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Prof Janine Kirby

@j9kirby.bsky.social
213 followers 107 following 7 posts

Researcher & Lecturer based in SITraN, University of Sheffield. Tweeting on MND/ALS, Neuroscience, Advanced Therapies and Education

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Reposted by Prof Janine Kirby
My Name'5 Doddie Foundation @mndoddie5.bsky.social · 14/07/2026
🎉 We’ve passed the AMRC @amrc-uk.bsky.social Expert Review Audit! Meeting AMRC's six principles of expert review confirms that we use robust and rigorous research funding processes, helping us to fund the best research.
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Reposted by Prof Janine Kirby
My Name'5 Doddie Foundation @mndoddie5.bsky.social · 04/07/2026
Today to mark Doddie's 56th birthday, we're reflecting on hope in the research landscape and what we are doing to accelerate progress. Together, with your help, we're carrying Doddie's legacy forward. Read 'How close are we to a cure?' below 👇 www.myname5doddie.co.uk/news-and-sto...
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Reposted by Prof Janine Kirby
My Name'5 Doddie Foundation @mndoddie5.bsky.social · 08/05/2026
🚨 Our Advancing Treatments Award is OPEN for applications! We’re looking to fund projects that will further the early-stage development of new treatments designed to slow, stop or reverse MND progression. For more details and how to apply, click below 👇 www.myname5doddie.co.uk/for-research...
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Reposted by Prof Janine Kirby
My Name'5 Doddie Foundation @mndoddie5.bsky.social · 13/02/2026
🚨There's only 2 weeks left to submit your application for our Catalyst Award! We want to help MND researchers bring bold, innovative and early-stage ideas to life. Applications close 27 February at midday. More details here 👉 www.myname5doddie.co.uk/whats-on/art...
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Reposted by Prof Janine Kirby
My Name'5 Doddie Foundation @mndoddie5.bsky.social · 13/01/2026
🚨 Our Catalyst Award is OPEN for applications! We’re looking for bold, early-stage ideas that need catalytic funding to get off the ground. 🔵 Awards are a maximum of £100k for up to 1 year 🟡 Applications close 27 February For more details and to apply 👇 www.myname5doddie.co.uk/whats-on/art...
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Reposted by Prof Janine Kirby
My Name'5 Doddie Foundation @mndoddie5.bsky.social · 09/01/2026
There's been plenty of snow and ice this week, thankfully 'My Name'5 Doddie Foundation' the gritter is on the case! ❄️
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Reposted by Prof Janine Kirby
My Name'5 Doddie Foundation @mndoddie5.bsky.social · 17/12/2025
We’ve just published a report to tell you all about what we’ve been up to in the second year of our research strategy ‘Catalysing a Cure’ - here are the highlights 🔬 For more details and to read the report in full, click below 👇 www.myname5doddie.co.uk/whats-on/art...
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Reposted by Prof Janine Kirby
My Name'5 Doddie Foundation @mndoddie5.bsky.social · 11/12/2025
Doddie said “love, fun & hope” should be one of our key pillars. That still guides us today💗💙💛 At our Discovery Network Showcase, researchers, people living with and affected by MND, and industry partners shared what inspires them (love), makes them smile (fun) & gives them hope in MND research
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Reposted by Prof Janine Kirby
My Name'5 Doddie Foundation @mndoddie5.bsky.social · 02/12/2025
Sign up for Doddie Aid 2026 now‼️ doddieaid.com
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Reposted by Prof Janine Kirby
My Name'5 Doddie Foundation @mndoddie5.bsky.social · 18/11/2025
We have invested almost £3m to help MND clinical trial centres recruit the staff they need. When Doddie was diagnosed, he was frustrated at the lack of clinical trials in the UK. Today’s landscape is significantly different and we’re proud to support that 👇 www.myname5doddie.co.uk/whats-on/art...
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Reposted by Prof Janine Kirby
My Name'5 Doddie Foundation @mndoddie5.bsky.social · 05/11/2025
We’ve spent £2 million on nine new MND research projects through our Advancing Treatments and Catalyst Awards, which all aim to accelerate the search for effective treatments 🔬 Find out more about the projects here 👇 www.myname5doddie.co.uk/whats-on/art...
