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Laura Dearden

@lauradearden.bsky.social
421 followers 198 following 31 posts

Group leader in the IMS at Cambridge Uni• interested in how obesity in pregnancy impacts on mum and baby hypothalamus• Mum to 2 kids & menagerie of pets• she/her

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Reposted by Laura Dearden
Dr. Rachel Lippert @rachellippert.bsky.social · 22/11/2025
Calling on my #science network! TeamNDF is #hiring a postdoc to start in 2026! Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause? Learn more about the team and our research here: www.dife.de/en/research/... Please share! 🧠 🍔 💉
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Jonny Kohl @jkohl.bsky.social · 22/10/2025
Out today in Nature: We uncover a neural mechanism for the integration of two internal states - hunger and estrous state - and how this integration shapes pup-directed behaviors in mice. www.nature.com/articles/s41...
nature.com
Integration of hunger and hormonal state gates infant-directed aggression - Nature
Combined behavioural, circuit-level and cellular approaches are used to demonstrate how hypothalamic neurons integrate hunger and oestrous state to drive a switch in how female mice interact with pups...
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Laura Dearden @lauradearden.bsky.social · 17/12/2025
Our new review out with @ozannelab.bsky.social exploring the current data from rodent and human studies of GLP1R agonist use in pregnancy and short/ long-term safety for mother and offspring. !https://portlandpress.com/clinsci/article/139/23/1597/236872/Incretin-receptor-agonism-during-pregnancy
portlandpress.com
Incretin receptor agonism during pregnancy: implications for mother and baby
Obesity has been described by the WHO as the largest health threat facing mankind. More than 55% of pregnancies in the United Kingdom occur in women who are overweight or living with obesity. Obesity ...
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Women’s Health Under the Microscope @whum-camuni.bsky.social · 24/10/2025
Your blood carries more than DNA — it carries clues🩸✨. New research shows that cell-free DNA (cfDNA) could help spot preeclampsia (PE) early, giving moms and babies a safer start👩‍🍼. (1/3)
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Diabetologia @diabetologiajnl.bsky.social · 09/09/2025
Up front & free to read in our Sept issue #editorspicks: Measurement of brain glucose metabolism in obesity and diabetes link.springer.com/article/10.1...
link.springer.com
Measurement of brain glucose metabolism in obesity and diabetes - Diabetologia
The brain consumes a large amount of glucose to fuel its high metabolic demands. Understanding brain glucose metabolism is critical for understanding the brain’s normal physiology and the pathological...
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Laura Dearden @lauradearden.bsky.social · 09/09/2025
Having a fantastic time at DOHAD 2025 in the beautiful Buenos Aires. The best place for catching up with friends and collaborators!
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Laura Dearden @lauradearden.bsky.social · 29/07/2025
I can’t be at #ssib2025 this year but the amazing Rosanne and L are there to present their data on the impact of maternal obesity/GDM on offspring hypothalamic development, and what metformin use in pregnancy does to the fetal brain.
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British Society for Neuroendocrinology @bsneuroendo.bsky.social · 21/07/2025
🏆 CONGRATULATIONS to Jo Lewis, 2025 winner of the Michael Harbuz Prize! Jo will speak at #BSNBradford2025 on Glucose-dependent insulinotropic polypeptide regulates food intake and body weight via the area postrema in mice. Register: bsnbradford2025.oa-e...
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Academy of Medical Sciences @acmedsci.bsky.social · 02/07/2025
The report calls for urgent action to: 🤰 Prioritise support during pregnancy 🍴 Ensure robust regulation of the food industry 🤝 Coordinate across govt departments i.e. food, education, urban planning and transport
Professor Susan Ozanne FMedSci next to a quote that reads: "The first 1,000 days, including time in the womb, represent an important window of opportunity to set children on a healthy trajectory for life. This isn’t about individual willpower or blaming and shaming – it's about creating an environment for parents, carers and their children that supports healthy development from the very beginning."
