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Jonathan G. Stine, MD MSc, FACP

@jonathanstinemd.bsky.social
622 followers 131 following 82 posts

Global Clinical Program Lead – Late CVRM @AstraZeneca | Clinical Professor of Medicine @PennState | #MASH researcher | Tackling liver health through science & lifestyle | #LiverSky #MASLD #run #lift #yoga #snowboard #read #garden | views my own

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Reposted by Jonathan G. Stine, MD MSc, FACP
The Baveno Cooperation: an EASL Consortium @bavenocoop.bsky.social · 16/07/2025
🖤 With deep sorrow, we announce the passing of Prof. Dr. Jaime Bosch, President of the Baveno Cooperation. A brilliant scientist, inspiring leader, and dear friend. His immense legacy in hepatology will endure. Rest in peace, Jaime
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 27/06/2025
Celebrated 8 incredible years of Stine Lab with a team lunch today! Grateful for the hard work, discoveries, and camaraderie that made our journey so impactful. Here’s to the science, the memories, and the friendships that last far beyond the lab. #MASLD #Research
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 01/06/2025
The muscle–adipose–liver axis is critical, yet underrecognized, in #MASLD. Sarcopenic obesity affects ~50% with #MASLD and drives ⬆️ ASCVD and liver fibrosis. Its time to standardize definitions and intervene early: link.springer.com/article/10.1...
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Reposted by Jonathan G. Stine, MD MSc, FACP
Tom Marjot @tom-marjot.bsky.social · 25/05/2025
📢Great to write this review for Hep Comms with Matt Armstrong & @jonathanstinemd.bsky.social 💪We've covered everything you need to know about #Muscle & #MASLD - Insulin resistance - Sarcopenia - Myosteatosis - Impact of weight loss drugs - Benefits of exercise 🔗 shorturl.at/aFO1Q #LiverSky
Graphic showing assessment methods for various domains of muscle quality and function in patients with MASLD including insulin resistance, myosteatosis, sarcopenia, and frailty.
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 23/05/2025
It was an absolute delight to contribute to this high-impact work with @tom-marjot.bsky.social and @mattarmstrong95.bsky.social in which we review all things #MASLD and #Muscle! If you're looking for holiday weekend reading, look no further: journals.lww.com/hepcomm/page... @ebtapper.bsky.social
journals.lww.com
Skeletal muscle and MASLD: Mechanistic and clinical insights : Hepatology Communications
, which all converge on the liver to drive disease progression and adverse patient outcomes. This review explores the mechanistic links between skeletal muscle and MASLD, including the role of abnorma...
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Reposted by Jonathan G. Stine, MD MSc, FACP
WHO @who.int · 16/05/2025
Choose to walk 🚶‍♂️ or cycle 🚲 whenever possible. It can help improve: ♥️ your heart, 😇 your mind, 🌏 and the planet. Learn more 👉 bit.ly/43eExcc #RoadSafety #BeActive
People walking, cycling, and using wheelchairs on a safa road. Text reads: “Hit that step count, or hop on your bicycle! Reclaim your health, and the health of the planet.”
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 12/05/2025
New review out! 🧬 Autophagy plays a key role in #MASLD, regulating lipid metabolism, insulin sensitivity & fibrosis. But effects vary by cell type. Precision targeting is key. Great work led by Prashant Nighot and Kofi Clarke Read here: sciencedirect.com/science/arti...
sciencedirect.com
Guts for Self-Eating: Role of Autophagy in Gastrointestinal Health and Disease
Autophagy, a highly conserved cellular degradation pathway promotes cell survival via lysosomal degradation of aberrant cellular proteins and recyclin…
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 12/05/2025
Heading to the PA State Capitol tomorrow to advocate for continued funding of PA CURE program. This is critical for advancing clinical and biomedical research in PA. This investment saves lives and is even more important given the status of federal research funding. #ResearchMatters #PublicHealth
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 22/04/2025
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 16/04/2025
#Exercise may protect the liver by blocking ferroptosis, a key cell death pathway in #MASLD. 🏃‍♀️🧬 New review highlights NRF2, GPX4, and iron regulation as targets. A fresh angle for #ExerciseIsMedicine and a possible link cellular senescence pubmed.ncbi.nlm.nih.gov/40206477/
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Reposted by Jonathan G. Stine, MD MSc, FACP
Eric Topol @erictopol.bsky.social · 14/04/2025
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is modulated by exercise and likely other lifestyle factors. Here’s (almost) everything we know about it erictopol.substack.com/p/the-breakt...
