The control of gene expression is central to cellular physiology and to various biotechnological applications. In higher eukaryotes, synthesis of most messenger RNAs involves removal of introns during...

Nature Reviews Genetics, Published online: 07 September 2026; doi:10.1038/s41576-026-01002-9The programmable insertion of large DNA sequences could overcome fundamental limitations of current genome-editing technologies. In this Review, Lampe, King and Sternberg describe recent advances in recombinases, retrotransposons and CRISPR-associated transposases, and discuss how these systems are enabling mutation-agnostic genome modification.

Fang, Ren, Zheng, Wang et al. developed Lantern, a variant of miniSOG, through directed evolution for subcellular transcriptomes and proteomes analyses inside living cells, enabling findings that RNA ...

Lin et al. developed an in vivo CRISPRi screening platform to map gene function directly in the mouse brain. Their genome-wide survey across neuronal types and ages reveals cell-type-specific and age-dependent vulnerabilities that are invisible to cell-based models, offering a functional view of the brain beyond gene expression atlases.

R programming foundations for bioinformatics, data science, and data visualization - cxli233/Section-301-R-Programming-Intro

From fun science enamel pins and patches to colorful zines explaining scientific concepts, we like to explore a multitude of science communication avenues and make them worth coveting!

Nature - Jaw-dropping patient videos and miraculous testimonials ignited a frenzy in China over a technique that aims to improve drainage from the brain. Now it is entering trials worldwide.

Mutations found in Colombian families raised hopes for treatments. Altered patient data and suspect images call their benefits into question

Mutations found in Colombian families raised hopes for treatments. Altered patient data and suspect images call their benefits into question

Mitochondrial dysfunction features prominently in tauopathies. The mechanistic link between tau and mitochondria remains uncertain. Li et al. show that tau enters mitochondria and interacts with complex I subunit NDUFS3 to promote reverse electron transport (RET) in Drosophila, mouse, and human iPSC models of tauopathies. Inhibition of RET offers neuroprotection.

The developing human cortex is composed of diverse cell types, but how nutrient metabolism shapes their fate has remained unclear. This study maps the metabolic landscape of the developing human cortex and identifies glycolysis and pentose phosphate pathway activity as key regulators of radial glia fate, controlling the generation of outer radial glia and inhibitory neurons.

Lysosomal dysfunction is a well-recognized feature of aging. Here, we used a suite of tools for rapid lysosomal isolation to construct a multitissue atlas of the metabolite changes lysosomes undergo d...

The coronavirus crisis is overwhelming New York’s system for burying the dead.

Protein domains: structure, classification, and evolution - An introductory tutorial for protein domains

Communiqué de la Maison générale : La Fraternité dépose un recours contre le décret du 2 juillet 2026