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Ammar Al-Chalabi

@ammaralchalabi.bsky.social
777 followers 775 following 37 posts

Professor of Neurology and Complex Disease Genetics, King's College London. Co-Director UK MND Research Institute ukmndri.org #MND #ALS Specialist. Deputy Editor, Brain

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Reposted by Ammar Al-Chalabi
My Name'5 Doddie Foundation @mndoddie5.bsky.social · 27/07/2026
In the first half of 2026 alone, we have committed £1.8 million to four new MND research projects, which will help identify and test promising therapeutic targets and support the development of new treatments for MND. Full details here: www.myname5doddie.co.uk/news-and-sto...
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Reposted by Ammar Al-Chalabi
UK MND Research Institute @ukmndri.bsky.social · 12/03/2026
We're thrilled to announce that the drug RT1999 has been selected for EXPERTS-ALS. This is how we accelerate progress for people with MND. Participants are expected to receive the drug by the end of 2026. ukmndri.org/2026/03/10/n...
ukmndri.org
New MND drug selected for EXPERTS-ALS platform
Raya Therapeutic's smilagenin has been selected for EXPERTS-ALS. Read how this new drug could accelerate the search for MND treatments.
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Reposted by Ammar Al-Chalabi
UK MND Research Institute @ukmndri.bsky.social · 16/02/2026
Industry partners are vital collaborators in our mission to find crucial new treatments for #MND/#ALS. Our co-director, @ammaralchalabi.bsky.social, teamed up with Raya Therapeutics at TRICALS to lead a discussion on Repurposing and Combination Therapies. Read more 👇 ukmndri.org/2025/11/13/r...
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Ammar Al-Chalabi @ammaralchalabi.bsky.social · 04/12/2025
Do you want to know about #ALS #MND genetics? Are you affected directly or indirectly by ALS MND or working as a scientist or clinician in this area? I was honoured to give the Hawking Lecture this year and it's now freely available to view. www.mndassociation.org/professional...
mndassociation.org
Annual Stephen Hawking MND Lecture
The Annual Stephen Hawking MND Lectures were launched 2017 – and are now and established and important part of the Association’s calendar.
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Reposted by Ammar Al-Chalabi
UK MND Research Institute @ukmndri.bsky.social · 03/12/2025
New research reveals what people with #MND/#ALS need when deciding on genetic testing: clear info, implications for family & tailored support.📃 This data can help inform decision aids to assist people when thinking about genetic testing. Read more🔗 ukmndri.org/2025/12/03/g...
ukmndri.org
Genetic Testing: What People Need to Make Informed Decisions
A new study reveals what people with MND need when deciding on genetic testing, including clear information and tailored support.
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Reposted by Ammar Al-Chalabi
Longitude Prize on ALS @longitudeprize.bsky.social · 02/12/2025
🚨 Final Call for the £7.5m (~$10m) Longitude Prize on ALS. Don’t miss your chance to make a real difference for those living with #ALS (the most common form of #MND). Submit your application by 15:00 GMT (10:00 AM EST) tomorrow! Apply here: bit.ly/4nyp6nq
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Reposted by Ammar Al-Chalabi
Longitude Prize on ALS @longitudeprize.bsky.social · 26/11/2025
⏰1 week to go! Entries to the £7.5M (~$10M) Longitude Prize on ALS are closing next week – submit your application before Wednesday 3rd December 2025. Your expertise could make the difference. 🔗Learn more and apply today: bit.ly/4nyp6nq
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Reposted by Ammar Al-Chalabi
Longitude Prize on ALS @longitudeprize.bsky.social · 25/11/2025
@ohenews.bsky.social estimates that eradicating ALS could deliver $143B+ in value over 10 years. The potential global value is huge. #ALS and #MND remain underfunded and breakthroughs are urgently needed. Full report: lnkd.in/e3-DMaiB Learn more about the Prize bit.ly/4nyp6nq
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Longitude Prize on ALS @longitudeprize.bsky.social · 19/11/2025
🚨 Only 2 weeks left to apply! The £7.5M (~$10M) Longitude Prize on ALS is closing soon – submit your application before 3 December 2025 and don’t miss your chance to make a real difference. 🔗 To learn more about the Prize, click here: bit.ly/4nyp6nq
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Ammar Al-Chalabi @ammaralchalabi.bsky.social · 14/11/2025
People with #ALS #MND with respiratory compromise should be offered COVID immunization by their GPs. united2endmnd.org/2025/11/14/c...
