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Jacob K McPherson PharmD PhD

@jacobkmcpherson.bsky.social
206 followers 657 following 13 posts

‘25 ‘21 University of Houston ‘15 University of Texas at Austin jacobKmcpherson.com

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Reposted by Jacob K McPherson PharmD PhD
Science Magazine @science.org · 16/09/2026
As #AI’s capabilities grow, researchers and publishers are exploring how it can support peer review—and where it still falls short. Learn more during #PeerReviewWeek: scim.ag/4y267b6
Can AI help solve the peer-review crisis? Here are its promises and pitfalls
Amid a shortage of human reviewers, tests indicate AI can assist—but is not a savior
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Reposted by Jacob K McPherson PharmD PhD
Clinical Infectious Diseases @cidjournal.bsky.social · 11/08/2026
Infectious Diseases Society of America 2026 Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections ✅ Just Accepted 🔗 bit.ly/3TED5Pv
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Reposted by Jacob K McPherson PharmD PhD
WHO @who.int · 01/08/2026
The Bundibugyo virus disease outbreak in the #DRC is intensifying, with sustained transmission, rising cases and deaths, and expanding geographic spread. This is now the largest #Ebola outbreak ever reported in the country. Full report, read here: bit.ly/4g6lLeH
Ebola disease caused by Bundibugyo virus, Democratic Republic of the Congo Disease Outbreak News, 1 Aug 2026
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Reposted by Jacob K McPherson PharmD PhD
Jenna Norton @jenna-m-norton.bsky.social · 20/07/2026
9 lessons from Bethesda Declaration organizers on how to rescue US science: www.ovid.com/jnls/dartmou... 1. Scientists can no longer safely claim the privilege of being outside of, or above, politics 2. Inaction can be riskier than action. 3. Progress requires work. 4. Do not wait for someone else.
ovid.com
Nine lessons from Bethesda Declaration organizers... : Dartmouth Journal of Healthcare Delivery Science
Abstract was not provided for this article.
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Reposted by Jacob K McPherson PharmD PhD
Clinical Infectious Diseases @cidjournal.bsky.social · 23/06/2026
Enhanced detection of Candidozyma auris colonization with universal screening on admission ✅ Just Accepted bit.ly/3QgBEFv
bit.ly
Enhanced detection of Candidozyma auris colonization with universal screening on admission
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Reposted by Jacob K McPherson PharmD PhD
The Economist @economist.com · 23/06/2026
Plenty of governments are eager to take in foreigners with money and skills. And a growing industry of trusted advisers stands ready to help them relocate
econ.st
The world’s wealthy are migrating like never before
A booming industry of advisers is easing their passage
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Reposted by Jacob K McPherson PharmD PhD
Nature Computational Science @natcomputsci.nature.com · 15/06/2026
📢Out now! Marta C. González, Yanyan Xu, and colleagues introduce neuroGravity, a model to reconstruct mobility networks in data-scarce regions. www.nature.com/articles/s43... #cssky 🔓 rdcu.be/fowww
nature.com
Transferable human mobility network reconstruction with neuroGravity - Nature Computational Science
This study presents neuroGravity—a model that merges physics with machine learning to reconstruct mobility networks in data-scarce regions. It provides crucial tools for equitable urban planning, reve...
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Reposted by Jacob K McPherson PharmD PhD
The Journal of Infectious Diseases @jidjournal.bsky.social · 14/06/2026
Induction of β-Defensin 1 (DEFB1) via synthetic mRNA reduces Cryptosporidium parvum infection in human intestinal cells ✅ Just Accepted 🔗 bit.ly/3PZzE4t
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Reposted by Jacob K McPherson PharmD PhD
Open Forum Infectious Diseases @ofidjournal.bsky.social · 15/06/2026
Impact of Methicillin Resistance on Outcomes of Staphylococcus aureus Bacteremia at a U.S. Center, 2023–2024 ✅ Just Accepted bit.ly/4ek9UYC
bit.ly
Impact of Methicillin Resistance on Outcomes of Staphylococcus aureus Bacteremia at a U.S. Center, 2023–2024
In a contemporary academic cohort of adults with Staphylococcus aureus bacteremia, methicillin resistance was associated with distinct epidemiologic charac
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Reposted by Jacob K McPherson PharmD PhD
JAMA Cardiology @jamacardiology.com · 13/06/2026
Among US veterans with #HeartFailure with reduced ejection fraction, fewer than one-quarter achieved quadruple guideline-directed medical therapy within 2.9 years, and medication copays were associated with lower rates of therapy achievement. ja.ma/3Qk1Tuv
A graph showing Probability of event vs. Time, d. A line indicates 'Achieved quadruple therapy,' steadily increasing from 0 to about 0.27 at 1750 days. Bar segments represent 'Death,' cumulatively increasing from 0 to approximately 0.38 at 1750 days.
