Reposted by Joseph D. ZakKevin A. Scott, PhD @sculpturatus.bsky.social · 17/09/2026found at ucsf 9554117
Reposted by Joseph D. Zak(((Dr Hannah Wirtshafter))) 🔬 @aheadofthenerve.bsky.social · 15/09/2026Hi friends & colleagues! I’m on the hunt for a tenure-track home! I’m a BRAIN Initiative K99/R00 scholar studying learning & memory at the intersection of experimental neuroscience, theory, & machine learning/AI. I’d love to connect & would appreciate help spreading the word! web.mit.edu/hsw/www/ 33021
Reposted by Joseph D. ZakAurora Scientific @aurorascientific.bsky.social · 24/08/2026⚡Publication Flash⚡ Our latest publication review, "Perception and Discrimination of Odor Stimuli," explores how animals use olfactory information to navigate environmental dangers. Read it now: aurorascientific.com/perception-and-discrimination-of-odor-stimuli/ #Olfaction #Neuroscience 041
Reposted by Joseph D. ZakJamie Roitman @jamiedroitman.bsky.social · 25/06/2026Photometry phriends preprint: excited to share @racheldonka.bsky.social's side quest to validate how multiple sensors of mesolimbic signaling respond to acute morphine treatment - with @mitchroitman.bsky.social and @basedownloh.bsky.social 085
Reposted by Joseph D. ZakJacob Zavatone-Veth @jzv.bsky.social · 23/06/2026Tremendously excited to announce that I will be joining @rockefeller.edu as an Assistant Professor and Head of Lab starting in January 2027! My group will be broadly focused on theoretical neuroscience, and mathematical problems in neural computation in the large. 910515
Joseph D. Zak @josephdzak.bsky.social · 17/06/2026Really neat work by my colleagues at UIC comparing ML to traditional ephys event detection tools. Happy that @zachfyke.bsky.social and I could make a contribution! 021
Joseph D. Zak @josephdzak.bsky.social · 12/06/2026Just a perfect @mblscience.bsky.social evening. 090
Joseph D. Zak @josephdzak.bsky.social · 04/06/2026I think Zach Fyke, a graduate student in our group may have broken some sort of patch-clamp record while teaching at @mblscience.bsky.social. Over the past three days, he has coached 21 people to patch at least one cell on our rig away from home. Photos are our “wall of success.” 3273
Reposted by Joseph D. ZakHarvard_MCB @harvardmcb.bsky.social · 01/05/2026Sniffing Out Distance: How the Brain Tracks Odor Dynamics 🧠 🧪🧬 #AcademicSky #higherEd. #Olfaction #Neuroscience www.mcb.harvard.edu/department/n... @luxorboero.bsky.social @josephdzak.bsky.social @paulmasset.bsky.social @siddjakes.bsky.social @neurovenki.bsky.social @harvardbrainsci.bsky.socialmcb.harvard.eduSniffing Out Distance: How the Brain Tracks Odor Dynamics - Harvard University - Department of Molecular & Cellular BiologyA dog unearths a bone buried months ago. A moth flies across a forest toward an orchard. A person opens container after container in the fridge, trying to […] 0226
Reposted by Joseph D. ZakVenki Murthy @neurovenki.bsky.social · 01/05/2026Our work on the perception of intermittent odor stimuli out in @natcomms.nature.com! Led by @luxorboero.bsky.social & former grad student Hao Wu; key contributions from @btolooshams.bsky.social, @siddjakes.bsky.social, @paulmasset.bsky.social, @josephdzak.bsky.social, Farhad Pashakhanloo, Demba Ba.nature.comPerception and neural representation of intermittent odor stimuli in mice - Nature CommunicationsAnimals navigate odor plumes by exploiting dynamic and intermittent cues. Here, the authors show that mice can discriminate among different fluctuating odor signals, and characterize their neural enco... 13013
Reposted by Joseph D. ZakBozza Lab @neuroboz.bsky.social · 30/03/2026Happy to share the latest from the lab! A microbiome-generated metabolite affects male-male aggression and social dominance in mice via the main olfactory system. Gut-Nose-Behavior. www.cell.com/current-biol...cell.comA microbiome-derived olfactory signal regulates inter-male aggression and social dominance in miceCichy et al. show that trimethylamine (TMA), a gut microbiome-derived metabolite, activates the receptor TAAR5 in the main olfactory system to regulate aggression and social dominance in male mice. Th... 12311
Joseph D. Zak @josephdzak.bsky.social · 24/04/2026Our latest work is available at @sfnjournals.bsky.social. This project was conceived of and completed by Kai Clane Belonio, an amazing postbac student who worked with us for the past two years. We learned that stress influences olfactory experience and activates microglia in the piriform cortex. 062
