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Ozanne Lab

@ozannelab.bsky.social
312 followers 99 following 5 posts

We are Sue Ozanne's lab in the IMS at the University of Cambridge. We study how the early life environment impacts on offspring cardio-metabolic health.

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Oklahoma Nathan Shock Center @oknathanshock.bsky.social · 23/09/2026
Thank you to everyone who joined us for the 2026 Geroscience Symposium! We’re grateful to our speakers, attendees, and collaborators for making this a great event and for advancing conversations around aging research. We appreciate you being part of it! #GeroscienceSymposium2026
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Oklahoma Nathan Shock Center @oknathanshock.bsky.social · 23/09/2026
We were thrilled to hear from our keynote speaker, Susan Ozanne of the University of Cambridge, yesterday at the 2026 Geroscience Symposium! @ozannelab.bsky.social Thank you for a wonderful lecture! #GeroscienceSymposium2026
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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 15/08/2026
Obesity treatment is expected to shift gradually from a one-size-fits-all approach towards more personalised medicine, in which the obesity phenotype and presence of related conditions will determine the treatment strategy www.thelancet.com/journals/lan... #obesity #GLP-1 receptor agonists #EndoSky
Colour coding reflects the overall direction of available evidence and does not account for heterogeneity between trials or differences in effect size. Green dot: currently available trials indicate exclusively or predominantly beneficial effects. Yellow dot: currently available trials indicate varying effects (or results are interpretable in varying ways), where evidence does altogether not indicate clear beneficial or clear adverse effects. Red dot: currently available trials indicate exclusively or predominantly adverse effects. Grey dot: currently available trials have not detected an effect on the outcome. White dot: unknown, currently no trials available.
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Laura Dearden @lauradearden.bsky.social · 17/12/2025
We are investigating GLP1R agonist use pre- and during- gestation in our mouse model of obese+GDM pregnancy. Interesting results coming soon, get in touch if you want to know more!
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Academy of Medical Sciences @acmedsci.bsky.social · 12/03/2026
We're celebrating 10 years of Springboard 🎉 Over the past decade, the programme has supported 400+ early career researchers across the UK, turning discovery science into real‑world health benefits 🔬✨ Meet the researchers behind Springboard: bit.ly/4sDdLW1 #BritishScienceWeek #Springboard
Text that reads "celebrating Springboard, 10 years" on a navy blue background
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BrunetLab @brunetlab.bsky.social · 09/02/2026
Interested in the mechanisms of aging and 'rejuvenation'? Our lab at Stanford has a Research Assistant/Lab manager position open!! Apply and join our awesome team! 😎 (please share) careersearch.stanford.edu/jobs/life-sc...
careersearch.stanford.edu
Life Science Research Professional 1 in School of Medicine, Stanford, California, United States
The Brunet lab in the Department of Genetics at Stanford University (https://web.stanford.edu/group/brunet/) is seeking an independent and motivated.....
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Carlos Guardia @charlyguardia.bsky.social · 08/02/2026
New issue of the #PlacentalCellBio reports by @biomednews.bsky.social biomed.news/bims-placeb/... My fav pick is this comprehensive review on the evolution of the study of the ultrastructure of the placenta using EM <3
pubmed.ncbi.nlm.nih.gov
Exploring placental ultrastructure: A review of electron microscopy techniques and emerging methods for resolving 3D organelle architecture - PubMed
Trophoblast cells line the surface of placental villi, facilitating the exchange of nutrients, gases, and wastes between the maternal and fetal circulations. The fusion of cytotrophoblast (CTB) cells into the surrounding multinucleated syncytiotrophoblast (STB), is accompanied by a shift in cellular …
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Kristin Connor @kconnor.bsky.social · 26/01/2026
Gutted to learn of the passing of Dr Kirsty Duncan. She was a tireless fighter for the people she served, not only her local community in Toronto but others, especially the science & research & athletics communities too. She championed equity, diversity, inclusion and made change happen. 🤍🙏🏻
richmond-news.com
Former Liberal cabinet minister Kirsty Duncan dies at 59
OTTAWA — Former Liberal cabinet minister Kirsty Duncan has died at the age of 59 following a years-long battle with cancer. Born on Oct.
