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John Soghigian

@jsoghigian.bsky.social
584 followers 661 following 44 posts

Evolution, biology, and genomics of disease vectors. Assistant Professor at University of Calgary's College of Veterinary Medicine. He/him. www.soghigian-lab.net

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John Soghigian @jsoghigian.bsky.social · 08/05/2026
Finally, we've provided additional analyses on codon position 3 and compositional heterogeneity ... The code we used is available at github.com/jsoghigian/m... ... We have files for alignments in the Culicitree github and subfolders (github.com/jsoghigian/c...).
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John Soghigian @jsoghigian.bsky.social · 08/05/2026
Pierce and colleagues were very collegial in discussions, and we appreciate their openness in discussing their results with us. Although we do not agree with their findings, we appreciate the enormous work that went into their manuscript.
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John Soghigian @jsoghigian.bsky.social · 08/05/2026
We do note that in this version of the letter, we were pressed for space; we originally were confined to a 500 word limit. We are considering where to go with our letter and possibly expand it, but we wanted to make sure the hard work of postdocs @genmorinaga.bsky.social and Huiqing Yeo was online.
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John Soghigian @jsoghigian.bsky.social · 08/05/2026
For codon position 3, when recoding purines and pyrimidines a R and Y (which resolves the compositional heterogeneity) or utilizing outgroups with higher GC content (thus addressing some heterogeneity), codon position 3 does indeed reflect two monophyletic subfamilies.
Recoding resolvs compositional heterogeneityWhile codon position 3 shows a non-monophyletic Culicinae, recoding or using different outgroups resolves this.
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John Soghigian @jsoghigian.bsky.social · 08/05/2026
Compositional heterogeneity in an alignment can violate assumptions of maximum likelihood inference, and we think this explains discrepancy between codon positions. Codon position 3 has strong evidence of GC content heterogeneity, moreso than either position 1 or 2.
GC content varies in some outgroups and some ingroups.
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John Soghigian @jsoghigian.bsky.social · 08/05/2026
In our letter, we summarize the diverse evidence for two monophyletic subfamilies of mosquitoes - from other sequence data, to genomics, to morphology. This includes codon positions 1 and 2, and amino acids of the same genes; generally, only codon position 3 shows support for alternatives.
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John Soghigian @jsoghigian.bsky.social · 08/05/2026
Pierce et al., with results primarily from UCEs and third codon position, argue that Anopheles is sister to Culex, and that the classic view of two (extant) mosquito subfamilies is incorrect. They also find a much younger divergence time for mosquitoes than past studies. www.pnas.org/doi/10.1073/...
pnas.org
Phylogenomics redefines the evolutionary history of mosquitoes | PNAS
Mosquitoes have a substantial impact on human and animal health, but their deeper evolutionary relationships have been difficult to resolve. We inf...
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John Soghigian @jsoghigian.bsky.social · 08/05/2026
Colleagues and I address a recent phylogenetic & evolutionary hypothesis on mosquito evolution (from Pierce et al. 2025), namely that the two subfamilies of mosquitoes were not reciprocally monophyletic, and that Culex and Anopheles were sister to one another. We do not agree.
A phylogeny of mosquitoes, showing synapormorphies as thatched lines, and comparing divergence time results among different publications.
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Andrea Gloria-Soria @agloriasoria.bsky.social · 24/04/2026
First domestic #aegypti wild assemblies! (Not from your favorite lab colony). Led by @genmorinaga.bsky.social, a collaboration between @ctcaes.bsky.social @yale.edu and @jsoghigian.bsky.social. Two chromosome-scale genomes of wild Aedes aegypti aegypti… academic.oup.com/jhered/artic...
academic.oup.com
Two chromosome-scale genomes of wild Aedes aegypti aegypti mosquitoes from North America and South-East Asia
Abstract. The yellow fever mosquito (Aedes aegypti) is the primary vector for diseases such as chikungunya, dengue fever, yellow fever, and Zika fever. The
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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 12/11/2025
Registration closes at the end of this week! bsky.app/profile/jlst...
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John Soghigian @jsoghigian.bsky.social · 02/02/2025
Also see the supplement of this paper for a discussion on Aedes... Long story short: Belkin recognized two sections that we find strong support for in genomic data. www.nature.com/articles/s41...
nature.com
Phylogenomics reveals the history of host use in mosquitoes - Nature Communications
Despite the significance of mosquitos for human health, little research has focused on their phylogeny. Here, the authors present a resolved phylogenetic history of mosquitoes based on phylogenomics s...
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John Soghigian @jsoghigian.bsky.social · 02/02/2025
As of Wilkerson et al 2015, most of us no longer use Ochlerotatus as a separate genus (but it is treated as a subgenus), as Don comments above. But, Aedes is not monophyletic and a growing consensus in the literature points to a few potentials, which could see the return of Ochlerotatus as a genus.
