Abstract. Pathogen infections disrupt multiple host cellular processes, and hosts have consequently evolved mechanisms to detect these perturbations and in

Researchers show that defects in RNA cap methylation act as cellular danger signals, activating protective innate immunity and revealing new opportunities for immunotherapy.

How Faulty RNA Processing Alerts Cells to Infection SciSoup July 15, 2026 RATNESHWAR THAKUR The findings, published in PLOS Pathogens, […]

Author summary The immune system is commonly thought to defend the body by recognizing invading microbes. However, organisms can also detect infections indirectly by sensing damage to their own cellul...

Probiotics can influence neuronal health, but how microbial signals are translated into neuroprotective host responses remains poorly understood. This study shows that Enterococcus faecium activates a...

Abstract. Cellular redox homeostasis depends on a finely tuned balance between oxidizing and reducing conditions, and disturbances in this balance lead to

Basal immune state under circadian control predicts infection outcome, and clock gene perturbation shifts survival patterns.

Bacterial metabolism of tryptophan causes toxicity in C. elegans. E. coli takes up tryptophan and catabolizes it to indole via tryptophanase (TnaA). Indole can freely diffuse through lipid membranes ...

Organisms can activate innate immunity not only by detecting pathogens but also by sensing disturbances to essential cellular processes. Such damage-based surveillance provides a means to identify cel...

Pathogen infections disrupt multiple host cellular processes, and hosts have consequently evolved mechanisms to detect these perturbations and initiate appropriate immune responses. In Caenorhabditis ...

imageimageGut microbes are key modulators of host lifespan, yet the underlying mechanisms remain poorly understood. This study shows that gut microbes, which induce oxidative stress in Caenorhabditis elegans, extend the host’s lifespan by ...

Web site created using create-react-app

Tryptophan is an essential amino acid required not only for protein biosynthesis but also for the production of several physiologically important metabolites, including serotonin, kynurenine, and nico...

The authors show that in C. elegans, Vitamin B12-driven changes in neuronal methionine cycle trigger a neuron-gut signalling axis, involving serotonin and neuropeptide secretion that modulate stress t...

About the Opportunity Job Summary The Apfeld Lab at Northeastern University is seeking a postdoctoral researcher to investigate how genes work together to determine the maximum lifespan of the nematod...

Join the C. elegans Community Mentor Match Program! sign up for mentors sign up for mentees and to join peer-mentoring groups https://forms.gle/DpGTWRMrNGL96wHy8 https://forms.gle/pVBD5DYGXyLT4waLA

The 2025 C. elegans Community Mentor Match is open to graduate students, postdocs, and faculty at any career stage. This survey collects information to help the committee (a) identify the most appropr...

Memory formation is necessary for the survival of animals across phyla. Here, we elucidate the mechanism underlying the formation of long-term associative memory (LTAM) formed by treating Caenorhabdit...

Gut microbes play a crucial role in modulating host lifespan. However, the microbial factors that influence host longevity and their mechanisms of action remain poorly understood. Using the expression...

Redox homeostasis, the balance between oxidative and reductive processes, is essential for cellular function and organismal health. Disruption, either through excessive oxidants (oxidative stress) or...