Jerzy Szablowski @jerzyszablowski.bsky.social · 15/05/2026Tenure - deeply grateful to the students, postdocs, mentors, collaborators, and colleagues who made this possible. The next chapter will expand the lab towards a couple of new directions, including multiplexed interfacing with deep tissues and reengineering drug discovery. 030
Reposted by Jerzy SzablowskiSandra Poulson @sandrapoulson.bsky.social · 05/05/2026I had the BEST time at #CanadianPain26 this year. Thank you SO much to everyone who came to my posters featuring our work with @jerzyszablowski.bsky.social and the Martin & Mogil collab paper. I hope to see you all again at future Canadian Pain meetings! 011
Reposted by Jerzy SzablowskiSandra Poulson @sandrapoulson.bsky.social · 22/03/2026#USASP_2026 Come see some cool research using novel tools to measure neuronal activity by the Szablowski Lab at Rice @jerzyszablowski.bsky.socialmedia.tenor.coma man in a suit and tie is smiling and says you 're gonna love itALT: a man in a suit and tie is smiling and says you 're gonna love it 011
Reposted by Jerzy SzablowskiVinny Costa @vincentcostaphd.bsky.social · 27/02/2026Because my lab was located at a @nprcnews.bsky.social we had resources to move fast and within months Jerzy and Sin had redesigned a version of the RMA protein for IG1 Fc receptor in primates they called, NHP-RMAs. We injected the protein into the brain and O.M.G it worked inspiring this tweet. 121
Jerzy Szablowski @jerzyszablowski.bsky.social · 05/03/2026We will be making a marmoset version soon fwiw, but the NHP version worked in mice, so I wouldn't be surprised if the macaque version worked in marmoset. 000
Jerzy Szablowski @jerzyszablowski.bsky.social · 02/03/2026i think i have an ipod shuffle somewhere 010
Reposted by Jerzy SzablowskiVinny Costa @vincentcostaphd.bsky.social · 27/02/2026Monitoring gene expression in the brain with a simple blood test? In collaboration with @jerzyszablowski.bsky.social & his lab we figured out how to do it nonhuman primates using noninvasive neuroengineering of synthetic serum markers. nam11.safelinks.protection.outlook.com?url=https%3A...nam11.safelinks.protection.outlook.comScienceDirect.com | Science, health and medical journals, full text articles and books. 56733
Reposted by Jerzy SzablowskiRice Neuroengineering Initiative @riceneuro.bsky.social · 03/12/2025How can serum marker tests be made more sensitive? The lab of @jerzyszablowski.bsky.social shows that editing markers in vivo to reduce their half-life can provide more sensitive measurement of gene expression dynamics. Read more: www.pnas.org/doi/10.1073/...pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans... 031
Jerzy Szablowski @jerzyszablowski.bsky.social · 18/06/2025Neat www.nature.com/articles/s41...nature.comA humanized NOVA1 splicing factor alters mouse vocal communications - Nature CommunicationsThe neuron-specific RNA binding protein NOVA1 has a single amino acid substitution unique to modern humans. Here, the authors characterize the evolutional specificity and the function of the substitut... 020
Jerzy Szablowski @jerzyszablowski.bsky.social · 10/06/2025I wonder if it's a statistically significant uptick. 100
Jerzy Szablowski @jerzyszablowski.bsky.social · 04/06/2025Addgene now has the NHP-RMAs available - the synthetic serum markers for measuring transgene and Cre-dependent expression, from the preprint (www.biorxiv.org/content/10.1...) with @vincentcostaphd.bsky.social lab. plasmids for order: www.addgene.org/browse/artic...addgene.orgAddgene: Synthetic Serum Markers Enable Noninvasive Monitoring of Gene Expression in Primate Brains 085
Jerzy Szablowski @jerzyszablowski.bsky.social · 03/06/2025It does take a lot. The hope is that all the companies doing BBB permeable AAVs like Apertura, Capsida, Sangamo, Voyager etc. will find something that works 10-100-fold more efficiently. 130
Jerzy Szablowski @jerzyszablowski.bsky.social · 03/06/2025Ultrasound BBB opening in large animals (or humans) is doable but somewhat complex. I do think the prices and complexity will go down over time for both gene delivery and BBB opening. 120
Jerzy Szablowski @jerzyszablowski.bsky.social · 03/06/2025Doing whole brain BBB-permeable gene delivery + with FUS release of synthetic markers could allow to study multiple sites without surgery and monitoring intracellular gene expression. e.g. pubmed.ncbi.nlm.nih.gov/39110811/pubmed.ncbi.nlm.nih.govAcoustically targeted measurement of transgene expression in the brain - PubMedGene expression is a critical component of brain physiology, but monitoring this expression in the living brain represents a major challenge. Here, we introduce a new paradigm called recovery of marke... 130