united2endmnd.org
Covid-19 Boosters in the UK – Statement
Covid-19 Boosters in the UK – Statement This autumn is the first since the Joint Committee on Vaccination and Immunisation (JCVI) changed its policy on who can receive Covid-19 vaccination bo…
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Reposted by Ammar Al-Chalabi
UK MND Research Institute @ukmndri.bsky.social · 14/11/2025
Drug development is a complex and costly process. By using medicines approved for other conditions, we can overcome barriers in drug development. Read our blog explaining why we believe repurposed drugs could help us find new treatments for #MND/#ALS. ukmndri.org/2025/11/13/r...
ukmndri.org
Repurposed Drugs: Accelerating MND Treatment Discovery
Discover how repurposed drugs are helping accelerate the search for effective treatments for MND through innovative UK research.
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Reposted by Ammar Al-Chalabi
UK MND Research Institute @ukmndri.bsky.social · 13/11/2025
Yesterday, we attended @mndoddie5.bsky.social's Discovery Network Showcase 2025. Researchers, clinicians, industry partners, and people affected by #MND/#ALS discussed how the network can drive forward progress in better understanding MND and the development of new treatments.
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Reposted by Ammar Al-Chalabi
UK MND Research Institute @ukmndri.bsky.social · 05/11/2025
Our Co-Director, Prof. @ammaralchalabi.bsky.social, gave a fantastic talk yesterday, hosted by @mndassoc.bsky.social, on #MND/#ALS genetics, why they matter and how discoveries are shaping new treatments. Thank you to everyone who joined in person & online! #MNDresearch #genetics
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Reposted by Ammar Al-Chalabi
Longitude Prize on ALS @longitudeprize.bsky.social · 21/10/2025
We had the pleasure of catching up with Dr Brian Dickie MBE (@bd365.bsky.social), Chief Scientist at the @mndassoc.bsky.social, the principal funder of the £7.5M Longitude Prize on ALS. 📖 Read the full Q&A here: bit.ly/3KTi1Ap
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Reposted by Ammar Al-Chalabi
Longitude Prize on ALS @longitudeprize.bsky.social · 14/10/2025
Join us at the #ASHG25 Annual Meeting in Boston, starting today! Visit us at Booth 46, we’d love to meet you and discuss how the ~$10M Longitude Prize on ALS is harnessing #AI to transform the future of neurodegenerative disease treatment. @challengeworks.bsky.social @geneticssociety.bsky.social
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Ammar Al-Chalabi @ammaralchalabi.bsky.social · 06/10/2025
We must find an effective treatment for #ALS #MND @ukmndri.bsky.social BBC News - Former England captain Moody reveals MND diagnosis www.bbc.com/sport/rugby-...
bbc.com
Lewis Moody: Former England captain reveals motor neurone disease diagnosis
Former England captain Lewis Moody reveals he has been diagnosed with motor neurone disease in an exclusive BBC interview.
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Reposted by Ammar Al-Chalabi
Longitude Prize on ALS @longitudeprize.bsky.social · 03/10/2025
⏰ 2 months to go until applications close for the £7.5 million Longitude Prize on ALS. You could help transform treatment for neurodegenerative diseases like hashtag #ALS, the most common form of motor neurone disease ( #MND ). Learn more: bit.ly/4mlzSg5
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end-the-legacy.bsky.social @end-the-legacy.bsky.social · 03/10/2025
Connect with us at #NealsMtg ! We are thrilled to be joining the NEALS meeting once again in person this coming week. For anyone impacted by ALS virtual registration is free. Cheers to NEALS for such an open policy. See more at meeting.neals.org . #EndtheLegacy #NEALS
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Ammar Al-Chalabi @ammaralchalabi.bsky.social · 29/08/2025
This is a landmark paper showing a predictive test for #ALS #MND up to 40 years before onset and able to predict age of onset. Huge implications www.nature.com/articles/s41...
