Abstract. Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions over a decade-plus, offering a window for interception in high-risk individuals, but current surveillance detects a mino...

Driessen et al. show that core benefits of sleep—reduced local sleep pressure, renormalized synaptic strength and memory consolidation—can be reproduced in awake, behaving mice by inducing sleep-like on/off activity patterns in cortex.

Through spatial multiomics, spatial stable isotope tracing and retrospective cohort analyses, this study identifies hyperglycosylation as a driver of Alzheimer’s disease and a promising therapeutic target.

The mechanisms underlying breathing interoception are unclear. Here authors show that distinct forebrain sites synchronize and entrain to breathing during wakefulness, sleep, and external mechanical v...

Narasimhan et al. show that muscle-resident fibroadipogenic progenitors (FAPs) are activated and contribute to muscle wasting in cachexia. They also show that cancer-induced downregulation of miR-27a-3p in FAPs activates an adipogenic program, whereas its upregulation in cancer increases tumor growth, highlighting the complexity of therapeutically targeting such pleiotropic molecules.

YouTube video by Stephen Colbert

A cross-organ, multi-omics U-shaped relationship between sleep duration and biological ageing clocks highlights the potential of sleep optimization to promote healthy ageing, lower disease risk and ex...

Sleep is one of medicine's underused data streams. Clinically, disturbed sleep has often been treated as a symptom of a disorder, but sleep is also a physiological state in which brain, cardiac, respi...

Mapping of neurogenesis in human hippocampi across ages and different cognitive abilities using multiomic single-cell sequencing reveals distinct signatures between cognitive preservation and decline.

Topography is a well-described and well-known concept for cortical organization in primary sensory and motor cortices of mammalian brains. Similar ...

Take a look to see what the kindergarten measles vaccination rates are in your area.

Particular Relevance to Sleep, Alzheimer's Disease and Immune Surveillance

Harmsen et al. compared the metabolic impact of natural daylight vs. artificial office lighting in individuals with type 2 diabetes over 5 days. Daylight improved glucose homeostasis, whole-body fat u...

A growing list of medications—such as zuranolone for postpartum depression, suzetrigine for pain, and the gepants class of migraine medicines—exist because of insights from basic research.

Special Report: The NIH has shut out hundreds of young scientists from funding to start their own labs.

Psilocybin reshapes brain networks through activity-dependent plasticity, including a weakening of recurrent cortical loops that could underlie its therapeutic effects.

To compete at iGEM, a sort of science Olympics, teens at a Georgia high school set their sights on finding a better way to detect and treat Lyme disease. Their approach uses CRISPR gene editing.

A live recording addressing many current women's health issues

YouTube video by European Research Council

He needs to go. Now.

SCN2A is a high-confidence risk gene for autism spectrum disorder. Loss-of-function mutations in Scn2a reduce dendritic excitability in neocortical...

Cuts and disruptions to federal research funding are causing many young brain scientists to reconsider their career choice.

Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology — although important caveats remain.

GLP-1s are being studied for a wide range of conditions. Now, scientists will test whether their anti-inflammatory properties can help alleviate symptoms of long Covid.

The titles of more than 700 multi-year NIH grants have been changed this year, according to an analysis by Jeremy Berg, a former agency official

The blood–brain barrier was conventionally seen as a static protective structure, but a more complex, dynamic view of this barrier has now emerged. In this Review, Friedman et al. discuss the dynamic ...

Emotional experience evokes signalling in astrocytes, which form an ensemble that is reinforced by secondary astrocytic state changes resulting from repeated experience, leading to memory stabilizatio...

Targeting modifiable risk factors is a promising approach to the primary prevention of dementia [1]. Growing evidence suggests that disturbed sleep is one

Myelin damage in multiple sclerosis can be detected up to 7 years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis.