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During latent pulmonary cryptococcal infection, Zheng et al. show that TH2-driven STAT6 signaling in monocyte-derived myeloid cells suppresses extracellula

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Nature Communications - Fungal spores can promote immune responses of both type 2 (IL-4 / IL-5 / IL-13) and type 17 (IL-17). Here the authors characterise the subsets of cDC2 associated with type 2...

Many hairy mammals perform rapid oscillations of their body, called wet dog shakes, to remove water and irritants from their back hairy skin. The somatosensory mechanisms that underlie this behavior are unclear. We report that Piezo2-dependent ...

Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.

The underlying mechanisms used by the intestinal microbiota to shape disease outcomes of the host are poorly understood. Here, we show that the gut co…

Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.

Zheng et al. show that acute liver failure leads to ferroptosis-mediated pancreatic damage accompanied by β-hydroxybutyrate reduction. β-hydroxybutyrate inhibits ferroptosis in pancreatic cell lines a...