nature.com
A plasma proteomics-based candidate biomarker panel predictive of amyotrophic lateral sclerosis - Nature Medicine
Plasma proteomic analysis of presymptomatic individuals with amyotrophic lateral sclerosis identifies novel disease-associated proteins and enables the development of an accurate diagnostic biomarker ...
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Longitude Prize on ALS @longitudeprize.bsky.social · 12/08/2025
🌍 Be part of the global effort to tackle #ALS. The £7.5m (~$10m) #LongitudePrizeOnALS is searching for innovators in #AI, #data, #biotech, and #neurology. 🧠 Meet the teams already registered, and find out how you can partner with them below. 🔗https://bit.ly/4mdHxxX
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Reposted by Ammar Al-Chalabi
Longitude Prize on ALS @longitudeprize.bsky.social · 05/08/2025
🧠 The @ukmndri.bsky.social is an #MND powerhouse, accelerating progress towards new treatments and, ultimately, a cure. Read their article about how the #LongitudePrizeOnALS could be a game-changer for drug discovery in neurodegenerative diseases. 🔗 bit.ly/40Tmmsh @ammaralchalabi.bsky.social
ukmndri.org
Longitude Prize launched to accelerate AI-driven drug discovery
A new international challenge prize has been launched to transform drug discovery for ALS, the most common form of MND through AI.
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Reposted by Ammar Al-Chalabi
Dementia Researcher @dementiaresearcher.bsky.social · 23/07/2025
Postdoc Research Assistant in Dr Arpan Mehta’s lab at University of Dundee, using CRISPR screens in iPSC-derived motor neurons to study ALS mechanisms. Closing date: 4th August www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
dementiaresearcher.nihr.ac.uk
Postdoc Research Assistant: Investigating C9ORF72
Postdoc Research Assistant in Dr Arpan Mehta’s lab at University of Dundee, using CRISPR screens in iPSC-derived motor neurons to study ALS mechanisms.
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Reposted by Ammar Al-Chalabi
Longitude Prize on ALS @longitudeprize.bsky.social · 22/07/2025
“MND is one of the most scientifically and biologically challenging diseases to tackle. That said, no mountain is insurmountable…” Dr. Mike Rogers (@mndassoc.bsky.social) shares why the #LongitudePrizeOnALS is key to creating new opportunities for #ALS & #MND 📰 longevity.technology/news/climbin...
longevity.technology
Climbing the ALS mountain
Mike Rogers, MND Association Director of Research and Innovation, looks at how data and AI could unlock new treatments.
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Reposted by Ammar Al-Chalabi
Scott McGrath @smcgrath.phd · 19/07/2025
Tagging 🧪 🧬🖥️
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Reposted by Ammar Al-Chalabi
UK MND Research Institute @ukmndri.bsky.social · 16/07/2025
New research has examined how disrupted sleep patterns may signal the early stages of #MND / #ALS or FTD, providing clues to earlier detection. Read more ⬇️ 🔗 ukmndri.org/2025/07/16/r... This post is part of our Research Snapshot series, powered by Readable Research at @sheffielduni.bsky.social
ukmndri.org
Could sleep changes signal the early stages of MND or FTD?
Research has found that disrupted sleep may offer some clues to possible early warning signs of the ALS or FTD.
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Reposted by Ammar Al-Chalabi
STITCHES Medicine - the Best of Medical Research @medicine.stitches.today · 09/07/2025
Researchers reveal that structural variants disrupting the 3D genome can drive diseases like cancer by altering gene expression. by Sreenivasan VKA, Yumiceba V and Spielmann M in Nat Rev Genet #MedSky 👉 get more here 📖 read the article:
nature.com
Structural variants in the 3D genome as drivers of disease - Nature Reviews Genetics
Disruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical consequences of position effects arising from disruptions to the genome architecture.
