iiinova — where your digital self keeps evolving

The monoclonal antibody VYD2311 is in clinical trials for preventing COVID-19. In this Research Letter, @ianmellis.bsky.social et al. report that a laboratory-synthesized version of it inhibits many SARS-CoV-2 variants in laboratory-based infection models: doi.org/10.1172/jci....

111

JCI insight @insight.jci.org · 05/10/2026

A finding in mice suggests a new target for severe COVID-19: doi.org/10.1172/jci.... Eltobgy et al. discover that blocking the inflammatory protein caspase-11 restores virus-fighting T cells and improves viral clearance in mice.

020

JCI insight @insight.jci.org · 04/10/2026

Weekend read💫 : Immune cells ring the alarm! doi.org/10.1172/jci.... Hongji Zhang use a multiomic approach to investigate the drivers of surgical stress in the liver. They identify a neutrophil-Kupffer cell communication axis with potential for reducing inflammation and liver damage.

020

JCI insight @insight.jci.org · 03/10/2026

Featured on the Cover: IFNG-producing self-reactive CD4+ T cells induce autoimmune adrenalitis in a mouse model of Addison’s disease: doi.org/10.1172/jci....

000

JCI insight @insight.jci.org · 03/10/2026

Saturday Spotlight💫: Presenting the first mouse model of Addison’s disease: doi.org/10.1172/jci.... Andreyeva et al. report on how immune cells destroy the adrenal glands in Addison's disease and identify IFNG as a promising target for future therapies.

100

JCI insight @insight.jci.org · 02/10/2026

Behind the paper: Dr. Toyohara and Dr. Oikawa are discuss the extracellular flux analysis experiment (1/3) and future research plans (2/3), while Dr. Kuranaga and Ms. Yuhan Luo consider Drosophila experiments (3/3).

100

JCI insight @insight.jci.org · 02/10/2026

This video shows the restoration of mitochondrial motility in ALS iPS-derived motor neurons. Oikawa et al. report the MA-5 improves mitochondrial function and ameliorates ALS phenotypes in Drosophila, patient-derived fibroblasts, and iPSC-derived motor neurons: doi.org/10.1172/jci....

100

JCI insight @insight.jci.org · 01/10/2026

Therapeutic approaches for polycystic kidney disease (PKD) have largely been focused on eliminating cysts. Remadevi et al. demonstrate that fibrosis is a promising therapeutic target for PKD that can reduce kidney scarring and preserve kidney function. doi.org/10.1172/jci....

021

JCI insight @insight.jci.org · 30/09/2026

Immune cells ring the alarm! doi.org/10.1172/jci.... Zhang et al. use a multiomic approach to reveal how immune cells communicate to other hepatic cells after liver surgery and identify a potential target to reduce inflammation and liver damage.

000

JCI insight @insight.jci.org · 29/09/2026

The immediate effects of vaping have long-term consequences 🚬 doi.org/10.1172/jci.... Irina Petrache & team show that short-term e-cigarette use damages lung cells, impairs repair, and weakens antiviral defenses, raising concerns about long-term health risks.

000

JCI insight @insight.jci.org · 28/09/2026

Blood-clotting complications in pediatric pneumonia infection can be life threatening. Huang et al. discover neutrophils promote thrombosis in pneumonia caused by Mycoplasma pneumoniae via NET-mediated endothelial activation involving TLR2 and JAK–STAT3 signaling: doi.org/10.1172/jci....

162

JCI insight @insight.jci.org · 27/09/2026

ICYMI💫: The GI symptoms that impair quality of life in childhood neurodegenerative disorders may be because bowel enteric neurons are also affected. In this Research Letter, Ziółkowska et al. characterize enteric pathology in MPSIIIA mice: doi.org/10.1172/jci.... @pattidickson.bsky.social

010

JCI insight @insight.jci.org · 26/09/2026

This Week in Research💫: Combination treatment offers a promising therapeutic approach for prostate tumors exhibiting lineage plasticity. Storck et al. report combined BET bromodomain & DNMT inhibition targets critical survival pathways in transdifferentiated prostate cancer: doi.org/10.1172/jci....

000

JCI insight @insight.jci.org · 25/09/2026

This study marks an important step toward future clinical use of a urinary factor as a biomarker of recovery in acute interstitial nephritis: doi.org/10.1172/jci.... Qian et al. report urine Leukemia Inhibitory Factor (LIF) predicts kidney function recovery in patients with AIN

020

JCI insight @insight.jci.org · 24/09/2026

Behind the scenes: First author Hu Yuqing at the microscope (images 3 & 4 of 5) and corresponding author Ye Lincai with co-first author Xue Yiting also at the scope (5/5)!