Reposted by Joseph D. ZakMatt Smear @mattsmear.bsky.social · 25/03/2026Visualizing and Sonifying NeuroData (ViSoND) github.com/Smear-Lab/Vi... is a strategy for observing multiple data streams in video and sound www.biorxiv.org/content/10.6... e.g., watch an animal move while you listen to their physiological signals (or vice versa) 2158
Reposted by Joseph D. ZakJens Notroff @jensnotroff.com · 01/03/2026Smelly past, or: history with all senses ... Glad to see @theguardian.com reporting on @barahuber.bsky.social and colleagues' brilliant research in #olfactory #archaeology. 👃🏺 www.theguardian.com/science/2026...theguardian.comT rex breath and Queen Elizabeth’s car: scientists creating ‘time machine for the nose’Researchers are recreating ancient odours for museumgoers as interest in the archaeology of smell grows 0159
Joseph D. Zak @josephdzak.bsky.social · 26/02/2026In case there was any doubt about what was going on behind these doors. 0100
Joseph D. Zak @josephdzak.bsky.social · 14/02/2026Balloon museum in #Chicago, absolutely fantastic instillations. 030
Joseph D. Zak @josephdzak.bsky.social · 06/02/2026Not exactly #fluorescencefriday, but #chicago was glowing beautifully yesterday evening. 151
Reposted by Joseph D. ZakJon Gill @jonvgill.bsky.social · 26/01/2026Excited to share our new preprint for this project! 1182
Reposted by Joseph D. ZakMatthew Cobb @matthewcobb.bsky.social · 05/01/2026Cool. Smell in the spider brain. onlinelibrary.wiley.com/doi/10.1002/...onlinelibrary.wiley.comPresumed Glomerular Neuropils in the Central Nervous Systems of Spiders (Araneae)Spiders sense chemicals in their environment with particular sensory hairs (sensilla) on their legs and feelers. Chemosensory neurons inside these sensilla send their axons into the central nervous s... 0164
Reposted by Joseph D. ZakCatherine Dulac @dulaclab.bsky.social · 09/12/2025I am thrilled to share our latest work led by @zurisullivan.bsky.social in collaboration with @moffittlab.bsky.social ! We find that the brain encodes distinct, pathogen-specific sickness states across behavior, physiology, neural activity, and gene expression 1/6 www.biorxiv.org/content/10.6...biorxiv.org 28323
Reposted by Joseph D. ZakAlexandra Keinath @atkeinath.bsky.social · 08/12/2025Another new paper from the lab: Predictive theories like the SR imply that navigators who navigate differently should have cognitive maps which differ in predictable ways. Here we show that this holds in mouse hippocampal CA1. www.sciencedirect.com/science/arti...sciencedirect.comEnvironmental representations in mouse hippocampal CA1 reflect the predictive structure of navigationPredictive theories of cognitive mapping propose that these representations encode the predictive relationships among contents as experienced by the n… 36422
Reposted by Joseph D. ZakPaul Masset @paulmasset.bsky.social · 04/11/2025First paper from the lab! We propose a model that separates estimation of odor concentration and presence and map it on olfactory bulb circuits Led by @chenjiang01.bsky.social and @mattyizhenghe.bsky.social joint work with @jzv.bsky.social and with @neurovenki.bsky.social @cpehlevan.bsky.social 23913
Joseph D. Zak @josephdzak.bsky.social · 08/10/2025Chicago is definitely burning. Just not in the way the news wants to portray. 020
Reposted by Joseph D. ZakRupinder Kaur, PhD @kaurr.bsky.social · 03/10/2025#Wolbachia has puzzled scientists with its power to rewire insect reproduction. What if I tell you that we found one of the keys Wolbachia use to rewire its host AND a small molecule inhibitor uses this key to mimic what this microbe has mastered for millions of years. www.cell.com/cell-reports...cell.comBeyond Wolbachia—Can a small molecule control insect reproduction?Kaur et al. demonstrate reduced histone acetylation as a key mechanism underpinning Wolbachia’s paternal-effect embryonic lethality trait in Drosophila melanogaster. Recapitulation of this trait by in... 26425
Reposted by Joseph D. ZakEvan Schaffer @esschaffer.bsky.social · 05/09/2025Very excited to see this out in the world. It was fun to play a (small) part in it. 151
Reposted by Joseph D. ZakNicholas Bellono @nbellono.bsky.social · 04/09/2025Octopuses sense environmental microbiomes to drive predatory and parental behaviors. Artwork by Lily Soucy. #evolution #sensation #microbiome @cellpress.bsky.social 610325
Reposted by Joseph D. ZakSiddharth Jayakumar @siddjakes.bsky.social · 02/09/2025Excited to share our latest!! Thanks to everyone involved especially @neurovenki.bsky.social! 0163