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 14/04/2025
Ok, I couldn't resist this trend any longer... I had to have ChatGPT make my action figure based on my bio and here is what it generated 😂 😂 😂
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Reposted by Jonathan G. Stine, MD MSc, FACP
Nicholas A. Christakis @nachristakis.bsky.social · 31/03/2025
I join >1900 members of US National Academies of Science, Engineering, and Medicine signing this letter, as individuals, decrying the present thoughtless assault on science, which is against our national interests. docs.google.com/document/d/1... Our health, wealth, and security depend on science.
docs.google.com
Public Statement on Supporting Science for the Benefit of All Citizens
TO THE AMERICAN PEOPLE We all rely on science. Science gave us the smartphones in our pockets, the navigation systems in our cars, and life-saving medical care. We count on engineers when we drive acr...
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Reposted by Jonathan G. Stine, MD MSc, FACP
Eric Topol @erictopol.bsky.social · 01/04/2025
How I will remember April Fools' Day 2025. Reckless. My heart is out for these dedicated folks at NIH, FDA and CDC www.statnews.com/2025/04/01/h...
statnews.com
HHS starts layoffs of thousands of workers across its agencies
Layoff notices began arriving early Tuesday for thousands of employees of HHS and its subsidiary agencies, with as many 10,000 workers potentially expected to be hit by the cuts.
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 28/03/2025
🔥🆙 to publish alongside my pre-doc #HannahMohrMS in AP&T where we offer our 🧠🧠🧠 about time restricted feeding and #MASLD including commentary on the recently published CHRONO-NAFLD study Read the full paper here: onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Editorial: Chrononutrition and MASLD—Its About Time (Restricted Feeding)!
Click on the article title to read more.
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Reposted by Jonathan G. Stine, MD MSc, FACP
Thanh Neville, MD, MSHS @thanh-neville.bsky.social · 18/03/2025
THIS: The Best Investment You Didn’t Know You Made: How NIH Funding Fuels Innovation and Economic Growth www.amfar.org/news/how-nih...
amfar.org
The Best Investment You Didn’t Know You Made: How NIH Funding Fuels Innovation and Economic Growth
Continued investment in the NIH is essential to fighting current and emerging health threats and to ensuring the U.S. remains a global leader in medical innovation.
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Reposted by Jonathan G. Stine, MD MSc, FACP
Elliot Tapper @ebtapper.bsky.social · 25/03/2025
The liver loves aerobic exercise journals.lww.com/hepcomm/full... #liversky
journals.lww.com
Aerobic exercise interventions lead to MASH resolution in... : Hepatology Communications
An abstract is unavailable.
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Reposted by Jonathan G. Stine, MD MSc, FACP
Hannes Hagström @liverepi.bsky.social · 24/03/2025
New paper from us in @jhepatology.bsky.social: www.journal-of-hepatology.eu/article/S016... Causes of death in >13,000 persons with #MASLD - check it out #liversky. So proud of co-senior author Axel Wester and first author medical student Gabriel Issa for the work!
journal-of-hepatology.eu
Cause-specific mortality in 13,099 patients with metabolic dysfunction-associated steatotic liver disease in Sweden
Data on cause-specific mortality in metabolic dysfunction-associated steatotic liver disease (MASLD) are limited. We aimed to determine the rate and risk of death from different causes in patients wit...