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Andrea Gloria-Soria @agloriasoria.bsky.social · 01/02/2025
First genome assembly of wild #Aedes mosquitoes. Paper coming soon! Pre-print is out! Thanks to our collaboration with @jsoghigian.bsky.social, @ird-fr.bsky.social, @yale.edu and #CT_CAES.
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John Soghigian @jsoghigian.bsky.social · 03/12/2024
Wow... This thread (and original plos post) are really interesting
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The Onion @theonion.com · 28/11/2024
"It’s us against the world now, turkey."
theonion.com
‘You’re The Bonnie To My Clyde,’ Says Biden Running Off With Pardoned Turkey
WASHINGTON—Participating in the annual tradition one last time before leaving office, President Joe Biden reportedly told a pardoned Thanksgiving turkey “You’re the Bonnie to my Clyde” on Monday befor...
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Maria Camila Ceballos @mariacceballos.bsky.social · 13/11/2024
I’m happy to share a little bit of my story and “Jam” with this video from Arch Magazine from @ucalgary.bsky.social. See it here 👇🏼 archmagazine.ucalgary.ca/providing-a-...
archmagazine.ucalgary.ca
Providing a Good Quality of Life is the Least We Can Do | arch magazine
Maria Camila Ceballos knew she wanted to care for animals. She just didn’t know it would be in Canada and in the field of animal science.
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John Soghigian @jsoghigian.bsky.social · 12/11/2024
It's really good to see an alternative social media platform rapidly expand! Time to get back to checking here more often 🙂
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Mark Cuban @mcuban.bsky.social · 12/11/2024
Hello Less Hateful World
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Rosemary Mosco @rosemarymosco.com · 11/03/2024
Because folks liked my latest pigeon comic so much, here's another pigeon piece! I made this a couple years ago for a sadly now defunct publication called Pipe Wrench. I hope this piece helps spread more pigeon love. #pigeon #bird #comic #cartoon #science 🪶
A comic titled "What is a City Pigeon? By Rosemary Mosco." There's a small pigeon shouting through a megaphone. Panel 1: A banner says "It's a Dinosaur. Like all birds, pigeons descended from dinos." A pigeon roars "coooo" over the silhouette of a dinosaur yelling RARR. Panel 2: The banner says "It's a Dove. A city pigeon or Rock Dove is a member of the pigeon and dove family." A pigeon stands in glorious rays of sparkling light, with a halo over its head. Panel 3: The banner says "It's a Domestic Animal. Pigeons were domesticated millennia ago for meat and fertilizer (poop)." A cow stands in a farmer's field, saying "moo." A pigeon looks up at it and says "coo." Both have just pooped. Panel 4: The banner says "It's a Purebred Pet. Like dogs & cats, pigeons come in fancy breeds." There are three fancy pigeons: A Birmingham Roller, with rusty feathers and splotches of white. A Fantail, with its head pushed back and a huge fanned out tail. A Saxon Fairy Swallow, with a crest and huge fan
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Nicholas Bauer PhD @bioturbonick.net · 29/12/2023
Hmm. The statistics in the first brain shrinking study seem screwy. Nonhospitalized (386) vs. Control (384) was not even close to significant, but all cases (401) vs control was just barely significant? Sorry, I don't buy this result as meaningful. www.nature.com/articles/s41...
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John Soghigian @jsoghigian.bsky.social · 29/11/2023
A case of measles in Calgary 😨 www.albertahealthservices.ca/news/Page178...
albertahealthservices.ca
Confirmed case of measles prompts public alert to potential exposures | Alberta Health Services
CALGARY– Alberta Health Services (AHS) has confirmed that an individual with lab-confirmed measles has been in public settings in Calgary while infectious.
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Jason Moore @moorejh.bsky.social · 09/11/2023
#academia I recall getting a handwritten note from my VD for Research when I got my first NIH R01 funded. A very nice gesture. We need more of this!
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John Soghigian @jsoghigian.bsky.social · 04/11/2023
Join us for an excellent symposium on some of the "other sides" of vector biology research!
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Don Yee @mosquitolab.bsky.social · 02/11/2023
Attending @entsocamerica.bsky.social meeting? Join @jsoghigian.bsky.social and myself for our symposium, Beyond the Bite: Natural History, Systematics, and Ecology Enhance Knowledge of Our Most Deadly Foe, cdmcd.co/B8PqPW #EntSoc23
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John Soghigian @jsoghigian.bsky.social · 31/10/2023
Thanks Don! Wouldn't have been possible without the hard work of @genmorinaga.bsky.social
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Don Yee @mosquitolab.bsky.social · 30/10/2023
Known of this work for a while now so really happy to see it out in print. Work by @jsoghigian.bsky.social and others, Phylogenomics reveals the history of host use in mosquitoes www.nature.com/articles/s41...