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Reposted by Jacob K McPherson PharmD PhD
Nature @nature.com · 13/06/2026
Training a neural network to collate data from several sources provides a high-resolution view of how people are moving around the world go.nature.com/4omsyUl
go.nature.com
Artificial intelligence shines a light on hidden global migration flows
Training a neural network to collate data from several sources provides a high-resolution view of how people are moving around the world.
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Reposted by Jacob K McPherson PharmD PhD
Nature Portfolio @natureportfolio.nature.com · 13/06/2026
A phase 3 trial reported in Nature Medicine shows weekly subcutaneous injections of survodutide, a glucagon receptor/GLP-1R dual agonist, lowered liver fat content and body weight in adults with obesity and at-risk metabolic dysfunction-associated steatotic liver disease (MASLD). #medsky 🧪
go.nature.com
Survodutide in adults with obesity and metabolic dysfunction-associated steatotic liver disease: SYNCHRONIZE-MASLD, a randomized, double-blind, placebo-controlled phase 3 trial - Nature Medicine
As presented at the American Diabetes Association Meeting, in this phase 3 trial, weekly subcutaneous injections of survodutide, a glucagon receptor/GLP-1R dual agonist, lowered liver fat content and body weight compared to placebo in adults with obesity and at-risk metabolic dysfunction-associated steatotic liver disease (MASLD).
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Reposted by Jacob K McPherson PharmD PhD
Nature @nature.com · 14/06/2026
Peptide injections are the hottest trend in wellness, but researchers say enthusiasm for these unregulated drugs has got ahead of the science. go.nature.com/4xrwSWf
go.nature.com
Is the peptide craze backed by science? The promise behind the hype
Nature - Peptide injections are the hottest trend in wellness. Researchers say enthusiasm for these unregulated drugs has got ahead of the science.
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Reposted by Jacob K McPherson PharmD PhD
Nature Portfolio @natureportfolio.nature.com · 13/06/2026
Jacques Cornwell describes in Nature a seven-step framework to help bridge the gap from passively reading a research paper to actively analysing it. “Although there is no universal framework for pulling apart a dense primary paper, having a consistent method is crucial.” #Academicsky 🧪
go.nature.com
Seven steps for critically analysing research papers
By sticking to a clear strategy when reading, I get much more out of the literature, says Jacques Cornwell.
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Reposted by Jacob K McPherson PharmD PhD
Clinical Infectious Diseases @cidjournal.bsky.social · 13/06/2026
Further unraveling the association between HIV, immune suppression, and cancer survival ✅ Just Accepted 🔗 bit.ly/4vGiXKk
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Reposted by Jacob K McPherson PharmD PhD
JAMA Network Open @jamanetworkopen.com · 12/06/2026
Nearly all systemic antifungal clinical trial sites in the US are metropolitan, with just 0.6% of rural residents living within 30 miles of a treatment trial site. ja.ma/4uB4a2L
A graph and two maps show US systemic antifungal trial sites. The bar chart details population (gray bars), treatment trials (blue line), and prophylaxis trials across census divisions. Treatment trials largely align with population. Map B shows numerous treatment sites (red dots), while Map C displays fewer prophylaxis sites (green dots) nationwide.
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Reposted by Jacob K McPherson PharmD PhD
Nature @nature.com · 11/06/2026
Nature research paper: A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases go.nature.com/4omsxQc
go.nature.com
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases - Nature
Linafexor is a rapidly cleared FXR agonist designed to mimic natural bile acid signalling, achieving transient receptor activation with strong efficacy and reduced toxicity in preclinical and early clinical studies.
