Super-enhancers have been proposed to cluster in the nucleus when compared to other genomic elements. Le et al. found that super-enhancer clustering was rare and driven by non-specific interactions. P...

Mikhova et al. used live-cell single-molecule imaging to track the nuclear dynamics of AID and switch region transcription in B cells undergoing class switch recombination and discovered an RNA hub formed by tethered nascent transcripts that facilitates the recruitment and retention of AID at the IgH locus.

Mikhova et al. used live-cell single-molecule imaging to track the nuclear dynamics of AID and switch region transcription in B cells undergoing class switch recombination and discovered an RNA hub fo...

The DNA damage response (DDR) is a complex network of cellular pathways that ensures the faithful maintenance of our genomes upon a wide array of genomic insults. To elucidate the functional architect...

Kinetic proofreading is a class of error-correcting mechanisms in biology that expend energy to avoid mistakes during replication, transcription, and translation. Proofreading is typically assumed to ...