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Institute of Metabolic Science-Metabolic Research Laboratories @ims-mrl.bsky.social · 09/01/2026
Editor's Choice Paper by @jmschoonejans.bsky.social @ozannelab.bsky.social 'Balancing maternal benefits and cardiovascular risks of metformin during pregnancy' now includes a video short by Josca www.youtube.com/watch?v=H2aB... Read paper - onlinelibrary.wiley.com/doi/full/10....
youtube.com
Exploring the cardiovascular outcome in the offspring of metformin-treated obese mice
YouTube video by The Physiological Society
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Laura Dearden @lauradearden.bsky.social · 17/12/2025
Our new review out with @ozannelab.bsky.social exploring the current data from rodent and human studies of GLP1R agonist use in pregnancy and short/ long-term safety for mother and offspring. !https://portlandpress.com/clinsci/article/139/23/1597/236872/Incretin-receptor-agonism-during-pregnancy
portlandpress.com
Incretin receptor agonism during pregnancy: implications for mother and baby
Obesity has been described by the WHO as the largest health threat facing mankind. More than 55% of pregnancies in the United Kingdom occur in women who are overweight or living with obesity. Obesity ...
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Jonny Kohl @jkohl.bsky.social · 22/10/2025
Out today in Nature: We uncover a neural mechanism for the integration of two internal states - hunger and estrous state - and how this integration shapes pup-directed behaviors in mice. www.nature.com/articles/s41...
nature.com
Integration of hunger and hormonal state gates infant-directed aggression - Nature
Combined behavioural, circuit-level and cellular approaches are used to demonstrate how hypothalamic neurons integrate hunger and oestrous state to drive a switch in how female mice interact with pups...
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Ozanne Lab @ozannelab.bsky.social · 17/12/2025
Read our new review that covers the fast moving topic of whether GLP1R agonists such as Semaglutide and Tirzepatide can be used safely in pregnancy.
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Carlos Guardia @charlyguardia.bsky.social · 06/12/2025
So many good reports this past week! Take a look at my #PlacentalCellBio selection thanks to @biomednews.bsky.social biomed.news/bims-placeb/... I really liked the preprint by Mike Soares' group on PPARG and invasive trophos using a combination of models: pubmed.ncbi.nlm.nih.gov/41278877/
biomed.news
bims-placeb 2025-11-30 papers
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Sophie Steculorum @sophiesteculorum.bsky.social · 01/12/2025
🤩 I’m beyond excited to finally share our paper! 🎉 It’s been a long journey and a true team effort. Congratulations to our outstanding first authors, @lcreimon.bsky.social and Ayden Gouveia, and to all of the co-authors who made this possible 🙌! www.nature.com/articles/s42...
nature.com
Fat sensory cues in early life program central response to food and obesity - Nature Metabolism
Non-nutritive sensory components of high-fat diet, such as bacon flavour, are sufficient to impair metabolic health in offspring in mice.
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Josca Schoonejans, PhD @jmschoonejans.bsky.social · 24/11/2025
Interesting new paper from the @ozannelab.bsky.social showing maternal iron homeostasis, not placental dysfunction, is associated with fetal hypoxia at e13.5 in obese mouse pregnancy physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com
Maternal obesity during pregnancy disrupts iron homeostasis and promotes fetal hypoxia in the mouse
Abstract figure legend Maternal obesity induces systemic inflammation and high insulin and leptin levels, potentially promoting hepcidin release into circulation and thus iron sequestration in specif....
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IMS Epidemiology, University of Cambridge @imsepidemiology.bsky.social · 12/11/2025
There are many reasons pregnant women can develop gestational diabetes & researchers from @ims-mrl.bsky.social are investigating interventions that can be used to mitigate the condition. Dr @dftwinn.bsky.social Dr Adriana Paz Cordona Casanova Dr Lais Vales Mennetti Listen - buff.ly/7Kymdzy
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Institute of Metabolic Science-Metabolic Research Laboratories @ims-mrl.bsky.social · 12/11/2025
An excellent podcast from the @ozannelab.bsky.social at @ims-mrl.bsky.social in the lead up to #WorldDiabetesDay 2025
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Diabetologia @diabetologiajnl.bsky.social · 05/11/2025
Up front & free to read in our Nov issue #editorspicks: The utility of early gestational OGTT and biomarkers for the development of gestational diabetes mellitus: an international prospective multicentre cohort study link.springer.com/article/10.1...
link.springer.com
The utility of early gestational OGTT and biomarkers for the development of gestational diabetes mellitus: an international prospective multicentre cohort study - Diabetologia
Aims/hypothesis There is no clear consensus regarding accurate risk stratification in early pregnancy for later developing gestational diabetes mellitus (GDM). Therefore, this study aims to evaluate t...