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Reposted by Jacob K McPherson PharmD PhD
Nature Portfolio @natureportfolio.nature.com · 11/06/2026
Nature wants to hear from researchers around the world about what it feels like to work in science today. Take the 2026 Science Job Satisfaction Survey until 26 June. go.nature.com/4nS0SWS #Academicsky
nature. Share the highs and lows of your career in science: take Nature's global survey. Image shows a winding coastal road with a yellow warning sign for curves, mountains, and blue sky. nature portfolio. Photo Credit: Pgiam/Getty
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Reposted by Jacob K McPherson PharmD PhD
Clinical Infectious Diseases @cidjournal.bsky.social · 07/06/2026
Population sensitive linezolid monitoring during global implementation of BPaL based regimens ✅ Just Accepted 🔗 bit.ly/4dRoBTY
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Reposted by Jacob K McPherson PharmD PhD
Nature Portfolio @natureportfolio.nature.com · 07/06/2026
Animal companions can be a lot of work and are difficult to fit into a busy professional’s life, but they can also enhance well-being. Scientists talk about their pets with Nature’s careers team. #Academicsky 🧪
go.nature.com
Should I get a dog? What to know about pet ownership as a scientist
Animal companions can be a lot of work, and are difficult to fit into a busy professional’s life, but they can also enhance well-being.
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Reposted by Jacob K McPherson PharmD PhD
Nature Portfolio @natureportfolio.nature.com · 07/06/2026
Between 2020 and 2023, in Massachusetts, receiving medically tailored meals was associated with reductions in hospitalizations and emergency department visits and lower healthcare costs, according to a paper in Nature Medicine. go.nature.com/3QoAtUm #medsky 🧪
This is figure 1, which shows healthcare cost reductions associated with MTM receipt in Massachusetts’ Section 1115 demonstration by tertile of medical morbidity.
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Reposted by Jacob K McPherson PharmD PhD
Nature Portfolio @natureportfolio.nature.com · 08/06/2026
Will medical trainees who rely on AI fail to develop foundational independent clinical reasoning? A Perspective in Nature Medicine outlines a precautionary framework to preserve foundational competence while supporting safe and effective AI integration in medical training. #medsky #Academicsky 🧪
go.nature.com
AI-induced never-skilling in medical education - Nature Medicine
Will medical trainees who rely on AI fail to develop foundational independent clinical reasoning? This Perspective outlines a precautionary framework to preserve foundational competence while supporting safe and effective AI integration in medical training.
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Reposted by Jacob K McPherson PharmD PhD
Open Forum Infectious Diseases @ofidjournal.bsky.social · 08/06/2026
Pharmacokinetics of Oral Amoxicillin for the Treatment of Syphilis in Pregnancy ✅ Just Accepted 🔗 bit.ly/4vuZFY6
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Reposted by Jacob K McPherson PharmD PhD
JAMA @jama.com · 06/06/2026
Among adults invited for colorectal cancer #FIT screening, adding H pylori stool antigen testing improved lifetime health outcomes and was cost-effective or cost-saving in most scenarios—even with incomplete adherence—when H pylori prevalence was moderate. ja.ma/3RNvmNY
Flowchart on cost-effectiveness of Fecal Immunochemical Testing vs. H. pylori co-testing. It illustrates clinical outcomes for patients with/without H. pylori, early colon cancer, and colon adenoma, showing test results, treatments, and disease progression.
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Reposted by Jacob K McPherson PharmD PhD
The Lancet @thelancet.com · 06/06/2026
Foodborne illnesses caused 1.5 million deaths and cost US$647 billion in economic losses in 2021, new analysis estimates in @lancetgh.bsky.social Read now 👉 spkl.io/633257Bk5V
Figure showing foodborne DALYs per 100 000 population by country, 2021. DALYs=disability-adjusted life-years. Copyright: 2026 World Health Organization. Published by Elsevier Ltd. This is an Open Access article published under the CC BY 3.0 IGO license.
