Reposted by Ammar Al-ChalabiMy Name'5 Doddie Foundation @mndoddie5.bsky.social · 27/07/2026In the first half of 2026 alone, we have committed £1.8 million to four new MND research projects, which will help identify and test promising therapeutic targets and support the development of new treatments for MND. Full details here: www.myname5doddie.co.uk/news-and-sto... 021
Reposted by Ammar Al-ChalabiUK MND Research Institute @ukmndri.bsky.social · 12/03/2026We're thrilled to announce that the drug RT1999 has been selected for EXPERTS-ALS. This is how we accelerate progress for people with MND. Participants are expected to receive the drug by the end of 2026. ukmndri.org/2026/03/10/n...ukmndri.orgNew MND drug selected for EXPERTS-ALS platformRaya Therapeutic's smilagenin has been selected for EXPERTS-ALS. Read how this new drug could accelerate the search for MND treatments. 021
Reposted by Ammar Al-ChalabiUK MND Research Institute @ukmndri.bsky.social · 16/02/2026Industry partners are vital collaborators in our mission to find crucial new treatments for #MND/#ALS. Our co-director, @ammaralchalabi.bsky.social, teamed up with Raya Therapeutics at TRICALS to lead a discussion on Repurposing and Combination Therapies. Read more 👇 ukmndri.org/2025/11/13/r... 021
Ammar Al-Chalabi @ammaralchalabi.bsky.social · 04/12/2025Do you want to know about #ALS #MND genetics? Are you affected directly or indirectly by ALS MND or working as a scientist or clinician in this area? I was honoured to give the Hawking Lecture this year and it's now freely available to view. www.mndassociation.org/professional...mndassociation.orgAnnual Stephen Hawking MND LectureThe Annual Stephen Hawking MND Lectures were launched 2017 – and are now and established and important part of the Association’s calendar. 010
Reposted by Ammar Al-ChalabiUK MND Research Institute @ukmndri.bsky.social · 03/12/2025New research reveals what people with #MND/#ALS need when deciding on genetic testing: clear info, implications for family & tailored support.📃 This data can help inform decision aids to assist people when thinking about genetic testing. Read more🔗 ukmndri.org/2025/12/03/g...ukmndri.orgGenetic Testing: What People Need to Make Informed DecisionsA new study reveals what people with MND need when deciding on genetic testing, including clear information and tailored support. 021
Reposted by Ammar Al-ChalabiLongitude Prize on ALS @longitudeprize.bsky.social · 02/12/2025🚨 Final Call for the £7.5m (~$10m) Longitude Prize on ALS. Don’t miss your chance to make a real difference for those living with #ALS (the most common form of #MND). Submit your application by 15:00 GMT (10:00 AM EST) tomorrow! Apply here: bit.ly/4nyp6nq 031
Reposted by Ammar Al-ChalabiLongitude Prize on ALS @longitudeprize.bsky.social · 26/11/2025⏰1 week to go! Entries to the £7.5M (~$10M) Longitude Prize on ALS are closing next week – submit your application before Wednesday 3rd December 2025. Your expertise could make the difference. 🔗Learn more and apply today: bit.ly/4nyp6nq 021
Reposted by Ammar Al-ChalabiLongitude Prize on ALS @longitudeprize.bsky.social · 25/11/2025@ohenews.bsky.social estimates that eradicating ALS could deliver $143B+ in value over 10 years. The potential global value is huge. #ALS and #MND remain underfunded and breakthroughs are urgently needed. Full report: lnkd.in/e3-DMaiB Learn more about the Prize bit.ly/4nyp6nq 021
Reposted by Ammar Al-ChalabiLongitude Prize on ALS @longitudeprize.bsky.social · 19/11/2025🚨 Only 2 weeks left to apply! The £7.5M (~$10M) Longitude Prize on ALS is closing soon – submit your application before 3 December 2025 and don’t miss your chance to make a real difference. 🔗 To learn more about the Prize, click here: bit.ly/4nyp6nq 021
