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Lisa Bauer

@lisabauervirus.bsky.social
528 followers 796 following 44 posts

Virologist| Assistant Professor @ErasmusMC #RielScience | previous ESR in Marie Curie Network Antivirals @UtrechtUni |🇦🇹🇪🇺🇳🇱| Opinions and Typos are my own!

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Reposted by Lisa Bauer
Ed Hutchinson @socialinfluenza.bsky.social · 18/05/2026
Absolutely extraordinary work from Hui Gao, John Briggs and co @mpibiochem.bsky.social on the structure of the influenza matrix protein in situ, particularly in filamentous virions. It's beautiful, and answers questions I've been wondering about for twenty years www.biorxiv.org/content/10.6...
A reconstruction of part of the M1 helix of influenza A virus (looking from the outside of the virion, down onto the top of the N terminal domain of M1), showing a helix of M1 protomers (blue) bound to phosphatidyl inositol (green), and a 'seam' of M1 protomers placed every fourth unit in a distinct conformation (pink) which allows them to bind to the C-terminal domains of the NA tetramer (yellow).
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Reposted by Lisa Bauer
Ed Hutchinson @socialinfluenza.bsky.social · 18/05/2026
Why do influenza viruses make ludicrously long filamentous virions? Probably lots of reasons, but in a new study Lu Liu et al. provide evidence for an appealing hypothesis: filaments are more stable in acidic solutions and hence survive for longer in aerosols www.nature.com/articles/s41...
Electron micrographs showing influenza virions of varying morphologies, from spheres to filaments
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Dr Emma Hodcroft @firefoxx66.bsky.social · 08/05/2026
I've built some initial Nextstrain phylogenies of the Andes Hantavirus variant, which include the sequence generated by HUG & UniZurich, Switzerland. Please interpret with caution. By segment: S: nextstrain.org/groups/hodcr... M: nextstrain.org/groups/hodcr... L: nextstrain.org/groups/hodcr...
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Lisa Bauer @lisabauervirus.bsky.social · 05/05/2026
@thijskuiken.bsky.social
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Reposted by Lisa Bauer
ESWI @eswinfluenza.bsky.social · 14/04/2026
🧠🦠 New #ESWIAirborne podcast episode out now! How do viruses move from environmental spillover to the brain—and what can this tell us about future #PandemicPreparedness? 🎧 Listen now: eswi.org/activities/p...
eswi.org
From Spillover to the Brain: Understanding Zoonotic Viruses Across the Life Cycle of Infection | ESWI
Our guests are early career scientists active in opposite ends of the infection spectrum: one scientist is a virus hunter, tracking viruses in urban environments, while the other investigates how viru...
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Reposted by Lisa Bauer
Daniel Hurdiss @danielhurdiss.bsky.social · 11/04/2026
For a plain-language overview of our work, see this lay summary courtesy of Kudos: www.growkudos.com/publications...
growkudos.com
Shapeshifting spike proteins help coronaviruses infect whales and dolphins
Coronaviruses use spike proteins to enter cells. This study shows these spikes can change shape, helping the viruses adapt to new hosts, including whales and dolphins. Understanding this flexibility may help predict and prevent future cross-species infections.
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Lisa Bauer @lisabauervirus.bsky.social · 03/04/2026
Had a blast in participating in this podcast about understanding zoonotic viruses across the life cycle of infection. 👇 ESWI Airborne: Shaping the Future of Respiratory Virus Research eswi.org/activities/p...
eswi.org
ESWI Airborne: Shaping the Future of Respiratory Virus Research | ESWI
Tune in to the new ESWI podcast podcast series featuring Early Career Scientist featuring researchers who will help shape the next decades of influenza and respiratory virus research.
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Reposted by Lisa Bauer
allen institute @alleninstitute.org · 01/04/2026
The Orange Cat Brain Atlas is here. 🧠🐈 Today, we published the first comprehensive cellular map of the orange cat brain. The new atlas reveals a single, specialized neuron responsible for behaviors like staring at walls, knocking objects off tables, and the 3am "zoomies."
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Kristian G. Andersen @kgandersen.bsky.social · 29/03/2026
Lab Leakers: "SARS-CoV-2 can't infect bats, so it must have been made in a lab". Science: "Let's do the experiment". SARS-CoV-2 behaves exactly like one would expect in a reservoir species - low-level infection, no overt disease, etc. Elegant study from Sato Lab: www.biorxiv.org/content/10.6...
