iiinova — where your digital self keeps evolving

Reposted by Kiarash Jamali

Sjors Scheres @sjorsscheres.bsky.social · 30/09/2026

Our adventures into #proteinfolding: GuideFlip designs flexible molecular interactions by discrete flow matching to design sequence & structure together! Grateful for funding by Love Tito's (@titosvodka.bsky.social) and the @ukri.org. 🥳

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Kiarash Jamali @kjamali.bsky.social · 29/09/2026

Please check out our cool new method, GuideFlip! Optimised for binders against disordered proteins

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Reposted by Kiarash Jamali

Kai Yi @kaiyi94.bsky.social · 29/09/2026

6/7 We further apply GuideFlip to a curated set of 285 human DisProt targets. For 177 (62.1%), at least one design passed our computational filters. These are predicted candidates. Explore complexes and download sequences: huggingface.co/spaces/ykiii...

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Kai Yi @kaiyi94.bsky.social · 29/09/2026

1/7 Excited to share GuideFlip! We use guided discrete flow matching to co-design protein sequences and structures for flexible interactions, with experimental validation across three systems: α-synuclein, RBX1 and active-state GPCR nanobodies.

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Tanmay Bharat @tbharat-lab.bsky.social · 15/07/2026

Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA led by @olivia--smith.bsky.social Collaboration with @alexbateman1.bsky.social , Andres Floto and @geiselbiofilm.bsky.social labs

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Kiarash Jamali @kjamali.bsky.social · 28/04/2026

Thrilled with this result, tune in for more soon!

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Reposted by Kiarash Jamali

Kai Yi @kaiyi94.bsky.social · 28/04/2026

Thrilled with the our results with @kjamali.bsky.social and @sjorsscheres.bsky.social from the recent binder competition! 🎉 2 of our 7 designs successfully bound to the target, with affinities ranking 2nd and 3rd overall. All of these designs targeted the disordered region of the protein.

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Reposted by Kiarash Jamali

Sjors Scheres @sjorsscheres.bsky.social · 28/04/2026

The #ADFLIP approach by @kaiyi94.bsky.social and @kjamali.bsky.social, combined with their approach to backpropagation through #AlphaFold2, is really powerful. Keep tuned for more exciting results! 🥳

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Reposted by Kiarash Jamali

Joe Greener @jgreener64.bsky.social · 01/04/2026

On this 1st April I'm happy to release a technical report from our startup MirageBio, describing a new protein structure model with state-of-the-art performance. jgreener64.github.io/posts/techni...

jgreener64.github.io

MirageBio technical report

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Reposted by Kiarash Jamali

Kelly Nguyen @kellythd-nguyen.bsky.social · 26/03/2026

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...

youtube.com

Cryo-EM structure of yeast telomerase

YouTube video by MRC Laboratory of Molecular Biology

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Reposted by Kiarash Jamali

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 24/02/2026

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme? Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues. Apply by 16 MAR www.nature.com/naturecareer...

Job opening for Research Group Leader in Structural Studies at MRC Laboratory of Molecular Biology, focusing on macromolecular structures.

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Reposted by Kiarash Jamali

bioRxivpreprint @biorxivpreprint.bsky.social · 24/02/2026

A portable orthogonal replication system enables continuous gene evolution near the biological speed limit www.biorxiv.org/content/10.64898/20…

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Reposted by Kiarash Jamali

Sjors Scheres @sjorsscheres.bsky.social · 16/02/2026

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

mrc.tal.net

Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council

Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55

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Sjors Scheres @sjorsscheres.bsky.social · 09/12/2025

Star student & postdoc Kiarash Jamali is setting up his own group at the Ellison institute in Oxford. Join him for the most exciting machine learning research in structural biology and beyond!! 🤩 #ProudPI

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Reposted by Kiarash Jamali

Bogdan Toader @btoader.com · 09/12/2025

Join ML wizard Kiarash to develop BioML methods that work

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Joe Greener @jgreener64.bsky.social · 09/12/2025

Kiarash is starting his research group on computational enzyme design, get in touch with him if you want to be part of it.

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Kiarash Jamali @kjamali.bsky.social · 09/12/2025

Thank you Randy! Will keep you updated :)

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Kiarash Jamali @kjamali.bsky.social · 09/12/2025

PS if the link above doesn't work, please try jamali-lab-2.pages.dev

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Kiarash Jamali @kjamali.bsky.social · 09/12/2025

The GBI will be a fantastic place to do protein design research, with a large scale GPU cluster, expert wet lab biology groups, and a collaborative environment. For more information, please see jamalilab.com. If you are interested in a postdoc, please reach out, applications will be open soon.

jamalilab.com

Jamali Lab

Jamali Lab at the EIT Generative Biology Institute engineers new proteins with AI, biology insight, and wet-lab validation in Oxford, UK.

