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Jeff Carroll, PhD

@jcarroll42.bsky.social
1.4K followers 2.5K following 331 posts

Neuroscientist; Assoc.Prof. at University of Washington; Huntington’s Disease researcher; Army veteran. sites.uw.edu/jeffcarr

PostsRepliesMedia
Jeff Carroll, PhD @jcarroll42.bsky.social · 03/11/2025
10000%
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Jeff Carroll, PhD @jcarroll42.bsky.social · 03/11/2025
If this is correct, it’s insane for the FDA to change its mind after the trial was already run to their desired design .
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Jeff Carroll, PhD @jcarroll42.bsky.social · 03/11/2025
Really horrible news in the Huntington’s field, sounds like the FDA completely chasing their mind about a study designed to they’d previously agreed to: en.hdbuzz.net/uniqure-and-...
en.hdbuzz.net
UniQure and FDA No Longer in Alignment on Approval Pathway for AMT-130 – HDBuzz
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Jeff Carroll, PhD @jcarroll42.bsky.social · 11/09/2025
Hey that's me! This was a huge and unexpected honor. The HDF and Wexler family has been a huge inspiration for me, and so this couldn't be a nicer recognition to receive.
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Jeff Carroll, PhD @jcarroll42.bsky.social · 31/07/2025
We speculate that this is due to lowering of HTT1a, a specific form of HTT mRNA that arises from a failure of exon-1 to splice to exon-2, leading to alternate cleavage and polyadenylation that was discovered and characterized by Gill Bates's lab at UCL.
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Jeff Carroll, PhD @jcarroll42.bsky.social · 31/07/2025
So, we can say that targeting intron-1 with an ASO in this case leads to really striking rescue of molecular features of HD in a knock-in mouse...
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Jeff Carroll, PhD @jcarroll42.bsky.social · 31/07/2025
Changing transcripts could be good or bad, but if we look at HD people's favorite genes, we see a very striking pattern of rescue when we target intron-1 with an ASO that we don't see if we target downstream:
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Jeff Carroll, PhD @jcarroll42.bsky.social · 31/07/2025
Surprisingly, this is the first mouse HTT ASO experiment to show robust transcriptional rescue. If we look at just the mutant mice by bulk RNASeq, a more distal HTT ASO (left) changes exactly two transcripts - one of which is HTT itself. But targeting intron-1 leads to a huge change of transcripts:
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Jeff Carroll, PhD @jcarroll42.bsky.social · 31/07/2025
The ASO targeting intron-1 basically eliminates aggregates while the more downstream one does nothing:
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Jeff Carroll, PhD @jcarroll42.bsky.social · 31/07/2025
Glad to see this out in the world. We observe remarkable rescue in an HD mouse using an ASO targeting intron-1 of Huntingtin, rather than downstream. The intron-1 targeting ASO essentially completely eliminates aggregates, whereas the more distal ASO does nothing: www.biorxiv.org/content/10.1...
biorxiv.org
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Jeff Carroll, PhD @jcarroll42.bsky.social · 21/07/2025
Scientists, especially Seattle ones! One of my research scientists is heading to her PhD and we're looking to fill her spot, if not replace her. If you know someone looking to do cool and impactful translational research give them this: uwhires.admin.washington.edu/ENG/Candidat...
uwhires.admin.washington.edu
UW Human Resources
University of Washington Human Resources
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Jeff Carroll, PhD @jcarroll42.bsky.social · 05/07/2025
And cost of living in several key cities (eg Vancouver and Toronto) not feasible with academic salaries in those towns. Even if you can get a grant!
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Jeff Carroll, PhD @jcarroll42.bsky.social · 04/07/2025
This sub-title from the @economist.com , ouch! But accurate. www.economist.com/briefing/202...
economist.com
The big beautiful bill reveals the hollowness of Trumponomics
Republicans mark America’s birthday with a profligate but insubstantial law
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Jeff Carroll, PhD @jcarroll42.bsky.social · 26/06/2025
This is pretty niche!
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Timothy Snyder @timothysnyder.bsky.social · 22/06/2025
5. Wars are easy to start and hard to stop
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Dan Savage @dansavage.bsky.social · 22/06/2025
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Jeff Carroll, PhD @jcarroll42.bsky.social · 10/06/2025
Support the troops baby!!