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Alisa Bokulich @alisabokulich.bsky.social · 29/08/2023
A Bluesky quick primer 🧵 for recent arrivals: 1. check default settings -- they set to min threshold likes before see in feed-- can change to show all.
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Twisteddoodles @twisteddoodles.bsky.social · 26/10/2023
The ghostest with the mostest
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Skype a Scientist @skypeascientist.bsky.social · 24/10/2023
We serve classrooms with connections to scientists for free. We put science into people's lives with public art & pop-ups. We help scientists connect with their creativity to communicate science. We rely on YOU to do this work. Monthly support keeps us alive ❤️ www.patreon.com/SkypeAScient...
patreon.com
Skype a Scientist | Patreon
Connecting people with science through conversations & art
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Yashar Ali 🐘 @yasharali.bsky.social · 17/10/2023
Get your Kleenex out. A group of Chicago area Rabbis attended the funeral of Wadea Al-Fayoume, the six year old Palestinian-American boy who was brutally murdered by his landlord due to his ethnicity and religion. Rabbi Ari Hart explains why the Rabbis attended the funeral in the screenshot below.
Rabbi Ari Hart, the Imam at the boys’s Mosque, and Rabbi Hodi"The Jerusalem Talmud teaches that the Jewish people are obligated to comfort the mourners of our people and of all people because of darchei shalom - the paths of peace.
Today, a group of rabbis of us went to the funeral of Wadea Al-Fayoume, a six year old Muslim boy who was killed in his home by his depraved landlord because he was Palestinian and Muslim.
This picture is with the imam of the mosque where the funeral was held. We met with the Imam, heard from the father, and stood with the boy's community as they mourned this horrific loss. We witnessed the pain. We expressed our shock and condemnation of the attack. We wept.
I can't say that it was simple to be there.
These are not simple times.
But the murder of a six year old because of his faith and his identity is not complicated. It is a heinous crime. And that's why we went today.
These days it really feels like the world has l These days it really feels like the world has lost its way.
But I can't give up on trying, yearning,
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John Gilleard @johngilleard.bsky.social · 16/10/2023
Hi Bluesky community My first post here after years on Twitter. Interests include all things science & Higher Ed. In particular Parasitology, drug resistance, molecular epidemiology/diagnostics, genetics/genomics genomics and veterinary medicine. Thanks for the invite @jsoghigian.bsky.social !
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Bluesky @bsky.app · 13/10/2023
Just published on our blog: Bluesky for Journalists FAQ This page also includes a link to a waitlist form for journalists, so members of the press no longer have to email our press inbox for a code. We appreciate everyone's help sharing this information!
blueskyweb.xyz
Bluesky for Journalists
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Amy J. Rutenberg @amyjay401.bsky.social · 14/10/2023
(Pls repost) Folks who majored in history, english, or something else “useless,”what was your first job out of school? What are you doing now? I know there are plenty of online resources about jobs but I’m trying to show my students that careers are often not straight lines.Thank you!!!!
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Rosemary Mosco @rosemarymosco.com · 12/10/2023
Some halloween costume ideas. 🪶🧪
A four-panel comic with some couples' costume ideas for Halloween. In panel 1, there's a male and female magnificent frigatebird, and the male has his throat pouch inflated. In panel 2, there's an elegant bridal veil stinkhorn and a flesh fly. In panel 3, there's a scarab beetle and a dung ball (just a huge brown ball being rolled by the beetle). In panel 4, there's a leopard sea cucumber and the pearlfish that lives in its anus.
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Jason Rasgon @vectorgen.bsky.social · 09/10/2023
Come be our colleagaue! Assistant/Associate Professor in Vector Biology/Ecology! Specific topic area open! psu.wd1.myworkdayjobs.com/en-US/PSU_Ac...
psu.wd1.myworkdayjobs.com
Assistant/Associate Professor of Arthropod Vector Biology and/or Ecology
APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...
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Dr. Stephanie @punkrockscience.bsky.social · 09/10/2023
Man who routinely gets ratioed attempts to kill the entire idea of being ratioed.
forbes.com
After Deleting Twitter/X Headlines, Elon Musk Will Hide Reply, Retweet And Like Numbers
This past week, Musk followed through on a promise to delete embedded headlines and lede copy from posted article links.
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Dani cRabaiotti 🦀 @danirabaiotti.bsky.social · 09/10/2023
Is science bluesky fully realised yet? Do we have a discourse about this absolutely bananas paper? 🧪 www.nature.com/articles/s41...
nature.com
Assembly theory explains and quantifies selection and evolution - Nature
Assembly theory conceptualizes objects as entities defined by their possible formation histories, allowing a unified language for describing selection, evolution and the generation of novelty.
