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Etwa 7 Millionen Menschen haben Typ-2-Diabetes. Jedes Jahr kommen 500.000 Menschen dazu. Die Zahlen im Überblick.

Enteroviruses (EVs), such as Coxsackievirus B5 (CVB5), are linked to pancreatic beta cell autoimmunity in type 1 diabetes (T1D). CVB5 infection of beta cells blocks their cap-dependent translation but...

Type 1 diabetes is an autoimmune disease characterised by the destruction of pancreatic beta cells, resulting in lifelong insulin dependence. Although exogenous insulin can maintain glycaemic control, this approach does not protect residual or replacement pancreatic beta cells from immune-mediated death. Current therapeutics designed to protect functional beta cell mass or promote beta cell proliferation and regeneration can have off-target effects, resulting in higher dose requirements and adverse side effects. Targeted drug delivery using nanocarriers has demonstrated potential for overcoming these limitations. The critical bottleneck limiting the development of beta cell-targeted therapies is a lack of highly specific beta cell markers. This review provides an overview of the use of nanocarriers for cell-targeted delivery and the current state of the field of beta cell targeting. Technologies such as systematic evolution of ligands by exponential enrichment (SELEX) aptamer selection, phage display screening, and omics datasets from human samples are highlighted as tools to identify novel beta cell-specific targets that can be combined with nanocarriers for targeted delivery of therapeutics. Ultimately, beta cell-targeted therapies using nanocarriers present a unique opportunity to develop tailored treatments for each stage of type 1 diabetes with the goal of providing individuals with treatment options that prevent further progression or reverse the course of the disease. Graphical Abstract

𝗙𝗶𝗻𝗮𝗹 𝗗𝗶𝗮𝗯𝗲𝘁𝗲𝘀 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗦𝗲𝗺𝗶𝗻𝗮𝗿 𝗼𝗳 𝟮𝟬𝟮𝟰!🎉 This is going to be the last chance for this year to listen to one of our experts…

The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.

𝗝𝗼𝗶𝗻 𝘂𝘀 𝗳𝗼𝗿 𝗮𝗻 𝗲𝘅𝗰𝗶𝘁𝗶𝗻𝗴 𝘀𝗲𝗺𝗶𝗻𝗮𝗿 𝗼𝗻 𝘀𝗶𝗻𝗴𝗹𝗲-𝗰𝗲𝗹𝗹 𝗮𝗻𝗱 𝘀𝗽𝗮𝘁𝗶𝗮𝗹 𝗽𝗿𝗼𝘁𝗲𝗼𝗺𝗶𝗰𝘀! On November 26 at 3pm, we'll…