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Reposted by Austin Daigle

Parul Johri @johriparul.bsky.social · 04/06/2026

Our preprint, where we infer the fitness effects of new mutations in regulatory regions of the D. melanogaster genome. We find an abundance of weakly deleterious effects - www.biorxiv.org/content/10.6... Led by @adaigle.bsky.social .

biorxiv.org

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Ryan Gutenkunst @ryangutenkunst.bsky.social · 15/12/2025

Congratulations to the winners of the 2025 Genomic History Inference Strategies Tournament challenges! Among the 9 challenges, we had five winners: @alwaysrong.bsky.social, @adaigle.bsky.social, @andrewhvaughn.bsky.social, @thymelicus.bsky.social, @rgollnisch.bsky.social

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Molecular Biology and Evolution @molbioevol.bsky.social · 06/11/2025

Community competitions help benchmark approaches in computational biology. Struck et al. now present GHIST 2024 - The First Genomic History Inference Strategies Tournament, for the inference of evolutionary history from genome data. 🔗 doi.org/10.1093/molbev/msaf257 #evobio #molbio #compbio #popgen

MBE | GHIST 2024: The First Genomic History Inference Strategies Tournament

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Reposted by Austin Daigle

James Hemker @jahemker.bsky.social · 25/04/2025

Excited to share the first manuscript from my PhD in which we leveraged ultra-long Nanopore sequencing, D. melanogaster inbred lines, and a ton of manual validation to investigate the effects of long-read length on population-level structural variant (SV) calling accuracy! doi.org/10.1101/2025...

doi.org

Manual validation finds only ultra-long long-read sequencing enables faithful, population-level structural variant calling in Drosophila melanogaster euchromatin

The increasing accessibility of long-read sequencing and the rapid development of automated variant callers are promoting the generation of population-level structural variation data. However, the eff...

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Tyler Kent @tylervkent.bsky.social · 07/04/2025

Excited to see the final version of this paper with @samurscicop.bsky.social and Daniel Matute out in @genomebiolevol.bsky.social! We took a dive into the complicated demographic history of Aedes aegypti mosquitoes and its impact on the distribution of genetic diversity doi.org/10.1093/gbe/...

doi.org

Demographic history, genetic load, and the efficacy of selection in the globally invasive mosquito Aedes aegypti

Abstract. Aedes aegypti is the main vector species of yellow fever, dengue, Zika and chikungunya. The species is originally from Africa but has experienced

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Reposted by Austin Daigle

Ryan Gutenkunst @ryangutenkunst.bsky.social · 17/03/2025

Amid the chaos, it was great to share results from the first Genomic History Inference Strategies Tournament at ProbGen25. Watch the talk to learn about the future of GHIST and @andrewhvaughn.bsky.social's nefarious metagaming of demographic inference. 😀 www.youtube.com/watch?v=3_dv...

youtube.com

Talk describing the results of GHIST1 at ProbGen 25.

YouTube video by Ryan Gutenkunst

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Austin Daigle @adaigle.bsky.social · 05/03/2025

Excited to share my first PhD project with my mentor, @johriparul.bsky.social! We examine how Hill–Robertson interference (HRI) in highly selfing species biases estimates of the distribution of fitness effects of new mutations (DFE). doi.org/10.1093/evol... @journal-evo.bsky.social #popgen #evobio

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Austin Daigle @adaigle.bsky.social · 11/12/2024

Thrilled to have been part of the inaugural GHIST competition in population genetics inference! Big thanks to the organizers for a fun and challenging event. Congrats to Andrew Vaughn and Ekaterina Noskova for their impressive performance, I'm looking forward to reading about everyone's methods.

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