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Fabíola Suano @fabiolasuano.bsky.social · 28/09/2025
www.bmj.com/content/389/... @ozannelab.bsky.social @ims-mrl.bsky.social
bmj.com
Challenges with developing nutritional recommendations to improve pregnancy outcomes
Susan Ozanne and colleagues argue that strategies are urgently needed to translate knowledge about how maternal nutrition affects children’s long term health into improved population health outcomes ...
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Dr Rebecca Dumbell @rebeccadumbell.bsky.social · 17/09/2025
This week @helferlab.bsky.social and I had a great and productive day visiting @mrcharwell.bsky.social to help get set up for my @acmedsci.bsky.social funded animal study. Really excited to be moving forward! 🐭🧠🍔🔬
Gisela Maria Rebecca and Tania in a selfie in front of the signage for the Mary Lyon Centre at MRC Harwell
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Giles Yeo @gilesyeo.bsky.social · 17/09/2025
I’ve been hosting the 7th International Melanocortin Meeting here in Cambridge with my co-organisers Roger Cone, Kate Ellacott @neuroendo.bsky.social and Anne White. Spectacular science! Here we are at the conference dinner! #obesityisnotachoice
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Kate Ellacott @neuroendo.bsky.social · 17/09/2025
The 7th International Melanocortin meeting was full of energy, science & connections old & new. I will miss the excuse to regularly catch up with my fellow organisers Giles @gilesyeo.bsky.social, Anne @annewhite-uom.bsky.social, & Roger Cone. Thanks to Bioscientifica @socendocrinology.bsky.social
Organisers of 7th International Melanocortin Meeting Kate Ellacott, Giles Yeo, Anne White and Roger Cone
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Diabetologia @diabetologiajnl.bsky.social · 18/09/2025
In our new special issue: Prevention of type 2 diabetes in migrant populations from low- and middle-income countries living in high-income countries link.springer.com/article/10.1.... See the full collection here diabetologia-journal.org/collections/...
link.springer.com
Prevention of type 2 diabetes in migrant populations from low- and middle-income countries living in high-income countries - Diabetologia
The rising prevalence of type 2 diabetes among migrant populations from low- and middle-income countries (LMICs) living in high-income countries (HICs) presents a significant public health challenge. ...
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Jim Johnson 🇨🇦 @jimjohnsonsci.bsky.social · 14/09/2025
Hey friends and colleagues ! Vancouver Coastal Health Research Institute - VCHRI is now on Bluesky, give them a follow @vchresearch.bsky.social
vchresearch.bsky.social
Vancouver Coastal Health Research Institute (@vchresearch.bsky.social)
Vancouver Coastal Health Research Institute — Leading innovative research with health impact in Canada. vchri.ca
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Carlos Guardia @charlyguardia.bsky.social · 14/09/2025
Here are the curated lists of pubs in the #PlacentalCellBio @biomednews.bsky.social report from the last two weeks! biomed.news/bims-placeb/... biomed.news/bims-placeb/... My personal choice: this resource from the Zernicka-Goetz's lab! pubmed.ncbi.nlm.nih.gov/40882624/ Enjoy!
pubmed.ncbi.nlm.nih.gov
Efficient stem cell-derived mouse embryo models for environmental studies - PubMed
Blastoids are stem cell-derived structures that mimic natural blastocysts by incorporating all three lineages: trophectoderm, epiblast, and primitive endoderm. However, current methods often yield inc...
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Institute of Metabolic Science-Metabolic Research Laboratories @ims-mrl.bsky.social · 19/08/2025
Sharing for our colleagues at @edinburgh-uni.bsky.social who are carrying out a survey on weight loss drugs and pregnancy. Please help us learn more. Take the survey 👇👇👇👇 app.onlinesurveys.jisc.ac.uk/s/edinburgh/...
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Ionel Sandovici @isandovici.bsky.social · 04/06/2025
Very cool paper connecting nutrition, epigenetics and developmental biology. rdcu.be/eptl7
rdcu.be
Maternal iron deficiency causes male-to-female sex reversal in mouse embryos
Nature - Iron-deficient conditions in pregnant mice can cause XY mouse embryos to develop female rather than male genitalia, revealing that iron metabolism has a role in determining male sex in mice.
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Bradley Jamieson @bradleyjamieson.bsky.social · 16/06/2025
🎉 Thrilled to share my postdoc work, with our preprint out now on BiorXiv here: www.biorxiv.org/content/10.1... We investigated how the juvenile brain develops the ability to carry out care behaviours towards neonates by an exciting and surprising switch in neural activity and behaviour
biorxiv.org
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British Society for Neuroendocrinology @bsneuroendo.bsky.social · 21/07/2025
🏆 CONGRATULATIONS to Jo Lewis, 2025 winner of the Michael Harbuz Prize! Jo will speak at #BSNBradford2025 on Glucose-dependent insulinotropic polypeptide regulates food intake and body weight via the area postrema in mice. Register: bsnbradford2025.oa-e...
