Reposted by Rupa Immanuel
New preprint from the lab! 🧫
Many anti-TB drugs work in some conditions but not others—and we rarely know why. We set out to solve this for a promising new class of drugs, Rv1625c agonists, that kill Mycobacterium tuberculosis inside macrophages and on cholesterol.
www.biorxiv.org/content/10.6...
biorxiv.org
An adenylyl cyclase switch reroutes carbon from growth to virulence lipids in Mycobacterium tuberculosis
Anti-TB drugs act non-uniformly on Mycobacterium tuberculosis (Mtb) because of its distinct physiological states across diverse infection niches shaped by host-derived nutrients and stresses. Agonists...
