The Francis Crick Institute’s expert scientists on how AI can help the healthcare industry

Temporal patterning is essential for generation of neuronal diversity in the developing vertebrate nervous system. A shared sequence of temporal transcription factors (tTFs) partitions neurons by birt...

The Francis Crick Institute’s expert scientists on how AI can help the healthcare industry

The Francis Crick Institute’s expert scientists on how AI can help the healthcare industry

Sandwich students join one of the Crick’s research groups or science technology platforms for 12 months to work on a research project.

Tissue morphogenesis integrates developmental programs with cell mechanics, yet the mechanisms coupling these processes remain poorly understood. We investigated this link during neuroepithelial morph...

I have written before about how two conceptual frameworks have shaped our thinking about cell fate, Waddington's epigenetic landscape and Davidson's gene...

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This book explores the enduring and emerging questions in developmental biology, offering a comprehensive overview that bridges traditional concepts with the innovative inquiries shaping future resear...

Applying dynamical systems theory to single-cell data can provide a detailed picture of the cellular states observed during cell fate decisions. This study presents a dynamic landscape analysis (DLA) ...

Applying dynamical systems theory to single-cell data can provide a detailed picture of the cellular states observed during cell fate decisions. This study presents a dynamic landscape analysis (DLA) ...

Applying dynamical systems theory to single-cell data can provide a detailed picture of the cellular states observed during cell fate decisions. This study presents a dynamic landscape analysis (DLA) ...

Summary: A guide to mechanics in development: unlock how forces, material properties and geometry shape the forms of life.

Applying dynamical systems theory to single-cell data can provide a detailed picture of the cellular states observed during cell fate decisions. This study presents a dynamic landscape analysis (DLA) ...

A new AI for Biological Discovery Seminar Series, presented by the Francis Crick Institute.

Are cardiac progenitors committed to fixed lineages, or do they carry probability distributions over heart regions in the epiblast that resolve during gastrulation? Reanalyzing mouse retrospective cl...

Why do mammalian species develop at different speeds? Nakanoh, Stamataki, et al. show that mouse neural progenitors have faster protein synthesis and proteasome-mediated degradation than human. Manipu...

The pace of embryonic development differs between mammalian species, yet the molecular basis for this remains unknown. By comparing protein dynamics i…

arXiv welcomes inaugural CEO and founding Board of Directors

How cells read the room - coordinated symmetry breaking and proportional cell fate allocation in neural organoids

Highlighted Article: Comparison of the patterning capacity of Drosophila embryos that have only one of the three maternal gradients known to control anterior posterior patterning.

Neural crest cells (NCCs) are progenitor cells vital in establishing the head, heart, gut and peripheral nervous system of vertebrate embryos. Disruptions to NCC development underlie neurocristopathie...

The reliable generation of diverse cell types in precise proportions is essential for the formation of functional tissues during embryonic development. Three-dimensional organoid models derived from p...

Multicellular organisms, as the name suggests, are composed of many cells that work together. Cells need to stick together to ensure efficient cell coordination. Cadherins, which are calcium-dependent...

Summary: A reaction-diffusion mechanism recapitulates pattern emergence in an in vitro model of neuromesodermal progenitors under a variety of boundary and geometrical perturbations.

A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.

A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.

Summary: A reaction-diffusion mechanism recapitulates pattern emergence in an in vitro model of neuromesodermal progenitors under a variety of boundary and geometrical perturbations.