Sign in

NealeLab

@labneale.bsky.social
1.7K followers 234 following 173 posts

Recombination, Meiosis, Chromosomes, DNA Break Repair twitter.com/LabNeale

PostsRepliesMedia
NealeLab @labneale.bsky.social · 05/10/2026
Crippling success rates at the MRC: www.researchprofessionalnews.com/rr-news-uk-r...
111
NealeLab @labneale.bsky.social · 30/09/2026
Ye gods! 12 years since I first explored this concept...And we are only now close to finalising the revisions...😱
011
Reposted by NealeLab
Pim Huis in 't Veld @huis.bsky.social · 24/09/2026
a glimpse into the future: www-cdn.anthropic.com/22573675ada5... described here: www.anthropic.com/news/claude-... with an expert first author: doi.org/10.1126/scie... doi.org/10.1126/scie... following the pattern from this excellent piece: giorgio.gilest.ro/the-weimar-o...
anthropic.com
Claude discovers a novel enzyme system
In early results from our new life sciences research lab, Claude agents found an enzyme system whose function is still unknown.
263
NealeLab @labneale.bsky.social · 18/08/2026
As someone now living with the long-term consequences of adult-contracted Pertussis—potentially enabled due to a short period in the 1970s when vaccines were paused (and I missed getting my childhood shot)—I find this anti-vax movement incredibly troubling.
010
NealeLab @labneale.bsky.social · 26/07/2026
Amazing images! How far apart are the centre of these merging galaxies? If one were one a habitable planet there, I assume that the distances are so great that it wouldn't actually affect much (in the short term)?
000
Reposted by NealeLab
NSF–DOE Rubin Observatory @rubinobservatory.org · 24/07/2026
Talk about a cosmic glow-up✨📸 This progression of images of galaxy group RSCG 55 shows the evolution of ground-based sky surveys spanning more than three decades🤯, ending with NSF–DOE Rubin Observatory's view. 🔭🧪
Five-panel image showing the progressive evolution of sky surveys from 1994 to 2025, revealing more and more detail in a triple merging galaxy system and the surrounding sky.
925490
NealeLab @labneale.bsky.social · 22/07/2026
#MSKCC 18-year reunion! One of the best things about research conferences!
030
NealeLab @labneale.bsky.social · 14/07/2026
Unreal.
020
NealeLab @labneale.bsky.social · 06/07/2026
Great to see you Luz! Enjoy the conference 😀
010
NealeLab @labneale.bsky.social · 18/06/2026
Gradual decline towards homogeneity? Or amplification of rarer creative forms that AI copies and makes more abundant, expanding overall variation?
020
Reposted by NealeLab
Stephen Curry @scurry.bsky.social · 10/06/2026
"Fellows shall not act or fail to act in any way which would […] bring the Society into disrepute." But this morning ministers condemned Elon Musk FRS for enabling violence on the streets of Belfast. www.theguardian.com/uk-news/2026... Would the @royalsociety.org like to comment?
Extract from linked article reads:

"Violence in Belfast that forced families to flee their homes on Tuesday night was fuelled by online commentators who would struggle to find the city on the map, Northern Ireland’s justice minister has said.

The condemnation by Naomi Long came as a UK cabinet minister said that Elon Musk also had a responsibility “not to stoke grievance”. The billionaire owner of X had used his own account to share images of a horrific knife attack in Belfast on Monday and had amplified far-right messaging about it."
25230
NealeLab @labneale.bsky.social · 09/06/2026
010
NealeLab @labneale.bsky.social · 06/06/2026
On my way to # www.grc.org/meiosis-conf... cruising 10 km in the air with a stable (and free) WIFI connection. Who knew such things were possible?!
grc.org
2026 Meiosis Conference GRC
The 2026 Gordon Research Conference on Meiosis will be held in New London, New Hampshire. Apply today to reserve your spot.
050
NealeLab @labneale.bsky.social · 08/05/2026
Don't get lost out there!
000
NealeLab @labneale.bsky.social · 28/04/2026
Before CRISPR there was VIPR
000
Reposted by NealeLab
Jamie Cate @jhdcate.bsky.social · 27/04/2026
The best thing since *before* sliced bread... VIPRs. www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...
biorxiv.org
14319
NealeLab @labneale.bsky.social · 25/04/2026
*six* black holes?!