Jerzy Szablowski @jerzyszablowski.bsky.social · 03/06/2025That would be neat. Hong Chen at WUSTL has done some pioneering work in using FUS to release native proteins from the brain into the blood. There's non zero chance that native proteins carry sufficient information. If not, then the synthetic markers probably will, but would need gene delivery. 110
Jerzy Szablowski @jerzyszablowski.bsky.social · 03/06/2025What do you want to study? I am always curious about what are the experimental hurdles people have. I am wondering if it site-specific liquid biopsy would be useful for you. It's much more technically complicated but can study different regions on different days. 010
Jerzy Szablowski @jerzyszablowski.bsky.social · 03/06/2025There are some hurdles for human translation eg need for exogenous gene delivery. There are also ways to mitigate them. If our bright focus grant works out it should make translation realistic. There will be more work on optimization in nhps like higher signal, longer duration, recording c-fos etc 110
Jerzy Szablowski @jerzyszablowski.bsky.social · 03/06/2025How can you know if gene delivery in a primate worked Typically through expensive scans or histology. With @vincentcostaphd.bsky.social and co-authors we made synthetic markers that monitor gene delivery and Cre-dependent expression with a blood test: www.biorxiv.org/content/10.1... 22710
Jerzy Szablowski @jerzyszablowski.bsky.social · 02/06/2025Thanks Mark. I think we were surprised it worked so robustly. Still lots of work to do, in mice we could do orders of magnitude signal and track c-fos, arc etc. Next paper, if we can get the funding. This was done on a shoestring. 130
Jerzy Szablowski @jerzyszablowski.bsky.social · 26/04/2025www.biorxiv.org/content/10.1... Lead author: Manwal Harb, who also contributed to engineering AAV.FUS, vector optimized for noninvasive site specific gene delivery to the brain. www.nature.com/articles/s41... Work supported by The G. Harold & Leila Y. Mathers Charitable Foundationbiorxiv.orgSite-Specific Noninvasive Delivery of Retrograde Viral Vectors to the BrainNeuronal activity underlies the brain function. Different behaviors, physiological processes, and disorders depend on which neurons are active at a given moment. Treating brain disorders without side ... 010
Jerzy Szablowski @jerzyszablowski.bsky.social · 26/04/2025What is the next frontier in brain therapy? Small molecules act everywhere; our work targets brain regions with mm precision. Next frontier? Targeting microscale - neuronal connections, ensembles. Here, we test AAV9.retro for noninvasive transduction of neuronal projections. preprint comments 120
Jerzy Szablowski @jerzyszablowski.bsky.social · 27/03/2025Jordan, we missed you at the ACS! I hope you're doing well 010
Reposted by Jerzy SzablowskiEd Boyden @eboyden3.bsky.social · 10/03/2025The MIT McGovern Institute’s story celebrating the 10th birthday of expansion microscopy (ExM). One highlight: ExM is not only easy to do, it’s easy to modify - so lots of people are altering and applying ExM for custom purposes, leading to unexpected innovations: mcgovern.mit.edu/2025/03/03/t... 06215
Reposted by Jerzy SzablowskiVinny Costa @vincentcostaphd.bsky.social · 07/03/2025Posting this image of neurons transfected to secrete proteins that @jerzyszablowski.bsky.social bioengineered to enable noninvasive monitoring of neuronal integrity in NHPs for #fluorescentfriday. This technology will eventually lead to improved treatments for neurodegenerative disorders. 14811
Jerzy Szablowski @jerzyszablowski.bsky.social · 17/02/2025We are starting our @ARIA_research Precision Neurotechnologies project and have two non-postdoc positions in neuroscience and bioengineering. This funding is independent of US government. Jobs: emdz.fa.us2.oraclecloud.com/hcmUI/Candid... More info: tinyurl.com/hwsnrwpe -- please RT -- 023
Jerzy Szablowski @jerzyszablowski.bsky.social · 06/02/2025Did you all start sciencing harder recently, or something? 010
Jerzy Szablowski @jerzyszablowski.bsky.social · 04/02/2025i think it would be for more surprising if the mixture wasn't racemic... 100
Jerzy Szablowski @jerzyszablowski.bsky.social · 28/01/2025They are about a half of what we get paid here, but money isn't everything. 110
Reposted by Jerzy SzablowskiAmanda Fanniff, PhD @amandafanniff.bsky.social · 24/01/2025A quick reminder: For every $1 of research funding, NIH generated $2.46 in economic activity. This includes funding jobs in all 50 states. This isn't a red/blue thing: 8.9 jobs per $1M in CA & 12 jobs per $1M in GA. #AcademicSky #PhDSky #MedSky #HealthSky #healthequity #SciComm bit.ly/40NkIc0unitedformedicalresearch.org 29984281
Jerzy Szablowski @jerzyszablowski.bsky.social · 21/01/2025I am looking forward to working with @LignaniLab_UCL and others on this @ARIA_research neurotechnologies grant. A ~$2.5m contribution to our lab's work that will help us make next generation noninvasive brain therapies for specific brain circuits. news.rice.edu/news/2025/ri...news.rice.edu 030
