Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 01/06/2025New standard of care for stage 3 MSI high colon cancer - adjuvant atezolizumab/FOLFOX #asco25 140
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 31/05/2025GI non-CRC oral abstracts at #asco25 is 🔥. A few things: 1️⃣Dr Saeed had excellent summary of the GE/gastric studies 2️⃣PAXG (Abraxane, cisplatin, capecitabine, gemcitabine) superior to FOLFIRINOX for borderline and resectable PDAC 3️⃣TTFields positive in LA-PDAC vs gem/Abrax with 2 mo OS advantage 131
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 31/05/2025Early morning CSC session at #asco25 about multi-cancer detection testing which was excellent! The discussant hit all the conclusions well - low sensitivity and need for a randomized trial before can be taking to clinic are the key points 040
Reposted by Noelle LoConte, MD, FASCOJulie Hallet, MD MSc @halletjulie.bsky.social · 31/05/2025Not in Chicago but getting the updates - #ASCO25 learnings today: 😀there's an option in BRAFV600 mCRC 😀Ipi+Nivo better in MSI-h unresectable mCRC 🫤ctDNA+ still not guiding care in CC 😳CRS+HIPEC no better with chemo @oncbrothers.bsky.social got the details 👉🏻 tinyurl.com/bd75xjw7 #OncSky #MedSkytinyurl.com 121
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 30/04/2025Congratulations to Alaska for passing into law bill SB15 which requires posting signs at point of sale for alcohol about the carcinogenic effects of alcohol for colon and breast cancer. (This is a first in the U.S.!) I am honored to have been able to testify on behalf of Rep Andrew Gray’s bill. 000
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 29/04/2025Join me tonight fir this Medscape event about alcohol and cancer register.gotowebinar.com/register/300...register.gotowebinar.com 000
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 19/04/2025New UW publication in Cancer Medicine - NCDB analysis of rectal cancer incidence/outcomes in Native Americans showing earlier onset and worse survival arguing for the critical importance of early CRC screening and target education outreach in this population onlinelibrary.wiley.com/doi/10.1002/...onlinelibrary.wiley.comRectal Cancer Disparities Among the American Indian/Alaskan Native PopulationsPurpose Recent work noted lower overall survival (OS) in American Indian/Alaskan Native (AI/AN) individuals diagnosed with colon cancer compared with non-Hispanic White (NHW) individuals. Rectal can..... 000
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 07/02/2025Sharing this good review I just read of Triple M Overlap Syndrome (TMOS) - rare but serious complication of oncology immunotherapy with myositis, myasthenia gravis and myocarditis pubmed.ncbi.nlm.nih.gov/39897316/ #oncology #immunotherapypubmed.ncbi.nlm.nih.govTriple M Overlap Syndrome: Myocarditis, Myositis and Myasthenia Gravis After a Single Administration of Pembrolizumab - PubMedTriple M Overlap Syndrome (TMOS) is a rare and severe complication of immune checkpoint inhibitor (ICI) therapy, characterized by concurrent myocarditis, myositis and myasthenia gravis. There is a sca... 100
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 01/02/2025New publication of the Million Women Study showing benefit of milk on incidence colorectal cancer (felt to be related to dietary calcium) and further showing alcohol and red meat are adversely associated with CRC development www.nature.com/articles/s41...nature.comDiet-wide analyses for risk of colorectal cancer: prospective study of 12,251 incident cases among 542,778 women in the UK - Nature CommunicationsColorectal cancer has been linked to multiple environmental factors, however, the role of diet remains incompletely understood. Here, the authors complete a diet-wide association study and identify a ... 020
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 30/01/2025New study by Burlile J et al from Mayo defining magnitude of harm to musicianship and performance by breast cancer treatment. Chemo was most harmful for endurance, accuracy, speed ascopubs.org/doi/pdf/10.1...ascopubs.orgMusician's Experience After Breast Cancer Treatment: Defining Musical Toxicity and its Frequency | JCO Oncology PracticePURPOSEOver 50% of households in the United States have at least one musician—many musicians are also breast cancer survivors. This group has not been well studied, and given the level of fine sensory... 042
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 26/01/2025STARTER-NET/JCOG1901 trial lanreotide +/- everolimus in 1L non-secretory poor prognosis GEP-NET (Ki67 5-20% or diffuse liver mets) was interesting. Big increase in PFS but no change in overall survival+ more toxicity would suggest sequential use is still ok #GI25 meetings.asco.org/abstracts-pr...meetings.asco.orgProgram Guide – ASCO Meeting Program Guide 020
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 07/01/2025This is an absolutely outstanding article about how to make the most out of academic conferences. Many tips for @ascocancer.bsky.social meeting attendees. (Not just first time ones either!) www.chronicle.com/article/how-...chronicle.comAdvice | How to Make the Most of an Academic ConferenceAdvice on navigating professional meetings in all formats — in person, virtual, and hybrid. 051
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 04/01/2025My perspective about the Surgeon General’s advisory about alcohol and cancer is included on this page, for those who are interested www.healio.com/news/hematol...healio.comUS Surgeon General calls for cancer warnings on alcoholic beveragesU.S. Surgeon General Vivek Murthy, MD, MBA, issued an advisory today that includes several recommendations designed to reduce the impact of alcohol on cancer incidence and mortality.One recommendation... 030
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 03/01/2025Oncologists can fully get behind this - glad the Surgeon General is pushing an important conversation forward! www.nytimes.com/2025/01/03/h...nytimes.comSurgeon General Calls for Cancer Warnings on AlcoholDr. Vivek Murthy’s report cites studies linking alcoholic beverages to at least seven malignancies, including breast cancer. But to add warning labels, Congress would have to act. 040
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 07/12/2024Important JCO editorial about phase 1 and 2 trial design and the peril of using fitness for FDA filing as the primary goal, with the development of ONC201 as the example ascopubs.org/doi/full/10....ascopubs.orgComments and Controversies in Oncology: The Tribulations of Trials Developing ONC201 020
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 07/12/2024Oncology leadership everywhere: please take note 030
Reposted by Noelle LoConte, MD, FASCOSteph Ressort @thelastressort.bsky.social · 04/12/2024Oncology appt: Onc: Your CT scan is clear Me: It must be nice to have a good news appointment Onc: it really is Me: Oh, and I've lost weight. Onc: What? *panics* Me: Sorry, sorry, on purpose. I have lost weight on purpose. Onc: *visibly relaxes* How to freak an oncologist out 🤪 #cansky 1384
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 24/11/2024Last week the UW Carbone Community Outreach and Engagement team got to present at UW extension conference about our lay abstract project where we try to get our science out into lay audiences (examples here cancer.wisc.edu/resources-fo...). Trying to make one for each national presentation to start 030
Noelle LoConte, MD, FASCO @noelleloconte.bsky.social · 24/11/2024Thinking about how I wish we could suspend all bad news in the oncology clinic on the weeks of major holidays or life events 130