and run it in FinnGen - it has an odds ratio of 1.44 for living to 95. #eshg2025

110

Luke Jostins-Dean @lukejostins.bsky.social · 24/05/2025

Dalia Kasperaviciute is reporting on the first few thousand of the NHS newborn screening Generation Study. 27 mutations identified (0.5% of cases), of which 19 would be missed by the current blood spots screening program. #eshg2025

120

Reposted by Luke Jostins-Dean

Aleena M Stolworthy @aleenamolbio.bsky.social · 24/05/2025

Who licks bones found in excavation sites? Archaeologists! To test if it's a bone or a stone. Johannes Krause at #eshg2025 on tackling modern human DNA contamination of samples from archaeological sites.

2177