Ammar Al-Chalabi @ammaralchalabi.bsky.social · 14/11/2025People with #ALS #MND with respiratory compromise should be offered COVID immunization by their GPs. united2endmnd.org/2025/11/14/c...united2endmnd.orgCovid-19 Boosters in the UK – StatementCovid-19 Boosters in the UK – Statement This autumn is the first since the Joint Committee on Vaccination and Immunisation (JCVI) changed its policy on who can receive Covid-19 vaccination bo… 000
Reposted by Ammar Al-ChalabiUK MND Research Institute @ukmndri.bsky.social · 14/11/2025Drug development is a complex and costly process. By using medicines approved for other conditions, we can overcome barriers in drug development. Read our blog explaining why we believe repurposed drugs could help us find new treatments for #MND/#ALS. ukmndri.org/2025/11/13/r...ukmndri.orgRepurposed Drugs: Accelerating MND Treatment DiscoveryDiscover how repurposed drugs are helping accelerate the search for effective treatments for MND through innovative UK research. 031
Reposted by Ammar Al-ChalabiUK MND Research Institute @ukmndri.bsky.social · 13/11/2025Yesterday, we attended @mndoddie5.bsky.social's Discovery Network Showcase 2025. Researchers, clinicians, industry partners, and people affected by #MND/#ALS discussed how the network can drive forward progress in better understanding MND and the development of new treatments. 051
Reposted by Ammar Al-ChalabiUK MND Research Institute @ukmndri.bsky.social · 05/11/2025Our Co-Director, Prof. @ammaralchalabi.bsky.social, gave a fantastic talk yesterday, hosted by @mndassoc.bsky.social, on #MND/#ALS genetics, why they matter and how discoveries are shaping new treatments. Thank you to everyone who joined in person & online! #MNDresearch #genetics 032
Reposted by Ammar Al-ChalabiLongitude Prize on ALS @longitudeprize.bsky.social · 21/10/2025We had the pleasure of catching up with Dr Brian Dickie MBE (@bd365.bsky.social), Chief Scientist at the @mndassoc.bsky.social, the principal funder of the £7.5M Longitude Prize on ALS. 📖 Read the full Q&A here: bit.ly/3KTi1Ap 022
Reposted by Ammar Al-ChalabiLongitude Prize on ALS @longitudeprize.bsky.social · 14/10/2025Join us at the #ASHG25 Annual Meeting in Boston, starting today! Visit us at Booth 46, we’d love to meet you and discuss how the ~$10M Longitude Prize on ALS is harnessing #AI to transform the future of neurodegenerative disease treatment. @challengeworks.bsky.social @geneticssociety.bsky.social 021
Ammar Al-Chalabi @ammaralchalabi.bsky.social · 06/10/2025We must find an effective treatment for #ALS #MND @ukmndri.bsky.social BBC News - Former England captain Moody reveals MND diagnosis www.bbc.com/sport/rugby-...bbc.comLewis Moody: Former England captain reveals motor neurone disease diagnosisFormer England captain Lewis Moody reveals he has been diagnosed with motor neurone disease in an exclusive BBC interview. 065
Reposted by Ammar Al-ChalabiLongitude Prize on ALS @longitudeprize.bsky.social · 03/10/2025⏰ 2 months to go until applications close for the £7.5 million Longitude Prize on ALS. You could help transform treatment for neurodegenerative diseases like hashtag #ALS, the most common form of motor neurone disease ( #MND ). Learn more: bit.ly/4mlzSg5 033
Reposted by Ammar Al-Chalabiend-the-legacy.bsky.social @end-the-legacy.bsky.social · 03/10/2025Connect with us at #NealsMtg ! We are thrilled to be joining the NEALS meeting once again in person this coming week. For anyone impacted by ALS virtual registration is free. Cheers to NEALS for such an open policy. See more at meeting.neals.org . #EndtheLegacy #NEALS 011