000

JCI insight @insight.jci.org · 24/09/2026

Unveiling a signaling pathway with implications for pediatric cardiovascular diseases associated with right ventricular pressure overload: doi.org/10.1172/jci.... Hu et al. show that RVPO impairs cardiomyocyte maturation via the MEF2D/BIN1 axis & restoring BIN1 rescues the defect

100

JCI insight @insight.jci.org · 23/09/2026

Combination treatment offers a promising therapeutic approach for prostate tumors exhibiting lineage plasticity: doi.org/10.1172/jci.... Storck et al. report Combined BET bromodomain and DNMT inhibition targets critical survival pathways in transdifferentiated prostate cancer.

010

JCI insight @insight.jci.org · 22/09/2026

Presenting the first mouse model of Addison’s disease: doi.org/10.1172/jci.... This issue’s Cover features work from Andreyeva et al., reporting on how immune cells destroy the adrenal glands in Addison's disease and identifying IFNG as a promising target for future therapies.

110

JCI insight @insight.jci.org · 21/09/2026

Adding a new perspective to STAT3 gain-of-function variants: doi.org/10.1172/jci.... Henrickson & team discover STAT3 GOF drives CD8+ T cell dysfunction, in part through a dysregulated purinergic axis, which is partially restored by targeted JAK inhibitor therapy.

030

JCI insight @insight.jci.org · 21/09/2026

Neonates have increased susceptibility to bacterial sepsis Here, Annamanedi et al. study murine neonatal sepsis induced by E. coli. and offer IL-27 neutralization as a new treatment strategy: doi.org/10.1172/jci....

111

JCI insight @insight.jci.org · 21/09/2026

Shamseldin et al. discover Bordetella pertussis T-cell antigens that, in an experimental subunit vaccine, induced protective T cell responses and reduced respiratory bacterial burden in mice: doi.org/10.1172/jci....

123

JCI insight @insight.jci.org · 20/09/2026

Sunday Spotlight💫: This review by Haikuo Li @haikuoli.bsky.social & colleagues aims to equip researchers with an understanding of the current technological landscape and to accelerate the adoption of spatial multiomics methods in biomedical research: doi.org/10.1172/jci....

020

JCI insight @insight.jci.org · 19/09/2026

Reader's Pick: Our most-accessed article in the past 30 days💫 : Apelin analog treatment reverses severe pulmonary arterial hypertension and right ventricular heart failure from Vu et al.: doi.org/10.1172/jci....

064

JCI insight @insight.jci.org · 18/09/2026

A new urine test may help doctors diagnose cystinosis earlier, potentially improving care for children with this rare kidney disease. doi.org/10.1172/jci..... Greenberg et al .provide a proof-of-concept study on the use of urine YKL-40 as a biomarker.

044

JCI insight @insight.jci.org · 17/09/2026

Transcriptional profiling of autoimmune myositis model recapitulates human immune signatures. doi.org/10.1172/jci..... Li et al. reveal a population of resident memory T cells in a murine HRS-induced myositis model that is also seen in patients. @SLG1717.bsky.social

011

JCI insight @insight.jci.org · 16/09/2026

This year’s theme for #PeerReviewWeek is Peer Review Capacity: Volume, Speed, and Quality. In today's changing publishing landscape, we commend our reviewers for meeting the demands, maintaining the highest standards, and staying true to the peer review process. Thank you Reviewers! #PRW #PRW2026

010

JCI insight @insight.jci.org · 16/09/2026

Miller et al. developed a single-cell atlas of polycystic kidney disease that integrates multiple disease models: doi.org/10.1172/jci.... The atlas identified the involvement of osteopontin across models and in human patients. The atlas: bmblx.bmi.osumc.edu/scPKD/ @daniyaljafree.bsky.social

011

JCI insight @insight.jci.org · 15/09/2026

The gastrointestinal symptoms that impair quality of life in childhood neurodegenerative disorders may be because bowel enteric neurons are also affected. In this Research Letter, Ziółkowska et al. characterize enteric pathology in MPSIIIA mice: doi.org/10.1172/jci.... @pattidickson.bsky.social

001

JCI insight @insight.jci.org · 14/09/2026

This review by Haikuo Li @haikuoli.bsky.social & colleagues aims to equip researchers with an understanding of the current technological landscape and to accelerate the adoption of spatial multiomics methods in biomedical research: doi.org/10.1172/jci....

000

JCI insight @insight.jci.org · 14/09/2026

Suggesting a novel therapy for systemic sclerosis: doi.org/10.1172/jci.... @eduardomarban.bsky.social & team report that an orally delivered noncoding RNA (TY1) reduces inflammation and organ fibrosis in models of systemic sclerosis through inhibition of the cGAS/STING axis. @the-asci.org

022

JCI insight @insight.jci.org · 13/09/2026

Weekend read💫 : Genes & environment influence the development of asthma. Here, Otoshi et al., investigate how genetic background & retinoid micronutrient perturbations affect lung developmental programs associated with airway hyperresponsiveness in mice: doi.org/10.1172/jci....