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Academy of Medical Sciences @acmedsci.bsky.social · 02/07/2025
🚨 Childhood obesity is rising at alarming rates around the world Our latest report, with Italy’s Accademia Nazionale dei Lincei, calls for early intervention to ensure healthier futures for all children 🌱 Read the report: bit.ly/46qy7tN And see our key takeaways 🧵
bit.ly
Child’s weight for life shaped by first 1,000 days, report health experts
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British Society for Neuroendocrinology @bsneuroendo.bsky.social · 17/06/2025
We've got something NEW for BSN ECRs! 🔬📹An Early Career Methodology video tutorial series Our first tutorial is an Introduction to single-cell transcriptomics by Dr Sreekala Nampoothiri. Watch: my.neuroendo.org.uk/... Not a BSN member? Join today and get access: www.neuroendo.org.uk...
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Stina Börchers, PhD @stinaborchers.bsky.social · 18/06/2025
🧠🍽️ A "hunger switch" in the nose? Smelling food activates a pathway from the olfactory bulb to medial septum glutamatergic neurons in mice, triggering anticipatory satiety: making them feel full before eating. This circuit works in lean mice but is disrupted in obesity. #neuroskyence 🧪
nature.com
A food-sensitive olfactory circuit drives anticipatory satiety - Nature Metabolism
The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.
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Bradley Jamieson @bradleyjamieson.bsky.social · 16/06/2025
🎉 Thrilled to share my postdoc work, with our preprint out now on BiorXiv here: www.biorxiv.org/content/10.1... We investigated how the juvenile brain develops the ability to carry out care behaviours towards neonates by an exciting and surprising switch in neural activity and behaviour
biorxiv.org
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Liisa Galea @liisagalea.bsky.social · 16/06/2025
Our latest review on perimenopause menopause and hormone therapy. What key issues have we missed and how can we do better from education to research to clinical care. With Laura Gravelsins! www.cambridge.org/core/journal...
cambridge.org
One size does not fit all: how type of menopause and hormone therapy matters for brain health | The British Journal of Psychiatry | Cambridge Core
One size does not fit all: how type of menopause and hormone therapy matters for brain health
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Ionel Sandovici @isandovici.bsky.social · 04/06/2025
Very cool paper connecting nutrition, epigenetics and developmental biology. rdcu.be/eptl7
rdcu.be
Maternal iron deficiency causes male-to-female sex reversal in mouse embryos
Nature - Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.
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Meenakshi Asokan @meenakshiasokan.bsky.social · 30/05/2025
Stoked to share our new review on why neuroendocrinology needs a systems lens and why hormones should matter to systems neuroscience. It’s time for serious cross-talk!
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RyanLab_TCD @ryanlab.bsky.social · 30/04/2025
It was fantastic to have @labliston.bsky.social give a talk at the @mrc-mbu.bsky.social on building a positive research culture. Valuable for all investigators/group leaders regardless of career stage, check out the resources below: listonlab.uk/careers/
listonlab.uk
Translational Immunology - Careers
Becoming a Scientist
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Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 25/04/2025
Food insecurity drives obesity and adiposity, but how is unclear. A recent study by @clemmensenc.bsky.social developed a mouse model for this phenomenon lnkd.in/d8pEp2qv Happy to share a commentary written with @johnspeakman4.bsky.social with our take on that study doi.org/10.1002/oby....
doi.org
Scarce and unpredictable, yet obesogenic: modeling the impact of food insecurity on adiposity in mice
Click on the article title to read more.
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Laura Dearden @lauradearden.bsky.social · 30/04/2025
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Laura Dearden @lauradearden.bsky.social · 25/04/2025
Two pics from cycling around Cambridge this week. I really want to know what animal is being transported around in that basket!
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Nature @nature.com · 24/04/2025
Neurons involved in forming memories of a cold environment communicate with the part of the brain that regulates metabolic responses to cold stress go.nature.com/4lP2EHa
go.nature.com
Memories of a cold place trigger bodily responses to warm up
Neurons involved in forming memories of a cold environment communicate with the part of the brain that regulates metabolic responses to cold stress.