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Reposted by Ammar Al-Chalabi
Longitude Prize on ALS @longitudeprize.bsky.social · 08/07/2025
⏰ Reminder: Our first Welcome Webinar is tomorrow, Tuesday 9th of July at 09:00 BST. 💻 Register below to learn everything you need to know about the #LongitudePrizeOnALS, including how to apply, how the Prize works, and what support is available.
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Dementia Researcher @dementiaresearcher.bsky.social · 06/07/2025
Research Fellow vacancy at UCL MND Centre. Join Prof Andrea Malaspina’s team to study immune responses and neoantigens in ALS using proteomics and cell phenotyping. Closing date: 20th July www.dementiaresearcher.nihr.ac.uk/job/research...
dementiaresearcher.nihr.ac.uk
Research Fellow: Glial-immune crosstalk and sporadic ALS
Research Fellow vacancy at UCL MND Centre. Join Prof Andrea Malaspina’s team to study immune responses & neoantigens in ALS using proteomics & cell phenotyping
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Reposted by Ammar Al-Chalabi
Longitude Prize on ALS @longitudeprize.bsky.social · 03/07/2025
🧠 As the principal funder, the @mndassoc.bsky.social has been instrumental in bringing the #LongitudePrizeOnALS to life. We were joined by Dr Usman Khan last week, who spoke on the power of cross-specialism collaboration. Learn more about the Prize: bit.ly/4kD3tSh #AIforGood #MND #ALS
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Longitude Prize on ALS @longitudeprize.bsky.social · 02/07/2025
Want to learn more about the £7.5M #LongitudePrizeOnALS? Join one of our welcome webinars to find out how the Prize works and how to get involved. Register here: 📅 9 July, 09:00 BST: bit.ly/4nzJuWA 📅 10 July, 17:00 BST: bit.ly/3Tl4u5u #AIForGood #MND #ALS
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Longitude Prize on ALS @longitudeprize.bsky.social · 30/06/2025
Check out this article from Dr Brian Dickie (@mndassoc.bsky.social), exploring how #AI and quality data can transform treatment progress—and how the £7.5M #LongitudePrizeonALS aims to support #innovation through global collaboration. 🧠 Read here: bit.ly/4nqi4lN #ALS #MND
bit.ly
Motor neurone disease affects one in 300, but hope for treatment is growing
One in 300 of us will develop motor neurone disease in our lifetime. It is a hideous disease that robs a person of their dignity and eventually their life.
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Dementia Researcher @dementiaresearcher.bsky.social · 30/06/2025
Apply now for the NIHR Senior Investigator award! £15K per year for 4 years to support top researchers shaping the future of health and social care in the UK. @nihr.bsky.social www.dementiaresearcher.nihr.ac.uk/funding/nihr...
dementiaresearcher.nihr.ac.uk
NIHR Senior Investigators Award - DEMENTIA RESEARCHER
Apply for the NIHR Senior Investigator award: £15K per year for 4 years to support leading applied research and shape the future of health and social care.
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Longitude Prize on ALS @longitudeprize.bsky.social · 27/06/2025
What a week for the #LongitudePrizeOnALS 🧠 Thank you to everyone who made it possible! 🎥 Watch the segment on BBC News here: bit.ly/4eoGyaR This is just the beginning. Entries close 3 Dec → Learn more on our website: bit.ly/4kD3tSh @trisdyson.bsky.social @ammaralchalabi.bsky.social #AIforGood
linkedin.com
What an incredible week! | Longitude Prize on ALS
What an incredible week! Thank you to everyone who helped make the launch of the #LongitudePrizeOnALS such a success — from the inspiring voices on stage, to the teams that made this Prize possible, ...
