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Sarah Keane

@keanelab.bsky.social
240 followers 249 following 47 posts

Associate Professor of Biophysics and Chemistry @Umich. Structural Biology. NMR. Biochemistry.

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Reposted by Sarah Keane
Chris Pickett @chrispickett5.bsky.social · 30/09/2026
[SENATOR ERIC SCHMITT]: So you’re telling under oath that you never studied transcription? [JACK SMITH]: No [SCHMITT]: WELL THEN *unveils poster* please explain this picture of you with RNA Pol II. [SMITH]: That is a ribosome, sir.
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Sarah Keane @keanelab.bsky.social · 10/09/2026
Another paper is out! See below for single molecule analysis of the prfA RNA thermosensor conformational accessibility. A collaboration with @nilswalterlab.bsky.social doi.org/10.1016/j.bp...
doi.org
Redirecting
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Sarah Keane @keanelab.bsky.social · 01/09/2026
This ASO approach was effective both in vitro and in cells and can be use to target any pre-miRNA containing a similar "junction" structure, estimated at ~20% of human pre-miRNAs.
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Sarah Keane @keanelab.bsky.social · 01/09/2026
We previously identified that the stability of a short base paired region within pre-miR-31 was a key regulator for Dicer/TRBP processing. Here, the team targeted that region with ASOs - locking the RNA into a conformation that was a poor substrate for Dicer/TRBP.
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Sarah Keane @keanelab.bsky.social · 01/09/2026
Congratulations to Megan, Sicong, Aiden, and Samantha on the publication of their ASO work! dx.doi.org/10.1039/D6CB...
dx.doi.org
Submit This Form
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Reposted by Sarah Keane
Alex Guseman @alexguseman.bsky.social · 11/08/2026
Im looking for a postdoc to help with protein engineering efforts. If you know who could be a good fit send them my way! see details below:
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Reposted by Sarah Keane
Jens Schmidt @jenscs83.bsky.social · 11/06/2026
I am looking to recruit 2 postdoctoral fellows to the lab to work on a recently funded project focused on class switch recombination in B cells. If you are interested in immunology, gene expression, and RNA and protein single molecule imaging, please reach out (schmi706@msu.edu). Please share!
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Sarah Keane @keanelab.bsky.social · 08/06/2026
My lab is currently recruiting 2(!!) postdocs in RNA structural biology/biochemistry! Full details can be found below and on our website (sites.lsa.umich.edu/keane-lab/op...).
Job posting. Details available at https://sites.lsa.umich.edu/keane-lab/openings/.
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Sarah Keane @keanelab.bsky.social · 29/04/2026
Way to go @berlowlab.bsky.social!!
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Sarah Keane @keanelab.bsky.social · 22/04/2026
Congratulations! So many wonderful people on this paper! It was a pleasure to read!
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Reposted by Sarah Keane
Woodson Lab @woodsonlab.bsky.social · 22/04/2026
Our new paper is out! Using 19F NMR, we show that Hfq rewires the conformational dynamics of a model sRNA in a site-specific manner. Uridines at the rim undergo faster exchange (~100 μs) than those in the proximal pore (~300 μs). Congrats Elise! 🎉🎉 www.sciencedirect.com/science/arti...
sciencedirect.com
19F NMR Strategy for Probing Site-specific RNA Dynamics in Large RNA-protein Complexes: Application to the Hfq RNA Chaperone
Nuclear magnetic resonance (NMR) spectroscopy is uniquely suited to probing motions on the microsecond to millisecond timescales that underlie RNA rec…
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Sarah Keane @keanelab.bsky.social · 14/04/2026
Very proud of UGs Sydney and Jocelyn. Sydney was awarded a GRFP and Jocelyn received an honorable mention! Both are off to Princeton for grad school this fall!
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Reposted by Sarah Keane
Steven R. Shaw, PhD @shawpsych.bsky.social · 09/04/2026
As baseball season ramps up, it is time to re-post my favorite inspirational quote of all time from the great Mets left fielder and philosopher, Mookie Wilson.
Greatest inspirational quote of all time by Mookie Wilson.
