Ancient viral warfare could be at the root of modern class 1 CRISPR bacterial defense systems

CRISPR-Cas provides RNA-mediated adaptive immunity, but how its first RNA-guided effector arose is unclear. In this study, we report the discovery of Viral Interference Programmable Repeat (VIPR) syst...

Scientists have discovered a powerful gene-targeting system in viruses. Billions of years old, VIPR seems to predate CRISPR and may be even more effective.

How researchers in the Doudna Lab discovered VIPR, an ancient progenitor of CRISPR found in viruses that snakes around genes

Ancient viral warfare could be at the root of modern class 1 CRISPR bacterial defense systems

CRISPR-Cas provides RNA-mediated adaptive immunity, but how its first RNA-guided effector arose is unclear. In this study, we report the discovery of Viral Interference Programmable Repeat (VIPR) syst...

The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic ...

Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

Microbial and viral co-evolution has created immunity mechanisms involving oligonucleotide signaling that share mechanistic features with human anti-viral systems. In these pathways, including CBASS a...