The allosteric mechanisms by which lipid binding controls protein activity remain poorly understood. Here, the authors identify a lipid-triggered allosteric site in LC3 that remodels its receptor-binding interface upon membrane interaction. This site can be engineered to precisely tune LC3-LIR interactions, offering a new strategy to regulate selective autophagy.

Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...

Mommy, a Western Santa Cruz tortoise, recently welcomed four hatchlings at the Philadelphia Zoo, where she has lived since 1932.

Hepatic stellate cells regulate hepatocyte functions via R-spondin 3.

Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

PhD Project - MRC DiMeN Doctoral Training Partnership: Macrophage reprogramming in response to the clearance of pathogen-induced cell death. at Newcastle University, listed on FindAPhD.com

In mouse and nonhuman primate models, treatment with selective, long-acting neurokinin 2 receptor agonists aids weight loss by suppressing appetite and increasing energy expenditure, as well as b...

Das et al. show that VPS4A regulates lysosomal LD turnover independent of its canonical endosomal function. Phosphorylated VPS4A tethers LDs to LC3, facilitating selective lipophagy. VPS4A levels corr...

Peripheral organ dysfunction can have considerable effects on brain health, contributing to neurodegeneration and dementia. This Review explores how clinical and subclinical dysfunction of specific or...