010
Reposted by NealeLab
Dr Space Junk (Alice Gorman) @drspacejunk.bsky.social · 15/04/2026
Could this be my finest moment? '"Your average space billionaire probably doesn't give a rat's arse about future generations," she said'. I'm not sure I was expecting this to be quoted! 🧪
abc.net.au
Mining on the Moon is closer than ever, but challenges remain
A scientist, an engineer, an archaeologist and a lawyer break down some of the physical, environmental, ethical and legal challenges of mining on the Moon.
20389106
NealeLab @labneale.bsky.social · 09/04/2026
Complementary Holliday Junction observations now available to absorb from @martinxaver.bsky.social and coauthors! www.biorxiv.org/content/10.6...
0175
NealeLab @labneale.bsky.social · 27/03/2026
Commentary: How do authors want to use AI for review? link.springer.com/article/10.1...
link.springer.com
How do authors want to use AI for review? - EMBO Reports
EMBO Reports - A survey of researchers who compared AI-generated scientific reviews with journal-agnostic human peer review reveals that they overwhelmingly prefer using AI as a self-checking tool...
000
Reposted by NealeLab
Compound Interest | Chemistry infographics @compoundchem.com · 26/03/2026
On #NationalSpinachDay, this graphic looks at the real story behind spinach’s iron content: www.compoundchem.com/2018/07/17/s... #ChemSky 🧪
An infographic titled "The Chemistry of Spinach" explores iron content, vitamin A, and the "spinach teeth" sensation. It compares spinach to sirloin steak, noting that while spinach has more iron (2.6mg vs 2.5mg per 100g), only 1.7% is absorbed compared to 20% from steak. Low absorption is attributed to polyphenols. It highlights spinach as a source of beta-carotene and explains that "spinach teeth" are caused by oxalic acid reacting with calcium to form insoluble calcium oxalate crystals.
35522
Reposted by NealeLab
Takashi Akera Lab @takashiakeralab.bsky.social · 26/03/2026
Amazing to receive the @hfspo.bsky.social Research Grant to pursue the project I have been dreaming of since I started my lab..!!🧬: how meiotic drive impacts sex ratios in vertebrates👩🏻‍🔬👨‍🔬 I am so fortunate to collaborate on this project with Jiri Hejnar at IMG and @amarques.bsky.social 🎉🙏🏼
2182
NealeLab @labneale.bsky.social · 24/03/2026
JOIN US!: PhD applications are still open. Deadline extended until 6th April due to Easter break. www.findaphd.com/phds/project...
findaphd.com
How Chromosome Structure Shapes Genetic Diversity and Genome Stability at University of Sussex on FindAPhD.com
PhD Project - How Chromosome Structure Shapes Genetic Diversity and Genome Stability at University of Sussex, listed on FindAPhD.com
011
NealeLab @labneale.bsky.social · 23/03/2026
Meiosis alert! Last few days to register for #BMM2026. Calling all postdocs/PhD students: your chance to meet the community, give a talk, present your poster! Hosted at the beautiful Royal Society HQ in London this year! www.rothamsted.ac.uk/event/xvi-br...
012
Reposted by NealeLab
The EMBO Journal @embojournal.org · 23/03/2026
Condensin loop extrusion properties, roadblocks, and role in homology search @aurelepiazza.bsky.social et al show yeast condensin unidirectionally extrudes long chromatin loops & contributes to biasing donor selection during recombinational DNA break repair link.springer.com/article/10.1...
link.springer.com
Condensin loop extrusion properties, roadblocks, and role in homology search during recombination in S. cerevisiae - The EMBO Journal
The in vivo mechanism, cis-acting roadblocks, and biological functions of DNA loop extrusion by eukaryotic SMC complexes remain incompletely defined. Here, we identify condensin-dependent Hi-C contact...
