Human cells face a wide range of external mechanical stimuli that vary with cell type, state, and pathological conditions. The rapidly growing field of mechanobiology investigates how cells sense and ...

Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…

Fibroblasts play crucial roles in wound healing, cancer, and fibrosis. Many aspects of these roles are driven by the process known as fibroblast activation. The

Nature - NINJ1 regulates plasma membrane fragility under mechanical strain

Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...

The 2025 Gordon Research Conference on Fibronectin, Integrins and Related Molecules will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.

The mechanisms regulating multipotency in glandular epithelia remain unclear. Here, the authors identify the key role of collagen signaling and ECM stiffness in regulating stem cell multipotency in gl...

Fu et al. showed that point mutations in MmTMC1/2 are localized in plasma membrane, and knockdown of UROD, RGP1, or ARL1 promotes plasma membrane localization of HsTMC1/2 in heterologous cells. HsTMC1/2 are activated by mechanical stimuli and function as pore-forming ion channels, supporting their roles as mechanotransduction channels in hair cells.

The organizing committee, Sylvain Gabriele, Marine Luciano, Jorge Barrasa Fano, Yohalie Kalukula, Bart Smeets, Apeksha Shapeti, Hans Van Oosterwyck

Scientific Reports - Differentiating erythroblasts adapt to mechanical stimulation by upregulation of cholesterol biosynthesis via S1P/SREBP-induced HMGCR expression

Nuclear deformation by osmotic shock or necrosis activates the cytosolic phospholipase A2 (cPla2) nuclear shape sensing pathway, a key regulator of tissue inflammation and repair. Ca²⁺ and inner nucle...

Endothelial cells respond to mechanical force by stimulating cellular signaling, but how these pathways are linked to elevations in cell metabolism and whether metabolism supports the mechanical respo...

Uroz et al. report that the distinct mechanical properties of brain vasculature versus parenchyma drive cancer cell migration through a talin-dependent mechanism, enabling vessel co-option and metasta...