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Paul Noth @paulnoth.bsky.social · 23/02/2026
Mine in this week’s @newyorker.com
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Reposted by Sarah Keane
Cade Harkner @chembiocade.bsky.social · 24/02/2026
If you’re around @biophysicalsoc.bsky.social 2026 and looking for some cool RNA-protein work related to microRNA biogenesis, stop by my poster today at 1:45 and I’ll tell you about some of my near-complete work with @keanelab.bsky.social! #BPS2026
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Sarah Keane @keanelab.bsky.social · 20/02/2026
New press about my mom, Prof. Susan Keane @uncg.edu and the impact of her work with Dream Camp, Right Track, and other mentoring in the Psychology Department. Very proud of the work she has done and luck to have her as a role model!
giving.uncg.edu
Bernard-Glickman Professorship elevates UNCG psychology  - University Advancement
UNC Greensboro psychology professor Dr. Susan Keane, the holder of the Candace Bernard and Robert Glickman Distinguished Professorship, says she can make a stronger impact because of the generosity of...
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Reposted by Sarah Keane
Bruce Springsteen @brucespringsteen.net · 28/01/2026
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good. Stay free
youtu.be
Bruce Springsteen - Streets Of Minneapolis (Official Audio)
YouTube video by Bruce Springsteen
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Reposted by Sarah Keane
Admirable Women @admirablewomen.bsky.social · 26/01/2026
Biochemist/molecular biologist Joan Steitz was born #OTD in 1941. She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM
Color photograph of Joan Steitz (Joan Argetsinger Steitz), the distinguished American molecular biologist and biochemist renowned for her groundbreaking discoveries in RNA biology, including the identification of small nuclear ribonucleoproteins (snRNPs) essential to RNA splicing. She is pictured in a close-up portrait within a laboratory or research setting, smiling warmly and directly at the camera with an engaging, approachable expression that conveys enthusiasm and expertise. Steitz has gray hair pulled back, striking blue eyes, and is wearing large, elaborate dangling earrings adorned with purple gemstones and metallic accents. She is dressed in a rich purple blouse. The softly blurred background includes scientific elements such as lab benches, equipment, monitors, charts, and partial signage, evoking the environment of her long career at Yale University where she served as Sterling Professor of Molecular Biophysics and Biochemistry. #JoanSteitz #MolecularBiology #WomenInScience #Biochemistry #RNA
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Timothy Bredy @twbredy.bsky.social · 21/01/2026
www.colorado.edu/today/2026/0...
colorado.edu
Tom Cech to Davos: RNA research is 'still a big deal'
The Nobel laureate and CU Boulder professor, recently ranked #1 globally for RNA research, will speak at the World Economic Forum annual meeting in Davos,
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Sarah Keane @keanelab.bsky.social · 14/12/2025
See you soon!
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Reposted by Sarah Keane
Communications Chemistry @commschem.nature.com · 05/12/2025
Just out: NMR data processing, visualization, analysis and structure calculation with NMRFx
bit.ly
NMR data processing, visualization, analysis and structure calculation with NMRFx
Communications Chemistry, Published online: 05 December 2025; doi:10.1038/s42004-025-01812-8NMR spectroscopy’s effectiveness across scientific disciplines hinges on robust computational tools for data analysis. Here, the authors introduce NMRFx, a software that enhances data processing and visualization, demonstrating its utility through diverse case studies, including protein, RNA, natural product, and metabolomics analyses.
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Sarah Keane @keanelab.bsky.social · 20/11/2025
all raw and processed data are also freely available doi.org/10.7302/5det...
doi.org
A practical guide to RNA NMR spectral analysis for undergraduate students - NMR datasets
Nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical tool that can be used to determine the structures of both small organic molecules and large biomacromolecules. Many undergradu...
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Sarah Keane @keanelab.bsky.social · 20/11/2025
I'm also late in posting this work, but really proud of Megan @mnwestwood.bsky.social, Sydney, and Jocelyn for their contributions to making RNA NMR spectroscopy more accessible for novice learners! Check out their preprint here: chemrxiv.org/engage/chemr...
chemrxiv.org
A practical guide to RNA NMR spectral analysis for undergraduate students
Nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical tool that can be used to determine the structures of both small organic molecules and large biomacromolecules. Many undergraduate...
