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Kristján Moore (Kris)🔸

@kristjanmoore.bsky.social
242 followers 172 following 329 posts

Research at Amgen/deCODE genetics: genomic ancestry, population data, ancient DNA, and whatever else needs doing. Trying to have true beliefs. Views expressed are my own. 🇬🇧🇮🇸

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Kristján Moore (Kris)🔸 @kristjanmoore.bsky.social · 26/09/2026
Hilarious, wonderful result on the effects of Zodiac sign on personality. Deserves an Ig Nobel.
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Adam Auton @adamauton.bsky.social · 18/09/2026
What can we learn about a single rare variant? Published today in Science: the 23andMe Research Institute and Dana-Farber studied the EGFR T790M in 10.1M 23andMe research participants. The variant has OR = 25.2 for lung cancer, rising to 61.7 in never-smokers(!). 🧵
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Kristján Moore (Kris)🔸 @kristjanmoore.bsky.social · 18/09/2026
Slightly unbelievable that studies like this are still being performed - based on targeted genotyping of 83 candidate SNPs in 380 individuals. They do at least candidly report null results.
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Richard Sever @richardsever.bsky.social · 17/09/2026
"mathematicians express extreme concern about the pace of development of AI and the implications of this for civilisation... believe this is an emergency, and call on the Royal Society to use its influence to convey this view to government and the media." docs.google.com/document/d/1...
docs.google.com
Open Letter to Paul Nurse
Open Letter to Sir Paul Nurse, President of the Royal Society Dear Paul We, as mathematicians, write to express our extreme concern about the pace of development of AI and the implications of this f...
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Guillaume Holley @guillaumeolesan.bsky.social · 20/08/2026
I am delighted to present with @hannespetur.bsky.social our new study on the Icelandic pangenome reference HPRC-ICE. This work goes all the way from pangenome construction to disease association! (1/7) www.nature.com/articles/s41...
nature.com
An Icelandic pangenome reference - Nature
Newly developed methods enable construction of Icelandic haplotypes and mapping of population-scale short reads to a pangenome by reducing reference bias and improving discovery in low-mappability reg...
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Stephen Turner @stephenturner.us · 19/08/2026
Autonomous de novo protein binder design with Claude (PDF) www-cdn.anthropic.com/30bf50e22a01...
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bioRxiv Genetics @biorxiv-genetic.bsky.social · 06/08/2026
Ancient DNA reveals matrilineal organisation and recurrent unions between dominant matrilines in Iron Age Britain www.biorxiv.org/content/10.64898/20…
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Brynja Sigurpálsdóttir @brynjad.bsky.social · 30/07/2026
Excited to share our new paper in Nature Communications! rdcu.be/fwOV9 We used @nanoporetech.com to sequence 7,284 individuals and measured DNA methylation at ~18 million high-quality CpG units across the genome (1/5)
rdcu.be
Nanopore sequencing identifies parent-of-origin specific age-associated methylation changes at imprinted loci in the human genome
Nature Communications - DNA methylation changes with age, but parent-of-origin effects remain poorly characterised. Here, the authors use nanopore sequencing to map age-associated methylation...
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Zach Weinersmith @zachweinersmith.bsky.social · 20/07/2026
Very worried about this sort of thing hitting more broadly:
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Aylwyn Scally @aylwyn-scally.bsky.social · 08/07/2026
The head-in-the-sand approach people are taking to the uses and consequences of AI, particularly in academia, is extremely frustrating. And quite worrying.
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Kristján Moore (Kris)🔸 @kristjanmoore.bsky.social · 02/07/2026
Pre-print on the impacts of the second plague pandemic and concurrent historical processes in 529 human genomes (mean 8.8x) from @ucph.bsky.social, Amgen/deCODE genetics, and many collaborators. We'd be grateful for any feedback before publication, so please share!
PCA of ancient individuals included in our study. We observe mostly northern European ancestry with three notable outliers.Selection scan in pre-Black Death versus post-Black Death samples showing no significant results.
