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Josh Lang

@joshlangmd.bsky.social
351 followers 182 following 54 posts

Professor and Associate Director of Translational Research, GU Medical Oncologist at the University of Wisconsin Carbone Cancer Center. langlab.labs.wisc.edu #prostatecancer #cancerbiology #biomarkers

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Reposted by Josh Lang
Ravi Madan @ravimadan.bsky.social · 04/08/2025
Restaging w/ #PSMA Imaging in #mCRPC #ProstateCancer: When Seeing More Is Detrimental to Care Sadly a year later this remains true & the frequency of this is 📈 @ascocancer.bsky.social @ascopost.bsky.social ascopubs.org/doi/pdf/10.1...
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Fumiko Ladd Chino, MD FASCO @fumikochino.bsky.social · 31/07/2025
🗣️"The system is horribly broken & it hurts patients unnecessarily” 🗣️"They wrote me off as a dead man”   Navigating #priorauth requires tech savvy, an understanding of insurance processes, knowledge of personal rights, & time to engage in the process.   @ascocancer.bsky.social @astro-org.bsky.social
jamanetwork.com
Patient Perspectives on Prior Authorization for Cancer Care
This qualitative study characterizes the perspectives of patients with cancer regarding their experience with prior authorization for cancer care.
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Don Moynihan @donmoyn.bsky.social · 30/07/2025
Shout out to the WSJ journalists who reported on Vought’s impoundment by footnote, causing the White House to walk it back. Impact journalism!!
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Josh Lang @joshlangmd.bsky.social · 25/07/2025
Such an honor and so much fun to join the Cancer Clear and Simple @uwhealth.bsky.social Carbone Cancer Center Podcast to discuss liquid biopsies in cancer! cancer.wisc.edu/community-ou...
cancer.wisc.edu
Cancer Clear and Simple Podcast
Welcome to ‘Cancer Clear and Simple,’ the podcast dedicated to simplifying cancer. Join us as we discuss the world of cancer, breaking down complex concepts for our listening audience. One of our goal...
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Fumiko Ladd Chino, MD FASCO @fumikochino.bsky.social · 15/07/2025
"We cure a lot of diseases, & we create a lot of medical debt. It’s a push/pull; right? The advances that we have within science & medicine are profound. We have people living longer & better. Yet, the cost of treatment is a side effect like any other." #financialToxicity @cancerletter.com
cancerletter.com
First-ever financial toxicity tumor board aims to change the standard of care Researchers focus on debt as a side effect of cancer, treatment amid cuts to Medicaid, NCI - The Cancer Letter
Nearly half of cancer patients and survivors in the United States face medical debt so crushing that it has sparked a relatively new focus within oncology: financial toxicity. To access this subscribe...
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Fumiko Ladd Chino, MD FASCO @fumikochino.bsky.social · 18/06/2025
"It is a nightmare waking up every day wondering if some people halfway across the country will approve what my doctors have said is my only chance." 📄 New #PriorAuth in cancer report shows the scope of the problem & the need to #fixpriorAuth @cancercare.bsky.social www.cancercare.org/redtape
THE HEALTH INSURANCE
MAZE
How Cancer Patients Get Lost in the Red Tape of Utilization ManagementKey Report Themes
CANCERCATE
Over 80 Years ef Help and Hope
• Prior authorization is widespread and repetitive
• Prior authorization leads to time burdens and care delays
• Coverage stoppages surprise patients and interrupt care
• Insurance problems affect stress, health, finances, and trust
• Self-advocacy barriers include gaps in insurance literacy and system awareness
• Employer-sponsored plans carried highest administrative burdens, followed by Medicare Advantage, then Traditional MedicareNeeded At Least One Prior Authorization for Cancer Treatment, Past 12 Months, by Insurance Type
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Tony Collier BEM @ethansgrumps.bsky.social · 29/05/2025
Better late than never I guess! Every year I try to write a review of the year just past, primarily for my grandkids to read when I’m no longer around and here is 2024 finally! runningintocancer.co.uk/2025/05/29/r...