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Oliver Harschnitz @harschnitz.bsky.social · 16/03/2026
Just two weeks left to apply to the IGNITION PhD Programme! We’re offering fully funded PhD positions. Join our team @humantechnopole.bsky.social to use cutting-edge human stem cell models to study immune mediated neurodegeneration. For more info check out: ignition-consortium.eu Please share 🙏
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Lisa Bauer @lisabauervirus.bsky.social · 14/03/2026
Thanks to everyone that contributed Feline Benavides, Syriam Sooksawasdi Na Ayudhya, Ashley Pereirinha Da Silva, Mark Power, Willemijn Rijnink, Auriane Deguergue, Björn Meyer, Femke de Vrij, Debby van Riel and Kristina Lanko
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Lisa Bauer @lisabauervirus.bsky.social · 14/03/2026
We show that NPEVs disrupt spontaneous neural activity in a virus-specific manner, and this disruption does not correlate with viral replication efficiency. Using a neural network model, we show that NPEVs can compromise neurotransmission.
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Lisa Bauer @lisabauervirus.bsky.social · 14/03/2026
NPEVs are known to cause serious neurological complications such as meningitis, encephalitis, and acute flaccid paralysis, yet the mechanisms behind their effects on neural function remain poorly understood.
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Lisa Bauer @lisabauervirus.bsky.social · 14/03/2026
🧠🦠Excited to share our latest work on non-polio enteroviruses (NPEVs) and their impact on the brain. #Enteroviruses #Neuroscience #Virology #Neurovirology #InfectiousDiseases www.thelancet.com/journals/ebi...
thelancet.com
Non-polio enterovirus infection and electrophysiological changes in human iPSC-derived neural networks
Our results demonstrate that neurotropic NPEVs lead to disruption of spontaneous neural activity in a virus-specific manner, which does not correlate with their replication efficiency.
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Reposted by Lisa Bauer
Meyer Lab @themeyerlab.bsky.social · 13/03/2026
Non-polio enterovirus infection and electrophysiological changes in human iPSC-derived neural networks Work led by @lisabauervirus.bsky.social and our tiny contribution with our former Erasmus+ student, Auriane. www.sciencedirect.com/science/arti...
sciencedirect.com
Non-polio enterovirus infection and electrophysiological changes in human iPSC-derived neural networks
The non-polio enteroviruses (NPEV) enterovirus D68 (EV-D68) and enterovirus A71 (EV-A71) are highly prevalent and considered pathogens of increasing h…
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Reposted by Lisa Bauer
Nature Microbiology @natmicrobiol.nature.com · 28/01/2026
go.nature.com
Genomic features associated with sustained mammalian transmission of avian influenza A viruses
Nature Microbiology, Published online: 27 January 2026; doi:10.1038/s41564-025-02257-4Reduced GC-related content in the influenza A virus genome may be a necessary condition for sustained mammalian transmission and should be included in risk assessment tools for pandemic influenza.
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Reposted by Lisa Bauer
Nature Microbiology @natmicrobiol.nature.com · 28/01/2026
Out Now! Genomic features associated with sustained mammalian transmission of avian influenza A viruses #MicroSky
go.nature.com
Genomic features associated with sustained mammalian transmission of avian influenza A viruses
Nature Microbiology, Published online: 27 January 2026; doi:10.1038/s41564-025-02257-4Reduced GC-related content in the influenza A virus genome may be a necessary condition for sustained mammalian transmission and should be included in risk assessment tools for pandemic influenza.
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Reposted by Lisa Bauer
Ed Hutchinson @socialinfluenza.bsky.social · 24/01/2026
Beautiful work from @efodor.bsky.social and Jonathan Grimes' labs - the first full structure of the influenza A virus NEP protein, and a clear indication that its role in viral replication is more nuanced that first thought www.science.org/doi/10.1126/...
science.org
Regulatory hotspot on the influenza A virus polymerase revealed through the structure of the NEP-polymerase complex
Structural studies reveal how influenza virus switches between making new RNA genomes and exporting them from the host nucleus.
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Thijs Kuiken @thijskuiken.bsky.social · 23/01/2026
First evidence in Europe of highly pathogenic avian influenza virus H5N1 infection in a dairy cow. Antibodies against H5N1 detected in a cow with mastitis and respiratory signs on a Dutch dairy farm at the end of December. A cat on that farm had died from H5N1. www.tweedekamer.nl/downloads/do...
