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Alexandra Keinath

@atkeinath.bsky.social
229 followers 196 following 42 posts

Hip, hip, hippocampus! Neuroscientist studying our personal space. Assistant professor at UIC. Head of the Keinath Lab since ‘23. 🏳️‍⚧️ wedobrainstuff.com

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Alexandra Keinath @atkeinath.bsky.social · 08/12/2025
Another new paper from the lab: Predictive theories like the SR imply that navigators who navigate differently should have cognitive maps which differ in predictable ways. Here we show that this holds in mouse hippocampal CA1. www.sciencedirect.com/science/arti...
sciencedirect.com
Environmental representations in mouse hippocampal CA1 reflect the predictive structure of navigation
Predictive theories of cognitive mapping propose that these representations encode the predictive relationships among contents as experienced by the n…
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Alexandra Keinath @atkeinath.bsky.social · 08/12/2025
Excited to share the first peer-reviewed work from the lab (what a moment)! We have two papers to share. First, some work on heading integration in humans. www.cell.com/iscience/ful...
cell.com
Rotating visual spaces induce behavioral biases consistent with recalibrated heading integration in humans
Neuroscience; Cognitive neuroscience; Computer simulation
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Denise J. Cai, Ph.D. @denisejcai.bsky.social · 14/07/2025
What’s better than a one-channel #Miniscope? 🥁 A TWO-CHANNEL Miniscope! Our new Miniscope2C is a dual-channel, open-source Miniscope that lets you record 2 fluorescent signals simultaneously in freely moving animals. Read the paper here: www.science.org/doi/10.1126/... (1/10)
Screenshot of the top of the article, including the title, authors, and abstract.
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Alexandra Keinath @atkeinath.bsky.social · 15/07/2025
Trans rights are human rights. Fresh work incoming: Here we quantitatively compare the representational geometry of mouse CA1 and human spatial memory during environmental deformations. Briefest TLDR: Human memory looks like a change-resistant version of mouse CA1. www.biorxiv.org/cgi/content/...
biorxiv.org
Change-resistance distinguishes the representational geometries of human spatial memory and mouse CA1 in deformed environments
Prior work has highlighted qualitative similarities between the neural instantiations of cognitive maps in rodents and memory-guided navigation in humans, suggesting a conservation of representational...
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Alexandra Keinath @atkeinath.bsky.social · 03/05/2025
Gotta make sure your results generalize to mascots! #uic
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Alexandra Keinath @atkeinath.bsky.social · 14/04/2025
Super excited to share that one of our outstanding founding undergrad RAs @dahery.bsky.social will be headed to the Kempner postbac program at Harvard to work with @gershbrain.bsky.social after graduation! Congratulations David! You cannot be replaced, and I’m so proud and excited for you!
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Quinn Lee @jquinnlee.bsky.social · 08/04/2025
The dataset and code for our recent paper in Neuron (tinyurl.com/yc48d6vr) is online now! The data is available on Zenodo (zenodo.org/records/1486...) and code on Github (github.com/jquinnlee/ge...). Big thanks to @markbrandonlab.bsky.social and @atkeinath.bsky.social on this effort! #neuroskyence 🧠
zenodo.org
Mouse CA1 Calcium Imaging and Behavioural Dataset in 3x3 Geometric Morph Paradigm
The following dataset was collected by Dr. J. Quinn Lee, Dr. Alexandra T. Keinath, and Erica Cianfarano in the laboratory of Dr. Mark P. Brandon. All methods and details are described in the original ...
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Mark Brandon @markbrandonlab.bsky.social · 09/04/2025
How good is your place cell model? Come benchmark yours against real data - nearly 70K CA1 rate maps in various geometric shapes across weeks - collected and curated in my lab by the great @jquinnlee.bsky.social and @atkeinath.bsky.social
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WIRED @wired.com · 02/02/2025
If you’ve been wondering what Elon Musk and his lackeys are up to since taking control of the US government, look no further. Our latest story names six 19- to 24-year-olds working with his DOGE organization, which now has access to sensitive federal systems. wrd.cm/4jzpiSN
wrd.cm
The Young, Inexperienced Engineers Aiding Elon Musk's Government Takeover
Engineers between 19 and 24, most linked to Musk’s companies, are playing a key role as he seizes control of federal infrastructure.
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andy alexander @andyalexander.bsky.social · 02/02/2025
Shoutout to all the millennial junior faculty who finally got their dream jobs right as the scientific enterprise in the states is functionally dismantled.
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Marisa Kabas @marisakabas.bsky.social · 01/02/2025
i think an important thing for people outside the US to understand is that elon musk seized control of the government today and most americans don’t even realize it happened.
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Adam Serwer @adamserwer.bsky.social · 29/01/2025
The campaign against trans rights is also about stripping away everyone’s protections against discrimination, reviving, as Douglass put it “the moral blindness” of those who “persuade themselves that they are safe, though the rights of others may be struck down.” www.theatlantic.com/ideas/archiv...
theatlantic.com
The Attack on Trans Rights Won’t End There
Once legal rights begin to fall, they fall for everyone.
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Reposted by Alexandra Keinath
Hugo Spiers @hugospiers.bsky.social · 27/01/2025
🚨 new publication from our lab in @pnas.org ! "Expert navigators deploy rational complexity–based decision precaching for large-scale real-world planning" Entropy of streets & successor representations explain planning speed Colab wth Daniel McNamee at Champalimaud www.pnas.org/doi/10.1073/...
