Jeff Carroll, PhD @jcarroll42.bsky.social · 03/11/2025If this is correct, it’s insane for the FDA to change its mind after the trial was already run to their desired design . 040
Jeff Carroll, PhD @jcarroll42.bsky.social · 03/11/2025Really horrible news in the Huntington’s field, sounds like the FDA completely chasing their mind about a study designed to they’d previously agreed to: en.hdbuzz.net/uniqure-and-...en.hdbuzz.netUniQure and FDA No Longer in Alignment on Approval Pathway for AMT-130 – HDBuzz 230
Jeff Carroll, PhD @jcarroll42.bsky.social · 11/09/2025Hey that's me! This was a huge and unexpected honor. The HDF and Wexler family has been a huge inspiration for me, and so this couldn't be a nicer recognition to receive. 2160
Jeff Carroll, PhD @jcarroll42.bsky.social · 31/07/2025We speculate that this is due to lowering of HTT1a, a specific form of HTT mRNA that arises from a failure of exon-1 to splice to exon-2, leading to alternate cleavage and polyadenylation that was discovered and characterized by Gill Bates's lab at UCL. 000
Jeff Carroll, PhD @jcarroll42.bsky.social · 31/07/2025So, we can say that targeting intron-1 with an ASO in this case leads to really striking rescue of molecular features of HD in a knock-in mouse... 100
Jeff Carroll, PhD @jcarroll42.bsky.social · 31/07/2025Changing transcripts could be good or bad, but if we look at HD people's favorite genes, we see a very striking pattern of rescue when we target intron-1 with an ASO that we don't see if we target downstream: 100
Jeff Carroll, PhD @jcarroll42.bsky.social · 31/07/2025Surprisingly, this is the first mouse HTT ASO experiment to show robust transcriptional rescue. If we look at just the mutant mice by bulk RNASeq, a more distal HTT ASO (left) changes exactly two transcripts - one of which is HTT itself. But targeting intron-1 leads to a huge change of transcripts: 100
Jeff Carroll, PhD @jcarroll42.bsky.social · 31/07/2025The ASO targeting intron-1 basically eliminates aggregates while the more downstream one does nothing: 100
Jeff Carroll, PhD @jcarroll42.bsky.social · 31/07/2025Glad to see this out in the world. We observe remarkable rescue in an HD mouse using an ASO targeting intron-1 of Huntingtin, rather than downstream. The intron-1 targeting ASO essentially completely eliminates aggregates, whereas the more distal ASO does nothing: www.biorxiv.org/content/10.1...biorxiv.org 142
Jeff Carroll, PhD @jcarroll42.bsky.social · 21/07/2025Scientists, especially Seattle ones! One of my research scientists is heading to her PhD and we're looking to fill her spot, if not replace her. If you know someone looking to do cool and impactful translational research give them this: uwhires.admin.washington.edu/ENG/Candidat...uwhires.admin.washington.eduUW Human ResourcesUniversity of Washington Human Resources 155
Jeff Carroll, PhD @jcarroll42.bsky.social · 05/07/2025And cost of living in several key cities (eg Vancouver and Toronto) not feasible with academic salaries in those towns. Even if you can get a grant! 010
Jeff Carroll, PhD @jcarroll42.bsky.social · 04/07/2025This sub-title from the @economist.com , ouch! But accurate. www.economist.com/briefing/202...economist.comThe big beautiful bill reveals the hollowness of TrumponomicsRepublicans mark America’s birthday with a profligate but insubstantial law 010
Reposted by Jeff Carroll, PhDTimothy Snyder @timothysnyder.bsky.social · 22/06/20255. Wars are easy to start and hard to stop 595743848
Jeff Carroll, PhD @jcarroll42.bsky.social · 09/06/2025Tump's bullying is just his psychopathic personality. Vance is, actually, kind of worse because he's strictly doing it to impress other guys he perceives as tougher. He's like the punk ass kid who takes a kick at someone after the bully knocks him down. 010
Reposted by Jeff Carroll, PhDex-Lethality Jane @lethalityjane.bsky.social · 08/06/2025A hell of a lot of the California National Guard is made up of people from immigrant communities, fwiw. 617927
Reposted by Jeff Carroll, PhDnaturepoker @binomicalabs.org · 03/06/2025Good lord, how can anyone serious about science even consider cutting funding for Flybase? 231
Reposted by Jeff Carroll, PhDEd Boyden @eboyden3.bsky.social · 30/05/2025Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/... 416854
Jeff Carroll, PhD @jcarroll42.bsky.social · 26/05/2025Being in the military is an interesting experience of what it means to be really filthy, which is kinda what I figure they’d look like? 000
Reposted by Jeff Carroll, PhDJeremy Berg @jeremymberg.bsky.social · 24/05/2025New York Times article on NSF www.nytimes.com/interactive/... 1/2nytimes.comTrump Has Cut Science Funding to Its Lowest Level in Decades (Gift Article)The lag in funding extends far beyond D.E.I. initiatives, affecting almost every area of science: chemistry, computing, engineering, materials and more. 37549
Reposted by Jeff Carroll, PhDKat McGowan @mcgowankat.bsky.social · 21/05/2025It's painful to read this, 5 years later. Study finds no increase in Covid spread in nursing home after visitation bans were lifted. Implication: The bans, which meant months of isolation for nursing home residents and heartbreak of their families, did no good. pubmed.ncbi.nlm.nih.gov/40383139/ 001