runningintocancer.co.uk
Review of 2024 – Palaces and Parliament
It’s great to start by celebrating still being alive at the end of another year given that, in May 2017, I was told I might only live 2 years! 2024 saw me enter my 8th year post diagnosis having su…
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Dr Joseph McCollom DO @realbowtiedoc.bsky.social · 08/05/2025
Grateful to @ascocancer.bsky.social Ed Book 📗@n8pennell.bsky.social for this #MedEd publication 🛣️ How to move forward in #EarlyCareer 🚧 Overcoming barriers ⚙️ Switching gears ⏰ Making time and space 🔗: ascopubs.org/doi/10.1200/... @ericroeland.bsky.social @ryannipp.bsky.social
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GU Cast | Declan Murphy & Renu Eapen @gu-cast.bsky.social · 23/04/2025
Special episode of GU Cast from Guy’s Hospital focused on #RadiationCystitis. Unique clinic dedicated to these unfortunate patients learn from Yasmin and Ramesh and team. Some great insights youtu.be/d4A2_swZOHw?...
youtu.be
Radiation cystitis!!! Help!!
YouTube video by GU Cast
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William C Phelps, PhD @wcphelps.bsky.social · 21/04/2025
Latest data on measles in the US. The total number of cases has already reached 800 in the first 4 months of 2025 with 85 hospitalizations and 3 deaths. There were 285 total cases last year. 🧪 www.cidrap.umn.edu/measles/us-m...
cidrap.umn.edu
US measles total climbs to 800 cases, 10 outbreaks
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Mark Cuban @mcuban.bsky.social · 17/04/2025
Ohio Medicaid got rid of big middlemen. Says it paid pharmacies a lot more — and saved $140M ohiocapitaljournal.com/2025/04/17/o...
ohiocapitaljournal.com
Ohio Medicaid got rid of big middlemen. Says it paid pharmacies a lot more — and saved $140M • Ohio Capital Journal
The Ohio Department of Medicaid department in 2022 gave powerful prescription drug middlemen the boot and created a new system. The result: Fees paid to pharmacies were boosted more than 1,200% while ...
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Yüksel Ürün @yukselurun.bsky.social · 10/04/2025
What if we screened smarter, not just more? In BARCODE1, men with high polygenic risk (top 10%) had MRI + biopsy— 40% had prostate cancer. Over half needed treatment. Most would’ve been missed by PSA alone. Genetics is rewriting the rules. @nejm.org @myesmo.bsky.social @oncoalert.bsky.social
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Stephanie L. Graff, MD FACP FASCO @drsgraff.bsky.social · 10/04/2025
The act will disenfranchise vets/active/overseas military from voting as well (who often have less access to reams of documents) LDF Denounces House Passage of SAVE Act, Urges Senate to Reject Bill that Will Disenfranchise Millions of Americans - naacpldf.org/press-release/… #HellNo #VotesForVets
naacpldf.org
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Don Moynihan @donmoyn.bsky.social · 10/04/2025
Whatever fraud there is in Medicaid is largely on the provider side, not beneficiaries. It's health insurance, its not cash. "Fraud" here means going to a doctor if you are unemployed.
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Vivek Subbiah, MD @viveksubbiah.bsky.social · 08/04/2025
🚨 Hot off the press! 🚨 The @myesmo.bsky.social ESMO Precision Oncology Working Group, has unveiled key "Recommendations for structuring Molecular Tumour Boards (MTBs) in clinical practice", now published in ESMO's flagship journal Annals of Oncology 🧬🏥 www.annalsofoncology.org/article/S092...
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The OncoAlert Network 🚨 @oncoalert.bsky.social · 02/04/2025
Low-dose CT for lung cancer screening in a high-risk population (SUMMIT): a prospective, longitudinal cohort study out on LANCET Oncology www.thelancet.com/journals/lan... These findings support the feasibility and effectiveness of large-scale lung cancer screening in a diverse population.
