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Joseph D. Zak

@josephdzak.bsky.social
780 followers 572 following 74 posts

Neurobiologist and Assistant Professor at the University of Illinois Chicago studying sensory cells and neural circuits. #Neuroscience and #Olfaction. www.zak-lab.org

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Reposted by Joseph D. Zak
Kevin A. Scott, PhD @sculpturatus.bsky.social · 17/09/2026
found at ucsf
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(((Dr Hannah Wirtshafter))) 🔬 @aheadofthenerve.bsky.social · 15/09/2026
Hi friends & colleagues! I’m on the hunt for a tenure-track home! I’m a BRAIN Initiative K99/R00 scholar studying learning & memory at the intersection of experimental neuroscience, theory, & machine learning/AI. I’d love to connect & would appreciate help spreading the word! web.mit.edu/hsw/www/
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Aurora Scientific @aurorascientific.bsky.social · 24/08/2026
⚡Publication Flash⚡ Our latest publication review, "Perception and Discrimination of Odor Stimuli," explores how animals use olfactory information to navigate environmental dangers. Read it now: aurorascientific.com/perception-and-discrimination-of-odor-stimuli/ #Olfaction #Neuroscience
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Jamie Roitman @jamiedroitman.bsky.social · 25/06/2026
Photometry phriends preprint: excited to share @racheldonka.bsky.social's side quest to validate how multiple sensors of mesolimbic signaling respond to acute morphine treatment - with @mitchroitman.bsky.social and @basedownloh.bsky.social
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Jacob Zavatone-Veth @jzv.bsky.social · 23/06/2026
Tremendously excited to announce that I will be joining @rockefeller.edu as an Assistant Professor and Head of Lab starting in January 2027! My group will be broadly focused on theoretical neuroscience, and mathematical problems in neural computation in the large.
Rockefeller campus image from https://commons.wikimedia.org/wiki/File:Rockefeller_University_Campus_aerial_2.jpg, licensed under the Creative Commons Attribution-Share Alike 2.5 Generic license.
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Joseph D. Zak @josephdzak.bsky.social · 17/06/2026
Really neat work by my colleagues at UIC comparing ML to traditional ephys event detection tools. Happy that @zachfyke.bsky.social and I could make a contribution!
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Joseph D. Zak @josephdzak.bsky.social · 12/06/2026
Just a perfect @mblscience.bsky.social evening.
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Joseph D. Zak @josephdzak.bsky.social · 04/06/2026
I think Zach Fyke, a graduate student in our group may have broken some sort of patch-clamp record while teaching at @mblscience.bsky.social. Over the past three days, he has coached 21 people to patch at least one cell on our rig away from home. Photos are our “wall of success.”
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Harvard_MCB @harvardmcb.bsky.social · 01/05/2026
Sniffing Out Distance: How the Brain Tracks Odor Dynamics 🧠 🧪🧬 #AcademicSky #higherEd. #Olfaction #Neuroscience www.mcb.harvard.edu/department/n... @luxorboero.bsky.social @josephdzak.bsky.social @paulmasset.bsky.social @siddjakes.bsky.social @neurovenki.bsky.social @harvardbrainsci.bsky.social
mcb.harvard.edu
Sniffing Out Distance: How the Brain Tracks Odor Dynamics - Harvard University - Department of Molecular & Cellular Biology
A dog unearths a bone buried months ago. A moth flies across a forest toward an orchard. A person opens container after container in the fridge, trying to […]
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Venki Murthy @neurovenki.bsky.social · 01/05/2026
Our work on the perception of intermittent odor stimuli out in @natcomms.nature.com! Led by @luxorboero.bsky.social & former grad student Hao Wu; key contributions from @btolooshams.bsky.social, @siddjakes.bsky.social, @paulmasset.bsky.social, @josephdzak.bsky.social, Farhad Pashakhanloo, Demba Ba.
nature.com
Perception and neural representation of intermittent odor stimuli in mice - Nature Communications
Animals navigate odor plumes by exploiting dynamic and intermittent cues. Here, the authors show that mice can discriminate among different fluctuating odor signals, and characterize their neural enco...
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Bozza Lab @neuroboz.bsky.social · 30/03/2026
Happy to share the latest from the lab! A microbiome-generated metabolite affects male-male aggression and social dominance in mice via the main olfactory system. Gut-Nose-Behavior. www.cell.com/current-biol...
cell.com
A microbiome-derived olfactory signal regulates inter-male aggression and social dominance in mice
Cichy et al. show that trimethylamine (TMA), a gut microbiome-derived metabolite, activates the receptor TAAR5 in the main olfactory system to regulate aggression and social dominance in male mice. Th...
