iiinova — where your digital self keeps evolving

Benjamin Furtwängler

@bfurtwa.bsky.social

PostDoc at Cell Diversity Lab, DTU

Benjamin Furtwängler @bfurtwa.bsky.social · 22/08/2025

We’re excited to present this integrative analysis of single-cell proteomics and transcriptomics of the human HSPC hierarchy. Now published in @science.org together with @fabiantheis.bsky.social, @erwinschoof.bsky.social, @porsebo.bsky.social. www.science.org/doi/10.1126/... 🧵

science.org

Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics

Single-cell transcriptomics (scRNA-seq) has facilitated the characterization of cell state heterogeneity and recapitulation of differentiation trajectories. However, the exclusive use of mRNA measurem...

24914

Reposted by Benjamin Furtwängler

Erwin Schoof @erwinschoof.bsky.social · 31/05/2025

The Cell Diversity Lab is well represented at this year's ASMS; please come and talk with Jakob Woessmann and Benjamin Furtwängler to hear all about their latest efforts in improving, and applying single-cell proteomics by MS. #singlecellproteomics #teammassspec #cellheterogeneity

2157

Reposted by Benjamin Furtwängler

Jakob Woessmann @jwoessmann.bsky.social · 31/05/2025

I am excited to share the first project of my PhD on bioRxiv and just in time for #ASMS2025 ! Increasing the sensitivity in single cell proteomics to quantify transcription factors in single hematopoietic stem and progenitor cells by iDIA. www.biorxiv.org/content/10.1...

biorxiv.org

Informed Data-Independent Acquisition Enables Targeted Quantification of Key Regulatory Proteins in Cell Fate Decision at Single-Cell Resolution

Cellular differentiation processes are largely orchestrated by variation in transcription factor (TF) abundance. Since these proteins are usually expressed at extremely low levels, studying TF-driven ...

2224