Lisa Beutler @lbeutler.bsky.social · 01/10/2026The last time I witnessed you ‘ruminating’ through such a haze you were laughing uncontrollably about Mike McCready shredding so hard that he burst into flames. So you’ve gotten better with time :) 100
Lisa Beutler @lbeutler.bsky.social · 19/09/2026Kristy Noem (admittedly a former member of the admin, but still) literally killed her dog. 011
Lisa Beutler @lbeutler.bsky.social · 04/09/2026The only midatlantic dialect I know is ‘jawn’ and I cannot imagine that word crossing @jfallows.bsky.social lips 020
Reposted by Lisa BeutlerSeth Trueger @mdaware.org · 08/08/2026or people who will, say, have cancer in 10 years what treatments could we have had? the recent explosion in targeted and immunotherapy, CAR-T, etc has been frankly incredible and this hardly seems like the time to pull the rug out from scientists 19510
Lisa Beutler @lbeutler.bsky.social · 06/08/2026Sometimes people (or their families) find out they have/had underlying conditions when they get super sick or die from flu/covid/cyclosporiasis/the plague 052
Reposted by Lisa BeutlerSeth Trueger @mdaware.org · 05/08/2026in addition to the ablism, it's false reassurance -- nearly half of adults have hypertension, a lot have diabetes or high cholesterol, 7% are immunocompromised… people we encounter in our daily lives all the time we think of as healthy take BP meds, cholesterol meds, take mAbs for IBD… 49627
Lisa Beutler @lbeutler.bsky.social · 01/08/2026Embrace it. So many people wear them and understand what they are and why they are good it really doesn’t matter. I suppose if you really can’t get over the dork factor you could throw some weights in a backpack. But that is less good ergonomically. 080
Lisa Beutler @lbeutler.bsky.social · 31/07/2026None Korean and all miniseries: If you’re up for something dark, ‘Half Man’. Also ‘Baby Reindeer’ on Netflix if you’ve not seen it yet. Also ‘Adolescence’ 010
Lisa Beutler @lbeutler.bsky.social · 23/07/2026In the meantime - for anyone who hasn’t seen it, Mary-Claire’s appearance on The Moth is legendary. m.youtube.com/watch?v=tOP5...m.youtube.comThe Moth Presents Dr. Mary-Claire King at the World Science FestivalYouTube video by The Moth 100
Lisa Beutler @lbeutler.bsky.social · 23/07/2026This is awesome. I did my MD/PhD at UW and can say that Dr. King is an inspiration and a force of nature. She was not a direct scientific mentor, but I can honestly say I continued doggedly on my career path in part because of her belief in me. If someone posts a link to the essay I’d be grateful. 200
Reposted by Lisa BeutlerMark D. Garfinkel, Ph.D. @mdgarfinkel.bsky.social · 23/07/2026Ali Velshi @velshi.com just gave a terrific video essay on the power of long-term curiosity-driven biomedical research — the kind of work DOGE & Trump & Vought are killing — using the career of Mary-Claire King as his example. Excellent commentary on @msnownews.bsky.social Eleventh Hour. 165
Lisa Beutler @lbeutler.bsky.social · 20/07/2026Not the point of this post but Landsman is just an exceptional term 😂 010
Reposted by Lisa BeutlerJames Fallows @jfallows.bsky.social · 20/07/2026Unlike my landsman @brianbeutler.bsky.social, I am old enough to be on Medicare. It works *so* much better than private insurance. So much less hassle for the patient. So much less overhead paid to insurance cos. So much more straightforward, like VA. Medicare For All (who want it) as the goal. 3143795
Lisa Beutler @lbeutler.bsky.social · 16/07/2026This is good! Would have been better if he used the words ‘explosive diarrhea’, ‘Diarrhea Donald’, or ‘waterygate’ 010
Lisa Beutler @lbeutler.bsky.social · 15/07/2026This outbreak has really captured the public interest (appropriately) and it would be great if Dems attacked Diarrhea Donald on Waterygate. 030
Lisa Beutler @lbeutler.bsky.social · 15/07/2026Your perception is because you didn’t grow up with a father who is an infectious disease specialist :) @brianbeutler.bsky.social 030
Lisa Beutler @lbeutler.bsky.social · 11/07/2026Or perhaps he’s on a toilet with horrendous diarrhea of *mysterious* provenance 040
Reposted by Lisa BeutlerSarah Gollust @sarahgollust.bsky.social · 11/07/2026Did you write your comment yet on the OMB rules on federally funded science yet? No? Don’t worry, you can do it this weekend. Here are some resources that can help you get started. 10414326
Lisa Beutler @lbeutler.bsky.social · 10/07/2026Kids in the future will die of cancers that we might otherwise have discovered cures or treatments for. This rule affects us all. Please comment! 021
Reposted by Lisa BeutlerMark Histed @markhisted.org · 09/07/2026Only a few days left to comment if you have not! Please take the time. Just a few paragraphs are needed. 19063
Lisa Beutler @lbeutler.bsky.social · 19/06/2026Hahaha. I promise you that if you had the choice between us and the Obamas as dinner guests we would not fault you for choosing them 😂. But yes we should get together! 010
Lisa Beutler @lbeutler.bsky.social · 19/06/2026The famous wine rooster I’ve heard so much about!! 👀 100
Reposted by Lisa BeutlerTimothy Snyder @timothysnyder.bsky.social · 19/06/2026In countries that have successfully reversed democratic backsliding in recent years—from Poland in 2023 to Hungary in 2026—opposition movements made prosecuting those who have broken laws a central campaign issue. 10731671182
Lisa Beutler @lbeutler.bsky.social · 18/06/2026That photo has the most amazing possible Ferris Bueller vibes 0260