Ammar Al-Chalabi @ammaralchalabi.bsky.social · 29/08/2025This is a landmark paper showing a predictive test for #ALS #MND up to 40 years before onset and able to predict age of onset. Huge implications www.nature.com/articles/s41...nature.comA plasma proteomics-based candidate biomarker panel predictive of amyotrophic lateral sclerosis - Nature MedicinePlasma proteomic analysis of presymptomatic individuals with amyotrophic lateral sclerosis identifies novel disease-associated proteins and enables the development of an accurate diagnostic biomarker ... 3113
Reposted by Ammar Al-ChalabiLongitude Prize on ALS @longitudeprize.bsky.social · 12/08/2025🌍 Be part of the global effort to tackle #ALS. The £7.5m (~$10m) #LongitudePrizeOnALS is searching for innovators in #AI, #data, #biotech, and #neurology. 🧠 Meet the teams already registered, and find out how you can partner with them below. 🔗https://bit.ly/4mdHxxX 044
Reposted by Ammar Al-ChalabiLongitude Prize on ALS @longitudeprize.bsky.social · 05/08/2025🧠 The @ukmndri.bsky.social is an #MND powerhouse, accelerating progress towards new treatments and, ultimately, a cure. Read their article about how the #LongitudePrizeOnALS could be a game-changer for drug discovery in neurodegenerative diseases. 🔗 bit.ly/40Tmmsh @ammaralchalabi.bsky.socialukmndri.orgLongitude Prize launched to accelerate AI-driven drug discoveryA new international challenge prize has been launched to transform drug discovery for ALS, the most common form of MND through AI. 032
Reposted by Ammar Al-ChalabiDementia Researcher @dementiaresearcher.bsky.social · 23/07/2025Postdoc Research Assistant in Dr Arpan Mehta’s lab at University of Dundee, using CRISPR screens in iPSC-derived motor neurons to study ALS mechanisms. Closing date: 4th August www.dementiaresearcher.nihr.ac.uk/job/postdoc-...dementiaresearcher.nihr.ac.ukPostdoc Research Assistant: Investigating C9ORF72Postdoc Research Assistant in Dr Arpan Mehta’s lab at University of Dundee, using CRISPR screens in iPSC-derived motor neurons to study ALS mechanisms. 076
Reposted by Ammar Al-ChalabiLongitude Prize on ALS @longitudeprize.bsky.social · 22/07/2025“MND is one of the most scientifically and biologically challenging diseases to tackle. That said, no mountain is insurmountable…” Dr. Mike Rogers (@mndassoc.bsky.social) shares why the #LongitudePrizeOnALS is key to creating new opportunities for #ALS & #MND 📰 longevity.technology/news/climbin...longevity.technologyClimbing the ALS mountainMike Rogers, MND Association Director of Research and Innovation, looks at how data and AI could unlock new treatments. 012
Reposted by Ammar Al-ChalabiUK MND Research Institute @ukmndri.bsky.social · 16/07/2025New research has examined how disrupted sleep patterns may signal the early stages of #MND / #ALS or FTD, providing clues to earlier detection. Read more ⬇️ 🔗 ukmndri.org/2025/07/16/r... This post is part of our Research Snapshot series, powered by Readable Research at @sheffielduni.bsky.socialukmndri.orgCould sleep changes signal the early stages of MND or FTD?Research has found that disrupted sleep may offer some clues to possible early warning signs of the ALS or FTD. 032
Reposted by Ammar Al-ChalabiSTITCHES Medicine - the Best of Medical Research @medicine.stitches.today · 09/07/2025Researchers reveal that structural variants disrupting the 3D genome can drive diseases like cancer by altering gene expression. by Sreenivasan VKA, Yumiceba V and Spielmann M in Nat Rev Genet #MedSky 👉 get more here 📖 read the article: nature.comStructural variants in the 3D genome as drivers of disease - Nature Reviews GeneticsDisruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical consequences of position effects arising from disruptions to the genome architecture. 062