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John Soghigian @jsoghigian.bsky.social · 07/10/2023
Exciting for this to finally be online! Was a privilege to be part of such a great international team. Excellent phylogenetic comparative work by @genmorinaga.bsky.social to cap it all off!
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John Soghigian @jsoghigian.bsky.social · 06/10/2023
What the actual....
AI generated image of a giraffe behind a physician with children
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Nicholas Mancuso @nmancuso.bsky.social · 03/10/2023
👋 Hi genetics/statgen/gen-epi trainees! 🧬 🧪 If you are interested in reviewing please let me know! We (HGG Advances, eLife) are constantly in need of knowledgeable reviewers and would be more than happy to work with you. Please feel free to email me (or other editors) if you're interested!
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Jack Maynard(he/him) @jhmsparky.bsky.social · 05/10/2023
Pete, the Townsend's Warbler back again. ( I like to think this is the same guy who visits every year around now). Just so happy we didn't miss him as we fly east tomorrow. #birding
Townsend's Warbler splashes in my fountain
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John Soghigian @jsoghigian.bsky.social · 05/10/2023
I have both active, as a lot of my non science follows do not use Bluesky yet. But I spend more time on here, since most of my science / professional interests and friends have migrated
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John Soghigian @jsoghigian.bsky.social · 05/10/2023
An absolutely crazy story...
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Surprised Eel Historian, PhD @greenleejw.bsky.social · 05/10/2023
It's Thursday. You need some eels in your life, right? And some otters? Here you go! A scene of otters & eels, from an early 15th C. copy of Gaston Phoebus's Livre de la chasse. Eel blood is toxic to mammals, but otters don't care. They love them some eels. Can you blame them? 🧪🗃️
A medieval painting of otters playing in a pool, chasing and catching eels and other fish. There are 10 adult otters, and what look to be 2 younger otters in a den at the base of a tree. The otters are doing serious otter things: playing, eating, cavorting, eating, gamboling, eating, swimming, and eating. They are having a good time. For now.

It can't last, though. This pond seems way too small to support all of these otters, and the painting has a border around it. They can't leave, and soon they will turn on each other in a bloodbath that will make the Donner Party look like a tea time at the Rotary Club. If you check back with these otters in two weeks, I suspect you'll find only carnage.

That, though, is a problem for Future Otters. Today's otters are carefree, with spotless souls.

Source:
Morgan (MS M.1044 fol. 28r)
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Rebekah Rogers @evolscientist.bsky.social · 05/10/2023
In need of a new postdoc for our work on evolution of genetic novelty. Multiple datasets in hand for Drosophila and other organisms. Email for more detail before applying. jobs.charlotte.edu/postings/52545
jobs.charlotte.edu
Postdoctoral Fellow - Bioinformatics
The employee will report to Professor Rebekah L. Rogers and will be a senior member of Professor Rogers’s research group, supporting projects through original research, collaboration with other team...
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Rosemary Mosco @rosemarymosco.com · 04/10/2023
It's mushroom season! Here are all the types you will see. My mailing list: buttondown.email/rosemarymosco
A comic titled "Types of mushrooms" with 12 mushroom species. A wrinkly-looking morel is labeled "creepy but tasty". A brownish deadly galerina is labeled "boring but deadly". A witch's butter on a branch is labeled "jiggles if you poke it". A large puffball is labeled "egg". A bleeding tooth fungus is labeled "deeply disconcerting". A fly agaric with a green treefrog sitting under it is labeled "frog umbrella". A black chanterelle is labeled "chalice for forbidden elixers". Three straight-stemmed entolomas are labeled "haha, nipples". A viscid violet cort is labeled "purple is nice". A birch polypore sticking out of a birch trunk is labeled "tree nose". A yellow-tpped coral fungus is labeled "cursed citadel where dwells a fairy queen". A Ravenel's stinkhorn is pixellated at the top for your safety, and labeled "NSFW".
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Read the book Read Raising Expectations (and Raising Hell) @jphillll.bsky.social · 04/10/2023
Bad working conditions for nurses literally mean bad patient care. Endless solidarity for every health care worker striking for better.
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FrontRangeWildflowers @frwildflowers.bsky.social · 04/10/2023
Blue sky over blue lupine and arrowleaf balsamroot above the Blue River🌿
A hillside of yellow and blue flower in front of snowy mountains
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Anne Fausto-Sterling @birdlady.bsky.social · 04/10/2023
How about a Lava heron and sally lightfoot crab from the Galapagos for a bedtime photo (i.e. bedtime on the east coast of the US). #birds #evolbiol #ecoevo
Lava heron and sally lightfoot crab, Galapagos
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