The uniquely human capacity for language is supported by a distributed brain network with cerebral cortical hubs in the left inferior frontal gyrus (LIFG) and left superior temporal sulcus (LSTS). Ind...

Het epische gevecht van David tegen Goliath moet worden overgespeeld vanwege ‘sterke vermoedens van matchfixing’.

Dutch bank Triodos argues that by prioritising “competitiveness” over tougher carbon pricing amid this summer's heat crisis, the EU is leaving its economy more exposed to future climate shocks.

The Cambridge academic has rightly now resigned. But that won’t end the targeting of senior black figures or the lazy way institutions promote faux equality, says Guardian columnist Jason Okundaye

Admixture between modern humans and extinct hominins has shaped the genomes of present-day individuals, but reconstructing this history has been constrained by the scarcity of archaic samples and unad...

Family demographic behavior is often studied as a response to structural conditions or parental characteristics, yet children may themselves shape ...

Siibra is a software suite for working with diverse human brain atlases. It links data acquired with different modalities and at different resolution, thereby creating a Multilevel Human Brain Atlas.

Just as humans unconsciously pick up words, accents and speech habits from the people around them, marmoset monkeys make their calls sound more and more alike when they bond together. This curious dis...

An encyclopedia of more than 92 million enhancer–gene regulatory interactions created as part of the ENCODE4 project provides a valuable resource for future studies of gene regulation and human geneti...

The idea of ‘biological agency’ — that life devises its own goals and behaves accordingly — complicates our understanding of what it means to be alive. But does it serve a scientific purpose?

Applications are invited for a PhD position in Social Science Genetics, a joint appointment at Vrije Universiteit Amsterdam and Amsterdam UMC. Eligible candidates may start their studentship between J...

New study uncovers how genetics influence children’s cognitive ability as they age.

The Canadian entrepreneur has always pushed the boundaries of gene editing, once attempting to turn horses into unicorns. Now she is set on modifying human embryos – something her controversial ex-hus...

Two high-profile tools have been shown to make up data and “p-hack” their results

This Review describes how an approach that starts from genetic changes under selection during human evolution and integrates comparative and functional studies can reveal adaptive phenotypes across di...

Ready to unravel the complex interplay between genes and environment shaping health and society? Join our interdisciplinary team analyzing large-scale genomic data across Europe. Are you eager to contribute to groundbreaking research on health and social inequalities?

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Noncoding RNAs (ncRNAs) regulate gene expression through RNA-chromatin interactions, yet their role in human brain evolution remains unclear. To map these interactions, we integrated FANTOM6 neurogenic data with a comprehensive atlas of regulatory regions active during early cortical development. This integration effort linked ncRNAs and transcription factors (TFs) to their genomic targets, revealing functional interactions captured by RNA-DNA contact mapping, yet largely missed by chromatin conformation data. Overlaying these interactions with nearly fixed variants in Homo sapiens relative to extinct hominins uncovered widespread rewiring of TF binding, affecting genes implicated in progenitor proliferation and neuronal differentiation. Gene regulatory network reconstruction identified TEAD2 and ONECUT2 as key regulators of intermediate progenitors and migrating neurons. Functional perturbation followed by Cut&Tag and ATAC-seq linked the two TFs to disease - and evolutionarily- relevant pathways. Together, these results show how ncRNA-TF cooperation and selective cis-regulatory rewiring contributed to sapiens-specific features of cortical development. ### Competing Interest Statement The authors have declared no competing interest. Spanish Ministry of Science, PID2023-146627NB-I00 AGAUR/Generalitat de Catalunya, 2021-SGR-313 Telethon Research Grant, GGP19226 RE-MEND, 101057604