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Madhu Pai, MD, PhD @madhupai.bsky.social · 23/04/2025
NIH cancels its first and largest study centered on women www.science.org/content/arti...
science.org
NIH cancels its first and largest study centered on women
The Women’s Health Initiative has produced numerous influential findings
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Jeremy Berg @jeremymberg.bsky.social · 21/04/2025
The report with the underlying data for the Washington Post story about firings of disproportionate numbers of women and underrepresented minorities from NIH Boards of Scientific Counselors. docs.google.com/document/d/1...
docs.google.com
Letter_to_CongressApril16_2025_updated
April 16, 2025 (updated 4/21/2025) Senate Committee on Health, Education, Labor and Pensions House Committee on Energy and Commerce - Subcommittee on Health Washington, DC 20510 Report: Scientists...
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Laura Dearden @lauradearden.bsky.social · 17/04/2025
What a terrible loss to the field of obesity research and global health in general.
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Orange Dick Tater Hater @realbiscuitspaw.bsky.social · 11/04/2025
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Carlos Guardia @charlyguardia.bsky.social · 08/04/2025
NIH PostBac program is open again! And I will be hiring! #JobPostComing www.training.nih.gov/research-tra...
training.nih.gov
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Baptiste Lacoste @blacoste.bsky.social · 26/02/2025
Very cool new paper showing that Ago2 gene in glutamatergic neurons is critical for the formation of cerebral blood vessels in the developing mouse brain 🤩 #cerebrovascular
science.org
Glutamatergic argonaute2 promotes the formation of the neurovascular unit in mice
Neurovascular unit formation is mediated by Ago2-dependent repression of PTEN in excitatory neurons.
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Oregon 🕎🎲 @oregonthedm.bsky.social · 09/04/2025
Biggest commitment to a 3 second joke I've ever seen
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Dr Kate Womersley @katewomersley.com · 09/04/2025
If you want to learn more about MESSAGE and how to get involved in our work, you can follow us here @messagetgi.bsky.social , and on our website www.messageproject.co.uk
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allen institute @alleninstitute.org · 09/04/2025
How does the brain work? Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵 🧠📈
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Laura Dearden @lauradearden.bsky.social · 09/04/2025
More children are drawing women scientists than ever before. Good! Although these children also assume a level of PPE that is not common among most scientists I know! www.science.org/content/arti...
science.org
What does a scientist look like? Children are drawing women more than ever before
Study is based on 20,860 sketches drawn by children over 5 decades
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James Russ-Silsby @jamesr-s.bsky.social · 04/04/2025
There are fewer than 10 documented genetic causes of Transient Neonatal Diabetes (TNDM) and now PAX4 is one of them! Really proud of this collaborative work done between the Neonatal Diabetes Research Team at Exeter and the Translational Genomics of Diabetes Lab in Stanford.
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Mehdi Hasan @mehdirhasan.bsky.social · 04/04/2025
The two most powerful Republican politicians in America - the president and co-president of the United States - are publicly praising and defending and excusing the crimes of a far-right foreign politician who leads a party founded by a Holocaust-denying neo-Nazi. We are in a very, very dark place.
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School of Biological Sciences @cambridgebiosci.bsky.social · 02/04/2025
A great opportunity for postdoctoral scientists from Black Heritage backgrounds! Join the online session on 8 April to find out more ⬇️
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Laura Dearden @lauradearden.bsky.social · 25/03/2025
Fun lab dinner last night. We ate about 10kg of sushi between us 😂
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Laura Dearden @lauradearden.bsky.social · 25/03/2025
Come and study with us for a Masters!
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Daniel Drucker @danieljdrucker.bsky.social · 20/03/2025
A conserved role of m6A signaling in arcuate nucleus neurogenesis in mice and human organoids shedding light on the developmental basis of epitranscriptomic regulation of food intake and energy homeostasis #obesity #RNA @cellcellpress.bsky.social www.cell.com/cell-stem-ce...
cell.com
m6A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice
Shen et al. revealed a conserved role of Mettl14/Ythdc1-dependent m6A signaling in arcuate nucleus neurogenesis of feeding-related neurons in mice and human organoids. Furthermore, deletion of Mettl14...