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Reposted by Jonathan G. Stine, MD MSc, FACP
aga-gihn.bsky.social @aga-gihn.bsky.social · 18/03/2025
Our March member spotlight is Dr. Pooja Singhal! She discusses the critical role women #GI docs play in assisting the unique needs of female patients, her involvement in the @amergastroassn.bsky.social Women in GI Workshop & more: buff.ly/dFGqZ2d
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Reposted by Jonathan G. Stine, MD MSc, FACP
Eric Topol @erictopol.bsky.social · 06/03/2025
In these unprecedented dark times for American life science and medical research (no less well beyond biomedicine), my coping mechanism is to laser focus on the unremitting and remarkable daily advances, and the fervent hope these will not be slowed or interrupted.
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 18/03/2025
Join us for Penn State Health MASH Day on June 12th for a high-yield medical conference covering the latest in MASLD/MASH diagnosis and management. Don't miss expert insights and practical takeaways! Register here: ce.med.psu.edu/mash/ It’s free!
ce.med.psu.edu
Penn State Health Metabolic Dysfunction-Associated Steatohepatitis (MASH) Day - Penn State College of Medicine Continuing Education
Penn State Health Metabolic Dysfunction-Associated Steatohepatitis (MASH) Day is a continuing education program of Penn State College of Medicine taking place in Hershey, Pa.
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Reposted by Jonathan G. Stine, MD MSc, FACP
Sherry Pagoto, PhD @drsherrypagoto.bsky.social · 12/03/2025
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...
forbes.com
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
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Reposted by Jonathan G. Stine, MD MSc, FACP
Jonathan Lambert @jonlambert.bsky.social · 07/03/2025
Pretty big turnout at Stand Up for Science, talked with scientists and non-scientists who came to DC from all over.
Stand up for science rally at Lincoln Memorial.Stand up for science rally at Lincoln Memorial.Stand up for science rally at Lincoln Memorial.
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 04/03/2025
Today is #WorldObesityDay and a good reminder that obesity is a major driver of #MASLD affecting billions worldwide. The good news? #Lifestyle interventions work! #Exercise can reverse liver fat & improve metabolic health. Let’s turn awareness into action! #ExerciseIsMedicine
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Reposted by Jonathan G. Stine, MD MSc, FACP
WHO @who.int · 04/03/2025
Today is #WorldObesityDay. #Obesity is a complex condition and each individual faces distinct needs & challenges. A healthier society is possible only if we prioritize community support & stand up against discrimination and stigma 🔗bit.ly/3SAcdeE
Obesity is complex. Say no to discrimination. Stand up against bullying. End the stigma.
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Reposted by Jonathan G. Stine, MD MSc, FACP
Eric Topol @erictopol.bsky.social · 03/03/2025
"Without drastic intervention, 3·80 billion adults over the age of 25 years will have overweight and obesity by 2050." www.thelancet.com/journals/lan... @thelancet.bsky.social
thelancet.com
Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021
No country to date has successfully curbed the rising rates of adult overweight and obesity. Without immediate and effective intervention, overweight and obesity will continue to increase globally. Pa...
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Reposted by Jonathan G. Stine, MD MSc, FACP
WHO @who.int · 04/03/2025
Did you know? 1 in 8 people worldwide are living with obesity. #Obesity can lead to serious health conditions like type 2 diabetes, hypertension & cardiovascular diseases. Learn how to prevent obesity 🔗 bit.ly/3SAcdeE #WorldObesityDay
Obesity leads to a range of diseases.
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 28/02/2025
🎙️ Just finished a great interview with HCPLive on the importance of a #multidisciplinary care model for #MASLD. Collaboration across specialties is key to improving outcomes and redefining liver care! #LiverHealth #TeamApproach 📢 Full thoughts here: www.hcplive.com/view/the-imp...
hcplive.com
The Importance of Multidisciplinary MASLD Care, with Jonathan Stine, MD, MSc
Stine explains the continued need for diet and exercise in MASH and the importance of a multidisciplinary approach to treating these patients.
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Reposted by Jonathan G. Stine, MD MSc, FACP
Renu Dhanasekaran @renumathyd.bsky.social · 24/02/2025
Presently, an estimated 60-70 million Americans are suffering from GI diseases. That is why consistent and sustainable funding from NIH is necessary to support innovative research and treatment development. Please take a minute to tell Congress to stop NIH cuts! gastro.quorum.us/campaign/109928
gastro.quorum.us
Tell Congress to Stop Harmful NIH Research Cuts!
