iiinova — where your digital self keeps evolving

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Elizabeth McKenna @elizsmckenna.bsky.social · 28/07/2026

Now online in Cancer Discovery @aacrjournals.bsky.social: Systematic Targeting of Protein Complexes with Molecular COUPLrs - by Diane Yang, Stefan Andrew Harry, Harrison Byron Chong, Neha Khandelwal, Edwin Zhang, John Iafrate, @liron1bar-peled.bsky.social, and colleagues doi.org/10.1158/2159...

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Ubellacker Lab @ubellackerlab.bsky.social · 18/08/2025

Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV

rdcu.be

Prospects for ferroptosis therapies in cancer

Nature Cancer - Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of...

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The Mark Foundation for Cancer Research @themarkfdn.bsky.social · 03/04/2025

Last night, past Mark Foundation Emerging Leader Award winners gathered with this year’s recipients, @marasherman.bsky.social , @liron1bar-peled.bsky.social, Kai Kessenbrock, Ansu Satpathy, and Dan Wahl, to celebrate seven years of this transformational program. #MarkSymposium

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Liron Bar-Peled @liron1bar-peled.bsky.social · 26/03/2025

I’m excited to share the latest work from our lab, led by a group of three amazing scientists: Junbing Zhang, Yousuf Ali and Harrison Chong, who describe @nature the discovery of a ROS sensor, VPS35, which links cytosolic H2O2 levels to regulation of mitochondrial translation and

nature.com

Oxidation of retromer complex controls mitochondrial translation - Nature

Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive ox...

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Brian Liau @brianliau.bsky.social · 12/02/2025

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

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Srinivas Viswanathan MD, PhD @srviswanathan.bsky.social · 06/02/2025

Excited to share our new study on translocation RCC (tRCC) in collaboration with @liron1bar-peled.bsky.social. We reveal how the TFE3 fusion drives a key oxidative phosphorylation (OXPHOS) metabolic program in this rare kidney cancer. trebuchet.public.springernature.app/get_content/... 1/

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The Mark Foundation for Cancer Research @themarkfdn.bsky.social · 15/01/2025

@liron1bar-peled.bsky.social will use his ELA to develop "molecular staples," a new class of drugs designed to disrupt oncogenic fusion proteins, which form when two genes abnormally join together and can drive many different types of cancers. @massgeneralbrigham.bsky.social

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Hank Adelmann @hankadel.bsky.social · 27/12/2024

We’ve preprinted a small follow-up to our identification of MFSD12 as a mediator of lysosomal cysteine import. Would love to discuss, so please get in contact if you have comments or suggestions!

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Behnam Nabet @behnamnabet.bsky.social · 27/12/2024

🧪 Ready, set, degrade! So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer. Link: www.jci.org/articles/vie...

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David Konrad @dbkonrad.bsky.social · 03/12/2024

We are moving one step closer to our goal to develop a general method to red-shift photoswitchable ligands as a foundation for in vivo photopharmacology with our latest work: "A platform for the development of highly red-shifted azobenzenes". Link: doi.org/10.26434/che....

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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 01/12/2024

“NIH produces an astounding return on investment to the American taxpayer. In Fiscal Year 2022, NIH research funding supported 568,585 jobs and generated $96.84 billion in economic activity — that’s $2.64 of economic activity for every $1 of research funding.” www.researchamerica.org/2023-oped-us...

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Christian Frezza @frezzalab.bsky.social · 21/11/2024

Like ‘old Twitter’: The scientific community finds a new home on Bluesky another incredible piece of news! www.science.org/content/arti...

science.org

Like ‘old Twitter’: The scientific community finds a new home on Bluesky

After recent changes to Elon Musk’s X, a gradual migration turns into a stampede

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