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bioRxivpreprint @biorxivpreprint.bsky.social · 02/07/2026
Genomic impact of the second plague pandemic on three human populations www.biorxiv.org/content/10.64898/20…
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Kristján Moore (Kris)🔸 @kristjanmoore.bsky.social · 02/07/2026
Pre-print on the impacts of the second plague pandemic and concurrent historical processes in 529 human genomes (mean 8.8x) from @ucph.bsky.social, Amgen/deCODE genetics, and many collaborators. We'd be grateful for any feedback before publication, so please share!
PCA of ancient individuals included in our study. We observe mostly northern European ancestry with three notable outliers.Selection scan in pre-Black Death versus post-Black Death samples showing no significant results.
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Reposted by Kristján Moore (Kris)🔸
Matthew @mapoochoo.bsky.social · 07/06/2026
The Met put its entire collection online for free so I made a game out of it! 10 artifacts a day, and you guess where and when each one's from. Anthropeum.com if anyone wants to give it a shot and leave feedback :) #history #archeology #arthistory #museums
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Bastien Llamas @dnatimetravel.bsky.social · 12/06/2026
Long-term isolation and archaic introgression shape functional genetic variation in Near Oceania doi.org/10.1126/scie...
doi.org
Long-term isolation and archaic introgression shape functional genetic variation in Near Oceania
Near Oceanic populations harbor substantial cultural, phenotypic, and genetic diversity yet are drastically underrepresented in human genomics. We generated 177 high-coverage Near Oceanian whole genom...
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bioRxiv Genetics @biorxiv-genetic.bsky.social · 11/06/2026
Buried in two places: Lineages from elite Maya tombs also found in distant caves www.biorxiv.org/content/10.64898/20…
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Kristján Moore (Kris)🔸 @kristjanmoore.bsky.social · 04/06/2026
At this point, shouldn't we describe Sholto David as "self-employed" rather than "amateur"? He's been doing this a long time, he's very good at it, and he recently earned $2.6m for his work.
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bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 20/05/2026
Promises and limitations of local ancestry inference in imputed ancient genomes www.biorxiv.org/content/10.64898/20…
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Richard Sever @richardsever.bsky.social · 19/05/2026
Unreliable data/poor data provenance in clinical prediction model research www.medrxiv.org/content/10.6... "repositories should improve their documentation....Anybody doing basic checks on the datasets would have seen that they do not look like real data" retractionwatch.com/2026/05/18/k...
medrxiv.org
Evidence of Unreliable Data and Poor Data Provenance in Clinical Prediction Model Research and Clinical Practice
Clinical prediction models are often created using large routinely collected datasets. It is essential that prediction models are developed with appropriate data and methods and transparently reported...
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Kristján Moore (Kris)🔸 @kristjanmoore.bsky.social · 13/05/2026
nature.com
Enamel proteins from six Homo erectus specimens across China - Nature
Palaeoproteomic analysis of ancient enamel proteins extracted from Middle Pleistocene Homo erectus specimens from the Zhoukoudian, Hexian and Sunjiadong sites in China suggests that they are a ne...
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Ian Hussey @ianhussey.mmmdata.io · 19/04/2026
Reminder: If researchers find Cohen's d = 6, no they didn't. trustworthy.scientific.claims/posts/if-res...
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bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 15/04/2026
Ancient DNA reveals that natural selection has upregulated the immune system over the last 10,000 years www.biorxiv.org/content/10.64898/20…
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Shai Carmi @shaicarmi.bsky.social · 11/04/2026
The area of genomics of named historical individuals is developing rapidly but feels like the Wild West. We need standards and ethical frameworks: - Who are the stakeholders (descendants/victims/countries etc) - Who gives consent - Destructive sampling - TV show "publication" - Data access
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bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 05/04/2026
Convergent natural selection at both ends of Eurasia during parallel radical lifestyle shifts in the last ten millennia www.biorxiv.org/content/10.64898/20…
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bioRxiv Genetics @biorxiv-genetic.bsky.social · 27/02/2026
Endometriosis lesions are oligoclonal structures derived from the normal endometrium www.biorxiv.org/content/10.64898/20…
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Harald Ringbauer @hringbauer.bsky.social · 21/03/2026
We just published a brief preprint on aDNA from two Medieval Ottonic emperors. 🧬👑 We confirm via IBD segments that remains attributed to Otto "the Great" and "Saint" Heinrich are third-degree relatives. As historically attested - suggesting that they are authentic. ✅️ doi.org/10.64898/202... (1/3)
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Kristján Moore (Kris)🔸 @kristjanmoore.bsky.social · 13/03/2026
I really wish that AI labs were not racing as fast as they can to train models that are much smarter than humans and unleash them on the world. I wish that they hadn't already released models which generate images and audio that are hard to distinguish from real footage or the work of artists.