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Jeff Carroll, PhD @jcarroll42.bsky.social · 09/06/2025
Tump's bullying is just his psychopathic personality. Vance is, actually, kind of worse because he's strictly doing it to impress other guys he perceives as tougher. He's like the punk ass kid who takes a kick at someone after the bully knocks him down.
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ex-Lethality Jane @lethalityjane.bsky.social · 08/06/2025
A hell of a lot of the California National Guard is made up of people from immigrant communities, fwiw.
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Jeff Carroll, PhD @jcarroll42.bsky.social · 05/06/2025
Wow, congrats!
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naturepoker @binomicalabs.org · 03/06/2025
Good lord, how can anyone serious about science even consider cutting funding for Flybase?
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Ed Boyden @eboyden3.bsky.social · 30/05/2025
Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...
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Jeff Carroll, PhD @jcarroll42.bsky.social · 30/05/2025
God please. One on every corner.
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Jeff Carroll, PhD @jcarroll42.bsky.social · 30/05/2025
Amazing news that she’s finally free
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Jeff Carroll, PhD @jcarroll42.bsky.social · 26/05/2025
Being in the military is an interesting experience of what it means to be really filthy, which is kinda what I figure they’d look like?
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Jeremy Berg @jeremymberg.bsky.social · 24/05/2025
New York Times article on NSF www.nytimes.com/interactive/... 1/2
nytimes.com
Trump Has Cut Science Funding to Its Lowest Level in Decades (Gift Article)
The lag in funding extends far beyond D.E.I. initiatives, affecting almost every area of science: chemistry, computing, engineering, materials and more.
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Kat McGowan @mcgowankat.bsky.social · 21/05/2025
It's painful to read this, 5 years later. Study finds no increase in Covid spread in nursing home after visitation bans were lifted. Implication: The bans, which meant months of isolation for nursing home residents and heartbreak of their families, did no good. pubmed.ncbi.nlm.nih.gov/40383139/
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Jeff Carroll, PhD @jcarroll42.bsky.social · 21/05/2025
So, if you search google scholar enough it will just flag you as a bot and then there's absolutely no recourse, nor a human that you can prove you're not a bot. Reminding me we shouldn't be outsourcing such a key academic service to a for profit company that normalized not talking to its customers.
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Paul Krugman @pkrugman.bsky.social · 21/05/2025
30 year Treasury above 5%. Also, I successfully used AI to do a Trump/Truss crossover, putting a Trump wig on a lettuce paulkrugman.substack.com/p/a-liz-trus...
paulkrugman.substack.com
A Liz Truss Moment for America?
Financial indicators are flashing yellow
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Ben Garcia @garcialabms.bsky.social · 21/05/2025
Although there has been many positive things happening lately for myself and my lab group, this week we've gotten the bad news of a grant termination, as the lead PI is at Harvard (and they've had all their federal funding terminated). It will be tough to stop the work that only last year 1/2
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ex-Lethality Jane @lethalityjane.bsky.social · 21/05/2025
I remember a story in the Army where a commander was dubious about intelligence soldiers working with people who had connections with the Taliban and could we trust people like that and the intel officer replied "the people who don't work with the Taliban have no information about them."
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Kevin Zollman @kevinzollman.com · 20/05/2025
I'm always intrigued by people who miss very obvious points in art they love. Things like: people who are mad that "Star Trek is woke" or Paul Ryan loving Rage Against the Machine.
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Kyle Swanson, MD, FAANS, FCNS @kiswanson.medsky.network · 20/05/2025
The profile that Vinay Prasad deserves. He's presence in this administration is sign of Trump's commitment to endangering public health. Excellent work @lauralew105.bsky.social ! 🩺 #medsky newrepublic.com/article/1949...
newrepublic.com
An Anti-Science MAHA Extremist Is Playing a Major Role at the FDA
On first glance, Dr. Vinay Prasad’s medical credentials sound impressive. But look closer and you’ll find a narcissistic attention-seeker peddling misinformation, whose views will cost lives.
