Neuropsychopharmacology - Top-down control of sustained attention by medial prefrontal cortex—locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT)

The high frequency of opioid overdose deaths often involves co-use of alcohol, which is reported in approximately 30% of fentanyl fatalities. Both substances depress respiratory function, and their combined effects can be lethal. The present study investigated physiological parameters of respiratory …

In a new computational analysis of previous work, this study shows that a control-free mechanism better accounts for value-based decisions than an account that assumes top-down control invigorating th...

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Temporary Extension to Early-Stage Investigator (ESI) Eligibility Period NOT-OD-26-020. OD

The medial prefrontal cortex (mPFC) plays a pivotal role in attention by exerting top-down control to allocate cognitive resources toward behaviorally relevant stimuli based on learned context and exp...

The 2026 Gordon Research Conference on Frontal Cortex will be held in Holderness, New Hampshire. Apply today to reserve your spot.

Translational Psychiatry - Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test