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Ethan Mollick @emollick.bsky.social · 10/03/2026
It is very clear that we could stop AI development right now and it would still transform a substantial portion of white collar work, often unrecognizably, over the next 5-10 years as people figure out how to make the technology work in various industries, even given current models' limitations.
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Richard McElreath 🐈‍⬛ @rmcelreath.bsky.social · 23/02/2026
I welcome Iceland to the EU if only so we might see Hlöllabátar in Europe. The continent needs Hlöllabátar.
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Harry Fokkens @harryfokkens.bsky.social · 11/02/2026
Proud that after five years of careful analysis and discussion our paper "Lasting Lower Rhine-Meuse forager ancestry shaped Bell Beaker expansion" has now been published.
doi.org
Lasting Lower Rhine–Meuse forager ancestry shaped Bell Beaker expansion - Nature
A distinctive population with high hunter-gatherer ancestry persisted 3,000 years later than in most European regions, contributing to later Lower Rhine–Meuse Bell Beaker users.
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Andrew Gelman et al. @statmodeling.bsky.social · 22/01/2026
This paper in Management Science has been cited more than 6,000 times. Wall Street execs, top govt officials, and even a former U.S. Vice President have all referenced it. It’s fatally flawed, and the scholarly community refuses to do anything about it. statmodeling.stat.columbia.edu/2026/01/22/a...
statmodeling.stat.columbia.edu
This paper in Management Science has been cited more than 6,000 times. Wall Street executives, top government officials, and even a former U.S. Vice President have all referenced it. It’s fatally fl...
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Kristján Moore (Kris)🔸 @kristjanmoore.bsky.social · 25/01/2026
Fun that this study is substantially motivated by the 2013 "Lizardman's constant" post on Slate Star Codex. Like seeing those polygenic score benchmarking studies citing Gwern (as they should).
slatestarcodex.com
Lizardman’s Constant Is 4%
Beware of Phantom Lizardmen I have only done a little bit of social science research, but it was enough to make me hate people. One study I helped with analyzed whether people from different countr…
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Rachel Nuwer @rachelnuwer.bsky.social · 22/01/2026
With most psychedelic drugs, you never know what you're going to get. But this mysterious mushroom from China - without fail - causes users to hallucinate tiny people: crawling up walls, popping out from under furniture and marching under doors. www.bbc.com/future/artic...
bbc.com
'They saw them on their dishes when eating': The mushroom making people hallucinate dozens of tiny humans
Only recently described by science, the mysterious mushrooms are found in different parts of the world, but they give people the same exact visions.
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David Shiffman, Ph.D. 🦈 @whysharksmatter.bsky.social · 02/01/2026
Brenna Henn Wanted to Improve Genetic Medicine. Then Her N.I.H. Grant Was Cut.
nytimes.com
Brenna Henn Wanted to Improve Genetic Medicine. Then Her N.I.H. Grant Was Cut.
Brenna Henn had a long-term grant to study the genetic diversity of Africans and people of African descent. Then her N.I.H. funding was cut.
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bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 26/12/2025
Paleogenomic insight into the collapse, recovery, and management of American bison www.biorxiv.org/content/10.64898/20…
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Michel Nivard @michelnivard.bsky.social · 20/12/2025
This smells distinctly like collider bias and/or selection bias and/or regression to the mean... You simply can't select teen prodigies, and world class athletes rom databases, and go run regressions without serious consideration of the selection process!
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Eugenie Reich @eugenie-reich.bsky.social · 16/12/2025
The U.S. Department of Justice has reached a $15 million NIH grant fraud settlement with Dana-Farber Cancer Center. This resolves a False Claims Act qui tam complaint that I filed on behalf of @sholtodavid.bsky.social in April 2024, with Gregg Shapiro as my co-counsel.
eugeniereichlaw.com
News & Publications
Eugenie Reich & Gregg Shapiro Announce $15 Million NIH Grant Fraud Settlement (December 2025) Complaint Settlement Agreement Scientific Fraud in the 21st Century (Video Lecture) Sandia Nationa…
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Shai Carmi @shaicarmi.bsky.social · 10/12/2025
Sperm banks should be much more strictly regulated. (particularly, only accepting donations from registered donors). The banks don't seem to make the slightest effort to avoid these cases. www.bbc.com/news/article...
bbc.com
Sperm from donor with cancer-causing gene was used to conceive almost 200 children
Some children have already died and only a minority who inherit the mutation will escape cancer in their lifetimes.