Reposted by Joseph D. ZakVenki Murthy @neurovenki.bsky.social · 01/09/2025Thrilled to share this work, long time in the making! Carried through creatively by @siddjakes.bsky.social after initial design & piloting by @trackingskills.bsky.social, with help from @trackingactions.bsky.social. Modeling in collaboration with Massimo Vergassola & Nicola Rigolli.biorxiv.orgMice navigate scent trails using predictive policiesAnimals actively sense their environment to extract features of interest to guide behaviors. For mammals, odors are prominent environmental features which are sampled by active modulation of sniffing ... 112441
Joseph D. Zak @josephdzak.bsky.social · 20/08/2025Proud to share Kai Clane Belonio’s latest work in our lab. Kai showed that induced-depression decreases behavioral tolerance of aversive odorants as well as increases in neuroinflammation in sensory affective areas. Also contributing are @nervenkidd.bsky.social and Eyerusalem Haile. 021
Reposted by Joseph D. ZakFelix Baier @felixbaier.bsky.social · 23/07/2025🚨Very happy that my PhD work is now out in @nature.com! We discovered that evolution, by acting in the midbrain, shifted the threshold to escape in Peromyscus mice, to fine-tune defensive strategies in different environments www.nature.com/articles/s41... This was a truly collaborative effort! 🧵⬇️ 26471103
Joseph D. Zak @josephdzak.bsky.social · 02/07/2025Some campus brutalism to accompany this brutal heatwave. 091
Reposted by Joseph D. ZakJoe Walker @evojfwalker.bsky.social · 26/06/2025@shawn-anthony.bsky.social helped ~20 undergrads learn transcriptomics in this budget friendly investigation into the dogbane family. A fun way to investigate the molecular evolution of the group. Also, a chance to collaborate with @phylonatworks.bsky.social and Jarrad! doi.org/10.1101/2025...doi.orgGoing green: Recycling transcriptomes to infer evolutionary relationships, gene duplication, gene tree conflict, and patterns of molecular evolution in the ApocynaceaeBackground and Aims: The flowering plant family Apocynaceae exhibits diverse adaptations with biological and pharmaceutical significance, many of which have been studied with RNA-seq. However, despite... 063
Reposted by Joseph D. ZakIzumi Fukunaga @ifukunaga.bsky.social · 13/06/2025Animals’ sniffing drives rhythmic input to the olfactory system. How does this timing contribute to perception, especially beyond first steps of olfactory processing? We tested this using simple closed-loop optogenetics in our new paper: www.cell.com/iscience/ful...cell.comDecoding olfactory bulb output: A behavioral assessment of rate, synchrony, and respiratory phase codingNeurogenetics; Behavioral neuroscience; Sensory neuroscience 1248
Joseph D. Zak @josephdzak.bsky.social · 03/06/2025What a special place. So grateful for all the friendships, learning, and science that fullfilled my time @harvard.edu. 190
Joseph D. Zak @josephdzak.bsky.social · 14/05/2025Proud of @nervenkidd.bsky.social (Zach Fyke), a graduate student in our group, for being recognized by @uicbios.bsky.social for both his research AND teaching over the past academic year. Here are links to some of his recent work: tinyurl.com/37vw5s5f tinyurl.com/23zu458t tinyurl.com/3mmjvw83 040
Reposted by Joseph D. ZakDatta Lab @dattalab.bsky.social · 09/05/2025Maps are everywhere in the brain...and finally we've discovered one in the nose! Led by @davidhbrann.bsky.social, we uncovered the logic that specifies the positions of each of the 1,000 sensory neuron subtypes in the nose and aligns their projections to the brain.👇👃see more details below👃👇biorxiv.orgA spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brainAlthough topographical maps organize many peripheral sensory systems, it remains unclear whether olfactory sensory neurons (OSNs) choose which of the ~1100 odor receptors (ORs) to express based upon t... 515252
Joseph D. Zak @josephdzak.bsky.social · 09/05/2025One of our new favorite images for #fluoresencefriday. Graduate student, Lindsay Vivona, labeled fibers from each anterior olfactory nucleus hemisphere as they bidirectionally pass through the anterior commissure. #neuroskyence #olfaction 1221
Reposted by Joseph D. ZakCarles Bosch @carlesbosch.bsky.social · 01/05/2025#preprint: We mapped the structure and function of olfactory bulb circuits with in vivo 2-photon microscopy and synchrotron #Xray holographic nanotomography. doi.org/10.1101/2025... @yuxinzhang.bsky.social @andreas-t-schaefer.bsky.social @apacureanu.bsky.social @crick.ac.uk @esrf.fr 16222