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Cambridge Reproduction @cam-repro.bsky.social · 03/07/2025
“Our children’s lifelong health starts in the first 1,000 days - from conception to age two" @acmedsci.bsky.social report, co-chaired by our very own co-chair Susan Ozanne @ozannelab.bsky.social underscores that habits and environments established early are hard to change later Read more 👇
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Lille Neuroendocrinology @neuroendolille.bsky.social · 02/07/2025
Huge congratulations to Serge Luquet on receiving the Silver Medal from @CNRS! So well deserved 👏🏻 www.insb.cnrs.fr/fr/personne/...
insb.cnrs.fr
Serge Luquet
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IMS Epidemiology, University of Cambridge @imsepidemiology.bsky.social · 02/07/2025
The BioRepository's Cambridge-based Nordic ULT Freezer System offers: 100% backup for sample security 24/7 monitoring & telemetry Energy savings & reduced carbon footprint Contact us to find out how we can support your research - BioRepManager@mrc-epid.cam.ac.uk
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Academy of Medical Sciences @acmedsci.bsky.social · 02/07/2025
Co-published with Italy’s Accademia Nazionale dei Lincei, this report shows that success comes from addressing the systems and environments shaping children’s health, not just individual behaviours. 🔗 Read the report: bit.ly/46qy7tN
Professor Paolo Vineis next to a quote that reads: "This collaboration between the UK and Italy has revealed that childhood obesity transcends borders – it is a shared challenge requiring coordinated action. The evidence demonstrates that success comes from addressing the systems and environments shaping children’s health, not just individual behaviours."
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Academy of Medical Sciences @acmedsci.bsky.social · 02/07/2025
This analysis comes ahead of the NHS 10-Year Health Plan to address health inequalities and echoes the Council for Science and Technology’s letter - co-chaired by our President Prof Andrew Morris CBE FRSE PMedSci - for bold leadership and cross-govt action to prioritise prevention.
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Academy of Medical Sciences @acmedsci.bsky.social · 02/07/2025
Key evidence includes: 👶 The first 1,000 days of life shape lifelong health 📉 Obesity rates are 2x higher in deprived areas 🏘️ Public health interventions beat individual fixes Our Vice President (Clinical), Prof @rosalindsmyth.bsky.social CBE FMedSci, shares the importance of early action 👇
Professor Rosalind Smyth CBE FMedSci next to a quote that reads: "When we address health inequalities in the earliest years, we’re not just improving individual outcomes – we're building the foundations for a healthier, more productive society. The evidence reinforces that prevention, which requires a cross-sectoral approach, must be coordinated across all government departments."
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Academy of Medical Sciences @acmedsci.bsky.social · 02/07/2025
🚨 Childhood obesity is rising at alarming rates around the world Our latest report, with Italy’s Accademia Nazionale dei Lincei, calls for early intervention to ensure healthier futures for all children 🌱 Read the report: bit.ly/46qy7tN And see our key takeaways 🧵
bit.ly
Child’s weight for life shaped by first 1,000 days, report health experts
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Academy of Medical Sciences @acmedsci.bsky.social · 02/07/2025
The report calls for urgent action to: 🤰 Prioritise support during pregnancy 🍴 Ensure robust regulation of the food industry 🤝 Coordinate across govt departments i.e. food, education, urban planning and transport
Professor Susan Ozanne FMedSci next to a quote that reads: "The first 1,000 days, including time in the womb, represent an important window of opportunity to set children on a healthy trajectory for life. This isn’t about individual willpower or blaming and shaming – it's about creating an environment for parents, carers and their children that supports healthy development from the very beginning."
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Josca Schoonejans, PhD @jmschoonejans.bsky.social · 23/06/2025
This highlights the need for long-term cardiovascular follow up in offspring (of both sexes!) from human metformin-treated pregnancies to inform decisions about its use in pregnancy - a tricky question that requires balancing mum and baby's health 👩‍🍼
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Josca Schoonejans, PhD @jmschoonejans.bsky.social · 23/06/2025
Offspring of obese mice had hypertension and diastolic dysfunction by 12mo. Maternal #metformin worsened the phenotype and introduced sex-dependent CV alterations in both male (cardiac stiffening, vascular dysfunction) & female (obesity-induced hypertension) offspring.