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Peter Sagal @petersagal.bsky.social · 11/03/2025
This letter appeared in the Bloomsburg PA Press Enterprise this morning. I am assured the writer is who he purports to be, an Air Force veteran.
benion
Grieving a wasted life
At a point in life when there are far too many days behind than ahead, one tends to
re-elected in contrast to standing up for the
reflect on a life lived. In my lifetime decades
greater good?
were devoted to protecting America. Sacri
A compromised Supreme Court recently
fices were made both by myself and my fam-
trotted out a shallow token standards of
Ily in military service. The tip of the spear:
conduct for themselves. Apparently it's
Countless weeks over the years were spent
not a bribe to accept favors after a deci-sion; only before. Corporations are people?
living at the end of a runway on alert with an Really? Whatever happened to Superman's armed B-52 as generations of aviators have motto of "truth, justice, and the American done before and since.
way?"
The purpose: if required, be airborne
Pay-to-play is the theme of the day. Un-
in minutes on a one-way trip bringing a
challenged and uncontested blatant conflicts
nuclear Armageddon to an adversary. Fly:
of interest abound. The rule of law is situ-
ing the unfriendly skies over North Viet-
ational if adhered to at all. America can no
nam provided a brief interlude, but overall,
longer be trusted. The unbridled pursuit of
this long line of silent sentinels stood firm
power and wealth driven by unquenchable
to protect America by deterring external
greed has left service above self and Con-
threats to our freedoms and way of life
stitutional norms in the dustbin of a quaint
across the decades. I was privileged to serve past. with men and women of integrity imbued
Recently the VA said exposure to Agent
with a sense of service.
Orange is the probable cause of the can-
I'm truly grateful that the B-52s we flew, which were built tough, were engineered
cers I live with. Actually I suspect it's more from yet unspecified sources, which cause
on scientific principles and fabricated by experienced, skilled workers rather than
military pilots to have significantly higher
founded on mere beli…
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Tomás Ryan @tjryan.bsky.social · 12/03/2025
What are we talking about, when we talk about 'representations'? My undergraduate student, Oyinkansola Olorunleke, is conducting a thesis project on the concept of representation in cognitive sciences & neuroscience. We are seeking interested participants in the below survey: tinyurl.com/2e6rcnxv
tinyurl.com
Representation: Past, Present & Future
This questionnaire is for a final year neuroscience student who is doing her capstone as part of the Representation: Past, Present & Future Project at Trinity College Dublin.
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Daniel Fazakerley @dfazakerley.bsky.social · 12/03/2025
We have a postdoc position available in our team to undertake a UKRI-funded project to develop a new cultured skeletal muscle model for studying glc metabolism and insulin action. www.jobs.cam.ac.uk/job/50597/ @ims-mrl.bsky.social Please RT. Please email if interested.
jobs.cam.ac.uk
Post-doctoral Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Post-doctoral Research Associate (Fixed Term) in the Department of Clinical Biochemistry at the University of Cambridge.
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Tristan Yates @tristansyates.bsky.social · 11/03/2025
Last year, I was overjoyed to receive an NIH NRSA fellowship to study toddler brains and caregiving effects on memory at Columbia. Last night, my grant was terminated.
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Laura Dearden @lauradearden.bsky.social · 11/03/2025
It's not just the hypothalamus that is sensitive to changes in nutrition during development 👀
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NC3Rs @nc3rs.bsky.social · 11/03/2025
We are halfway through The Togeth3R Consortium’s webinar series and 1,600 people from 42 different countries have joined us to hear about non-animal approaches in fields associated with high levels of animal use. Watch the webinar recordings: nc3rs.org.uk/3rs-resource...
nc3rs.org.uk
Non-animal approaches across Europe
A webinar series from The Togeth3R Consortium of European 3Rs centres showcasing non-animal methods.