Lisa Beutler @lbeutler.bsky.social · 04/06/2026This was fast, meaningful, and kind of cathartic. Please leave a comment in defense of science. 120
Lisa Beutler @lbeutler.bsky.social · 02/06/2026Even though I promise I can read, I consistently find myself calling it ORCID ID - an ID card for a flower 🌺 010
Lisa Beutler @lbeutler.bsky.social · 31/05/2026Now and then. Happy 7th adoptaversary to Shiloh - our little family’s heart and soul. 190
Lisa Beutler @lbeutler.bsky.social · 29/05/2026Per @brianbeutler.bsky.social, abolish the filibuster AND… open.substack.com/pub/brianbeu...open.substack.comFilibuster Reform Is No Longer EnoughA plea for strategic forethought. 020
Reposted by Lisa BeutlerNPR @npr.org · 21/05/2026Even with federal grants largely restored, scientists say the Trump administration is still preventing those funds from reaching them. The consequences, they say, are already becoming clear. n.pr/4dwU7Fin.prResearchers say the Trump administration is finding new ways to punish scienceEven with federal grants largely restored, scientists say the Trump administration is still preventing those funds from reaching them. The consequences, they say, are already becoming clear. 10324135
Reposted by Lisa BeutlerDavid Ho @davidho.bsky.social · 09/05/2026We should fully fund science.nytimes.comIn a Milestone for A.L.S., a Treatment Helps Some Patients Improve 51258259
Reposted by Lisa Beutlersouthpaw @nycsouthpaw.bsky.social · 29/04/2026One must imagine Lukas happy 1035831
Reposted by Lisa BeutlerCell Reports @cp-cellreports.bsky.social · 03/04/2026GIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuitsdlvr.itGIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuitsProvince et al. show that parabrachial CGRP neurons mediate aversion due to interleukin-1β (IL-1β) administration. Glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism blocks aversion and CGRP activation caused by IL-1β while potentiating its anorectic effect. Dorsal vagal complex GIPR mediates anorexia due to GIPR agonism but may be dispensable for anti-aversion. 072
Reposted by Lisa BeutlerDaniel Drucker @danieljdrucker.bsky.social · 22/03/2026Localization of the inflammation associated anti-aversive actions of GIPR agonism via sites distinct from those that suppress appetite in the DVC www.cell.com/cell-reports...cell.comGIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuitsProvince et al. show that parabrachial CGRP neurons mediate aversion due to interleukin-1β (IL-1β) administration. Glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism blocks aversion ... 082
Lisa Beutler @lbeutler.bsky.social · 24/03/2026So sorry you’re going through this. Our path to getting our old dog Lewis’s lymphoma diagnosis was so incredibly stressful - fingers and toes crossed that you wind up at a manageable diagnosis and that Luigi feels better soon ❤️ 030
Lisa Beutler @lbeutler.bsky.social · 20/03/2026A much needed argument against fatalism that is also clear eyed about our grim situation (and how much grimmer it could get!) 0306
Reposted by Lisa BeutlerJeremy Berg @jeremymberg.bsky.social · 19/03/2026There are many problems with this statement from Director Bhattacharya. (1) As @michaeldgreen.phd notes, applicants have no option to requests multi-year funding. An applicant may request a front-loaded budget with more funding in early years with justification (may or may not be approved). 1/6 17633
Reposted by Lisa BeutlerMitch Roitman @mitchroitman.bsky.social · 14/03/2026The world is a vampire...get yourself good colleagues. Thanks to @jonesparker.bsky.social for the invite to Northwestern and to Jones and @lbeutler.bsky.social for having me and @jamiedroitman.bsky.social over for post-visit dinner! 051
Reposted by Lisa BeutlerJoshua Weitz @joshuasweitz.bsky.social · 07/03/2026The data also reinforce a message that should be clear: American leadership in science and medical research requires far more than getting across the line on top-line budget negotiations and will require continued vigilance to track how HHS treats applications and existing awards. 18226
Lisa Beutler @lbeutler.bsky.social · 27/02/2026How many 50s of millions do you reckon you’re owed? 020
Lisa Beutler @lbeutler.bsky.social · 25/02/2026Thank you! I initially got interested in this in part because I’ve had IBD since I was a kid. Appetite loss is an early indicator of flares and it has fascinated and frustrated me for as long as I can remember :) 010
Lisa Beutler @lbeutler.bsky.social · 25/02/2026New work from the lab on how sickness reduces appetite. Turns out, it’s complicated :) We focused on a single inflammatory cytokine, IL-1b, and even that reduces appetite via multiple mechanism. Thanks to Nik Hayes for leading and sticking with this project and to everyone else who contributed! 0116
Reposted by Lisa BeutlerJeremy Berg @jeremymberg.bsky.social · 30/01/2026To summarize: Most important Max Perutz was NOT an example of someone with a great idea who went against the establishment wisdom to solve an important problem that he had uniquely identified. He was part of an organized team working on this problem. He got lots of help. 11/14 39023
Reposted by Lisa BeutlerJournal of Clinical Investigation @jci.org · 25/01/2026Previously shared: GLP-1 physiology and pharmacology along the gut-brain axis This Review by @lbeutler.bsky.social summarizes proposed gut-brain and central mechanisms through which GLP-1 and its synthetic analogs regulate food intake and bodyweight: doi.org/10.1172/JCI194744 031
