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Koen Rademaker

@krademaker.bsky.social
69 followers 142 following 11 posts

Running code and kilometers in Cambridge. Spatial omics, neurodevelopment and more in Bayraktar lab, @sangerinstitute.bsky.social

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Koen Rademaker @krademaker.bsky.social · 23/09/2026
From @vw1234.bsky.social with our contributions in @bayraktarlab.bsky.social: - MR finds genetically predicted reduced cortical size to have modest but causal links to ADHD - New spatiotemporal neurogenesis gene program enriches for polygenic effects of both traits www.medrxiv.org/content/10.6...
medrxiv.org
Polygenic effects on cortical size and ADHD converge on a mid-gestational progenitor-to-neuron transition programme
Neurodevelopmental and psychiatric conditions have long been hypothesised to emerge from changes in the structure and function of the brain. However, the molecular and cellular mechanisms linking brai...
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Koen Rademaker @krademaker.bsky.social · 22/05/2026
Honoured to have received the Trainee Award for my talk together with @drjimmylee.bsky.social at the International Conference on Genomics and Systems Biology of Human Disease and Aging (@aegeanconf.bsky.social), with strong @bayraktarlab.bsky.social presence to showcase our spatial omics research.
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Hilary Martin @hilarycmartin.bsky.social · 25/02/2026
I have an opening for a staff scientist or bioinformatician in my group at the Sanger Institute (closing date 24 March). Our current projects focus on disentangling rare and common variant contributions to rare neurodevelopmental conditions and to neurodevelopmental and perinatal traits. 1/2
sanger.wd103.myworkdayjobs.com
Bioinformatician/Staff Scientist in Medical Genomics
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
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Danai Vagiaki @danaivagiaki.bsky.social · 08/02/2026
Delighted to present Latent Interaction Variational Inference (LIVI), a framework for trans-eQTL mapping at single-cell resolution that I developed during my PhD together with colleagues from @steglelab.bsky.social 1/n
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Koen Rademaker @krademaker.bsky.social · 29/01/2026
The webinar series on spatial transcriptomics analysis is now open for registration! Join me on 18 March to learn how we at @bayraktarlab.bsky.social integrate single-cell and spatial transcriptomics to map the rules of neurological conditions.
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Koen Rademaker @krademaker.bsky.social · 11/11/2025
Beyond excited to share my first work with Omer's group at Sanger! With amazing co-authors Alexander & Fani we are passionate about neurodevelopmental genetics and this work really showed us the power of uncovering new genetics with spatial transcriptomics! 🧵👇 Background / motivation / key results
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Bas van Steensel lab (NKI) @basvansteensellab.bsky.social · 02/09/2025
Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!
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Koen Rademaker @krademaker.bsky.social · 30/06/2025
Bayraktar, Bassett and Lotfollahi labs are studying how neurodegenerative diseases (ALS, PD, AZ) spatially organise 🧠🧬 Join us to generate & analyse wealths of Xenium data: - Tech specialist: sanger.wd103.myworkdayjobs.com/en-US/Wellco... - AI postdoc: sanger.wd103.myworkdayjobs.com/en-US/Wellco...
sanger.wd103.myworkdayjobs.com
Technical Specialist: Neurodegenerative Disease Spatial Transcriptomics and Data Generation
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
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Manu Saraswat @manusaraswat.bsky.social · 16/05/2025
🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇
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Omer Ali Bayraktar @bayraktarlab.bsky.social · 16/05/2025
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
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Erick Armingol @erickarmingol.bsky.social · 15/05/2025
I’m happy to share that our scCellFie manuscript is finally on bioRxiv — a project that was an amazing opportunity to return to my roots in metabolism! We infer metabolic activity from single-cell & spatial transcriptomics 🧬 Read the pre-print here👇 📄 doi.org/10.1101/2025...
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Lucía Barbadilla Martínez @luciabarmar.bsky.social · 14/05/2025
Our review "Predicting gene expression from DNA sequence using deep learning models" is finally out! 🤗
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Jimmy Lee @drjimmylee.bsky.social · 12/03/2025
Thrilled to share our new @naturecomms.bsky.social study with @sam-n-barnett.bsky.social on early vs late #COVID19 lung damage 🫁. Using single-cell & histopathology-informed #SpatialTranscriptomics, we uncovered key biomarkers & immune patterns. Thanks to collaborators, UKCIC & @humancellatlas.org
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Koen Rademaker @krademaker.bsky.social · 03/03/2025
Another great computational method out of the Bayraktar lab! Alexander Aivazidis has been a great colleague in our lab and it's amazing to see the capstone of his PhD is now published.
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Koen Rademaker @krademaker.bsky.social · 01/03/2025
Next weekend I will run the Cambridge half marathon with @sangerinstitute.bsky.social colleagues 🏃‍♂️ Two amazing people are running for charities, please support them!
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Anshul Kundaje @anshulkundaje.bsky.social · 04/12/2024
This is really horrific. These single cell reference atlases are widely used as is to train all kinds of models! This is one of the reasons I've constantly harping about uniform reprocessing & extremely careful QC of large atlases. 1/
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