Joseph D. Zak @josephdzak.bsky.social · 30/04/2025Now in its final form, our recent work on how olfactory transduction currents help ensure sparse sensory coding. Led by a post-bac Kai Clane Belonio and a graduate student, Eyerusalem Haile, this was a group effort by the entire laboratory. www.jneurosci.org/content/45/1...jneurosci.orgAmplification of Olfactory Transduction Currents Implements Sparse Stimulus EncodingSensory systems must perform the dual and opposing tasks of being sensitive to weak stimuli while also maintaining information content in dense and variable sensory landscapes. This occurs in the olfa... 1132
Reposted by Joseph D. ZakAlexander Mathis @trackingskills.bsky.social · 22/04/2025My lab has several postdoctoral fellow and software engineering positions available. Please email me if you’re interested. 13022
Reposted by Joseph D. ZakThe Transmitter @thetransmitter.bsky.social · 16/04/2025Olfactory neuroscientists have known for a while that their stimuli stink. A new analysis illuminates the extent of the problem. By @callimcflurry.bsky.social #neuroskyence www.thetransmitter.org/olfaction/sm...thetransmitter.orgSmell studies often use unnaturally high odor concentrations, analysis revealsIt’s time to fashion olfactory neuroscience stimuli based on odor concentrations in the wild, say study investigators Elizabeth Hong and Matt Wachowiak. 03414
Reposted by Joseph D. ZakVictoria K. Switacz @victoria-swi.bsky.social · 16/04/2025Now out in @sfnjournals.bsky.socialjournals.bsky.social : bit.ly/3YzVjRv. In VSNs, Ca²⁺ doesn’t tell a 'simple' story. Ca²⁺ at the knob excites, while at the soma it can activate K⁺ channels, dampening excitability. This channel diversity and compartmentalization refine vomeronasal sensory output-bit.lyCa2+-Activated Ion Channels Exert Opposite Effects in Different Signaling Compartments of Vomeronasal Sensory NeuronsIn most mammals, conspecific chemical cues that drive innate social and sexual behavior are detected by the vomeronasal organ (VNO) and processed in the accessory olfactory bulb (AOB). Chemosensory st... 172
Reposted by Joseph D. ZakKelsey Anbuhl @anbuhlk.bsky.social · 04/04/2025Excited to share my latest work just out in @pnas.org! This NIH MOSAIC K99-funded project identifies a top-down cortical circuit—from cingulate to auditory cortex—that supports auditory perceptual performance in challenging listening conditions: www.pnas.org/doi/10.1073/...pnas.orgThe cingulate cortex facilitates auditory perception under challenging listening conditions | PNASWe often exert greater cognitive resources (i.e., listening effort) to understand speech under challenging acoustic conditions. This mechanism can ... 14816
Reposted by Joseph D. ZakHattie Chung @hattaca.bsky.social · 02/04/2025🚨 Job alert! 🚨 The Chung Lab @ Yale seeks a motivated, creative postdoc to examine tissue remodeling in health and disease. We study ovarian aging and cardiovascular disease in human samples and animal models. Passionate about single-cell, spatial genomics, machine learning & therapeutics? Join us! 1107
Reposted by Joseph D. ZakTrevor Sorrells @trevorsorrells.bsky.social · 20/03/2025Reminder: apply for our research assistant position! 0610
Reposted by Joseph D. Zakmatthew capek @matthewcapek.bsky.social · 06/03/2025🎉 so excited to share my first first-author paper is out in @Nature.com, from my PhD work in the Gallio Lab! we uncover the neurobiological mechanisms that drive the evolution of temperature preference behavior in flies of the genus Drosophila 👇 go.nature.com/4i1VQn9go.nature.comEvolution of temperature preference in flies of the genus Drosophila - NatureA study using flies of the genus Drosophila adapted to life in diverse thermal environments shows how evolution has shaped temperature preference by acting on both molecular heat receptors and th... 0239
Reposted by Joseph D. ZakElisa Galliano @elisagalliano.bsky.social · 05/03/2025Our first “Icelandic” paper is out 🥳🌋 Led by our country-hopping, cold-adapted patcher extraordinaire @neurosana.bsky.social and done between Cambridge & the Petersen lab in Reykjavík, here’s our offering on the mitral vs tufted cell debate in the olfactory bulb www.eneuro.org/content/12/3... 1/🧵 1204
Reposted by Joseph D. ZakDing Liu @dingliu.bsky.social · 26/02/2025Our paper @dulaclab.bsky.social on social homeostasis is online today! We characterized “social rebound” behavior after social isolation in multiple mouse strains and revealed its neural basis. Intriguingly, soft touch plays a key role in satisfying social need! www.nature.com/articles/s41... 68524
Reposted by Joseph D. ZakPaul Masset @paulmasset.bsky.social · 18/02/2025Honoured to have been selected as a #SloanFellow Thankful for all the support from family, mentors, collaborators, colleagues and students along the way! @sloanfoundation.bsky.social 3489