Tell Congress to Stop Harmful NIH Research Cuts!
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Reposted by Jonathan G. Stine, MD MSc, FACP
Jeremy Berg @jeremymberg.bsky.social · 21/02/2025
New York Times article now up on Federal Register stuff. www.nytimes.com/2025/02/21/s... 1/n
nytimes.com
Trump Administration Stalls Scientific Research Despite Court Ruling (Gift Article)
Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.
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Reposted by Jonathan G. Stine, MD MSc, FACP
Nature @nature.com · 20/02/2025
Almost all grant-review meetings under Trump 2.0 remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget. go.nature.com/4gM6oW4
go.nature.com
Revealed: NIH research grants still frozen despite lawsuits challenging Trump order
The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 20/02/2025
Federal Register Blackout Blocks NIH Funding www.medpagetoday.com/special-repo...
medpagetoday.com
Federal Register Blackout Blocks NIH Funding
New strategy is like pouring 'cement in the pipes of the federal funding infrastructure'
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Reposted by Jonathan G. Stine, MD MSc, FACP
Jorge Ganem, MD FAAP @jfganem.medsky.social · 19/02/2025
Vaccines save lives. Share widely. #PedSky #MedSky #Pediatrics #Vaccinessavelives
A photograph of the Pediatric vaccinations schedule.
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Reposted by Jonathan G. Stine, MD MSc, FACP
Steven Salzberg @stevensalzberg.bsky.social · 12/02/2025
98% of NIH grants that should have gone out this month, didn't. Despite court orders 'unfreezing' the funds, they are frozen. Biomedical research will grind to a halt. Clinical trials will end. All for no reason: the total impact on the US budget is miniscule
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 13/02/2025
Had a great time on Your Health First with Dr. Joe Galotti discussing how exercise improves fatty liver, even without weight loss! #LiverHealth #ExerciseIsMedicine Listen here: podcasts.apple.com/us/podcast/j...
podcasts.apple.com
Jonathan Stine M.D. : Fatty Liver and Exercise
Podcast Episode · Dr. Joe Galati Podcast · 02/13/2025 · 36m
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Reposted by Jonathan G. Stine, MD MSc, FACP
Eric Topol @erictopol.bsky.social · 12/02/2025
Defying defiance to the laws. Good for NIH!
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 11/02/2025
Happy #InternationalDayofWomenandGirlsinScience! 🌟 Today, we celebrate the brilliant and innovative women pushing boundaries in research. A special shoutout to the incredible women in the Stine Lab, whose talent and dedication drive scientific discovery daily! #WomenInScience
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Reposted by Jonathan G. Stine, MD MSc, FACP
Chris Geidner @chrisgeidner.bsky.social · 11/02/2025
BREAKING: In response to doctors' lawsuit, Judge John Bates, a George W. Bush appointee, orders CDC, NIH, and FDA to put back up websites and datasets cited by the doctors in their lawsuit as having been relied upon and pulled down without notice. storage.courtlistener.com/recap/gov.us...
TOTE ASTRICT COLOR
DOCTORS FOR AMERICA,
Plaintiff,
Civil Action No. 25-322 (JDB)
OFFICE OF PERSONNEL MANAGEMENT et al.,
Defendants.
ORDER
Upon consideration of [6] Plaintiff's motion for a temporary restraining order, [8]
Plaintiff's supplemental declarations, [9] Defendants' opposition, [10] Plaintiff's reply, the
hearing on February 10, 2025, and the entire record herein, and for the reasons stated in the
accompanying Memorandum Opinion, it is hereby ORDERED that
1. Defendants Department of Health and Human Services, Center for Disease Control, and Food
and Drug Administration (hereinafter "defendants") shall, by not later than 11:59 pm on
February 11, 2025, restore to their versions as of January 30, 2025, each webpage and dataset
identified by Plaintiff on pages 6-12 of its Memorandum of Law in Support of the Motion for
a Restraining Order [ECF No. 6-1];
2. Defendants shall, in consultation with Plaintiff, identify any other resources that DF A members
rely on to provide medical care and that defendants removed or substantially modified on or
after January 29, 2025, without adequate notice or reasoned explanation; and defendants shall,
by February 14, 2025, restore those resources to their versions as of January 30, 2025;
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Reposted by Jonathan G. Stine, MD MSc, FACP
Jeremy Berg @jeremymberg.bsky.social · 11/02/2025
STAT story www.statnews.com/2025/02/11/j...
