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Lingchen He 何灵尘

@lingchenhe.bsky.social
90 followers 170 following 33 posts

Someone‖‖Postdoc‖MGEs‖HGT‖Phage person but sometimes anti-phage

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Reposted by Lingchen He 何灵尘
Jorge Moura de Sousa @jmouradesousa.bsky.social · 20/09/2026
Happy to see our work on the evolution of antiviral repertoires in P4-like satellites and their P2-like helper phages (check out the 🧵 👇) out in @narjournal.bsky.social 🔗 doi.org/10.1093/nar/... #phagesky #MicroSky #evosky
doi.org
Shuttling, swapping, and mixing: the rapid modular evolution of antiviral repertoires in temperate phages and their satellites
Abstract. Interactions between bacteria, bacteriophages, and their satellites are shaped by a myriad of defence and counter-defence mechanisms. Here, we id
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 18/09/2026
Ideas are not cheap and the provement is even more expensive
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 16/09/2026
What a beautiful work! Must read for understanding how plasmids emerge 🌿🌿🌿
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 24/07/2026
It was a crime.
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 09/07/2026
Magnificent
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Jakob T Rostøl @jakob-tr.bsky.social · 20/05/2026
Like a prophage being awakened from its slumber, the phage field has seen a lot of renewed activity during the last decade. Check out our new @natrevmicro.nature.com review on the temperate phage life cycle here to stay up-to-date 🧫🦠 www.nature.com/articles/s41...
nature.com
Revisiting the life cycle of temperate phages - Nature Reviews Microbiology
The life cycle of temperate bacteriophages involves lytic or lysogenic cycles and has historically served as a model for studying genetic regulation. This Review provides an updated overview of these ...
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Kranzusch Lab @kranzuschlab.bsky.social · 12/06/2026
How do human cells defend against viruses? @sgfern.bsky.social discovers that human immune proteins named ISGs target ancient features of replication shared between animal and bacterial viruses – opening analysis of human immunity to the power of bacterial genetics www.biorxiv.org/content/10.6...
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Tominaga K. (tomiken) @pacyc184.bsky.social · 12/05/2026
Phage satellites induced by virulent phages are mobilized by natural competence leading to phage resistance in a new host | Nature Communications www.nature.com/articles/s41467-026-…
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Tung Le @tunglejic.bsky.social · 16/04/2026
Finally published. Many thanks to a wonderful collaborative team and scientific platforms!!! And thanks to editors and reviewers for enthusiasm and a great review. www.nature.com/articles/s41...
nature.com
A bacterial CARD–NLR-like immune system controls the release of gene transfer agents - Nature Microbiology
An immunity-like system functions as a lysis control hub to promote gene transfer agent particle release from host bacterial cells, suggesting that bacterial immune systems may be co-opted to promote ...
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 17/04/2026
Very cool, happy to see it out!
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 13/04/2026
No enough drink for jokes
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 01/04/2026
01, April
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 23/03/2026
Pizza gratis!
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 20/03/2026
I am educated by human beings, so I am actually an AI...
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Reposted by Lingchen He 何灵尘
Waggoner Lab @labwaggoner.bsky.social · 12/03/2026
Capturing dynamic phage–pathogen coevolution by clinical surveillance @nature.com @ucberkeleyofficial.bsky.social www.nature.com/articles/s41...
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Tiago Costa @tcostalab.bsky.social · 04/03/2026
Please RT:📢We are hiring a Post-Doc in Structural Biology to join our multidisciplinary team. Project: study molecular mechanisms of horizontal gene transfer using cryo-EM and integrative structural biology. Apply: shorturl.at/ecrVL #StructuralBiology #CryoEM #Postdoc
shorturl.at
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
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Reposted by Lingchen He 何灵尘
ugobananas @uugobananas.bsky.social · 04/03/2026
This is the first time we observed bacteria use plasmolysis to defence against phages! biorxiv.org/content/10.6... Thanks all the authors to discover this together! @fnobrega.bsky.social Zhiying @garushyants.bsky.social Dinshaw and Eugene
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 12/02/2026
I finally read the paper overnight and found it is really good and worthy to read. Thank you Thomas.