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Dr. Glaucomflecken @glaucomflecken.bsky.social · 31/03/2025
I understand this concern, but the anti-vaxx arguments are already everywhere on social media. We have to have people refuting this stuff. Can’t let it go completely unchecked.
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Mark Cuban @mcuban.bsky.social · 29/03/2025
Just in NIH grants, It looks like beautiful Iowa City, home of the U of Iowa, will lose $71m in funding. That's almost $1k per resident. And that's before all the other cuts to SSA, FDA, etc. Anyone in Iowa City that can offer more insight? scienceimpacts.org H/T to Prathima !
scienceimpacts.org
SCiMaP
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Governor JB Pritzker @govpritzker.illinois.gov · 27/03/2025
This is not efficiency, this is abandonment. Americans deserve health care that works for them — and instead, the Trump administration is wreaking havoc on seniors, people with disabilities, and our most vulnerable. In Illinois, we will stand up against these attacks.
npr.org
The Trump administration restructures federal health agencies, cuts 20,000 jobs
The reduction in force comes along with a reorganization of the Department of Health and Human Services, consolidating 28 divisions to 15.
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Rowan Walrath @rowanwalrath.bsky.social · 27/03/2025
The NIH is set to lose ~1,200 ppl as part of the HHS restructuring. An NIH researcher had not yet received news internally about plans to restructure the agency as of Thursday morning, less than an hour after Kennedy's statement published. cen.acs.org/policy/US-De... @cenmag.bsky.social #chemsky
cen.acs.org
US Department of Health and Human Services to lay off 10,000 employees
Cuts will affect the Food and Drug Administration, Centers for Disease Control and Prevention, and the National Institutes of Health
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Davide Ruggero @ruggerolab.bsky.social · 20/03/2025
Happy to share our new work with @haognguyen on targeting mRNA translation of oncogenes by RNA structure remodeling with a small molecule zotatifin. Congrats to ⁦@DuyguKuzuoglu⁩ an amazing postdoc and all the authors and collaborators! cell.com/cancer-cell/fu…
cell.com
Small-molecule RNA therapeutics to target prostate cancer
Kuzuoglu-Ozturk et al. showcase a therapeutic approach, “translatome therapy,” to combat lethal prostate cancer. Zotatifin, a clinical molecule, targets the RNA-helicase eIF4A. Zotatifin decreases the select translation of key oncogenes, androgen receptor (AR), and HIF1α through remodeling their 5′ UTR RNA structure. Zotatifin enhances anti-androgen and radiotherapy sensitivity, highlighting a promising anti-cancer treatment.
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Jon Rauch @jonrauch.bsky.social · 20/03/2025
A friend drove two hours today for her breast cancer chemotherapy only to learn it was canceled due to NIH cuts. Clinical trial ended midstream. No treatment, no restart, no plan, no information. Her bro-in-law's chemo was also canceled.
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Fumiko Ladd Chino, MD FASCO @fumikochino.bsky.social · 20/03/2025
"more transparency throughout [the #priorAuth] process is great, I remain concerned that relying on patients & physicians to recognize & initiate appeals places disproportionate burden on our patients who can least afford it." @michaelannica.bsky.social @ascocancer.bsky.social
ascopubs.org
ASCO Publications
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Josh Lang @joshlangmd.bsky.social · 17/03/2025
Do these clinical trial failures demonstrate a failure of traditional pre-clinical models to reflect the human disease? In addition to the complete avoidance of biomarker-driven clinical trials to find the subset of patients that would benefit.? @asharpmedonc.bsky.social @pcf-science.bsky.social
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Ravi Madan @ravimadan.bsky.social · 17/03/2025
Dr. Susan Slovin from MSK asks some key questions regarding #ProstateCancer #Immunotherapy @ascocancer.bsky.social ascopubs.org/doi/10.1200/...
ascopubs.org
Immune Checkpoint Combos in Metastatic Castration-Resistant Prostate Cancer: Where Are We Going, What Are We Doing, and Why?