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Thijs Kuiken @thijskuiken.bsky.social · 24/01/2026
However, highly pathogenic avian influenza H5N1 no longer occurs just in birds. Worldwide, nearly 100 species of mammals have been found positive, including farmed maammals like cows, pigs and minks, and wild mammals like seals, sea lions, foxes and skunks. www.nature.com/articles/s41...
nature.com
Evolution, spread and impact of highly pathogenic H5 avian influenza A viruses - Nature Reviews Microbiology
In this Review, Fouchier and colleagues explore the evolution, spread and zoonotic risks of highly pathogenic H5 avian influenza viruses. They highlight recent unusual outbreaks, discuss future prepar...
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Reposted by Lisa Bauer
Thijs Kuiken @thijskuiken.bsky.social · 24/01/2026
Second, it raises the question whether national governments should start systematic avian influenza in mammals. Currently, this is only performed in birds.
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Thijs Kuiken @thijskuiken.bsky.social · 24/01/2026
This first probable case of highly pathogenic avian influenza in a dairy cow in Europe raises two points. First, it suggests that virus incursion is possible in the Dutch housing system, which differs from that in the southern U.S., where cows were first infectted. www.science.org/content/arti...
science.org
Bird flu antibodies found in cow in the Netherlands, a first outside of U.S.
Dead cat led to discovery, but officials stress no further spread of H5N1 has been detected
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Lars-Anders Carlson @lacarlson.bsky.social · 23/01/2026
I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look! #virology #teamtomo www.nature.com/articles/s41...
nature.com
Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation - Nature Communications
In this study, Dahmane et al use a method called cryo-electron tomography to uncover new details of how tick-borne flaviviruses transform cells into virus factories.
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ATgliaNet @atglianet.bsky.social · 16/12/2025
*ATgliaNet Symposium 2026* 📅 March 20th, 2026, 9:30 - 18:00 📍 Location: Center for Brain Research, Spitalgasse 4, Vienna Keynote speaker Prof. Leda Dimou (University of Ulm) Website for registration and abstract submission (until February 13th): hirnforschung.meduniwien.ac.at/ueber-uns/ev...
hirnforschung.meduniwien.ac.at
ATgliaNet Symposium 2026, March 20th, 2026 | MedUni Wien
Large Seminar Room 1st Floor on the left, Center for Brain Research, Spitalgasse 4
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Flo Débarre @flodebarre.eurosky.social · 20/12/2025
#H5N1 : An infected herd was recently detected in Wisconsin, and genome sequencing indicates that this is yet another spillover event, making it the fourth detected one. How do these spillovers happen and why are they restricted, so far, to the US? www.aphis.usda.gov/news/agency-...
WASHINGTON, D.C., December 19, 2025—On December 14, 2025, USDA’s Animal and Plant Health Inspection Service (APHIS) announced the first detection of highly pathogenic avian influenza (HPAI) in a dairy herd in Wisconsin. On December 17, the National Veterinary Services Laboratories (NVSL) completed whole genome sequencing and confirmed that the virus is H5N1 clade 2.3.4.4b genotype D1.1. Analysis indicates that this detection is a new spillover event from wildlife into dairy cattle, separate from previous events.

Key Points

Most detections in U.S. dairy herds have resulted from movements linked to the original spillover event that occurred in the Texas Panhandle in late 2023, involving the B3.13 strain.
In early 2025, through the National Milk Testing Strategy, USDA detected two spillover events in Nevada and Arizona dairy herds. Both were identified early, and no further herd infections occurred through animal movements. These events involved the D1.1 strain.
The Wisconsin herd, also detected through the National Milk Testing Strategy, represents a new, separate spillover event and involves the D1.1 strain. At this time, no additional dairy herds have been identified as infected in association with this event.
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Lisa Bauer @lisabauervirus.bsky.social · 19/12/2025
@thijskuiken.bsky.social
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Ed Hutchinson @socialinfluenza.bsky.social · 19/12/2025
BBC News - Drones detect deadly virus in Arctic whales' breath www.bbc.co.uk/news/article... (it is, in case you're wondering, cetacean morbillivirus)
bbc.co.uk
Drones detect deadly virus in Arctic whales' breath
Whale breath collected by drones is giving clues to the health of wild humpbacks and other whales.