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Reposted by Jacob K McPherson PharmD PhD
Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 06/06/2026
ICYMI: New Online! Tight junction structure, assembly and (dys)function
dlvr.it
Tight junction structure, assembly and (dys)function
Nature Reviews Molecular Cell Biology, Published online: 03 June 2026; doi:10.1038/s41580-026-00978-wTight junctions form essential paracellular barriers and regulate cell polarity and tissue mechanics. This Review discusses how tight junction components assemble into strand networks, and explores tight junction function in development and disease, and emerging therapeutic strategies.
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Reposted by Jacob K McPherson PharmD PhD
Nature Medicine @natmed.nature.com · 30/05/2026
An open-label randomized controlled phase II trial comparing #favipiravir to #ribavirin for the treatment of mild to moderate #LassaFever in Nigeria found that favipiravir was safe, well-tolerated and support its further optimization as a treatment.
dlvr.it
Favipiravir for Lassa fever: an open-label, randomized controlled phase 2 trial - Nature Medicine
An open-label, randomized controlled phase 2 trial comparing favipiravir with ribavirin for the treatment of mild-to-moderate Lassa fever in Nigeria found that favipiravir was safe and well tolerated and supports its further optimization as a treatment alternative.
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Reposted by Jacob K McPherson PharmD PhD
Nature Communications @natcomms.nature.com · 30/05/2026
#Ebola : The current Ebola outbreak is a public health emergency of international concern We welcome any studies that provide insights into the current outbreak or can help guide local surveillance efforts and effective international response
dlvr.it
The current Ebola outbreak is a public health emergency of international concern - Nature Communications
The Ebola outbreak reported to the World Health Organization (WHO) on 5th May is now believed to have resulted in 139 deaths in the Democratic Republic of Congo. The current outbreak is of particular concern due to the high fatality rate of the causal Bundibugyo strain, its spread into neighboring Uganda, and the absence of an approved vaccine or targeted treatments. Following the WHO’s declaration on 17th May that the outbreak constitutes a public health emergency of international concern1, we outline the urgent need for sustained research into diagnostic tools, life-saving vaccines, and antiviral therapies directed against this virus.
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Reposted by Jacob K McPherson PharmD PhD
JAMA @jama.com · 30/05/2026
@ritarubin.bsky.social spoke with semiretired oncologist Stephen Kornfeld, MD, about how he managed limited resources and isolation while caring for passengers during the MV Hondius #Hantavirus outbreak. 🎧 Listen now: ja.ma/4uGhwM1
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Reposted by Jacob K McPherson PharmD PhD
Nature Portfolio @natureportfolio.nature.com · 30/05/2026
Two papers in Nature present AI systems that can assist throughout multiple processes involved in scientific research. The systems are designed to assist researchers in accelerating scientific discovery, not to replace them. go.nature.com/4tFHspz go.nature.com/3RQzXyL #Academicsky 🧪
This is figure 1, which shows Co-Scientist design, multi-agent architecture, and experimental validation summary.
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Reposted by Jacob K McPherson PharmD PhD
Clinical Infectious Diseases @cidjournal.bsky.social · 25/05/2026
Changes in Epidemiology of Candidemia in the United States with a Focus on Candida auris ✅ Just Accepted 🔗 bit.ly/4x5MrTF
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Reposted by Jacob K McPherson PharmD PhD
Nature Portfolio @natureportfolio.nature.com · 26/05/2026
AI is rapidly accelerating scientific output, but risks narrowing inquiry, weakening judgement and undermining how scientists are trained. The authors of a Comment article in Nature highlight the key risks and outline the potential remedies. 🧪
go.nature.com
The uncritical adoption of AI in science is alarming — we urgently need guard rails
Artificial intelligence is rapidly accelerating scientific output, but risks narrowing inquiry, weakening judgement and undermining how scientists are trained.