0103
Reposted by NealeLab
Compound Interest | Chemistry infographics @compoundchem.com · 20/03/2026
Spring is here in the northern hemisphere! Here's a graphic from the #PeriodicGraphic archives in @cenmag.bsky.social looking at the pigments that give daffodils their golden glow: cen.acs.org/articles/93/... #ChemSky 🧪
An infographic titled "The Chemistry of Daffodils" by Compound Interest for C&EN explains the flower's biological makeup. It features a bouquet of yellow daffodils and three main sections. The Aroma section highlights (E)-beta-ocimene for its woody scent, plus 1,4-dimethoxybenzene and (E,E)-alpha-farnesene. The Color section identifies carotenoids like zeaxanthin and beta-carotene. The Poison & Medicine section shows the toxic alkaloid lycorine and galantamine, used to treat Alzheimer's.
18131
Reposted by NealeLab
James Rae @mudwaterclimate.bsky.social · 14/03/2026
Chair in Earth Sciences position @uniofstandrews.bsky.social closing soon - Monday 23 March. Very broad remit, so if you’d like to join our lovely school, and get to live in the super beautiful and friendly wee nation of Scotland, please apply! www.st-andrews.ac.uk/earth-scienc... ⚒️🌊🧪
East Sands beach, St Andrews, in the sunshine (which happens more often than you probably think!)
05634
Reposted by NealeLab
Prof Stephen Serjeant @stephenserjeant.bsky.social · 18/03/2026
Wow. @pallabg.bsky.social has a obtained leaked document from STFC Council suggesting the origin of the STFC funding crisis was a deliberate decision (by?) 🧪🔭 www.bbc.co.uk/news/article...
Minutes of STFC's governing council, which are not publicly available, talk of the Council's head of strategy describing "a major shift of funding from curiosity-driven research to priority areas and targeted programmes".
1176
Reposted by NealeLab
Peter Lind @peteralind.bsky.social · 17/03/2026
Associate Senior Lecturer/Assistant Professor position in Molecular Microbiology available at Lund University, Sweden: lu.varbi.com/en/what:job/...
lu.varbi.com
Associate Senior Lecturer/Assistant Professor in Molecular Microbiology
The Department of Biology conducts research and teaching in many subject areas such as ecology, evolutionary biology, organismal biology and molecular biology. A total of approximately 300 people curr
02552
NealeLab @labneale.bsky.social · 16/03/2026
@gdsc-sussex.bsky.social
010
NealeLab @labneale.bsky.social · 16/03/2026
www.biorxiv.org/content/10.6...
biorxiv.org
120
NealeLab @labneale.bsky.social · 16/03/2026
Fantastic to share the work of @whgittens.bsky.social and Tom Powell. World-first detection of Topoisomerase 3 activity on chromosomes in vivo. Top3 maps to meiotic hotspots then migrates, indicating that branched Holliday junctions migrate codirectionally with transcription; resolve at the axis.
1132
NealeLab @labneale.bsky.social · 13/03/2026
Three-legged race?
001
NealeLab @labneale.bsky.social · 13/03/2026
Some of my favourite plants 🙃
011
NealeLab @labneale.bsky.social · 09/03/2026
Two weeks left to get in your applications! ✍️ www.sussex.ac.uk/study/fees-f...
sussex.ac.uk
School of Life Sciences Studentship: How Chromosome ...
013
Reposted by NealeLab
Rajiv McCoy @rajivmccoy.bsky.social · 21/01/2026
Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk. First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
nature.com
Common variation in meiosis genes shapes human recombination and aneuploidy - Nature
Analysis of data from pre-implantation genetic testing sheds light on the genetic basis of meiotic-origin aneuploidy, the leading cause of human pregnancy loss, identifying common genetic variants ass...
112556
NealeLab @labneale.bsky.social · 24/02/2026
www.biorxiv.org/content/10.6...
biorxiv.org
031
NealeLab @labneale.bsky.social · 24/02/2026
After a long incubation, it is a huge pleasure to finally share the work of @luzmlopez.bsky.social, Jon Harper and their coauthors: "Localised negative feedback shapes genome-wide patterning of meiotic DNA breaks". @gdsc-sussex.bsky.social www.biorxiv.org/content/10.6...
193
NealeLab @labneale.bsky.social · 18/02/2026
I think you are right on the A-DNA...in addition to the tilts, there may well be 11 bases per turn here.