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Joseph D. Zak @josephdzak.bsky.social · 24/04/2026
Our latest work is available at @sfnjournals.bsky.social. This project was conceived of and completed by Kai Clane Belonio, an amazing postbac student who worked with us for the past two years. We learned that stress influences olfactory experience and activates microglia in the piriform cortex.
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Matt Smear @mattsmear.bsky.social · 25/03/2026
Visualizing and Sonifying NeuroData (ViSoND) github.com/Smear-Lab/Vi... is a strategy for observing multiple data streams in video and sound www.biorxiv.org/content/10.6... e.g., watch an animal move while you listen to their physiological signals (or vice versa)
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Jens Notroff @jensnotroff.com · 01/03/2026
Smelly past, or: history with all senses ... Glad to see @theguardian.com reporting on @barahuber.bsky.social and colleagues' brilliant research in #olfactory #archaeology. 👃🏺 www.theguardian.com/science/2026...
theguardian.com
T rex breath and Queen Elizabeth’s car: scientists creating ‘time machine for the nose’
Researchers are recreating ancient odours for museumgoers as interest in the archaeology of smell grows
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Joseph D. Zak @josephdzak.bsky.social · 26/02/2026
In case there was any doubt about what was going on behind these doors.
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Joseph D. Zak @josephdzak.bsky.social · 14/02/2026
Balloon museum in #Chicago, absolutely fantastic instillations.
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Joseph D. Zak @josephdzak.bsky.social · 06/02/2026
Not exactly #fluorescencefriday, but #chicago was glowing beautifully yesterday evening.
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Jon Gill @jonvgill.bsky.social · 26/01/2026
Excited to share our new preprint for this project!
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Matthew Cobb @matthewcobb.bsky.social · 05/01/2026
Cool. Smell in the spider brain. onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Presumed Glomerular Neuropils in the Central Nervous Systems of Spiders (Araneae)
Spiders sense chemicals in their environment with particular sensory hairs (sensilla) on their legs and feelers. Chemosensory neurons inside these sensilla send their axons into the central nervous s...
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Catherine Dulac @dulaclab.bsky.social · 09/12/2025
I am thrilled to share our latest work led by @zurisullivan.bsky.social in collaboration with @moffittlab.bsky.social ! We find that the brain encodes distinct, pathogen-specific sickness states across behavior, physiology, neural activity, and gene expression 1/6 www.biorxiv.org/content/10.6...
biorxiv.org
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Alexandra Keinath @atkeinath.bsky.social · 08/12/2025
Another new paper from the lab: Predictive theories like the SR imply that navigators who navigate differently should have cognitive maps which differ in predictable ways. Here we show that this holds in mouse hippocampal CA1. www.sciencedirect.com/science/arti...
sciencedirect.com
Environmental representations in mouse hippocampal CA1 reflect the predictive structure of navigation
Predictive theories of cognitive mapping propose that these representations encode the predictive relationships among contents as experienced by the n…
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Paul Masset @paulmasset.bsky.social · 04/11/2025
First paper from the lab! We propose a model that separates estimation of odor concentration and presence and map it on olfactory bulb circuits Led by @chenjiang01.bsky.social and @mattyizhenghe.bsky.social joint work with @jzv.bsky.social and with @neurovenki.bsky.social @cpehlevan.bsky.social
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Joseph D. Zak @josephdzak.bsky.social · 08/10/2025
Chicago is definitely burning. Just not in the way the news wants to portray.
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Rupinder Kaur, PhD @kaurr.bsky.social · 03/10/2025
#Wolbachia has puzzled scientists with its power to rewire insect reproduction. What if I tell you that we found one of the keys Wolbachia use to rewire its host AND a small molecule inhibitor uses this key to mimic what this microbe has mastered for millions of years. www.cell.com/cell-reports...
cell.com
Beyond Wolbachia—Can a small molecule control insect reproduction?
Kaur et al. demonstrate reduced histone acetylation as a key mechanism underpinning Wolbachia’s paternal-effect embryonic lethality trait in Drosophila melanogaster. Recapitulation of this trait by in...
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Evan Schaffer @esschaffer.bsky.social · 05/09/2025
Very excited to see this out in the world. It was fun to play a (small) part in it.
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Nicholas Bellono @nbellono.bsky.social · 04/09/2025
Octopuses sense environmental microbiomes to drive predatory and parental behaviors. Artwork by Lily Soucy. #evolution #sensation #microbiome @cellpress.bsky.social
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Siddharth Jayakumar @siddjakes.bsky.social · 02/09/2025
Excited to share our latest!! Thanks to everyone involved especially @neurovenki.bsky.social!