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Reposted by Prof Janine Kirby
Ammar Al-Chalabi @ammaralchalabi.bsky.social · 29/08/2025
This is a landmark paper showing a predictive test for #ALS #MND up to 40 years before onset and able to predict age of onset. Huge implications www.nature.com/articles/s41...
nature.com
A plasma proteomics-based candidate biomarker panel predictive of amyotrophic lateral sclerosis - Nature Medicine
Plasma proteomic analysis of presymptomatic individuals with amyotrophic lateral sclerosis identifies novel disease-associated proteins and enables the development of an accurate diagnostic biomarker ...
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Prof Janine Kirby @j9kirby.bsky.social · 25/07/2025
Great couple of days attending the School of Medicine and Population Health graduations of PGR and MBChB students @sheffielduni.bsky.social
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Prof Janine Kirby @j9kirby.bsky.social · 19/07/2025
@lifearc.bsky.social are now on Bluesky
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Reposted by Prof Janine Kirby
My Name'5 Doddie Foundation @mndoddie5.bsky.social · 17/07/2025
We’re proud to feature in the AMRC's new report on translating research for our jointly funded work with Motor Neurone Disease Association and LifeArc 🤝 @amrc-uk.bsky.social @mndassoc.bsky.social @lifearc.bsky.social You can view the full report here 👇 bit.ly/4lTL049
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Prof Janine Kirby @j9kirby.bsky.social · 10/05/2025
Great to see this work come to fruition and highlighted by @sheffielduni.bsky.social
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Reposted by Prof Janine Kirby
Ammar Al-Chalabi @ammaralchalabi.bsky.social · 10/05/2025
Our paper describing the results of the MIROCALS trial of low-dose interleukin-2 in #ALS #MND is out in the Lancet @thelancet.bsky.social Open access Read it here: www.thelancet.com/journals/lan...
thelancet.com
Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial
With this treatment schedule, IL-2LD resulted in a non-significant reduction in mortality in the primary unadjusted analysis. However, the difference between the results of unadjusted and adjusted ana...
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Reposted by Prof Janine Kirby
UK MND Research Institute @ukmndri.bsky.social · 14/04/2025
Introducing our new Research snapshot series. Where we highlight the latest #MND studies reported by Readable Research @sheffielduni.bsky.social 🔬 First up: a look at toxic proteins in a mouse model of C9orf72-related MND and what it tells us about future treatments. ukmndri.org/2025/04/14/r...
ukmndri.org
Understanding the production of toxic proteins in MND
A new study has explored how toxic proteins build up in the nervous system and whether future treatments might help stop them.
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Reposted by Prof Janine Kirby
My Name'5 Doddie Foundation @mndoddie5.bsky.social · 14/04/2025
Did you catch Hamish, Kenny Logan & our Director of Research, Dr Madina Kara, on BBC Breakfast this morning?📺 Kenny unveiled the plans for his Doddie’s Lions Challenge, a 555-mile cycle round Ireland, with the aim to raise over £500,000 for the Foundation & Irish Motor Neurone Disease Association
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Reposted by Prof Janine Kirby
Adrian Isaacs @adrianisaacs.bsky.social · 21/02/2025
Check out our new review of C9orf72 ALS in @thelancetneuro.bsky.social with Sarah Mizielinska, Rosa Rademakers and others! Was fun to co-write but tough to collate such incredible progress into a one article: authors.elsevier.com/c/1ke765FFzL...
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Prof Janine Kirby @j9kirby.bsky.social · 20/02/2025
SMA treated in the womb www.nature.com/articles/d41...
nature.com
Rare genetic disorder treated in womb for the first time
The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.
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Reposted by Prof Janine Kirby
Coleman Lab @colemanlab.bsky.social · 19/02/2025
Welcome to Brian Dickie @bd365.bsky.social on BlueSky! Please give him a follow if you work on neurodegeneration, especially ALS/MND!
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UK MND Research Institute @ukmndri.bsky.social · 07/02/2025
Many people with #MND are asking about ellorarxine. How are new drugs approved, and what does the evidence say about this research and drug? 🔬 We break down the drug development process and how we’re working to speed it up. ukmndri.org/2025/02/07/a...
ukmndri.org
An update on Ellorarxine - UKMNDRI
As neurologists specialising in the care of people living with motor neuron disease, we are receiving increasing enquiries about a drug called ellorarxine. Many of our patients are asking for access, ...