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Aberle Judith @aberlejudith.bsky.social · 19/12/2025
Woche 2 der Grippewelle in Österreich: Über 100 Influenzafälle 📈 im #Sentinelsystem #ZentrumVirologie Virus Subtypverteilung verschiebt sich weiter Richtung H3N2 (80% der Influenza-Proben) Anstieg der Influenza-Hospitalisierungen (SARI Dashboard) Wenn ihr Symptome habt, bleibt bitte zu Hause
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Thijs Kuiken @thijskuiken.bsky.social · 16/12/2025
See also the comment by Jessica Belser (@jessbelser.bsky.social): "A pandemic toolbox for clade 2.3.4.4b A(H5N1) influenza virus risk assessment": www.thelancet.com/journals/lan...
thelancet.com
A pandemic toolbox for clade 2.3.4.4b A(H5N1) influenza virus risk assessment
Since 1997, more than 1000 cases of highly pathogenic avian influenza A(H5N1) have been reported in humans.1 During this time, A(H5N1) viruses have evolved into dozens of clades, showing ever-expandin...
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Thijs Kuiken @thijskuiken.bsky.social · 16/12/2025
Current H5N1 avian influenza viruses replicate better in human respiratory tissues than a historic one, warranting "the urgency to prevent cross-species transmission to humans by controlling spillover events to mammals and limiting viral spread in farmed mammals." www.thelancet.com/journals/lan...
Replication of clade 2.3.4.4b H5N1 virus, clade 2.1.3.2 H5N1 virus and H3N2 virus in human primary nasal and tracheobronchial respiratory epithelium Replication kinetics of H3N2 , H5N1 , H5N1 Polecat2022 , or H5N1 Bovine2024 in two independent experiments in nasal respiratory epithelium (A, B) and tracheobronchial epithelium (C) cultures with a multiplicity of infection of 0⋅1. Replication kinetics were performed in technical duplicates in three independent experiments and data represented show the mean with 95% CIs. (D) Detection of influenza A virus nucleoprotein by immunohistochemistry in the nasal and tracheobronchial epithelium cultures 24 h after inoculation. Source: Attachment and replication of clade 2.3.4.4b influenza A (H5N1) viruses in human respiratory epithelium: an in-vitro study
Bauer, Lisa et al. The Lancet Microbe, Volume 0, Issue 0, 101230
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The Lancet Microbe @lancetmicrobe.bsky.social · 15/12/2025
Plus linked comment A pandemic toolbox for clade 2.3.4.4b A(#H5N1) #influenza virus risk assessment www.thelancet.com/journals/lan... #IDSky #ClinMicro #ViroSky #OpenAccess #OA
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The Lancet Microbe @lancetmicrobe.bsky.social · 15/12/2025
New research article Attachment and replication of clade 2.3.4.4b #influenza A (#H5N1) viruses in human respiratory epithelium: an in-vitro study www.thelancet.com/journals/lan... #IDSky #ClinMicro #ViroSky #OpenAccess #OA
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NWO XL Consortium "Viruses like it Sweet" @viruseslikeitsweet.bsky.social · 15/12/2025
Check out the new publication of Viruses like it 🍬🍭! @lisabauervirus.bsky.social and @debbyvanriel.bsky.social investigated the clade 2.3.4.4b A(H5N1) influenza virus attachment and replication in human respiratory epithelium! Congratulation to all involved!
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Lisa Bauer @lisabauervirus.bsky.social · 15/12/2025
Excited to share that our mansucript is finally published! Check it out here: www.thelancet.com/journals/lan...
thelancet.com
Attachment and replication of clade 2.3.4.4b influenza A (H5N1) viruses in human respiratory epithelium: an in-vitro study
Clade 2.3.4.4b H5N1 viruses have phenotypic characteristics that are different from a clade 2.1.3.2 H5N12005 virus. The ability of clade 2.3.4.4b viruses to attach to and replicate in respiratory epit...
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Gesa Hoffmann @gesahoffmann.bsky.social · 02/12/2025
Have you ever wondered how it is possible that systemically infected plants produce (a certain percentage of) healthy progeny? 💚 Check out the first preprint of the @incavirus.bsky.social lab and first preprint of my postdoc! 🍀 We'd be very happy about feedback and discussions!