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Josca Schoonejans, PhD @jmschoonejans.bsky.social · 23/06/2025
Our new paper showing sex-specific adverse #cardiovascular outcomes of prenatal #metformin exposure in a mouse model of diet-induced glucose intolerance is out now in @jphysiol.bsky.social ! 🐁❤️ ♂️♀ Find it here shorturl.at/VKqjD (in collab with @ozannelab.bsky.social & Giussani labs) #DOHaD
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Institute of Metabolic Science-Metabolic Research Laboratories @ims-mrl.bsky.social · 09/06/2025
For our next @ims-mrl.bsky.social seminar, we look forward to welcoming Professor @brent-richards.bsky.social ‪‪from McGill University, Montreal, Canada to talk to us about ‘Causality, Calories, and COVID: Chasing Disease through the Human Genome’‬
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The Royal Society @royalsociety.org · 30/05/2025
Professor Edward Bullmore FRS is elected a Fellow of the Royal Society. His work has focused on developing new tools for analysis of the complex network organization of the human brain, and understanding how schizophrenia & other major mental health disorders arise. royalsociety.org/people/ed-bu...
royalsociety.org
Professor Edward Bullmore FMedSci FRS | Royal Society
Explore the history of the Royal Society, including our motto and discover our timeline of key events.
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Institute of Metabolic Science-Metabolic Research Laboratories @ims-mrl.bsky.social · 10/05/2025
Congratulations to Professor Sadaf Farooqi as Joint ‘Endocrinology Across the Life Course Award’ winner from @esendocrinology.bsky.social & European Society for Paediatric Endocrinology (ESPE). www.mrl.ims.cam.ac.uk/news/profess...
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Institute of Metabolic Science-Metabolic Research Laboratories @ims-mrl.bsky.social · 15/05/2025
This is a very exciting time for research into Hyperemesis Gravidarum (HG) and we are fully supportive of International HG Awareness Day taking place today. #HGProgress #IHGAD25 #HyperemesisGravidarum #PregnancySicknessSupport
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Institute of Metabolic Science-Metabolic Research Laboratories @ims-mrl.bsky.social · 22/05/2025
👏 Congratulations to Professor Frank Reimann, Professor of Endocrine Signalling at the @ims-mrl.bsky.social on being elected as a new Fellow at the @acmedsci.bsky.social More details 👇 www.mrl.ims.cam.ac.uk/news/profess...
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Institute of Metabolic Science-Metabolic Research Laboratories @ims-mrl.bsky.social · 22/05/2025
Delighted that Professor Sir @stephenorahilly.bsky.social from the @ims-mrl.bsky.social has been announced as joint winner of the Distinguished Service Award at the 2nd Lund Spring Symposium, along with Professor Jens Juul Holst More details 👇 www.mrl.ims.cam.ac.uk/news/profess...
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Institute of Metabolic Science-Metabolic Research Laboratories @ims-mrl.bsky.social · 22/05/2025
Congratulations to our own Professor Frank Reimann www.mrl.ims.cam.ac.uk/news/profess...
mrl.ims.cam.ac.uk
Professor Frank Reimann announced as a new Academy of Medical Sciences Fellow | Institute of Metabolic Science
The Academy of Medical Sciences (AMS) has announced its newly elected biomedical and health scientists to its prestigious Fellowship, and we are delighted that Professor Frank Reimann from the IMS-MRL...
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Florian T. Merkle, PhD @florianmerkle.bsky.social · 20/05/2025
I'm excited to share our latest pre-print on proximity proteomics of primary cilia in human hypothalamic neurons, led by Viviana Macarelli, which revealed proteins involved in synapses and neurotransmission and the obesity-associated GPCR LPAR1. Details at bit.ly/4jcTodq
bit.ly
Proximity proteomics of primary cilia in human hypothalamic neurons
Primary cilia are hair-like sensory organelles that project from the cell bodies of most cell types, including appetite-regulatory hypothalamic neurons where they likely help sense metabolic factors t...
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Dr Rebecca Dumbell @rebeccadumbell.bsky.social · 20/05/2025
I was delighted to host former colleague Dr Rajesh Pandey at Nottingham Trent today, after not having seen each other in person for about 6 years!
Drs Rebecca Dumbell and Rajesh Pandey at Nottingham Trent University Clifton CampusRajesh Pandey introducing his talk
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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 20/05/2025
Read our June Issue, featuring maternal diabetes and neurodevelopment in children, central diabetes insipidus, primary polydipsia, muscle composition, T2D, obesity, thyroid cancer, hypertriglyceridaemia-induced acute pancreatitis, ultra-processed foods, & more bit.ly/2LArJXX #MedSky #EndoSky
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