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Sarah Keane @keanelab.bsky.social · 20/11/2025
Congratulations are in order!! Cade @chembiocade.bsky.social received the Sokol, Margaret and Herman, Fellowship in the Chemical Sciences and Antigone was selected as a departmental nominee for the Rackham-wide outstanding GSI award!
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Sarah Keane @keanelab.bsky.social · 27/10/2025
Congratulations to postbac Sydney Steele for receiving a poster award at the Rustbelt RNA meeting last weekend!
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Reposted by Sarah Keane
RSC Medicinal Chemistry @rscmedchem.rsc.org · 24/10/2025
🔓Explore recent #OpenAccess work by @keanelab.bsky.social and colleagues where they describe a virtual screening approach to explore the druggability of the precursor structure of microRNA-31👀 pubs.rsc.org/en/content/articlelanding/2025/md/d5md00553a 📍 @umich.edu 🧪
pubs.rsc.org
Integrated in silico and experimental screening identifies novel ligands that target precursor microRNA-31 at the dicer cleavage site
MicroRNAs (miRNAs) regulate gene expression and the dysregulation in mature miRNA levels has been implicated in a wide variety of diseases. In particular, altered levels of mature microRNA-31…
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Sarah Keane @keanelab.bsky.social · 26/09/2025
Wonderful news!! Congratulations!!
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Sarah Keane @keanelab.bsky.social · 03/09/2025
Congratulations to the lab for placing 1st for the College of Literature, Science, and the Arts unit in the 2025 Freezer Challenge! A big thanks to Antigone and @chembiocade.bsky.social for leading the lab in sustainable practices.
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Sarah Keane @keanelab.bsky.social · 14/08/2025
Work funded by #NIH, #RCSA, and #Pew
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Sarah Keane @keanelab.bsky.social · 14/08/2025
Grace then applied this virtual screening pipeline to pre-miR-31. Here, she screened an NCI database and experimentally validated in silico hits. She then conducted a structure similarity search on the validated hits and found a more potent binder!
doi.org
Integrated in silico and experimental screening identifies novel ligands that target precursor microRNA-31 at the dicer cleavage site
MicroRNAs (miRNAs) regulate gene expression and the dysregulation in mature miRNA levels has been implicated in a wide variety of diseases. In particular, altered levels of mature microRNA-31 (miR-31)...
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Sarah Keane @keanelab.bsky.social · 14/08/2025
Grace developed a virtual screening approach focused on cavities identified in the (NPSL2) RNA structure. She then validated screening "hits" experimentally. Importantly, this approach is broadly applicable to any RNA with a known 3D structure.
nature.com
Structure guided discovery of small molecule ligands targeting the oncomiR-1 NPSL2 hairpin - Scientific Reports
Scientific Reports - Structure guided discovery of small molecule ligands targeting the oncomiR-1 NPSL2 hairpin
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Sarah Keane @keanelab.bsky.social · 14/08/2025
Two papers from Grace's thesis have been published! Our journey into the world of small molecule RNA targeting.
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Sarah Keane @keanelab.bsky.social · 26/07/2025
And another poster award! This one to Antigone, who presented at the Karle Symposium today!!
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Sarah Keane @keanelab.bsky.social · 25/07/2025
Congratulations are in order! Two members of the lab, Moriah (a @NSF funded D-RISE high school student) and Diane (a UM undergrad) were awarded poster prizes at the URAN|UM symposium today!
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Reposted by Sarah Keane
Jon Paczkowski🌹 @paczkowskilab.bsky.social · 16/07/2025
I am (optimistically) looking for a postdoc with solution state biomolecular NMR expertise to join our group. I can provide access to high-end instrumentation and technical assistance via our membership at the New York Structural Biology Center. #nmr #academicsky #postdoc
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Sarah Keane @keanelab.bsky.social · 11/07/2025
Glad to see this work out in its final form! Congrats to the team! www.sciencedirect.com/science/arti...
sciencedirect.com
Structural Features Within Precursor microRNA-20a Regulate Dicer-TRBP Processing
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression of target messenger (m) RNAs. To maintain proper miR…
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Reposted by Sarah Keane
Jill Townley @jilltownley.bsky.social · 09/07/2025
Learn more about how Eterna puzzles are being used for RNA education and outreach at the middle school, high school, and college level in the latest RCSB PDB newsletter. 🧬 🧪 cdn.rcsb.org/rcsb-pdb/gen...
cdn.rcsb.org
EDUCATION CORNER: Interactive RNA Education with the Eterna Game
Eterna is an online game which models the base pairing and secondary structure of RNA sequences.