Jeff Carroll, PhD @jcarroll42.bsky.social · 21/05/2025So, if you search google scholar enough it will just flag you as a bot and then there's absolutely no recourse, nor a human that you can prove you're not a bot. Reminding me we shouldn't be outsourcing such a key academic service to a for profit company that normalized not talking to its customers. 041
Reposted by Jeff Carroll, PhDPaul Krugman @pkrugman.bsky.social · 21/05/202530 year Treasury above 5%. Also, I successfully used AI to do a Trump/Truss crossover, putting a Trump wig on a lettuce paulkrugman.substack.com/p/a-liz-trus...paulkrugman.substack.comA Liz Truss Moment for America?Financial indicators are flashing yellow 41921178
Reposted by Jeff Carroll, PhDBen Garcia @garcialabms.bsky.social · 21/05/2025Although there has been many positive things happening lately for myself and my lab group, this week we've gotten the bad news of a grant termination, as the lead PI is at Harvard (and they've had all their federal funding terminated). It will be tough to stop the work that only last year 1/2 382
Reposted by Jeff Carroll, PhDex-Lethality Jane @lethalityjane.bsky.social · 21/05/2025I remember a story in the Army where a commander was dubious about intelligence soldiers working with people who had connections with the Taliban and could we trust people like that and the intel officer replied "the people who don't work with the Taliban have no information about them." 829241
Reposted by Jeff Carroll, PhDKevin Zollman @kevinzollman.com · 20/05/2025I'm always intrigued by people who miss very obvious points in art they love. Things like: people who are mad that "Star Trek is woke" or Paul Ryan loving Rage Against the Machine. 3121
Reposted by Jeff Carroll, PhDKyle Swanson, MD, FAANS, FCNS @kiswanson.medsky.network · 20/05/2025The profile that Vinay Prasad deserves. He's presence in this administration is sign of Trump's commitment to endangering public health. Excellent work @lauralew105.bsky.social ! 🩺 #medsky newrepublic.com/article/1949...newrepublic.comAn Anti-Science MAHA Extremist Is Playing a Major Role at the FDAOn first glance, Dr. Vinay Prasad’s medical credentials sound impressive. But look closer and you’ll find a narcissistic attention-seeker peddling misinformation, whose views will cost lives. 02412
Reposted by Jeff Carroll, PhDInnovative Genomics Institute @innovativegenomics.bsky.social · 15/05/2025In a medical breakthrough, a team including IGI’s @urnov.bsky.social & @giannikopoulosp.bsky.social created an on-demand #CRISPR therapy for an infant with a deadly gene mutation — developed, approved, and delivered to the patient in just 6 months. Read more: ow.ly/G0Bg50VTonC #RareDisease 🧬 04919
Reposted by Jeff Carroll, PhDJohn Doench @johndoench.bsky.social · 15/05/2025Amazing that this has happened. Maddening that we are actively destroying the capability to do it again. www.nytimes.com/2025/05/15/h...nytimes.comBaby Is Healed With World’s First Personalized Gene-Editing Treatment 0338
Reposted by Jeff Carroll, PhDAndrew Deans @genomestability.bsky.social · 15/05/2025Some seriously nice biochemistry and cryo-EM of FAN1-PCNA-flapDNA complexes! www.nature.com/articles/s41... 094
Reposted by Jeff Carroll, PhDSpace Telescope Science Institute @stsci.edu · 14/05/2025NEW: Saturn’s moon Titan has weather similar to Earth’s, but driven by methane evaporation and condensation. Astronomers have found evidence for clouds bubbling up over Titan’s northern hemisphere for the first time, using #NASAWebb and Keck observatory: webbtelescope.pub/3GofvQ1 🔭 🧪 22905142
Reposted by Jeff Carroll, PhDMichael Baym @baym.lol · 14/05/2025Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab 145875575
Jeff Carroll, PhD @jcarroll42.bsky.social · 12/05/2025Really appreciate having experts help track this kind of stuff! 001
Reposted by Jeff Carroll, PhDRobert Cruickshank @robertcruickshank.com · 12/05/2025NYC seems to love congestion pricing. Let's bring it to Seattle! 4357
Reposted by Jeff Carroll, PhDKevin M. Kruse @kevinmkruse.bsky.social · 10/05/2025Your daily reminder that the U.S. Postal SERVICE is a service that is designed to benefit taxpayers and not a business that should be expected to turn a profit. 267129033184
Jeff Carroll, PhD @jcarroll42.bsky.social · 08/05/2025Oh amazing! Such a huge need for oligo studies to have a PET tracer. 000
Jeff Carroll, PhD @jcarroll42.bsky.social · 08/05/2025Wow, as an early 90's computer nerd this guy was the enemy. Amazing to see him becoming one of the rare billionaire putting his money where his mouth is, and using his unique skills for good. 90's Jeff would be shocked. 030
Jeff Carroll, PhD @jcarroll42.bsky.social · 08/05/2025@nytimes.com - "Doctor", in this context is for a physician. She's never had a license or seen patients right? So not a doctor. 100
Reposted by Jeff Carroll, PhDLaurie Winkless @lauriewinkless.bsky.social · 08/05/2025I've just published my May article for @forbes.com. As usual, it was meant to be short. But it isn't 😅 🧪👩🔬 www.forbes.com/sites/laurie...forbes.comSUVs Make Traffic Worse And Are More Dangerous Than CarsTwo new research papers show the downsides of upsizing our vehicles. SUVs have a disproportionate impact on traffic jams, and they injure more people than cars 59927
Jeff Carroll, PhD @jcarroll42.bsky.social · 06/05/2025Really sick of this bot feeling eerily appropriate. 000