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Sam J Wilson @samjwilsonphd.bsky.social · 27/11/2025
How does fever work? Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence. This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵 www.science.org/doi/10.1126/...
science.org
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
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Lisa Bauer @lisabauervirus.bsky.social · 08/11/2025
Congratulations to both of you🥳! Can't wait to see what the new chapter brings you @nicolapalazzi.bsky.social
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Oliver Harschnitz @harschnitz.bsky.social · 07/11/2025
Huge congratulations to @nicolapalazzi.bsky.social for successfully passing his PhD viva. It has been an amazing journey and a privilege to work with you over the past years! Can't wait to share the exciting discoveries you made. Thanks also to the examiners Mirko Cortese and Ilija Brizic. #ProudPI
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Lisa Bauer @lisabauervirus.bsky.social · 06/11/2025
We are currently looking for a postdoc within Viruses like it Sweet! If you are interested come and join us!
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Thijs Kuiken @thijskuiken.bsky.social · 24/10/2025
Australian government: "Suspected H5 bird flu in elephant seals at Australian sub-Antarctic Island". If this is correct, then highly pathogenic avian influenza will have invaded Oceania, the last continental region that was still free of the disease. www.agriculture.gov.au/about/news/s...
Southern elephant seals on Heard Island (Australian territory). Photo: Matt CurnockLocation of Heard Island, Australian territory. Source: Google Maps.
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NWO XL Consortium "Viruses like it Sweet" @viruseslikeitsweet.bsky.social · 30/09/2025
You can find my details here: www.linkedin.com/in/shannon-v...
linkedin.com
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NWO XL Consortium "Viruses like it Sweet" @viruseslikeitsweet.bsky.social · 30/09/2025
I'll be investigating virus-glycan interactions using ion mobility-MS. When I'm not in the lab, you'll find me reading or doing cross-stitch embroidery! 🧵📚 #PhDLife #Glycoscience #MassSpectrometry
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NWO XL Consortium "Viruses like it Sweet" @viruseslikeitsweet.bsky.social · 30/09/2025
We welcome Shannon Vogelaar to the NWO consortium “Viruses like it Sweet” 🍭🍬🍫 .
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Björn Meyer @bmeyer.bsky.social · 02/09/2025
EBV induces CNS homing of B cells attracting inflammatory T cells. www.nature.com/articles/s41...
nature.com
EBV induces CNS homing of B cells attracting inflammatory T cells - Nature
Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.
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NWO XL Consortium "Viruses like it Sweet" @viruseslikeitsweet.bsky.social · 28/08/2025
Even though it is not #glycotime, we are happy to share a new research project from our consortium members @debbyvanriel.bsky.social and @lisabauervirus.bsky.social! Well done #RielScience Team🧪🦠🔬🎉. Find👇 a guide through the project
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Lisa Bauer @lisabauervirus.bsky.social · 28/08/2025
My special gratitude goes to my amazing co-workers. Feline and Syriam who kickstarted the project with me. Kristina Lanko another experimental partner in crime. @bmeyer.bsky.social for sharing reagents and @debbyvanriel.bsky.social for all the helpful discussions.
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Lisa Bauer @lisabauervirus.bsky.social · 28/08/2025
🤔 Why does this matter? Understanding HOW NPEVs damage the brain could lead to new treatments for patients with NPEV-induced neurological complications! 💊🧠 Our data represent a step to understanding the mechanisms of NPEV induced neuropathologies.
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Lisa Bauer @lisabauervirus.bsky.social · 28/08/2025
⚡We used the micro-electrode array from Axion to study the effect of NPEVs on neural networks. All viruses inhibited the electrophysiology- but at different kinetics: 🥇 EV-D68 A2/2018: Fastest, most severe damage 🥈 EV-D68 B3/2019: Moderate speed/severity 🥉 EV-A71: Slower but significant
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Lisa Bauer @lisabauervirus.bsky.social · 28/08/2025
🧪 To study this, we established a neural co-culture model consisting of hiPSC-derived neurons & astrocytes. We focused on EV-D68 (all clades) & EV-A71: Almost all viruses replicated well, but showed different "tastes"—EV-D68 preferred neurons while EV-A71 infected both cell types equally! 🦠
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Lisa Bauer @lisabauervirus.bsky.social · 28/08/2025
🧠🦠 Non-polio enteroviruses (NPEV) cause neurological complications like meningitis, encephalitis & acute flaccid paralysis—but we still don't fully understand HOW these viruses disrupt neural function! Here we have evidence that NPEV compromise neurotransmission 👇 doi.org/10.1101/2025...
doi.org
Non-polio enteroviruses compromise the electrophysiology of a human iPSC-derived neural network
The non-polio Enteroviruses enterovirus-D68 (EV-D68) and enterovirus-A71 (EV-A71) are highly prevalent and considered pathogens of increasing health concern. While most enterovirus infections are mild...
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