Map of london with the planned routes of 43 taxi drivers overlaid in yellow lines.
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Mark Joseph Stern @mjsdc.bsky.social · 28/01/2025
Trump is attempting to unilaterally freeze trillions of dollars in federal spending that’s been duly appropriated by Congress. This is completely insane and illegal. He’s seizing unlawful control over the constitutional spending power? Five alarm fire www.washingtonpost.com/business/202...
washingtonpost.com
White House pauses all federal grants, sparking confusion
The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.
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Nancy Kanwisher @nancykanwisher.bsky.social · 25/01/2025
RFkJr is a threat to human health: when the next pandemic hits we need disease tracking (CDC now silenced) and fast vaccine development (which he opposes). If you live in ME, NC, SD, LA, AK, ID, KY or SD call your senators to oppose his confirmation (hearing this Wed.). (continued, please retweet):
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Brooke Fitzwater, PhD (she/her) 🐟🪱🏳️‍🌈♾️ @oceanfilly.bsky.social · 23/01/2025
This is a very scary time for early career scientists like people looking for/who are postdocs and new faculty trying to get funding. Any words of encouragement to share for people in this category?
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Blake Richards @tyrellturing.bsky.social · 23/01/2025
Okay, this is very cool: evidence from Peter Jonas' group that human CA3 follows a different logic of synaptic connectivity than rodent CA3, focussing more on sparser, but highly reliable synapses. www.cell.com/cell/fulltex... CC @dlevenstein.bsky.social & @repromancer.bsky.social #neuroscience 🧪
cell.com
Human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory
Human hippocampal CA3 networks use sparse and broad synaptic connectivity, and their recurrent synapses employ reliability, precision, and long integration times to enhance memory capacity. Thus, the ...
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Alexandra Keinath @atkeinath.bsky.social · 23/01/2025
Tough week to be a trans neuroscientist with an immigrant spouse in the US… … anyway, see y’all at Winter Brain!
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Blake Richards @tyrellturing.bsky.social · 19/12/2024
Out now in Nature from @behrenstimb.bsky.social and crew: www.nature.com/articles/s41... Understanding this kind of schematic pattern learning and transfer will be key, IMO, to moving towards models of what we might call "higher-order cognition" or "reasoning". 🧠📈 🧪
nature.com
A cellular basis for mapping behavioural structure - Nature
Mice generalize complex task structures by using neurons in the medial frontal cortex that encode progress to task goals and embed behavioural sequences.
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Caswell Barry @caswell.bsky.social · 26/11/2024
Our latest preprint has landed www.biorxiv.org/content/10.1... Fantastic work from @laurenb29.bsky.social and Will de Cothi showing how many of the cell types associated with subiculum (e.g. boundary vector cells, corner cells) can be understood as successor features. TLDR: SUB not CA1 is the SR
biorxiv.org
Unifying Subicular Function: A Predictive Map Approach
The successor representation has emerged as a powerful model for understanding mammalian navigation and memory; explaining the spatial coding properties of hippocampal place cells and entorhinal grid ...
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Alexandra Keinath @atkeinath.bsky.social · 26/11/2024
Super excited to share our first preprint of work from the lab! We monitor and manipulate the CA1 representation of mice exploring a multicompartment environment to contrast geometric vs. predictive theories of cognitive mapping. TLDR: All signs point to a predictive theory! tinyurl.com/yeyv5p3x
tinyurl.com
Idiosyncratic navigation determines mouse CA1 representational structure in a multicompartment environment
Organisms from mice to humans rely on cognitive maps instantiated by the hippocampal formation to flexibly and efficiently navigate the world. Traditional theories of cognitive mapping posit that thes...
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Mitch Roitman @mitchroitman.bsky.social · 25/11/2024
Just in time for Thanksgiving, we're grateful for the publication of our paper in #eLife doi.org/10.7554/eLif... We measured dopamine and behavioral responses to intraorally delivered sucrose across acquisition and extinction of a conditioned taste aversion. 1/n
media.tenor.com
It Tastes Bad Melissa GIF
ALT: It Tastes Bad Melissa GIF
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Quinn Lee @jquinnlee.bsky.social · 22/11/2024
Psyched that my postdoc work w @markbrandonlab.bsky.social + @atkeinath.bsky.social is now in Neuron! TL/DR: remapping in CA1 has a representational structure that is reliable across brains, and we use this representation to test models of cognitive maps. #NeuroSky #NeuroAI 🧪🧠 tinyurl.com/4juhmad8
tinyurl.com
Identifying representational structure in CA1 to benchmark theoretical models of cognitive mapping
Decades of theoretical and empirical work have suggested the hippocampus instantiates some form of a cognitive map. Yet, tests of competing theories h…
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Alexandra Keinath @atkeinath.bsky.social · 22/11/2024
My last postdoc pub with @markbrandonlab.bsky.social and @jquinnlee.bsky.social is out. Here we use RSA and miniscopes to characterize CA1 responses to diverse deformations and compare to models. The dataset is public, and we'll build on it in future work. authors.elsevier.com/c/1k8j8_KOmx...
authors.elsevier.com
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Alexandra Keinath @atkeinath.bsky.social · 19/11/2024
Exciting day for us at the Keinath Lab! Last day of data collection for our first set of immersive VR experiments. 300+ participants across three experiments, this last one in an extra-large space! Stay tuned!
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