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Innovative Genomics Institute @innovativegenomics.bsky.social · 15/05/2025
In a medical breakthrough, a team including IGI’s @urnov.bsky.social & @giannikopoulosp.bsky.social created an on-demand #CRISPR therapy for an infant with a deadly gene mutation — developed, approved, and delivered to the patient in just 6 months. Read more: ow.ly/G0Bg50VTonC #RareDisease 🧬
The patient, KJ, reaching out after infusion of the CRISPR therapy, with a big smile! Photo credit Children's Hospital of Philadelphia
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John Doench @johndoench.bsky.social · 15/05/2025
Amazing that this has happened. Maddening that we are actively destroying the capability to do it again. www.nytimes.com/2025/05/15/h...
nytimes.com
Baby Is Healed With World’s First Personalized Gene-Editing Treatment
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Andrew Deans @genomestability.bsky.social · 15/05/2025
Some seriously nice biochemistry and cryo-EM of FAN1-PCNA-flapDNA complexes! www.nature.com/articles/s41...
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Jeff Carroll, PhD @jcarroll42.bsky.social · 14/05/2025
Terrifying
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Space Telescope Science Institute @stsci.edu · 14/05/2025
NEW: Saturn’s moon Titan has weather similar to Earth’s, but driven by methane evaporation and condensation. Astronomers have found evidence for clouds bubbling up over Titan’s northern hemisphere for the first time, using #NASAWebb and Keck observatory: webbtelescope.pub/3GofvQ1 🔭 🧪
Two rows of three images. Top row is labeled Webb 11 July 2023 and the bottom row Keck 14 July 2023). The first column, labeled atmosphere and surface, shows two full-color images of Titan, appearing in mottled shades of yellow and brown with a blue haze around the edges. A bright spot near the top of Titan in each has an arrow pointing to it. The second column, labeled troposphere, shows two images in shades of orange. Each image is relatively featureless except for a bright spot near the top with an arrow. The third column, labeled stratosphere, also shows two images in shades of orange. The top image, taken July 11, is featureless and has no arrow. The bottom image, taken July 14, has a bright spot near the top with an arrow.
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Michael Baym @baym.lol · 14/05/2025
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
A screenshot of the termination notice showing "Outstanding Investigator Grants"A screenshot of the termination notice with "This award is terminated effective the date of this award, due to unsafe antisemitic actions that suggest the institution lacks concern for the safety and wellbeing of Jewish students." highlighted
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Jeff Carroll, PhD @jcarroll42.bsky.social · 12/05/2025
Really appreciate having experts help track this kind of stuff!
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Robert Cruickshank @robertcruickshank.com · 12/05/2025
NYC seems to love congestion pricing. Let's bring it to Seattle!
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Kevin M. Kruse @kevinmkruse.bsky.social · 10/05/2025
Your daily reminder that the U.S. Postal SERVICE is a service that is designed to benefit taxpayers and not a business that should be expected to turn a profit.
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Jeff Carroll, PhD @jcarroll42.bsky.social · 10/05/2025
This is the perfect crypto story .
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Jeff Carroll, PhD @jcarroll42.bsky.social · 08/05/2025
Oh amazing! Such a huge need for oligo studies to have a PET tracer.
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Jeff Carroll, PhD @jcarroll42.bsky.social · 08/05/2025
Wow, as an early 90's computer nerd this guy was the enemy. Amazing to see him becoming one of the rare billionaire putting his money where his mouth is, and using his unique skills for good. 90's Jeff would be shocked.
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Jeff Carroll, PhD @jcarroll42.bsky.social · 08/05/2025
@nytimes.com - "Doctor", in this context is for a physician. She's never had a license or seen patients right? So not a doctor.
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Laurie Winkless @lauriewinkless.bsky.social · 08/05/2025
I've just published my May article for @forbes.com. As usual, it was meant to be short. But it isn't 😅 🧪👩‍🔬 www.forbes.com/sites/laurie...
forbes.com
SUVs Make Traffic Worse And Are More Dangerous Than Cars
Two new research papers show the downsides of upsizing our vehicles. SUVs have a disproportionate impact on traffic jams, and they injure more people than cars
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Jeff Carroll, PhD @jcarroll42.bsky.social · 08/05/2025
Wow!
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Jeff Carroll, PhD @jcarroll42.bsky.social · 06/05/2025
Really sick of this bot feeling eerily appropriate.
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Jeff Carroll, PhD @jcarroll42.bsky.social · 06/05/2025
What’s a lady Mensch?
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