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Reposted by Jacob K McPherson PharmD PhD
JAMA @jama.com · 26/05/2026
Among patients with #GramNegativeBacteremia, rapid #AntimicrobialSusceptibilityTesting did not improve 30-day clinical outcomes compared with standard testing, despite providing faster guidance for antibiotic escalation or deescalation. ja.ma/4uyTmCP
JAMA study: Rapid blood culture AST for GNB wasn't superior to standard AST. Population: 486 males, 364 females, median age 72. Intervention: 413 rapid AST, 437 standard AST. Findings: Alive w/o events: Rapid 47%, Standard 49%. DOOR probability: 48.8%.
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Reposted by Jacob K McPherson PharmD PhD
JAMA @jama.com · 26/05/2026
📌 Editor’s Choice from this week's issue of JAMA: ➡️ Synopsis of ACS Guidelines, ➡️ #Cardiac Resynchronization in HF Review, ➡️ Fast #Antimicrobial Susceptibility Testing for Gram-Negative Bacteremia, and more. ja.ma/4uxLX6J
JAMA (Journal of the American Medical Association) cover for May 19, 2026, Volume 335, Number 19. It lists research articles, opinion pieces, and clinical reviews. Article topics include trauma triage guidelines@1672, and prepregnancy care@1706.
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Reposted by Jacob K McPherson PharmD PhD
Science Magazine @science.org · 26/05/2026
Past Ebola outbreaks spawned clever strategies for testing antivirals and antibodies, but researchers will still face major challenges on the ground. scim.ag/4dA9puo
science.org
Can fast, nimble clinical trials deliver a drug to halt the new Ebola outbreak?
Past outbreaks spawned clever strategies for testing antivirals and antibodies, but researchers will still face major challenges on the ground
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Reposted by Jacob K McPherson PharmD PhD
JAMA @jama.com · 25/05/2026
💬 Viewpoint: Legal and policy uncertainty surrounds a rebate-based pilot for the 340B Drug Pricing Program, raising concerns about rural and safety-net hospital access. ja.ma/4fEaEK7
JAMA viewpoint: "The 340B Drug Pricing Program at a Crossroads" by Ryan P. Knox, JD@1; Ameet Sarpatwari, PhD, JD@2. Published online May 18, 2026. doi: 10.1001/jama.2026.6812. Includes links to author affiliations and article information.
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Reposted by Jacob K McPherson PharmD PhD
Nature @nature.com · 25/05/2026
There's a growing concern that AI tools used to help produce innovative drugs could also make it easier to create new threats go.nature.com/3Rsx1Z6
go.nature.com
AI can design viruses, toxins and other bioweapons. How worried should we be?
Nature - Scientists are debating whether to limit biological AI software to ward off threats.
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Reposted by Jacob K McPherson PharmD PhD
The Lancet @thelancet.com · 25/05/2026
Want to stay up to date with the latest clinical research & reviews? 📚 Discover The Lancet’s Clinical Resources: spkl.io/63320ANWGC
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Jacob K McPherson PharmD PhD @jacobkmcpherson.bsky.social · 23/05/2026
A growing focus of my work is PK/PD in infectious diseases and antimicrobial development. @sidpharm.bsky.social Breakpoints @cmicomms.bsky.social Communicable E51 discusses this 🎙️Sootify link here: open.spotify.com/episode/64ZI... #PKPD #Pharmacokinetics #DrugDevelopment #Pharmacology
open.spotify.com
Communicable E51: We will make you love PK/PD, part 1
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Reposted by Jacob K McPherson PharmD PhD
The Lancet Microbe @lancetmicrobe.bsky.social · 22/05/2026
New series on Human Microbiome Dynamics And Health Paper 1 of 2 Temporal variations of the gut #microbiome in human health www.thelancet.com/journals/lan... #IDSky #ClinMicro #OpenAccess #OA
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Reposted by Jacob K McPherson PharmD PhD
Society of Infectious Diseases Pharmacists - SIDP @sidpharm.bsky.social · 22/05/2026
A special thanks to the collaborating organizations celebrating with us!🎉 @pharmacists.bsky.social, @sccmcriticalcare.bsky.social, @hivma.bsky.social, @ashpofficial.bsky.social, @sustainabil-id.bsky.social, EPASG 💬Use #BeyondTheRx to share your favorite multidisciplinary project
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Reposted by Jacob K McPherson PharmD PhD
Nature Microbiology @natmicrobiol.nature.com · 22/05/2026
Out Now! Preserving the future of vaccine science in the USA #MicroSky
go.nature.com
Preserving the future of vaccine science in the USA
Nature Microbiology, Published online: 22 May 2026; doi:10.1038/s41564-026-02358-8Vaccines have saved an estimated 154 million lives in 50 years, yet that infrastructure is under threat. We highlight the global impact of vaccine scientists who trained in the USA and urge for stronger communication, advocacy and public engagement to safeguard vaccine science.