100
NealeLab @labneale.bsky.social · 18/02/2026
The one thing I *did* check for. And yet still got paranoid...
211
NealeLab @labneale.bsky.social · 18/02/2026
Is it?! I'm just a lowly molecular biologist looking for a GIF... 😅 microbenotes.com/wp-content/u...
100
NealeLab @labneale.bsky.social · 17/02/2026
Now live on Find-A-PhD-dot-com: Joint project between @labneale.bsky.social and @drjonbaxter.bsky.social @gdsc-sussex.bsky.social Get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis. www.findaphd.com/phds/project...
findaphd.com
How Chromosome Structure Shapes Genetic Diversity and Genome Stability at University of Sussex on FindAPhD.com
PhD Project - How Chromosome Structure Shapes Genetic Diversity and Genome Stability at University of Sussex, listed on FindAPhD.com
183
Reposted by NealeLab
Di Jiang @dijiang319.bsky.social · 14/02/2026
@science.org A small polymerase ribozyme that can synthesize itself and its complementary strand | Science www.science.org/doi/10.1126/... #RNA #ribozyme #evolution
1328
NealeLab @labneale.bsky.social · 12/02/2026
Indeed! And this depiction is just of one... www.nature.com/articles/sre...
152
NealeLab @labneale.bsky.social · 12/02/2026
NOW LIVE!: PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis. www.sussex.ac.uk/study/fees-f...
sussex.ac.uk
School of Life Sciences Studentship: How Chromosome ...
075
Reposted by NealeLab
Biochemistry & Biomedicine @ University of Sussex @biochembiomeduos.bsky.social · 06/02/2026
Super strong representation from our department in SussexRNA at the RNA UK meeting in Windermere this week. Many congrats to Jake, Courtney and Hope from the Ben Towler group, and Leandro Castellano, Lidia Vasilieva, Ben and Nikos for having abstracts accepted for presentation. 👏
032
NealeLab @labneale.bsky.social · 05/02/2026
Beautiful! Is this in real time (20 seconds?) (Speed also seem to slow over time?)
010
NealeLab @labneale.bsky.social · 04/02/2026
Changes in the UK R&I funding landscape - doing fewer things better. An open letter from Ian Chapman to research and innovation community: www.ukri.org/news/open-le...
ukri.org
Open letter from Ian Chapman to research and innovation community
UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.
000
Reposted by NealeLab
Richard Sever @richardsever.bsky.social · 04/02/2026
"Writing papers is rarely (probably never) the rate-limiting step in scientific research" Important to remember this. However painful writing is, however much more efficient we can make it, for experimental work it's the research that takes the time. www.linkedin.com/feed/update/...
linkedin.com
𝗢𝗽𝗲𝗻𝗔𝗜 𝗷𝘂𝘀𝘁 𝗹𝗮𝘂𝗻𝗰𝗵𝗲𝗱 𝗣𝗿𝗶𝘀𝗺—𝗮 𝗳𝗿𝗲𝗲 𝗟𝗮𝗧𝗲𝗫 𝗲𝗱𝗶𝘁𝗼𝗿 𝗳𝗼𝗿 𝘀𝗰𝗶𝗲𝗻𝘁𝗶𝘀𝘁𝘀. But this isn't about LaTeX. And it's not about training data. They could get… | Adam Hyde | 25 comments
𝗢𝗽𝗲𝗻𝗔𝗜 𝗷𝘂𝘀𝘁 𝗹𝗮𝘂𝗻𝗰𝗵𝗲𝗱 𝗣𝗿𝗶𝘀𝗺—𝗮 𝗳𝗿𝗲𝗲 𝗟𝗮𝗧𝗲𝗫 𝗲𝗱𝗶𝘁𝗼𝗿 𝗳𝗼𝗿 𝘀𝗰𝗶𝗲𝗻𝘁𝗶𝘀𝘁𝘀. But this isn't about LaTeX. And it's not about training data. They could get papers from arXiv or partner with Overleaf for that. So w...
31810
NealeLab @labneale.bsky.social · 04/02/2026
I'm just thankful that I successfully picked a right-handed GIF...😇
000