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 05/02/2026
What does that mean?
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Emmanuele Severi @emmseveri.bsky.social · 30/10/2025
#phagesky jumbo #phage -mediated HGT www.pnas.org/doi/10.1073/...
pnas.org
Jumbo phage–mediated transduction of genomic islands | PNAS
Bacteria acquire new genes by horizontal gene transfer, typically mediated by mobile genetic elements (MGEs). While plasmids, bacteriophages, and c...
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 22/10/2025
🤟🤟🤟🤟🤟
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 30/09/2025
Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces www.gla.ac.uk/postgraduate... please repost
gla.ac.uk
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Paul A Hoskisson
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 26/09/2025
🔥🔥🔥
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 24/09/2025
Congrats!!
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Reposted by Lingchen He 何灵尘
Sorek Lab @soreklab.bsky.social · 11/09/2025
Phage "satellites" that produce capsids but have no genes to produce tails have puzzled scientists for a long time. These are abundant as prophages in bacteria, but it was unclear how they can infect without tails Now, Penadés & co show that they hijack tails from other phages. Incredible!
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 10/09/2025
Thank you Joao!
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 10/09/2025
😃 www.cell.com/cell-host-mi...
cell.com
(Ph)ighting Phages: How Bacteria Resist Their Parasites
Bacteria are threatened by viral attack in every environment they colonize. For more than 100 years, microbiologists have investigated the mechanisms in place to contain these attacks. Rostøl and Marr...
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 10/09/2025
😉Thank you Aisling!
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 10/09/2025
😊Thank you Nuria!
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 09/09/2025
A big thank you for everyone involved Jinlong, @alfredfisa.bsky.social, Laura and Christopher. For more details, plz read www.cell.com/cell/fulltex...
cell.com
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails from unrelated species to transfer their DNA across bacterial hosts. This tail piracy enables broad dissemination and ...
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 09/09/2025
Finally, we demonstrated evolutionary homology between cf-PICI and phage HK97 capsids, while showing that cf-PICIs avoid interference during capsid assembly through finely tuned interactions, thereby ensuring efficient and specific packaging of their own DNA. @jonaszpatkowski.bsky.social
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 09/09/2025
In addition, we identified adaptor and connector genes as central to capsid–tail chimeric assembly, with high variability during the evolution of tail-less capsids.
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 09/09/2025
This uncovers unexpected complexity in phage–satellite interactions, challenging the long-held view that satellites rely on a single helper phage to complete their lifecycle.
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 09/09/2025
We revealed a key feature of tail piracy: cf-PICIs can exploit multiple helper phages—one inducing their cycle, another supplying tails. Remarkably, cf-PICIs can even accumulate tail-less particles without helper phage induction, and factors causing cell lysis can release them.
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 09/09/2025
We discovered a new horizontal gene transfer mechanism: tail-less cf-PICIs hijack free phage tails extracellularly, forming infectious chimeric virions that drive both intra- and inter-species transfer among bacteria. @jonaszpatkowski.bsky.social @tcostalab.bsky.social @jrpenades.bsky.social
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PHD Comics @phdcomics.com · 10/08/2025
Did you get the email I sent 😭
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cc 🌷 @ccsartcafe.bsky.social · 01/08/2025
Picking blueberries 💙🐦
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Emmanuele Severi @emmseveri.bsky.social · 29/07/2025
#phagesky www.cell.com/cell-host-mi...
cell.com
The prototypic crAssphage is a linear phage-plasmid
Schmidtke et al. demonstrate that C. communis, a ubiquitous human gut phage that evades conventional plaque-based isolation, predominately replicates as a low-copy linear phage-plasmid with a broad ho...
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 28/07/2025
Congratulations Franklin, Yi and all the authors!! Very beautiful work!
