iiinova — where your digital self keeps evolving

Reposted by Joachim Weischenfeldt

Barbara Hernando @bhernando.bsky.social · 12/09/2026

17/ Enormous effort from co-first authors Andreas Gruber (Konstanz), André Olsen (BRIC Copenhagen) and Kevin Cheng (OICR), and from @gmaci.bsky.social, @reimand.bsky.social and @jweischenfeldt.bsky.social who co-led it. Thanks to #PPCG, to the men who donated samples, and to our funders.

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Barbara Hernando @bhernando.bsky.social · 12/09/2026

1/ NEW PAPER 🎉 🧵 We mapped the mutational processes shaping 959 prostate cancer genomes from the Pan Prostate Cancer Group (PPCG), integrating SBS, ID, CX and complex SV signatures. Eight footprints account for the processes in 85% of cases www.nature.com/articles/s41... @nature.com

nature.com

Integrated signatures define mutational processes in prostate cancer - Nature

Eight integrated mutational footprints collectively explain the mutational processes in 85% of primary prostate cancer genomes.

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Daniel Brewer @danbrewer.bsky.social · 09/09/2026

If one paper out today wasn't enough, from the PanProstate Cancer Group (panprostate.org), we've got another outstanding paper. This one looking at biallelic epigenetic inactivation in the first PPCG data set. Great work. Lucky to be involved. doi.org/10.1038/s414...

panprostate.org

Pan Prostate Cancer Group - Home

PanProstate Cancer Group website.

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Mathieu Lupien @matlupien.bsky.social · 23/12/2025

Back-to-back: Integrating single-nuclei RNA-seq and whole-genome sequencing, @joachimwei.bsky.social and his team show how prostate cancer metastasis is shaped by plasticity-driven convergence alongside ongoing clonal evolution, with distinct clones adopting shared transcriptional trajectories.

nature.com

Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer - Nature Communications

The impact of tumour heterogeneity on metastatic potential in prostate cancer remains poorly understood. Here, the analysis of single nuclei RNA sequencing and whole-genome sequencing from samples fro...

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American Association for Cancer Research (AACR) @theaacr.bsky.social · 12/12/2025

Joachim Weischenfeldt, Ashani Weeraratna, Karuna Ganesh, Elaine Fuchs, Ana Anderson, and Sheetal Hardikar discussed "Endogenous Mechanisms of Early Onset Carcinogenesis" at #AACRearlyonset25. @jweischenfeldt.bsky.social @ashi-w.bsky.social @karunamdphd.bsky.social @thefuchslab.bsky.social

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Joachim Weischenfeldt @jweischenfeldt.bsky.social · 31/10/2025

Great participation and discussions at our PhD course in Cancer Genomics at @bric-ucph.bsky.social organized together with prof Jesper Andersen. Exciting talks and interactions with external speakers incl @ecuppen.bsky.social and @matlupien.bsky.social 🙏💪👇

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James Bonfield @jbonfield.bsky.social · 15/09/2025

Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change. Ie: it's not us (Samtools team)! Be warned

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Bo Porse @porsebo.bsky.social · 22/08/2025

So excited to see it out in @science.org. See details below in the 🧵 from stellar former PhD student @bfurtwa.bsky.social. Many thanks to all involved, especially Blueskyless Nil Uresin and Sabrina Richer and my co-PIs @fabiantheis.bsky.social and @erwinschoof.bsky.social

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Nature @nature.com · 20/02/2025

Almost all grant-review meetings under Trump 2.0 remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget. go.nature.com/4gM6oW4

go.nature.com

Revealed: NIH research grants still frozen despite lawsuits challenging Trump order

The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.

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Magdalena Skipper @magdalenaskipper.bsky.social · 15/02/2025

“I’ve spent over five decades as a scientist in academia & the federal government, including as director of the National Institutes of Health. Never before have I seen my profession so politicized as it is now under the Trump administration” #AcademicSky 🧪 www.nytimes.com/2025/02/14/o...

nytimes.com

Opinion | American Science is Under Attack (Gift Article)

The Trump administration hobbles research and endangers the public health.

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