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Dementia Researcher @dementiaresearcher.bsky.social · 21/06/2025
Join Dr Arpan Mehta's lab at MRC PPU, Dundee, for a 12-month postdoc using CRISPR screens to explore ALS in iPSC-derived motor neurons. Closing date: 18th July www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
dementiaresearcher.nihr.ac.uk
Postdoc Research Assistant: Mechanisms of the C9ORF72
Join Dr Arpan Mehta's lab at MRC PPU, University of Dundee, for a 12-month postdoc using CRISPR screens to explore ALS in iPSC-derived motor neurons.
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UK MND Research Institute @ukmndri.bsky.social · 21/06/2025
Today is #MNDAwarenessDay, a moment to highlight the hidden realities of living with #MND. Our translational research projects aim to find treatments for MND through a national, coordinated approach. 👉 Discover more: ukmndri.org/2025/06/20/f...
ukmndri.org
How our translational research will find new treatments for MND
On MND Awareness Day, we’re spotlighting the projects accelerating real progress and explaining why translational research is key.
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King's College London @kingscollegelondon.bsky.social · 14/06/2025
Professor Sir Simon Wessely is a world-renowned academic psychiatrist and epidemiologist and has been awarded this GBE in recognition of his distinguished position as 'the pre-eminent psychiatrist of his generation in the UK.' ⬇️ www.kcl.ac.uk/news/profess...
kcl.ac.uk
Professor Sir Simon Wessely awarded Knight Grand Cross of the Order of the British Empire (GBE) in King's Birthday Honours
Sir Simon Wessely, Professor of Psychological Medicine at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has been awarded the honour for services to mental hea...
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King's College London @kingscollegelondon.bsky.social · 14/06/2025
We are delighted to announce that Professor Sir Simon Wessely has been awarded a Knight Grand Cross of the Order of the British Empire (GBE) in this year's King’s 2025 Birthday Honours. 🎉 🧵⬇️ @kingsioppn.bsky.social
A dark blue quote card with King's logo and photo of Sir Simon. The quote reads: Being the first psychiatrist to receive this honour shows just how far mental health in general, and psychiatry in particular, has advanced since I started my psychiatry training at the Maudsley Hospital back in 1984. I was fortunate to then move to the Institute of Psychiatry in 1991, where I have been ever since. Whatever I have achieved since then would never have been possible without the support of both what is now the IoPPN and the wider King’s College London. But the most important thing of all has been the privilege to work with such generous, talented and extraordinary colleagues over all these years. My thanks to each and every one of you.”
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Dementia Researcher @dementiaresearcher.bsky.social · 13/06/2025
Join a leading dementia research team as a Clinical Research Fellow at UCL. Work on trials for novel Alzheimer’s and FTD therapies. Closing date: 2nd July www.dementiaresearcher.nihr.ac.uk/job/clinical...
dementiaresearcher.nihr.ac.uk
Clinical Research Fellow: Dementia Clinical Trials
Join a leading dementia research team as a Clinical Research Fellow at UCL. Work on trials for novel Alzheimer’s and FTD therapies.
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ALS Advocacy @alsadvocacy.bsky.social · 10/06/2025
Back from Torino where I was able to hear hundreds of smart young ALS investigators from all corners of Europe. (This pic was taken at the very last session on a Friday afternoon. They stayed.) 1/
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ALS Advocacy @alsadvocacy.bsky.social · 06/06/2025
Day 3
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UK MND Research Institute @ukmndri.bsky.social · 05/06/2025
Read about our latest findings from the @MNDRegister showcased at the @ENCALS Meeting 2025.🌍 Findings ranged from a new #MND/#ALS incidence and prevalence analysis to clinical characteristics and outcomes. Read more here⬇️ ukmndri.org/2025/06/04/m...
ukmndri.org
Our latest findings from the MND Register at ENCALS 2025 - UKMNDRI
Read about some of our latest findings from the MND Register that were showcased at the ENCALS Meeting 2025 in Turin, Italy.
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ALS Advocacy @alsadvocacy.bsky.social · 30/05/2025
source.washu.edu/2025/05/rese...
source.washu.edu
Research untangles role of stress granules in neurodegenerative disease
Researchers at Washington University in St. Louis and St. Jude Children’s Research Hospital have found that biomolecular condensates play a role in suppressing the effects of ALS-causing mutations.