Reposted by Ammar Al-ChalabiLongitude Prize on ALS @longitudeprize.bsky.social · 08/07/2025⏰ Reminder: Our first Welcome Webinar is tomorrow, Tuesday 9th of July at 09:00 BST. 💻 Register below to learn everything you need to know about the #LongitudePrizeOnALS, including how to apply, how the Prize works, and what support is available. 052
Reposted by Ammar Al-ChalabiDementia Researcher @dementiaresearcher.bsky.social · 06/07/2025Research Fellow vacancy at UCL MND Centre. Join Prof Andrea Malaspina’s team to study immune responses and neoantigens in ALS using proteomics and cell phenotyping. Closing date: 20th July www.dementiaresearcher.nihr.ac.uk/job/research...dementiaresearcher.nihr.ac.ukResearch Fellow: Glial-immune crosstalk and sporadic ALSResearch Fellow vacancy at UCL MND Centre. Join Prof Andrea Malaspina’s team to study immune responses & neoantigens in ALS using proteomics & cell phenotyping 024
Reposted by Ammar Al-ChalabiLongitude Prize on ALS @longitudeprize.bsky.social · 03/07/2025🧠 As the principal funder, the @mndassoc.bsky.social has been instrumental in bringing the #LongitudePrizeOnALS to life. We were joined by Dr Usman Khan last week, who spoke on the power of cross-specialism collaboration. Learn more about the Prize: bit.ly/4kD3tSh #AIforGood #MND #ALS 022
Reposted by Ammar Al-ChalabiLongitude Prize on ALS @longitudeprize.bsky.social · 02/07/2025Want to learn more about the £7.5M #LongitudePrizeOnALS? Join one of our welcome webinars to find out how the Prize works and how to get involved. Register here: 📅 9 July, 09:00 BST: bit.ly/4nzJuWA 📅 10 July, 17:00 BST: bit.ly/3Tl4u5u #AIForGood #MND #ALS 033
Reposted by Ammar Al-ChalabiLongitude Prize on ALS @longitudeprize.bsky.social · 30/06/2025Check out this article from Dr Brian Dickie (@mndassoc.bsky.social), exploring how #AI and quality data can transform treatment progress—and how the £7.5M #LongitudePrizeonALS aims to support #innovation through global collaboration. 🧠 Read here: bit.ly/4nqi4lN #ALS #MNDbit.lyMotor neurone disease affects one in 300, but hope for treatment is growingOne in 300 of us will develop motor neurone disease in our lifetime. It is a hideous disease that robs a person of their dignity and eventually their life. 023
Reposted by Ammar Al-ChalabiDementia Researcher @dementiaresearcher.bsky.social · 30/06/2025Apply now for the NIHR Senior Investigator award! £15K per year for 4 years to support top researchers shaping the future of health and social care in the UK. @nihr.bsky.social www.dementiaresearcher.nihr.ac.uk/funding/nihr...dementiaresearcher.nihr.ac.ukNIHR Senior Investigators Award - DEMENTIA RESEARCHERApply for the NIHR Senior Investigator award: £15K per year for 4 years to support leading applied research and shape the future of health and social care. 032
Reposted by Ammar Al-ChalabiLongitude Prize on ALS @longitudeprize.bsky.social · 27/06/2025What a week for the #LongitudePrizeOnALS 🧠 Thank you to everyone who made it possible! 🎥 Watch the segment on BBC News here: bit.ly/4eoGyaR This is just the beginning. Entries close 3 Dec → Learn more on our website: bit.ly/4kD3tSh @trisdyson.bsky.social @ammaralchalabi.bsky.social #AIforGoodlinkedin.comWhat an incredible week! | Longitude Prize on ALSWhat an incredible week! Thank you to everyone who helped make the launch of the #LongitudePrizeOnALS such a success — from the inspiring voices on stage, to the teams that made this Prize possible, ... 032