statnews.com
Halt on Trump administration’s cuts to NIH research payments expanded nationwide
A federal judge issued a nationwide temporary pause on plans by the NIH to substantially slash research overhead payments.
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Reposted by Jonathan G. Stine, MD MSc, FACP
Eric Topol @erictopol.bsky.social · 11/02/2025
A Direct Hit, by @holdenthorp.bsky.social @science.org www.science.org/doi/full/10.... "This is a moment to unite."
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Reposted by Jonathan G. Stine, MD MSc, FACP
WHO @who.int · 11/02/2025
It is International Day of Women and Girls in Science. Gagandeep Kang’s research on enteric infections has contributed to the rotavirus vaccine rollout in #India, protecting millions of children and shaping a healthier future. for all. 🔬 #WomenInScience #WomenInSTEM
When you have women leaders in science, they think about problems differently.
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Reposted by Jonathan G. Stine, MD MSc, FACP
WHO @who.int · 11/02/2025
Today is International Day of Women & Girls in Science. Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM
Nothing in life is to be feared, it is only to be understood. Marie Curie, Physicist and chemist.
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Reposted by Jonathan G. Stine, MD MSc, FACP
Eric Topol @erictopol.bsky.social · 10/02/2025
How to get 146% return on investment? The NIH. That's just the economic benefit. Biomedical research promotes human health.
the yield on NIH research for economic activity
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Reposted by Jonathan G. Stine, MD MSc, FACP
Jonathan Lambert @jonlambert.bsky.social · 08/02/2025
This 15% cap on indirect costs for NIH grants is yet another example of the 'unprecedented' moves the Trump administration is taking to change how science is done that I wrote about today. www.npr.org/sections/sho...
npr.org
'Unprecedented': White House moves to control science funding worry researchers
If the Trump administration continues targeting DEI in science and seeking to slash funding, American science will look fundamentally different.
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Reposted by Jonathan G. Stine, MD MSc, FACP
Elliot Tapper @ebtapper.bsky.social · 07/02/2025
Wherein @jonathanstinemd.bsky.social spills all his secrets for improving outcomes in #masld journals.lww.com/hepcomm/full... #liversky
journals.lww.com
Multidisciplinary clinic model enhances liver and metabolic ... : Hepatology Communications
An abstract is unavailable.
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 07/02/2025
For those of you who missed the broadcast ♫ on @iHeartRadio with @drjoegalati, the podcast is available now: www.iheart.com/podcast/44-y...
iheart.com
The Role of Exercise in Your Liver w/ Dr. Jon Stine - Your Health First | iHeart
Dr. Galati is back in the KTRH studios for the show tonight. He starts with a quick chat about diet soda and why you should avoid it. Dr. Galati also has Dr. Stine join the show to talk about his jour...
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Reposted by Jonathan G. Stine, MD MSc, FACP
NPR @npr.org · 04/02/2025
There's widespread confusion and fear among scientists and doctors on the sprawling National Institutes of Health campus and at institutions dependent on the agency's funding.
npr.org
A sense of foreboding hangs over the National Institutes of Health
There's widespread confusion and fear among scientists and doctors on the sprawling National Institutes of Health campus and at institutions dependent on the agency's funding.
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Jonathan G. Stine, MD MSc, FACP @jonathanstinemd.bsky.social · 03/02/2025
Our multidisciplinary care model for adults with fibrotic #MASH leads to clinically meaningful improvements in #liver and metabolic health: 🔹 Individualized Rx plans 🔹 Lifestyle intervention + pharmacotherapy 🔹 Inclusion of EPs, obesity medicine journals.lww.com/hepcomm/page...
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