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Venki Murthy @neurovenki.bsky.social · 01/09/2025
Thrilled to share this work, long time in the making! Carried through creatively by @siddjakes.bsky.social after initial design & piloting by @trackingskills.bsky.social, with help from @trackingactions.bsky.social. Modeling in collaboration with Massimo Vergassola & Nicola Rigolli.
biorxiv.org
Mice navigate scent trails using predictive policies
Animals actively sense their environment to extract features of interest to guide behaviors. For mammals, odors are prominent environmental features which are sampled by active modulation of sniffing ...
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Joseph D. Zak @josephdzak.bsky.social · 20/08/2025
Proud to share Kai Clane Belonio’s latest work in our lab. Kai showed that induced-depression decreases behavioral tolerance of aversive odorants as well as increases in neuroinflammation in sensory affective areas. Also contributing are @nervenkidd.bsky.social and Eyerusalem Haile.
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Felix Baier @felixbaier.bsky.social · 23/07/2025
🚨Very happy that my PhD work is now out in @nature.com! We discovered that evolution, by acting in the midbrain, shifted the threshold to escape in Peromyscus mice, to fine-tune defensive strategies in different environments www.nature.com/articles/s41... This was a truly collaborative effort! 🧵⬇️
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Joseph D. Zak @josephdzak.bsky.social · 02/07/2025
Some campus brutalism to accompany this brutal heatwave.
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Joe Walker @evojfwalker.bsky.social · 26/06/2025
@shawn-anthony.bsky.social helped ~20 undergrads learn transcriptomics in this budget friendly investigation into the dogbane family. A fun way to investigate the molecular evolution of the group. Also, a chance to collaborate with @phylonatworks.bsky.social and Jarrad! doi.org/10.1101/2025...
doi.org
Going green: Recycling transcriptomes to infer evolutionary relationships, gene duplication, gene tree conflict, and patterns of molecular evolution in the Apocynaceae
Background and Aims: The flowering plant family Apocynaceae exhibits diverse adaptations with biological and pharmaceutical significance, many of which have been studied with RNA-seq. However, despite...
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Reposted by Joseph D. Zak
Izumi Fukunaga @ifukunaga.bsky.social · 13/06/2025
Animals’ sniffing drives rhythmic input to the olfactory system. How does this timing contribute to perception, especially beyond first steps of olfactory processing? We tested this using simple closed-loop optogenetics in our new paper: www.cell.com/iscience/ful...
cell.com
Decoding olfactory bulb output: A behavioral assessment of rate, synchrony, and respiratory phase coding
Neurogenetics; Behavioral neuroscience; Sensory neuroscience
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Joseph D. Zak @josephdzak.bsky.social · 03/06/2025
What a special place. So grateful for all the friendships, learning, and science that fullfilled my time @harvard.edu.
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Joseph D. Zak @josephdzak.bsky.social · 14/05/2025
Proud of @nervenkidd.bsky.social (Zach Fyke), a graduate student in our group, for being recognized by @uicbios.bsky.social for both his research AND teaching over the past academic year. Here are links to some of his recent work: tinyurl.com/37vw5s5f tinyurl.com/23zu458t tinyurl.com/3mmjvw83
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Datta Lab @dattalab.bsky.social · 09/05/2025
Maps are everywhere in the brain...and finally we've discovered one in the nose! Led by @davidhbrann.bsky.social, we uncovered the logic that specifies the positions of each of the 1,000 sensory neuron subtypes in the nose and aligns their projections to the brain.👇👃see more details below👃👇
biorxiv.org
A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain
Although topographical maps organize many peripheral sensory systems, it remains unclear whether olfactory sensory neurons (OSNs) choose which of the ~1100 odor receptors (ORs) to express based upon t...
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Joseph D. Zak @josephdzak.bsky.social · 09/05/2025
One of our new favorite images for #fluoresencefriday. Graduate student, Lindsay Vivona, labeled fibers from each anterior olfactory nucleus hemisphere as they bidirectionally pass through the anterior commissure. #neuroskyence #olfaction
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Carles Bosch @carlesbosch.bsky.social · 01/05/2025
#preprint: We mapped the structure and function of olfactory bulb circuits with in vivo 2-photon microscopy and synchrotron #Xray holographic nanotomography. doi.org/10.1101/2025... @yuxinzhang.bsky.social @andreas-t-schaefer.bsky.social @apacureanu.bsky.social @crick.ac.uk @esrf.fr
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Joseph D. Zak @josephdzak.bsky.social · 30/04/2025
Now in its final form, our recent work on how olfactory transduction currents help ensure sparse sensory coding. Led by a post-bac Kai Clane Belonio and a graduate student, Eyerusalem Haile, this was a group effort by the entire laboratory. www.jneurosci.org/content/45/1...
jneurosci.org
Amplification of Olfactory Transduction Currents Implements Sparse Stimulus Encoding
Sensory systems must perform the dual and opposing tasks of being sensitive to weak stimuli while also maintaining information content in dense and variable sensory landscapes. This occurs in the olfa...