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Reposted by Prof Janine Kirby
Oxford MND Research @mndoxford.bsky.social · 29/01/2025
Perspective, led by Martin, on the current application and future potential for blood neurofilament light chain level in neurological disorders, including #ALS pubmed.ncbi.nlm.nih.gov/39845125/
pubmed.ncbi.nlm.nih.gov
Blood level of neurofilament light chain as a biomarker for neurological disorders - PubMed
Blood level of neurofilament light chain as a biomarker for neurological disorders
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Reposted by Prof Janine Kirby
UK MND Research Institute @ukmndri.bsky.social · 29/01/2025
🚨We're working to accelerate the development of new treatments for #ALS. Read more about how our pioneering study, EXPERTS-ALS, aims to rapidly screen potential drugs for evidence that they can slow progression in people with ALS. 🔗 Find out more 👇 ukmndri.org/2025/01/29/s...
ukmndri.org
Showcasing our groundbreaking EXPERTS-ALS study for MND treatments - UKMNDRI
EXPERTS-ALS is a ground-breaking initiative to accelerate the development of new treatments for amyotrophic lateral sclerosis (ALS). We’re excited to showcase one of our flagship projects, the EXPErim...
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Reposted by Prof Janine Kirby
Sancha Brody-Stalker @sanchabrodystalker.bsky.social · 15/01/2025
Take a look at the 'Countdown to a Cure' report which demonstrates some of the exciting and promising translational UK research being funded by the MND Association. www.mndassociation.org/research/cou...
mndassociation.org
Countdown to a cure
Get access to 'Countdown to a cure' which provides an overview of the innovative research the MND Association is funding, the increased collaboration across MND research, and a look at new and improve...
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Reposted by Prof Janine Kirby
Ruben van Eijk @rpavaneijk.bsky.social · 10/12/2024
New paper to reflect on the main challenges in phase 2 #ALS #MND trials. Key issues relate too short study durations, reliance on the wrong outcome measures, absence of biomarkers, statistical issues, over-interpretation of 'clinical trends' and miscommunication. academic.oup.com/brain/articl...
academic.oup.com
Rethinking phase 2 trials in amyotrophic lateral sclerosis
There is a long history of ALS therapies being promoted on the basis of Phase 2 data, which then fail to translate into meaningful benefits in Phase 3 tria
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Reposted by Prof Janine Kirby
Ryan West @westwingslab.bsky.social · 07/12/2024
Poster session B, 5.30-7 7th December
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UK MND Research Institute @ukmndri.bsky.social · 07/12/2024
We are delighted to announce that Dr Alfredo Iacoangeli was awarded the esteemed Paulo Gontijo Award at the opening of the Montreal 32nd International #ALS/#MND Symposium. This global accolade celebrates excellence in MND research. Read more here: ukmndri.org/2024/12/07/u...
ukmndri.org
UK researcher wins prestigious Paulo Gontijo Award for MND Research - UKMNDRI
Dr. Alfredo Iacoangeli has been awarded the prestigious Paulo Gontijo Award, recognising his vital contributions to MND research. We are delighted to announce that Dr Alfredo Iacoangeli was awarded t...
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Reposted by Prof Janine Kirby
MND Association @mndassoc.bsky.social · 18/11/2024
Hey everyone 👋 New platform, same vision… a world free from motor neurone disease 🌍 #MND
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Reposted by Prof Janine Kirby
MND Association @mndassoc.bsky.social · 06/12/2024
We were delighted to welcome Kevin Sinfield and his team to our National Office this morning. Alongside BBC Breakfast, the team began the penultimate day of the #RunningHomeForChristmas Challenge. Good luck to the team 💙 donate.giveasyoulive.com/fundraising/kevin-sinfield-and-teams-fundraising
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Prof Janine Kirby @j9kirby.bsky.social · 29/11/2024
Beautiful sky this morning coming into work
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Lee Millard @onein300.bsky.social · 22/11/2024
Some brief updates from #united2endmnd and our work with the UK MND Research Institute @ukmndri.bsky.social as we move towards the end of 2024. united2endmnd.org/2024/11/22/u... #mnd #als
united2endmnd.org
UK MND Research Institute: Updates for late 2024
UK MND Research Institute: Updates for late 2024 As we move towards the end of 2024, having recently marked the 1st anniversary of the formal launch of the UK MND Research Institute, we bring you 4…
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Prof Janine Kirby @j9kirby.bsky.social · 19/11/2024
Great news for those living with MND/ALS who carry a variant in the SOD1 gene. www.mndassociation.org/media/latest...
mndassociation.org
Drug closer to approval as MND Association hails Prescribe Life campaign success
Over 15,000 people signed the charity’s petition.
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