iiinova — where your digital self keeps evolving

Mikhail Shapiro

@mikhailshapiro.bsky.social

921 followers 231 following 3 posts

Bio-Acousto-Magneto-Neuro-Chemical Engineer Max Delbrück Professor @Caltech Investigator @HHMI Fulbright-Tocqueville Chair @PhysMedParis @ESPCI_Paris '24-5 shapirolab.caltech.edu

Posts Replies Media

Mikhail Shapiro @mikhailshapiro.bsky.social · 23/12/2024

Can we make a brain tumor visible under ultrasound? 🧠 🔉 Yes, using intravenous #gasvesicles! This can help guide brain surgery and monitor for tumor recurrence. Congrats to Claire Rabut, George Daghlian and collaborators! www.biorxiv.org/content/10.1...

1181

Reposted by Mikhail Shapiro

Jerzy Szablowski @jerzyszablowski.bsky.social · 12/12/2024

qPCR can measure expression of virtually any gene... in homogenized tissues. Here, we show an "in-vivo qPCR" equivalent, where we measure a sequence-specific transcript with synthetic serum markers and enzyme-based signal amplification. www.biorxiv.org/content/10.1...

Schematic explaining In vivo tracking of active transcription. Injection of gene therapy is followed by measurement of the transcripts with RNA sensors, which produce a synthetic serum marker called RMA.

084

Mikhail Shapiro @mikhailshapiro.bsky.social · 18/11/2024

What happens when you can take videos of acoustic proteins in 3D inside the body? 🧊 You can see things like the flow of CSF in the brain! 🧠 Congrats to Sunho Lee, co-senior author Claire Rabut, and colleagues on "Takoyaki" ultrasound. 🥟 #gasvesicles www.biorxiv.org/content/10.1...

1378