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Sarah Keane @keanelab.bsky.social · 02/07/2025
Congrats Qi!!
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Sarah Keane @keanelab.bsky.social · 25/06/2025
Grace's manuscript describing a combined virtual/experimental screening approach for identifying small molecule ligands that bind pre-miR-31 is online! www.biorxiv.org/content/10.1...
biorxiv.org
Integrated in silico and experimental screening identifies novel ligands that target precursor microRNA-31 at the Dicer cleavage site
MicroRNAs (miRNAs) regulate gene expression and the dysregulation in mature miRNA levels has been implicated in a wide variety of diseases. In particular, altered levels of mature microRNA-31 (miR-31)...
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Sarah Keane @keanelab.bsky.social · 25/06/2025
2nd defense of the summer! Congratulations to Dr. Aldrex Munsayac! It has been a pleasure to work with and learn from you!
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Magnetic Resonance News @nmr900.bsky.social · 20/06/2025
ACS Bio & Med Chem Au (open) Consolidated 3-Fold Isotopic Lens for Probing RNAs, Solomon K. Attionu, Lukasz T. Olenginski, Frances P. Stump, Theodore K. Dayie* pubs.acs.org/doi/10.1021/... #NMRchat 🧲
pubs.acs.org
Consolidated 3-Fold Isotopic Lens for Probing RNAs
Undesired scalar and dipolar couplings are two major interactions that complicate structural and dynamic studies in solution nuclear magnetic resonance (NMR) spectroscopy. Recent developments in site-...
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Sarah Keane @keanelab.bsky.social · 11/06/2025
Great news!! Congratulations!!!
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 09/06/2025
Please join the chorus of voices, including my own, in support of the talented, hardworking and dedicated scientists and staff at NIH. They serve their country by deploying their training and skills to improve the health and quality of life of all Americans 🙏 🇺🇸
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Sarah Keane @keanelab.bsky.social · 06/06/2025
Congratulations to Dr. Arhin for an outstanding thesis defense earlier this week!
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Sarah Keane @keanelab.bsky.social · 04/06/2025
Thrilled that @mnwestwood.bsky.social and I have been recognized with a PACE Fellowship for Graduate Student-Faculty Mentor Pairs! More great things to come!
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Neil Lewis, Jr. @neillewisjr.bsky.social · 03/06/2025
After resigning from Michigan and bending over backwards to try and appease them, "The Florida Board of Governors voted Tuesday to reject Santa Ono as the next president of the University of Florida" www.insidehighered.com/news/governa...
insidehighered.com
Florida Board Rejects Ono for UF Job
The Florida Board of Governors decided against confirming Santa Ono as president of the University of Florida in a contentious vote focused on diversity, equity and inclusion.
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Sarah Keane @keanelab.bsky.social · 27/05/2025
CONGRATULATIONS DENISE!! cen.acs.org/biological-c...
cen.acs.org
2025 Talented 12: Denise Okafor
Studying protein-drug interactions to avoid side effects
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Yamuna Krishnan @krishnanyamuna.bsky.social · 16/05/2025
This is why he is The Boss
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Goss Scientific @goss-scientific.bsky.social · 12/05/2025
It's National Limerick day! A slight deviation from our regular posts. English artist, illustrator, author and poet Edward Lear was born on this day in 1812. To celebrate, Goss Scientific have put their own spin* on the classic limerick form. #NationalLimerickDay #nmr *pun intended
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Sarah Keane @keanelab.bsky.social · 12/05/2025
Another preprint posted! Yaping and Cade @chembiocade.bsky.social uncovered important structural elements in pre-miR-20a that impact Dicer processing. Huge thanks to both Megan @mnwestwood.bsky.social and Aldrex whose experiments rounded out this work! www.biorxiv.org/content/10.1...
biorxiv.org
Structural features within precursor microRNA-20a regulate Dicer-TRBP processing
MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression of target messenger (m) RNAs. To maintain proper miRNA expression levels, the enzymatic processing of ...
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