Reposted by Kevin WaskobioRxivpreprint @biorxivpreprint.bsky.social · 23/06/2026Programming T cells for intercellular genome editing www.biorxiv.org/content/10.64898/20… 011
Reposted by Kevin WaskoDoudna Lab @doudna-lab.bsky.social · 27/04/2026We present VIPR, a phage-encoded RNA-guided system that recognizes DNA with a noncontiguous code unlike CRISPR. Tiny, programmable, possibly ancestral to CRISPR immunity; VIPR is built around a striking RNA-DNA-DNA triplex. 116050
Reposted by Kevin WaskoNature Biotechnology @natbiotech.nature.com · 11/03/2026Engineered TnpB genome editors for plants and human cells identified by ribonucleoprotein mutational scanning - @savagecatsonly.bsky.social go.nature.com/4loaOGngo.nature.comEngineered TnpB genome editors for plants and human cells identified by ribonucleoprotein mutational scanning - Nature BiotechnologyTnpB endonucleases are engineered for improved genome editing. 0109
Reposted by Kevin WaskobioRxivpreprint @biorxivpreprint.bsky.social · 14/01/2026Amplified genome editing by in vivo editor production www.biorxiv.org/content/10.64898/20… 032
Reposted by Kevin WaskoNature Biotechnology @natbiotech.nature.com · 12/01/2026Targeted delivery of genome editors in vivo - @doudna-lab.bsky.social @innovativegenomics.bsky.social go.nature.com/4qKp6Tb 0147
Reposted by Kevin WaskoSavage Lab @savagecatsonly.bsky.social · 22/12/2025New from Ugrappa Nagalakshmi and Jorge Rodriguez 🌱✂️– Gene editing in plants just got a lot easier! Using engineered TnpB, they demonstrate high-efficiency, heritable, transgene-free editing in plants. (1/7) 1116
Reposted by Kevin WaskoPetr Skopintsev @petrskopintsev.bsky.social · 09/12/2025Excited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! 💫 0268
Reposted by Kevin WaskoOwen Tuck @owentuck.bsky.social · 13/11/2025Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/... Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.socialscience.orgRecurrent acquisition of nuclease-protease pairs in antiviral immunityAntiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin... 58434
Reposted by Kevin WaskoErin Doherty @erinedoherty.bsky.social · 02/10/2025Now online at @nature.com we show how the Panoptes defense system protects against viruses that attempt immune evasion - and expands our understanding of the role of oligonucleotides in immunity. Check out this work co-led with @benadler.bsky.social here: www.nature.com/articles/s41...nature.comA miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - NaturePanoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed. 25622
Reposted by Kevin WaskoOwen Tuck @owentuck.bsky.social · 29/07/2025Excited to finally share this work! We noticed a pair of genes - a nuclease and a protease - shuffles between antiviral systems. We show how proteolysis activates the nuclease, triggering defense in known and unknown immune contexts. tinyurl.com/2uwwy4tytinyurl.comRecurrent acquisition of nuclease-protease pairs in antiviral immunityAntiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin... 25830