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Franklin Nobrega @fnobrega.bsky.social · 19/06/2025
Thank you to everyone who attended the 3rd UK MGE workshop. What an incredible few days of science and community building! Next stop: York 2026, hosted by @pcmfogg.bsky.social. See you all next year! #UKMGE
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Tung Le @tunglejic.bsky.social · 09/05/2025
1/ Excited to share our latest work on gene transfer agents (GTAs) in Caulobacter crescentus, led by Emma Banks in collaboration with Pavol Bardy and Mai Nguyen from York!!! See a brief thread below. shorturl.at/o6S1w
shorturl.at
A bacterial CARD-NLR immune system controls the release of gene transfer agents
Bacteria have evolved a wide array of immune systems to detect and defend against external threats including mobile genetic elements (MGEs) such as bacteriophages, plasmids, and transposons. MGEs are ...
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Reposted by Lingchen He 何灵尘
Fernando Gonzalez-Candelas @fgonzalef.bsky.social · 07/05/2025
Good papers, like good wine, need maturing. I'm proud and thrilled to share our work on genomic epidemiology of K.pneumoniae in Valencia and differential transmission patterns of resistances, part of Neris Garcia's PhD thesis and the NLSAR consortium. go.uv.es/td8iL4c #publichealth #EpiSky 🧬🖥️
go.uv.es
Genomic surveillance reveals different transmission patterns between third-generation cephalosporin and carbapenem resistance in Klebsiella pneumoniae in the Comunidad Valenciana (Spain), 2018–2020 - ...
Background The emergence and spread of third-generation cephalosporins (3GC) and carbapenem-resistant Klebsiella pneumoniae pose a global critical challenge. Understanding the transmission dynamics wi...
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Reposted by Lingchen He 何灵尘
Jose A Escudero @jaescudero.bsky.social · 08/05/2025
🧪 Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉 Short 🧵 www.science.org/doi/10.1126/...
science.org
Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 08/05/2025
Three to one, tales! (✓)
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Andreas Haag @andreashaag.bsky.social · 01/05/2025
Interested in fighting AMR? Come and join us at St Andrews. applications are open until 15th May to students worldwide!
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Trevor Lithgow @trevor-lithgow.bsky.social · 01/05/2025
"That telomere phages are so prevalent means that they are a selective force, one that we know little about. We now want to understand how the telomere-toxin is secreted and also understand how this ‘telocin’ wheedles its way into unsuspecting bacterial neighbors” www.science.org/doi/10.1126/...
science.org
Telomere bacteriophages are widespread and equip their bacterial hosts with potent interbacterial weapons
Klebsiella host strains infected with telomere phages can grow to be the dominant lineage in mixed populations.
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Reposted by Lingchen He 何灵尘
Alex Crits-Christoph @acritschristoph.bsky.social · 25/04/2025
Unique investigation of some errors in long read assemblers. In particular these remarkably chimeric contigs are 😱, if rare.... Improving long read assemblers is definitely the space to be in when it comes to the future of metagenomics, as short reads won't be part of it 😉
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 16/04/2025
?
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Eduardo Rocha @epcrocha.bsky.social · 14/04/2025
New paper @isme-microbes.bsky.social : Among a sample of 1044 vibrio phages, we found 17 new Schizotequatrovirus with large genomes (>250kb), a broad host range, and yet a low frequency in our samples (?!). #MicroSky #PhageSky
morphological and genomic distinctions of the phage
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PLOS Biology @plosbiology.org · 08/04/2025
The BASEL collection of E. coli #phages is limited by its host strain. @humollidorentina.bsky.social @damienpiel.bsky.social @aharms485.bsky.social &co use a modified host to add 36 new phages, revealing roles of O-antigen in recognition & R-M systems in immunity @plosbiology.org 🧪 plos.io/4jirGvX
A fanciful depiction of BASEL phages on a roadmap. Credit: Fabienne Estermann
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