'Protect the NHS' and 'Save Lives' by continuing to fund NHS COVID boosters for Clinically Vulnerable people, including most previously shielded as CEV, rather than limiting them to over-75s, care hom...

I hope the slightly provocative little title caught your eye. This is my latest post in my The Devil is the Detail series. I try to sketch out the landscape of drug repurposing in our disease. My a…

Discover the cutting-edge research latest breakthroughs we fund to advance the knowledge and treatment of Motor Neurone Disease (MND)

Researchers across the country are carrying out world-leading MND research in a coordinated way to accelerate the search for a cure.

A new study has explored how toxic proteins build up in the nervous system and whether future treatments might help stop them.

EXPERTS-ALS Accelerating MND Drug Development You may have seen the recent news from the UK MND Research Institute announcing that one of its first projects, EXPERTS-ALS, funded by the NIHR from th…

Why this statement? As neurologists specialising in the care of people living with motor neuron disease, we are receiving increasing enquiries about a drug called ellorarxine. Many of our patients are...

Why this statement? As neurologists specialising in the care of people living with motor neuron disease, we are receiving increasing enquiries about a drug called ellorarxine. Many of our patients are...

Patients and palliative care experts have debated what the assisted dying bill could mean for them.

In amyotrophic lateral sclerosis, sleep defects occur in patients, risk gene carriers, and mouse models in which they are rescued preclinically by an orexin antagonist.

EXPERTS-ALS is a ground-breaking initiative to accelerate the development of new treatments for amyotrophic lateral sclerosis (ALS). We’re excited to showcase one of our flagship projects, the EXPErim...

Terminally Ill Adults (End of Life) Bill

Dr. Alfredo Iacoangeli has been awarded the prestigious Paulo Gontijo Award, recognising his vital contributions to MND research. We are delighted to announce that Dr Alfredo Iacoangeli was awarded t...

While some agree with Robert F. Kennedy Jr. that the agency needs reform, their ideas for fixing it are very different from his.

This page unites my special research posts on the subject of that “Devil detail”. You all know the sort of thing? Your immediate reaction to a subject, or proposition, is perhaps is not always the …

Supporting Doddie Weir in his quest to further research into more effective MND treatments

There is a long history of ALS therapies being promoted on the basis of Phase 2 data, which then fail to translate into meaningful benefits in Phase 3 tria

There is a long history of ALS therapies being promoted on the basis of Phase 2 data, which then fail to translate into meaningful benefits in Phase 3 tria

There is a long history of ALS therapies being promoted on the basis of Phase 2 data, which then fail to translate into meaningful benefits in Phase 3 tria

Our researchers have launched a new digital platform to improve access to research for people living with MND and accelerate the search for a cure. Our researchers, based at the University of Sheffie...

Opinion: The U.S. has a major problem with chronic illness. But RFK Jr. and Dr. Oz won’t be able to make much of a difference.