Reposted by Ammar Al-ChalabiDementia Researcher @dementiaresearcher.bsky.social · 21/06/2025Join Dr Arpan Mehta's lab at MRC PPU, Dundee, for a 12-month postdoc using CRISPR screens to explore ALS in iPSC-derived motor neurons. Closing date: 18th July www.dementiaresearcher.nihr.ac.uk/job/postdoc-...dementiaresearcher.nihr.ac.ukPostdoc Research Assistant: Mechanisms of the C9ORF72Join Dr Arpan Mehta's lab at MRC PPU, University of Dundee, for a 12-month postdoc using CRISPR screens to explore ALS in iPSC-derived motor neurons. 055
Reposted by Ammar Al-ChalabiUK MND Research Institute @ukmndri.bsky.social · 21/06/2025Today is #MNDAwarenessDay, a moment to highlight the hidden realities of living with #MND. Our translational research projects aim to find treatments for MND through a national, coordinated approach. 👉 Discover more: ukmndri.org/2025/06/20/f...ukmndri.orgHow our translational research will find new treatments for MNDOn MND Awareness Day, we’re spotlighting the projects accelerating real progress and explaining why translational research is key. 021
Reposted by Ammar Al-ChalabiKing's College London @kingscollegelondon.bsky.social · 14/06/2025Professor Sir Simon Wessely is a world-renowned academic psychiatrist and epidemiologist and has been awarded this GBE in recognition of his distinguished position as 'the pre-eminent psychiatrist of his generation in the UK.' ⬇️ www.kcl.ac.uk/news/profess...kcl.ac.ukProfessor Sir Simon Wessely awarded Knight Grand Cross of the Order of the British Empire (GBE) in King's Birthday HonoursSir Simon Wessely, Professor of Psychological Medicine at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has been awarded the honour for services to mental hea... 4112
Reposted by Ammar Al-ChalabiKing's College London @kingscollegelondon.bsky.social · 14/06/2025We are delighted to announce that Professor Sir Simon Wessely has been awarded a Knight Grand Cross of the Order of the British Empire (GBE) in this year's King’s 2025 Birthday Honours. 🎉 🧵⬇️ @kingsioppn.bsky.social 1183
Reposted by Ammar Al-ChalabiDementia Researcher @dementiaresearcher.bsky.social · 13/06/2025Join a leading dementia research team as a Clinical Research Fellow at UCL. Work on trials for novel Alzheimer’s and FTD therapies. Closing date: 2nd July www.dementiaresearcher.nihr.ac.uk/job/clinical...dementiaresearcher.nihr.ac.ukClinical Research Fellow: Dementia Clinical TrialsJoin a leading dementia research team as a Clinical Research Fellow at UCL. Work on trials for novel Alzheimer’s and FTD therapies. 035
Reposted by Ammar Al-ChalabiALS Advocacy @alsadvocacy.bsky.social · 10/06/2025Back from Torino where I was able to hear hundreds of smart young ALS investigators from all corners of Europe. (This pic was taken at the very last session on a Friday afternoon. They stayed.) 1/ 131
Reposted by Ammar Al-ChalabiUK MND Research Institute @ukmndri.bsky.social · 05/06/2025Read about our latest findings from the @MNDRegister showcased at the @ENCALS Meeting 2025.🌍 Findings ranged from a new #MND/#ALS incidence and prevalence analysis to clinical characteristics and outcomes. Read more here⬇️ ukmndri.org/2025/06/04/m...ukmndri.orgOur latest findings from the MND Register at ENCALS 2025 - UKMNDRIRead about some of our latest findings from the MND Register that were showcased at the ENCALS Meeting 2025 in Turin, Italy. 033
Reposted by Ammar Al-ChalabiALS Advocacy @alsadvocacy.bsky.social · 30/05/2025source.washu.edu/2025/05/rese...source.washu.eduResearch untangles role of stress granules in neurodegenerative diseaseResearchers at Washington University in St. Louis and St. Jude Children’s Research Hospital have found that biomolecular condensates play a role in suppressing the effects of ALS-causing mutations. 011
Reposted by Ammar Al-ChalabiALS Advocacy @alsadvocacy.bsky.social · 30/05/2025EVERY ALS MND scientific conference needs to allow for those with ALS MND who want to attend to be there in person or virtually. It is simply wrong to exclude them. 162