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ALS Advocacy @alsadvocacy.bsky.social · 30/05/2025
EVERY ALS MND scientific conference needs to allow for those with ALS MND who want to attend to be there in person or virtually. It is simply wrong to exclude them.
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UK MND Research Institute @ukmndri.bsky.social · 29/05/2025
We are pleased to announce that the @ucl Queen Square Motor Neuron Disease Centre Sixth Hybrid #ALS/#MND International Symposium in Partnership will be held on Friday 5/9/25. The theme is Translating Targets to Therapies. To register, click below⬇️ www.eventbrite.co.uk/e/ucl-queen-...
eventbrite.co.uk
UCL Queen Square MND Centre Sixth ALS/MND International Symposium
International Conference, in partnership with the UK MND Research Institute, on ALS / MND - TRANSLATING TARGETS TO THERAPIES
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UK MND Research Institute @ukmndri.bsky.social · 28/05/2025
This week, we launched our brand new and redesigned website for the @MNDRegister.🗺️ But why is it so important? Find out how this vital resource is helping researchers understand who is affected by #MND/#ALS and why. 📖Read more below. ukmndri.org/2025/05/28/m...
ukmndri.org
Why our MND Register is a vital resource for MND research - UKMNDRI
The new MND Register website helps track MND across the UK and support research into who is affected, how, and why. Visit to learn more.
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Arslan Zaidi @aazaidi.bsky.social · 25/05/2025
Our paper on the theoretical properties of SNP heritability in admixed populations is out in Genetics: academic.oup.com/genetics/adv... with @jinguohuang.bsky.social, @nicole-kleman.bsky.social , Saonli Basu, and Mark Shriver
academic.oup.com
Interpreting SNP heritability in admixed populations
Abstract. SNP heritability (h2snp) is defined as the proportion of phenotypic variance explained by genotyped SNPs and is believed to be a lower bound of h
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Sarah Marzi @sj-marzi.bsky.social · 15/05/2025
So lucky to have the best lab. Will miss @kittybmurphy.bsky.social so much 😢❤️ but excited to see her future successes in ancient genome research!
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UK MND Research Institute @ukmndri.bsky.social · 15/05/2025
📄The UK MND Clinical Studies Group has released an official statement in response to the MIROCALS study results. Find out what it means for future research into #MND / #ALS 🔗 ukmndri.org/2025/05/15/uk-mnd-clinical-studies-group-issues-statement-on-mirocals-trial-findings/
ukmndri.org
UK MND Clinical Studies Group statement on MIROCALS trial
The UK MND Clinical Studies Group has released a statement regarding the MIROCALS clinical trial results, recently published in The Lancet.
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Ammar Al-Chalabi @ammaralchalabi.bsky.social · 15/05/2025
The #MIROCALS study has now been assessed by the UK MND Clinical Studies Group. Their consensus statement can be found here: ukmndri.org/2025/05/15/u... #ALS #MND #clinicaltrials @ukmndri.bsky.social @mndassoc.bsky.social @mndoddie5.bsky.social @mndscotland.bsky.social
ukmndri.org
UK MND Clinical Studies Group statement on MIROCALS trial
The UK MND Clinical Studies Group has released a statement regarding the MIROCALS clinical trial results, recently published in The Lancet.
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The University of Sheffield @sheffielduni.bsky.social · 10/05/2025
We may be closer to treating motor neuron disease (or #ALS) thanks to a new clinical trial involving Sheffield University scientists. We've a primer 🧵 from the MIROCALS trial, published in @thelancet.bsky.social, below, or jump to the story on our website 👇 1/5 www.sheffield.ac.uk/news/landmar...
sheffield.ac.uk
Landmark MIROCALS clinical trial provides new insight into treatment of MND
Results of the landmark MIROCALS clinical trial, involving researchers from the University of Sheffield, have revealed new insights into the treatment of motor neuron disease (MND).
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