Background and ObjectivesAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a complex etiology. Although a range of genetic and lifestyle factors have been implicated, the potenti...

Cell Death & Disease - Mutant TDP-43 drives impairments in axonal transport and glycolysis in a mouse stem-cell-derived motor neuron model of amyotrophic lateral sclerosis (ALS)

Background Due to its proximity to cells of the central nervous system, cerebrospinal fluid (CSF) is an important source of novel biomarkers for neurological diseases. Membrane-bound extracellular ves...

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Yoganathan et al. found reduced connectivity between brain and muscle (corticomuscular coherence) in motor neuron disease patients using magnetoencephalogr

Objective Identifying modifiable factors influencing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) risk is important for prevention. Blood biomarkers, particularly cholestero...

I hope the slightly provocative little title caught your eye. This is my latest post in my The Devil is the Detail series. I try to sketch out the landscape of drug repurposing in our disease. My a…

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Neuronal and glial cytoplasmic inclusions positive for TAR DNA-binding protein 43 (TDP-43) are the defining pathological hallmark of 97% of amyotrophic lateral sclerosis (ALS) and 50% of frontotempora...

A non-invasive measure of cerebral motor system dysfunction would be valuable as a biomarker in amyotrophic lateral sclerosis (ALS). Task-based magnet…

The C9orf72 hexanucleotide repeat expansion is associated with ALS and certain forms of dementia, though its exact penetrance remains unclear. In a UK popu

Severe weight loss in amyotrophic lateral sclerosis (ALS) is common, multifactorial, and associated with shortened survival. Using longitudinal weight data from over 6000 patients with ALS across thr...

As part of its renewed commitment, the Alan Davidson Foundation will continue to fund a full-time project manager to facilitate the ongoing coordination and growth of the ACORN study. The foundation i...

Extracellular vesicles (EVs) are membrane-enclosed nanoparticles released by most cell types, and from multiple sub-cellular compartments. They carry a range of cargo biomolecules, including protein a...

European Journal of Human Genetics - Penetrance and pleiotropy in ATXN2-related amyotrophic lateral sclerosis

Objectives To characterise the clinical characteristics and longitudinal outcomes in primary lateral sclerosis (PLS), including median survival from symptom onset and age at death. Methods The author...

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Amyotrophic lateral sclerosis (ALS) is marked by significant phenotypic heterogeneity. By examining clinical, neuroimaging, and postmortem histopathologica

The role of microglia in amyotrophic lateral sclerosis (ALS) is unclear. Here, the authors show that iPSC microglia from C9orf72-ALS patients are toxic to motor neurons and identify microglial MMP9 as...

Despite remaining challenges, drug repurposing offers the opportunity to improve therapeutic options for ALS patients. Nevertheless, stringent preclinical research will be necessary to identify the mo...

Blood level of neurofilament light chain as a biomarker for neurological disorders

Objective To identify biochemical changes in individuals at higher risk of developing amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD) via C9orf72 hexanucleotide repeat expansion...

Objective To identify biochemical changes in individuals at higher risk of developing amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD) via C9orf72 hexanucleotide repeat expansion...