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Carina Schlebusch @cschlebu.bsky.social · 03/12/2025
Our new ancient DNA paper has just been published! We present 28 new genomes from southern Africa - several of them high-coverage whole genomes. Exciting to be moving towards population-level representation of ancient southern African genetic diversity! www.nature.com/articles/s41...
nature.com
Homo sapiens-specific evolution unveiled by ancient southern African genomes - Nature
The genomes of 28 ancient southern African individuals dated to between 10,200 and 150 years before present offer insights into the evolution of Homo sapiens.
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bioRxiv Genetics @biorxiv-genetic.bsky.social · 01/12/2025
Bayesian inference of population structure using identity-by-descent-based stochastic block models www.biorxiv.org/content/10.1101/202…
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Charles West @pseudo-isidore.bsky.social · 12/11/2025
I learn from my students of the Icelandic Saga map: hours of fun! sagamap.hi.is/is/
sagamap.hi.is
Icelandic Saga Map
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bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 06/11/2025
Revisiting the Evolution of Lactase Persistence: Insights from South Asian Genomes www.biorxiv.org/content/10.1101/202…
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Kristján Moore (Kris)🔸 @kristjanmoore.bsky.social · 27/10/2025
Apropos of nothing in particular, I think it's useful to signal-boost this old paper on "how not to over-interpret ADMIXTURE bar plots". www.nature.com/articles/s41...
nature.com
A tutorial on how not to over-interpret STRUCTURE and ADMIXTURE bar plots - Nature Communications
Clustering methods such as STRUCTURE and ADMIXTURE are widely used in population genetic studies to investigate ancestry. Here, the authors provide a tutorial on how to interpret results of these anal...
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Kristján Moore (Kris)🔸 @kristjanmoore.bsky.social · 20/10/2025
cell.com
Long shared haplotypes identify the southern Urals as a primary source for the 10th-century Hungarians
Genome-wide ancient DNA data from early medieval populations across the broader Ural region and adjacent areas identify the southern Urals as the primary ancestral source of 10th-century Hungarians.
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Kristján Moore (Kris)🔸 @kristjanmoore.bsky.social · 09/10/2025
Can't believe I'd never heard of Euplotes before today: single-celled organisms who scurry around on little "legs"! Around 50 μm long, so ~1000x smaller than a tardigrade. This one has a kind of horseshoe crab habitus, flattened and with a "carapace". Incredible. youtu.be/uJF30emkWt8?...
youtu.be
Ciliates Euplotes
YouTube video by Microvisum
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Kristján Moore (Kris)🔸 @kristjanmoore.bsky.social · 15/09/2025
Something deeply strange happened to the ADMIXTURE run here! The American component, and to some extent the European one, seem to have been co-opted to describe Arab variation. Very little real indigenous American ancestry here, as indicated by e.g. mitochondrial haplogroup counts.
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Jack Kosmicki @jakphd.bsky.social · 11/09/2025
Kristin Tsuo, @genetisaur.bsky.social, & Mark Daly just wrote the best proteomics paper I've read. They convincingly show how smoking and alcohol (aka, the environment) dramatically influences proteomics data. Some 🤯 results 1) proteomics predicts frequency (5a) & quanity (5b) of alcohol consumed
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Andrew Curry @andrewcurry.com · 03/09/2025
A study led by @zhofmanova.bsky.social @mpi-eva-leipzig.bsky.social used ancient DNA to investigate the spread of Slavic language and culture 1,500 years ago. “This wasn’t a migration of elites, or a few male warriors,” 1 co-author says. “This was the migration of an entire population.” @science.org
science.org
Ancient skeletons’ genes reveal origin of the Slavic people
DNA connects modern Slavs to a wave of migration following the fall of the Roman Empire
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