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Kiarash Jamali @kjamali.bsky.social · 09/12/2025

I’m excited to announce that I will be starting my research group on computational enzyme design at the Generative Biology Institute, Oxford, UK (@eitoxford.bsky.social)! PhD applications are open, deadline is Jan 8th (www.chem.ox.ac.uk/genbio-dtp). Email kiarash.jamali@eit.org with any questions!

chem.ox.ac.uk

GenBio DTP

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Reposted by Kiarash Jamali

Gautam Dey @gautamdey.bsky.social · 07/11/2025

And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function. Beautiful tomography and microscopy - congrats all 🤩

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Reposted by Kiarash Jamali

Tanmay Bharat @tbharat-lab.bsky.social · 07/11/2025

An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

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Max Wilkinson @maxewilkinson.bsky.social · 31/10/2025

The Wilkinson Lab is open for science! @mskcancercenter.bsky.social 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬 annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)

wilkinsonlab.bio

Wilkinson Lab

We discover and study reverse transcriptases

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John Rubinstein @johnrubinstein.bsky.social · 30/10/2025

New lab preprint! @zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes 🧵 tinyurl.com/ukny4ptz

Cryo-EM maps and atomic models of the biotin-containing 3-methylcrotonyl-CoA carboxylase (MCC) complex and long-chain acyl-CoA carboxylase (LCC) complex

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Reposted by Kiarash Jamali

Sjors Scheres @sjorsscheres.bsky.social · 29/10/2025

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated. mrc.tal.net/vx/appcentre...

mrc.tal.net

Quick Check Needed

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Reposted by Kiarash Jamali

Sjors Scheres @sjorsscheres.bsky.social · 05/10/2025

If you are interesting in developing new algorithms for #cryoEM as a #PhD student or as a #postdoc, then do email or DM me. We have exciting opportunities coming up.

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Reposted by Kiarash Jamali

Annika Inampudi @annikainampudi.bsky.social · 06/08/2025

Researchers found that low lithium levels are linked to Alzheimer's disease in humans, and restoring it can reverse cognitive decline in mice. For a field still searching for cure, this paper may offer a clever new approach 🧠 Read more about it in @science.org www.science.org/content/arti...

science.org

Could lithium stave off Alzheimer’s disease?

The metal is depleted in brains of people with disease and can reverse memory symptoms in mice, new study shows

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Reposted by Kiarash Jamali

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 01/08/2025

Rewriting the language of life: Jason Chin’s group in the LMB’s PNAC Division have synthesised E. coli with just 57 codons instead of the usual 64. Syn57 required 101000+ codon changes & represents a bold step towards programmable life. Read more: www2.mrc-lmb.cam.ac.uk/syn57-repres... #LMBResearch🧪

Glowing E. coli bacteria in green and blues on a background of DNA bases

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Kiarash Jamali @kjamali.bsky.social · 26/07/2025

Good luck Martin! I’m sure you will do great 😊

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Reposted by Kiarash Jamali

Martin Pacesa @martinpacesa.bsky.social · 25/07/2025

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

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Kieran Didi @kdidi.bsky.social · 19/07/2025

Very excited about our latest all-atom generative model proteina, check out the project page (research.nvidia.com/labs/genair/...) and stay tuned for the code release soon!

research.nvidia.com

La-Proteina: Atomistic Protein Generation via Partially Latent Flow Matching

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Julien Capin @ju-cap.bsky.social · 17/07/2025

You designed binders for your favourite protein and wish there was a way to experimentally screen them within 24h w/ only a set of pipettes and a plate reader? Check out our Cell-Free 2-Hybrid approach (CF2H) Full post: tinyurl.com/48cz5nb6 Preprint: www.biorxiv.org/cgi/content/...

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Sjors Scheres @sjorsscheres.bsky.social · 15/07/2025

Our entrance into protein design! Inverse folding steered by external sources of information, and for multiple conformations. By the amazing @kaiyi94.bsky.social and @kjamali.bsky.social! Download our code and try it yourself. 🥳

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Kiarash Jamali @kjamali.bsky.social · 08/07/2025

Thank you so much Randy 😊 It was lots of fun

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Reposted by Kiarash Jamali

Sjors Scheres @sjorsscheres.bsky.social · 07/07/2025

Many congratulations to Dr Kiarash Jamali @kjamali.bsky.social for successfully defending his PhD thesis today! 🥳 Also many thanks to Jonas Adler and Randy Read for examining him. I expect great things from Dr Jamali in his career, so do keep an eye on him. #ModelAngelo

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Joe Parham @joeparham19.bsky.social · 29/05/2025

We are excited to share our preprint describing how Sulfolobus cells coordinate DNA segregation with cell division! In eukaryotes this type of regulation involves checkpoints and CDK-cyclins. But how does this work in archaea? This is the question we ask in our paper: www.biorxiv.org/content/10.1...

biorxiv.org

Temporal and spatial coordination of DNA segregation and cell division in an archaeon.

Cells must coordinate DNA segregation with cytokinesis to ensure that each daughter cell inherits a complete genome. Here, we explore how DNA segregation and division are mechanistically coupled in ar...

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Reposted by Kiarash Jamali

Arjen Jakobi @cryotud.bsky.social · 26/05/2025

LocScale-SURFER is now also available for quick install via the ChimeraX toolshed: cxtoolshed.rbvi.ucsf.edu

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Reposted by Kiarash Jamali

Dawid Zyla @dzyla.bsky.social · 27/04/2025

1/5: Over the last few months, I have been working on an update for the #FollowRelionGracefully dashboard, which offers improved real-time job previews for #cryoEM #Relion jobs.

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