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Alexander Mathis @trackingskills.bsky.social · 22/04/2025
My lab has several postdoctoral fellow and software engineering positions available. Please email me if you’re interested.
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The Transmitter @thetransmitter.bsky.social · 16/04/2025
Olfactory neuroscientists have known for a while that their stimuli stink. A new analysis illuminates the extent of the problem. By @callimcflurry.bsky.social #neuroskyence www.thetransmitter.org/olfaction/sm...
thetransmitter.org
Smell studies often use unnaturally high odor concentrations, analysis reveals
It’s time to fashion olfactory neuroscience stimuli based on odor concentrations in the wild, say study investigators Elizabeth Hong and Matt Wachowiak.
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Victoria K. Switacz @victoria-swi.bsky.social · 16/04/2025
Now out in @sfnjournals.bsky.socialjournals.bsky.social : bit.ly/3YzVjRv. In VSNs, Ca²⁺ doesn’t tell a 'simple' story. Ca²⁺ at the knob excites, while at the soma it can activate K⁺ channels, dampening excitability. This channel diversity and compartmentalization refine vomeronasal sensory output-
bit.ly
Ca2+-Activated Ion Channels Exert Opposite Effects in Different Signaling Compartments of Vomeronasal Sensory Neurons
In most mammals, conspecific chemical cues that drive innate social and sexual behavior are detected by the vomeronasal organ (VNO) and processed in the accessory olfactory bulb (AOB). Chemosensory st...
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Joseph D. Zak @josephdzak.bsky.social · 12/04/2025
Commute home
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Kelsey Anbuhl @anbuhlk.bsky.social · 04/04/2025
Excited to share my latest work just out in @pnas.org! This NIH MOSAIC K99-funded project identifies a top-down cortical circuit—from cingulate to auditory cortex—that supports auditory perceptual performance in challenging listening conditions: www.pnas.org/doi/10.1073/...
pnas.org
The cingulate cortex facilitates auditory perception under challenging listening conditions | PNAS
We often exert greater cognitive resources (i.e., listening effort) to understand speech under challenging acoustic conditions. This mechanism can ...
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Hattie Chung @hattaca.bsky.social · 02/04/2025
🚨 Job alert! 🚨 The Chung Lab @ Yale seeks a motivated, creative postdoc to examine tissue remodeling in health and disease. We study ovarian aging and cardiovascular disease in human samples and animal models. Passionate about single-cell, spatial genomics, machine learning & therapeutics? Join us!
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Trevor Sorrells @trevorsorrells.bsky.social · 20/03/2025
Reminder: apply for our research assistant position!
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matthew capek @matthewcapek.bsky.social · 06/03/2025
🎉 so excited to share my first first-author paper is out in @Nature.com, from my PhD work in the Gallio Lab! we uncover the neurobiological mechanisms that drive the evolution of temperature preference behavior in flies of the genus Drosophila 👇 go.nature.com/4i1VQn9
go.nature.com
Evolution of temperature preference in flies of the genus Drosophila - Nature
A study using flies of the genus Drosophila adapted to life in diverse thermal environments shows how evolution has shaped temperature preference by acting on both molecular heat receptors and th...
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Elisa Galliano @elisagalliano.bsky.social · 05/03/2025
Our first “Icelandic” paper is out 🥳🌋 Led by our country-hopping, cold-adapted patcher extraordinaire @neurosana.bsky.social and done between Cambridge & the Petersen lab in Reykjavík, here’s our offering on the mitral vs tufted cell debate in the olfactory bulb www.eneuro.org/content/12/3... 1/🧵
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Ding Liu @dingliu.bsky.social · 26/02/2025
Our paper @dulaclab.bsky.social on social homeostasis is online today! We characterized “social rebound” behavior after social isolation in multiple mouse strains and revealed its neural basis. Intriguingly, soft touch plays a key role in satisfying social need! www.nature.com/articles/s41...
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Paul Masset @paulmasset.bsky.social · 18/02/2025
Honoured to have been selected as a #SloanFellow Thankful for all the support from family, mentors, collaborators, colleagues and students along the way! @sloanfoundation.bsky.social
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