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Yüksel Ürün @yukselurun.bsky.social · 09/03/2025
Vaccines work. Measles, polio, smallpox—once devastating, now nearly gone. This is what science achieves when we trust it. Let’s not turn back. #VaccinesSaveLives #PublicHealth #ScienceMatters @statista.bsky.social
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Kari Wisinski, MD @kariwisinskimd.bsky.social · 08/03/2025
What a great day at our 2025 retreat- celebrating and socializing with colleagues and planning for the upcoming year. @marina-sharifi.bsky.social @noelleloconte.bsky.social @joshlangmd.bsky.social
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Toni Choueiri, MD @drchoueiri.bsky.social · 07/03/2025
Our new paper in JITC with a group of fine international friends, mentees and colleagues about immunotherapy in patients with cardiac metastasis. jitc.bmj.com/content/13/3/e… @danafarber.bsky.social jitc.bmj.com/content/13/3...64
jitc.bmj.com
Safety and efficacy of immune checkpoint therapy for the treatment of patients with cardiac metastasis: a multicenter international retrospective study
Background Data on the safety profiles and clinical outcomes of patients with solid tumors and cardiac metastasis treated with immune checkpoint inhibitors (ICIs) are limited. Methods This is an inte...
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NPR @npr.org · 04/03/2025
Harrison, whose plasma contained a rare antibody, rolled up his sleeve 1,173 times from 1954 to 2018. The Australian is credited with helping 2.4 million babies and advancing scientific research.
npr.org
James Harrison, whose blood donations saved over 2 million babies, has died
Harrison, whose plasma contained a rare antibody, rolled up his sleeve 1,173 times from 1954 to 2018. The Australian is credited with helping 2.4 million babies and advancing scientific research.
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Elizabeth McKenna @elizsmckenna.bsky.social · 06/02/2025
Now online in Cancer Discovery: High-Purity Circulating Tumor Cell RNA Sequencing Identifies #ProstateCancer Lineage Phenotypes Prognostic for Clinical Outcomes - by Marina Sharifi, Jamie Sperger, Shuang Zhao, Joshua Lang, and colleagues doi.org/10.1158/2159...
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Elizabeth McKenna @elizsmckenna.bsky.social · 13/02/2025
Now online in Cancer Discovery: The Germline and Somatic Origins of #ProstateCancer Heterogeneity - by Takafumi Yamaguchi, Kathleen Houlahan, Helen Zhu, Natalie Kurganovs, Julie Livingstone, Natalie Fox, Niall Corcoran, Juri Reimand, Christopher Hovens, Paul Boutros, et al. doi.org/10.1158/2159...
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Zwartlab NKI @zwartlab.bsky.social · 17/02/2025
Check out our latest preprint! Interested in Androgen Receptor, gene regulation and TRIM proteins? Well, in that case, I believe you’ll like this story! www.biorxiv.org/content/10.1...
biorxiv.org
TRIM33 loss reduces Androgen Receptor transcriptional output and H2BK120 ubiquitination
The Androgen Receptor (AR) is a ligand-dependent transcription factor that drives prostate cancer development and progression. Although, a detailed effect on AR biology has been described for a number...
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Adam Sharp @asharpmedonc.bsky.social · 03/03/2025
Thanks for coming out today. A home game 🥰
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Nima Sharifi MD @nimasharifimd.bsky.social · 03/03/2025
Grateful for the invitation to give a seminar March 4 at UCLA! Hope to see those there with any interest in prostate cancer, androgen physiology or steroid metabolism! Any chance to talk science these days is particularly therapeutic and a distraction from the distractions. @dgsomucla.bsky.social 🧪
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Stephanie L. Graff, MD FACP FASCO @drsgraff.bsky.social · 02/03/2025
In science, we expand our knowledge & change our thinking through peer-reviewed, evidence based publications—it is what separates science from, well, political power grabs evidently trying to stop science. #FundScience #PublishScience #ShareScience
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Josh Lang @joshlangmd.bsky.social · 27/02/2025
A tremendous program to inspire and train the next generation of biomedical researchers. No good comes from cancelling this program.