Reposted by Jerzy Szablowskiadamezracohen.bsky.social @adamezracohen.bsky.social · 12/12/2024If some calcium enters a dendrite, how far does it diffuse? Rebecca Frank Hayward (who is on the job market!) measured this. www.sciencedirect.com/science/arti... She combined a blue light-activated Ca++ channel with a red-fluorescent Ca++ sensor. The length constant is about 5 microns.sciencedirect.comAll-optical mapping of Ca2+ transport and homeostasis in dendritesCalcium mediates many important signals in dendrites. However, the basic transport properties of calcium in dendrites have been difficult to measure: … 2144
Reposted by Jerzy SzablowskiJohn Ngo @johntngo.bsky.social · 30/11/2024We designed MS2 and PP7 binding coat proteins that are degraded in cells except when bound by their hairpin RNAs. You can check out our pre-print here: tinyurl.com/27p7hyt9, and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71... 511943
Jerzy Szablowski @jerzyszablowski.bsky.social · 12/12/2024qPCR can measure expression of virtually any gene... in homogenized tissues. Here, we show an "in-vivo qPCR" equivalent, where we measure a sequence-specific transcript with synthetic serum markers and enzyme-based signal amplification. www.biorxiv.org/content/10.1... 084
Jerzy Szablowski @jerzyszablowski.bsky.social · 12/12/2024That sounds like the field is ready for a paradigm shift. 010
Reposted by Jerzy SzablowskiMichael Fischbach @mfgrp.bsky.social · 11/12/2024Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55 23693294
Reposted by Jerzy SzablowskiEd Boyden @eboyden3.bsky.social · 03/12/2024"E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains." -CEO Andrew Payne e11.bio/news/roadmape11.bioE11 Bio Roadmap | E11 Bio 05010
Jerzy Szablowski @jerzyszablowski.bsky.social · 09/12/2024Our recent study now out in print at Nature Biotech: Gene expression in the mouse brain is measured with a simple blood draw go.nature.com/48NC0a5 rdcu.be/d1rY1go.nature.comEngineered serum markers for non-invasive monitoring of gene expression in the brain - Nature BiotechnologyGene expression in the mouse brain is measured with a simple blood draw. 010
Reposted by Jerzy SzablowskiAlice Ting @aliceyting.bsky.social · 04/12/2024Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation.. 33434138
Jerzy Szablowski @jerzyszablowski.bsky.social · 02/12/2024www.aria.org.uk/scalable-neu...aria.org.ukScalable Neural Interfaces – Opportunity seeds - ARIATo support scientific and technological breakthroughs, outside of programmes, ARIA Programme Directors can award opportunity seeds to support ambitious research aligned to the opportunity spaces they’... 000
Jerzy Szablowski @jerzyszablowski.bsky.social · 28/11/2024We have two postdoc positions coming up for early next year in NHP neuroscience with FUS-BBBO and molecular engineering foci. Let me know if you know someone interested! 030
Reposted by Jerzy SzablowskiRitu Raman @rituraman.bsky.social · 25/11/2024Excited to share a new review on Magnets for Mechanobiology - teamed up w/ fellow 🧲 enthusiasts from Boston/Madrid/Zurich/Singapore to share how we manipulate cellular microenvironments w/ magnetic fields! Thanks to @danielgmadrid11.bsky.social for bringing us together! doi.org/10.1002/aisy...doi.orgMagnetic Actuation for MechanomedicineIn this perspective, the emergence of magneto-mechanical actuation systems in biomedical research and mechanomedicine is explored. These materials, ranging from single particles to 3D scaffolds, enab... 0345
Jerzy Szablowski @jerzyszablowski.bsky.social · 21/11/2024We got a summary statement from NIH just 17 days after the study section. Is that a new record? 000
Jerzy Szablowski @jerzyszablowski.bsky.social · 19/11/2024I am looking forward to coming back to @MIT for Neurotech 2024 tomorrow in Bldg 46! I will talk about noninvasive interfacing with the brain, including new projects with our postdoc Sho Watanabe and collaborators @vincentcostaphd.bsky.social and Rui Chen (UCI). neurotech.mit.eduneurotech.mit.eduneurotech.mit.edu 001
Jerzy Szablowski @jerzyszablowski.bsky.social · 18/11/2024I will make sure to quarantine all my fresh vegetables for 8 weeks, to match the FDA's response time. 👌 100
Reposted by Jerzy SzablowskiMikhail Shapiro @mikhailshapiro.bsky.social · 18/11/2024What happens when you can take videos of acoustic proteins in 3D inside the body? 🧊 You can see things like the flow of CSF in the brain! 🧠 Congrats to Sunho Lee, co-senior author Claire Rabut, and colleagues on "Takoyaki" ultrasound. 🥟 #gasvesicles www.biorxiv.org/content/10.1... 1378
Jerzy Szablowski @jerzyszablowski.bsky.social · 17/11/2024www.science.org/content/arti...science.orgThis is our first direct look at a multiplanet system around a Sun-like starImage could help astronomers understand how our own solar system formed 010