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School of Biological Sciences @cambridgebiosci.bsky.social · 08/03/2025
Read our final reflections from our inspiring Women in Leadership positions across the School of Biological Sciences this International Women’s Day (and make sure to check out our other posts!) #IWD2025 #InternationalWomensDay
Anne Willis, Head of MRC Toxicology Unit, with quote on Cambridge Blue background: ‘Half the workforce in Biomedical Sciences are women, who make an enormous contribution to the subject area.  However, women still face challenges in their career progression. It is essential that women are fully represented at all levels, and especially in strategic leadership positions where their contributions have the potential to motivate and, I hope, inspire others'
Sandra Fulton, School of Biological Sciences, Director of Education (Natural Sciences and Psychological and Behavioural Sciences), smiling, wearing glasses, with blue scarf, with quote on Cambridge Blue background: ‘I think it is important for women to be involved in education strategy/leadership to bring a broad perspective to the roles, to ensure that strategic development takes into account the particular challenges faced by women in undertaking research and teaching and to encompass a range of learning styles and teaching delivery in our deliberations.'


Catherine Lindon, Pharmacology, Biomolecular Science MPhil Lead, smiling, with quote on Cambridge Blue background: ‘It’s important for women to be involved in education strategy/ leadership positions – to ensure the diversity of leadership that gives rise to creative decision-making and enhanced educational experience and outcomes for all students, regardless of gender.'Heike Laman, Head of Department of Pathology, with quote on Cambridge Blue background: ‘When we spoke to people in Pathology about career progression in science, they highlighted the challenges of advancing in academic science and the scarcity of women in senior leadership roles. I believe it’s essential for the next generation of scientists to see and experience women in leadership—not only to raise aspirations but also to redefine expectations of what effective leadership looks like and who can embody it. My hope is that by seeing more women in these roles, future scientists will be able to imagine themselves there too.'
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Institute of Metabolic Science-Metabolic Research Laboratories @ims-mrl.bsky.social · 08/03/2025
For International Women’s Day, we are celebrating the women of the @ims-mrl.bsky.social, the @mrcepid.bsky.social and GDAR Network. Meet Agnes Lukasik, Patient and Public Involvement and Engagement (PPIE) Manager at the IMS-MRL 👉 www.mrl.ims.cam.ac.uk/staff/agnes-... #AccelerateAction #IWD2025
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Cathy Abbott @cathyabbott.bsky.social · 06/03/2025
I spent yesterday interviewing candidates for a DEI related scheme. They had all faced barriers but were utterly inspiring. This is just *stupid* as well as evil. "NIH staff members ..cancel grants for projects studying ... (DEI) in the scientific workforce" www.nature.com/articles/d41...
nature.com
Exclusive: NIH to terminate hundreds of active research grants
Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.
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Catherine Dulac @dulaclab.bsky.social · 05/03/2025
After last week publication from the lab on circuits of social isolation/satiety, today we publish a different line of research by @harriskaplan.bsky.social et al., on the development trajectories of hypothalamic POA cell types driving survival and social behavior. www.nature.com/articles/s41...
nature.com
Sensory input, sex and function shape hypothalamic cell type development - Nature
Paired transcriptomic and chromatin accessibility profiling are used to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, including cell types with ke...
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Sebastien G Bouret @sebastienbouret.bsky.social · 05/03/2025
Another successful eprObes consortium meeting in Brussels, where we discussed our progress in identifying early risk factors for obesity and intervention/prevention strategies 🇪🇺 @ec.europa.eu @neuroendolille.bsky.social
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Institute of Metabolic Science-Metabolic Research Laboratories @ims-mrl.bsky.social · 04/03/2025
Researchers at the @ims-mrl.bsky.social are trying to understand how signals between the mother and baby in pregnancy cause increased obesity risk, & whether changes in pregnancy eg increased exercise, can stop the inter-generational transmission of obesity risk. 👇 doi.org/10.1098/rstb...
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