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Nima Sharifi MD @nimasharifimd.bsky.social · 27/02/2025
More tragic news about NIH and NIH science. Grant system is frozen and intramural program is being slashed. All will claw back on treatments and cures for cancer and other human diseases. This can’t be what the public wants. 🧪 www.science.org/content/arti...
science.org
NIH ban on renewing senior scientists adds to assaults on its in-house research
Policy follows firings of tenure-track scientists and suspension of training programs
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David Shiffman, Ph.D. 🦈 @whysharksmatter.bsky.social · 25/02/2025
New in Peru: 27 species previously undiscovered by science : Short Wave
buff.ly
New in Peru: 27 species previously undiscovered by science : Short Wave
What happens when a team of scientists and local Awajún guides go on a 38-day trip into the Alto Mayo region of Peru? Over 2000 species are identified, of course! Tucked in this lush landscape where…
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PCF Science @pcf-science.bsky.social · 24/02/2025
NOW AVAILABLE: The 2024 State of Science Report, which summarizes the scientific presentations from the 2024 @PCFnews Annual Scientific Retreat! #PCFRetreat24 Download to learn about cutting-edge recent advances in #ProstateCancer research & treatment! www.pcf.org/stateofscien...
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Nima Sharifi MD @nimasharifimd.bsky.social · 23/02/2025
About $74 million in US govt funding (including NIH) went into developing enzalutamide - a multibillion dollar drug that prolonged life for countless men with prostate cancer. Why would anyone cut this support? We need more, not less! @ascocancer.bsky.social @theaacr.bsky.social
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Nima Sharifi MD @nimasharifimd.bsky.social · 22/02/2025
Just terrible.
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Josh Lang @joshlangmd.bsky.social · 21/02/2025
Opportunities to cure are being missed. There would be an immediate impact if @ascocancer.bsky.social recommendations are implemented. @mcuban.bsky.social
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PCF Science @pcf-science.bsky.social · 20/02/2025
PCF Science is now on BlueSky! Follow us for prostate cancer research news & building the prostate cancer research community.
Prostate Cancer Foundation logo
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Toni Choueiri, MD @drchoueiri.bsky.social · 16/02/2025
#GU25 was an outstanding @ascocancer.bsky.social meeting: catching up with friends/ colleagues, watching mentees grow, learn up-to-date GU cancers management, and presenting a new HIF-2 inhibitor (casdatifan) data. Energized! The future is bright! @danafarber.bsky.social @jrgralow.bsky.social
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Josh Lang @joshlangmd.bsky.social · 13/02/2025
So much fun moderating this session! @ascocancer.bsky.social
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Ravi Madan @ravimadan.bsky.social · 11/02/2025
#PARP inhibitors in #ProstateCancer will again take center stage at #GU25 @ascocancer.bsky.social Here is refresher on some thoughts of the earlier data in #mCRPC ascopubs.org/doi/10.1200/...
ascopubs.org
Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits
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Josh Lang @joshlangmd.bsky.social · 12/02/2025
There is even less biology/relevant biomarkers available in RWD that further exacerbates the data gap. Are we being pushed further from personalized medicine and personalized care? @ravimadan.bsky.social
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Mark Cuban Cost Plus Drug Company @costplusdrugs.com · 11/02/2025
One year ago, we launched the Cost Plus Marketplace to help healthcare businesses access affordable medications. Today, we proudly supply thousands of hospitals, clinics, long-term care facilities, surgery centers, and retail pharmacies. ➡️ Sign up today: business.costplusdrugs.com
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American Society of Clinical Oncology @ascocancer.bsky.social · 10/02/2025
The #GU25 abstracts are now available! Late-Breaking Abstracts (LBAs) will be released at 7:00 AM PT on their day of presentation. Check out the latest practice-changing science in GU cancers here: brnw.ch/21wQBxm Co-sponsored by @astro-org.bsky.social and Society of Urologic Oncology
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