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Reposted by Jacob K McPherson PharmD PhD
Science Magazine @science.org · 17/05/2026
WHO Director-General Tedros Adhanom Ghebreyesus declared the outbreak a Public Health Emergency of International Concern in the early morning of 17 May, an indication of how serious the situation is. Our story below has been updated to include the latest information. ⬇️
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Reposted by Jacob K McPherson PharmD PhD
Nature Portfolio @natureportfolio.nature.com · 17/05/2026
A Review in Nature Reviews Bioengineering highlights human organoids applications in studying host–virus interactions, supporting therapeutic and vaccine development, and improving pandemic preparedness, while emphasizing the need for greater complexity, standardization and scalability. 🔒
go.nature.com
Organoids as platforms for infectious disease research - Nature Reviews Bioengineering
Human organoids offer experimental models that closely replicate human biology, enabling the investigation of infectious disease mechanisms across diverse organ systems, especially for viral pathogens. This Review highlights their applications in studying host–virus interactions, supporting therapeutic and vaccine development, and improving pandemic preparedness, while emphasizing the need for greater complexity, standardization and scalability.
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Reposted by Jacob K McPherson PharmD PhD
Clinical Infectious Diseases @cidjournal.bsky.social · 10/05/2026
Electronic Clinical Quality Measures of Antibiotic Use in Hospitalized Adults with Uncomplicated Community-acquired Pneumonia ✅ Just Accepted 🔗 bit.ly/4wsbrnJ
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Reposted by Jacob K McPherson PharmD PhD
Nature @nature.com · 10/05/2026
Experienced researchers are less likely to produce ‘disruptive’ science than are those just starting their careers, finds an analysis of scientific papers published by 12.5 million researchers over 60 years go.nature.com/3Pb1lqg
go.nature.com
Early-career researchers do more ‘disruptive’ science than veterans
Nature - Analysis of papers from millions of scientists shows that older researchers tend to stick with ideas from their past.
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Reposted by Jacob K McPherson PharmD PhD
Clinical Infectious Diseases @cidjournal.bsky.social · 10/05/2026
Rethinking How We Provide Guidance When Evidence is Limited ✅ Just Accepted #IDTwitter 🔗 bit.ly/3RbRfpN
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Reposted by Jacob K McPherson PharmD PhD
Science Magazine @science.org · 08/05/2026
“I will miss the creativity of teaching.” During #TeacherAppreciationWeek, check out this #ScienceWorkingLife essay from a retired professor emeritus on how she challenged students to think beyond facts—and how she learned to teach like a scientist. scim.ag/4en9MsX
People diving into a pool of books and figures, with text: How I learned to teach like a scientist
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Reposted by Jacob K McPherson PharmD PhD
NEJM.org @nejm.org · 07/05/2026
Avian influenza can jump from birds to humans. A video shows abnormal behavior by two ducks kept by a woman who fed and handled them daily, before she herself became ill. Learn more about how avian influenza A(H5N5) could cause severe human illness in a new report: nej.md/4tob22K
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Science Magazine @science.org · 06/05/2026
A new clinical trial reveals that combining antiretroviral therapy with anti-HIV antibodies is safe in infants, scientists refashion rapamycin into a dual therapy and drug delivery tool for venous malformations, and more in #ScienceTranslationalMedicine. scim.ag/4evTT3A
The cover image shows a cross section of a mouse hind limb after Achilles tendon injury, with ectopic bone (blue-green) visible near the injury site; muscle, marrow, and cartilage appear as purple-red tones. 

Credit: S. Jiang and G. Eis-Janzyk/Universitatsklinikum Hamburg-Eppendorf
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