Reposted by Ammar Al-ChalabiUK MND Research Institute @ukmndri.bsky.social · 29/05/2025We are pleased to announce that the @ucl Queen Square Motor Neuron Disease Centre Sixth Hybrid #ALS/#MND International Symposium in Partnership will be held on Friday 5/9/25. The theme is Translating Targets to Therapies. To register, click below⬇️ www.eventbrite.co.uk/e/ucl-queen-...eventbrite.co.ukUCL Queen Square MND Centre Sixth ALS/MND International SymposiumInternational Conference, in partnership with the UK MND Research Institute, on ALS / MND - TRANSLATING TARGETS TO THERAPIES 035
Reposted by Ammar Al-ChalabiUK MND Research Institute @ukmndri.bsky.social · 28/05/2025This week, we launched our brand new and redesigned website for the @MNDRegister.🗺️ But why is it so important? Find out how this vital resource is helping researchers understand who is affected by #MND/#ALS and why. 📖Read more below. ukmndri.org/2025/05/28/m...ukmndri.orgWhy our MND Register is a vital resource for MND research - UKMNDRIThe new MND Register website helps track MND across the UK and support research into who is affected, how, and why. Visit to learn more. 012
Reposted by Ammar Al-ChalabiArslan Zaidi @aazaidi.bsky.social · 25/05/2025Our paper on the theoretical properties of SNP heritability in admixed populations is out in Genetics: academic.oup.com/genetics/adv... with @jinguohuang.bsky.social, @nicole-kleman.bsky.social , Saonli Basu, and Mark Shriveracademic.oup.comInterpreting SNP heritability in admixed populationsAbstract. SNP heritability (h2snp) is defined as the proportion of phenotypic variance explained by genotyped SNPs and is believed to be a lower bound of h 04023
Reposted by Ammar Al-ChalabiSarah Marzi @sj-marzi.bsky.social · 15/05/2025So lucky to have the best lab. Will miss @kittybmurphy.bsky.social so much 😢❤️ but excited to see her future successes in ancient genome research! 041
Reposted by Ammar Al-ChalabiUK MND Research Institute @ukmndri.bsky.social · 15/05/2025📄The UK MND Clinical Studies Group has released an official statement in response to the MIROCALS study results. Find out what it means for future research into #MND / #ALS 🔗 ukmndri.org/2025/05/15/uk-mnd-clinical-studies-group-issues-statement-on-mirocals-trial-findings/ukmndri.orgUK MND Clinical Studies Group statement on MIROCALS trialThe UK MND Clinical Studies Group has released a statement regarding the MIROCALS clinical trial results, recently published in The Lancet. 031
Ammar Al-Chalabi @ammaralchalabi.bsky.social · 15/05/2025The #MIROCALS study has now been assessed by the UK MND Clinical Studies Group. Their consensus statement can be found here: ukmndri.org/2025/05/15/u... #ALS #MND #clinicaltrials @ukmndri.bsky.social @mndassoc.bsky.social @mndoddie5.bsky.social @mndscotland.bsky.socialukmndri.orgUK MND Clinical Studies Group statement on MIROCALS trialThe UK MND Clinical Studies Group has released a statement regarding the MIROCALS clinical trial results, recently published in The Lancet. 163
Reposted by Ammar Al-ChalabiThe University of Sheffield @sheffielduni.bsky.social · 10/05/2025We may be closer to treating motor neuron disease (or #ALS) thanks to a new clinical trial involving Sheffield University scientists. We've a primer 🧵 from the MIROCALS trial, published in @thelancet.bsky.social, below, or jump to the story on our website 👇 1/5 www.sheffield.ac.uk/news/landmar...sheffield.ac.ukLandmark MIROCALS clinical trial provides new insight into treatment of MNDResults of the landmark MIROCALS clinical trial, involving researchers from the University of Sheffield, have revealed new insights into the treatment of motor neuron disease (MND). 283