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The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social

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We start with Carmen Herranz-Ors from @sangerinstitute.bsky.social giving us an overview of the impressive work done to generate Tumour Organoid Biobank and develop a 3D Dependency Map @eurocancerdepmap.bsky.social

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Dr Lizzie Coker @lizziecoker.bsky.social · 20/11/2025

Now @alejandrapcelab.bsky.social is taking us through the multidimensional map of early adaptation to treatment and how targeting cell plasticity can prevent childhood cancer relapse @eurocancerdepmap.bsky.social

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First session of the @eurocancerdepmap.bsky.social symposium and so much fantastic work presented already! #CancerResearch #TranslationalScience #plasticity

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2nd European Cancer Dependency Map Symposium @eurocancerdepmap.bsky.social · 20/11/2025

To wrap up the second session, Roland Rad from the Institute of Molecular Oncology and Functional Genomics is sharing their work on mapping genetic interactions in cancer evolution and therapy @eurocancerdepmap.bsky.social

Roland Rad gives the final talk of the second session of the 2nd European Cancer Dependency Map Symposium

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2nd European Cancer Dependency Map Symposium @eurocancerdepmap.bsky.social · 20/11/2025

We continue with the talk from @icrlordlab.bsky.social focusing on the complexity of synthetic lethality in cancer and how we can move forward in exploiting it @eurocancerdepmap.bsky.social

Talk by Chris Lord at the 2nd European Cancer Dependency Map Symposium

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2nd European Cancer Dependency Map Symposium @eurocancerdepmap.bsky.social · 20/11/2025

The Synthetic Lethality and Innovations in CRISPR Screening session begins with @manuelkaulich.bsky.social telling us about exciting CRISPR libraries they have developed and how nuclear mRNA processing can mask the CRISPRko phenotypes @eurocancerdepmap.bsky.social

Start of the second session of the 2nd EuroCancerDepMap symposium with a talk from Manuel Kaulich

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IorioLab @ioriolab.bsky.social · 19/11/2025

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Delighted to host Traver Hart (MD Anderson Cancer Center), who delivered an engaging seminar on synthetic lethality at #HumanTechnopole. He showed how bridging #CRISPR and predictive modeling can advance design and interpretation of genetic interaction screens and inform new therapeutic strategies.

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Kudos to Nevenka Radic for winning the best poster award! Very well deserved 🎉

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Francesco Iorio’s invited talk highlights how we integrate clinically relevant mutational profiles with CRISPR functional genomics data to uncover vulnerabilities associated with mutations currently considered non-actionable, expanding potential therapeutic opportunities.

Vanessa Spagnolo presents how we dissect cancer dependencies using CRISPR functional genomics, and how we are applying these approaches across multiple projects in our lab to identify new therapeutic vulnerabilities.

Nevenka Radic is showcasing our work charting the genetic dependencies of drug-resistant cancer cells. By identifying context-specific vulnerabilities, we aim to inform the rational design of combinatorial treatments to advancing precision oncology.

The Iorio Lab is at the 37th AICC International Meeting in Florence this week. With our Francesco Iorio presenting as an invited speaker, Nevenka Radic with a flash talk and Vanessa Spagnolo with a poster. Excited to share our latest results and connect with colleagues in the field.

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Kudos to Nevenka Radic for winning the best poster award! Very well deserved 🎉

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IorioLab @ioriolab.bsky.social · 23/10/2025

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Kudos to our Flavio Passante for winning with his team the REMEDi4ALL Hackathon in Barcellona! Researchers from 10 countries tackled real-world challenges in drug repurposing for rare neurodevelopmental disorders, spanning the whole pipeline from early target discovery to market access.

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IorioLab @ioriolab.bsky.social · 22/10/2025

A big Thanks is obviously also adressed to the thesis commitee composed of Maximilian Billmann (University of Bonn, Germany) and Jose Davila-Velderrain (Human Technopole, Italy)