000

JCI insight @insight.jci.org · 12/09/2026

Spotlight 💫: Could platelets serve as a therapeutic target in alcohol-associated hepatitis? doi.org/10.1172/jci.... Matthew J. McConnell & colleagues report platelets upregulate inflammatory mediators in alcohol-associated hepatitis that can contribute to liver inflammation. #livertwitter #AlcHep

000

JCI insight @insight.jci.org · 11/09/2026

The heart’s halo: doi.org/10.1172/jci.... Hassanabad et al. discover immune cells in the pericardial fluid have anti-fibrotic properties. The team found macrophages that surround the heart release a factor (cystatin C) that prevents scarring following a heart attack.

022

JCI insight @insight.jci.org · 10/09/2026

Changing the paradigm for loss of the Y chromosome: doi.org/10.1172/jci.... Dan Theodorescu & team report Y chromosome loss increases progressively from healthy tissues to cancer, suggesting it is an early and previously unrecognized driver of cancer development. @the-asci.org

011

JCI insight @insight.jci.org · 09/09/2026

Proposed mechanism of potential GPR30/IGF1R/mTOR crosstalk: doi.org/10.1172/jci....

000

JCI insight @insight.jci.org · 09/09/2026

Dysregulation of UGDH is associated with tumorigenesis in breast cancer. Price et al. find genetic knockdown of UGDH blunts estrogen-stimulated breast cancer phenotypes in vitro, ex vivo and in vivo, irrespective of estrogen receptor status: doi.org/10.1172/jci....

100

JCI insight @insight.jci.org · 08/09/2026

Genes & environment influence the development of asthma doi.org/10.1172/jci.... On the cover: Otoshi et al., investigate how genetic background & retinoid micronutrient perturbations affect lung developmental programs associated with airway hyperresponsiveness in mice.

100

JCI insight @insight.jci.org · 07/09/2026

Could platelets serve as a therapeutic target in alcohol-associated hepatitis? doi.org/10.1172/jci.... Matthew J. McConnell & team report platelets upregulate inflammatory mediators in alcohol-associated hepatitis that can contribute to liver inflammation.

032

JCI insight @insight.jci.org · 06/09/2026

Sunday read💫: This proteomic score outperforms widely used clinical risk models: doi.org/10.1172/jci.... Corey et al. report on blood proteins that help predict heart disease risk in diabetes and are modified by GLP-1 therapy, improving risk assessment beyond traditional clinical factors.

010

JCI insight @insight.jci.org · 05/09/2026

Saturday Special💫: Welcome to the kidney! R Ariel Gomez & team examine the role of renin cells in renal neurovascular morphogenesis & remodeling. The video: mouse kidney cortex with renin cells (magenta), the renal arterial tree (green), nerve fibers (yellow): doi.org/10.1172/jci.... @the-asci.org

131

JCI insight @insight.jci.org · 04/09/2026

Time savers: doi.org/10.1172/jci.... Roby P. Bhattacharyya @roby-b.bsky.social & team directly compare blood sample collection methods for scRNA-seq in patients with sepsis. Their Cryo-PRO approach saves time and is highly scalable, with comparable results to standard methods.

030

JCI insight @insight.jci.org · 03/09/2026

Welcome to the kidney! R Ariel Gomez & team examine the role of renin cells in renal neurovascular morphogenesis & remodeling. The video: mouse kidney cortex with renin cells (magenta), the renal arterial tree (green), nerve fibers (yellow): doi.org/10.1172/jci.... @the-asci.org

153

JCI insight @insight.jci.org · 02/09/2026

A VPS16 gene variant underlies movement disorder in an infant.: doi.org/10.1172/jci.... Darius Ebrahimi-Fakhari & team show that this missense mutation blocks cellular waste clearance and is potentially treatable with deep brain stimulation.

000

JCI insight @insight.jci.org · 01/09/2026

This proteomic score outperforms widely used clinical risk models: doi.org/10.1172/jci.... Corey et al. report on blood proteins that help predict heart disease risk in diabetes and are modified by GLP-1 therapy, improving risk assessment beyond traditional clinical factors. @the-asci.org

011

JCI insight @insight.jci.org · 31/08/2026

It can be hard to diagnose chronic pancreatitis in children doi.org/10.1172/jci.... Farrell et al. @cincychildrens.bsky.social find TRANCE is elevated in plasma samples from pediatric patients with chronic pancreatitis compared to other participants & may serve as a unique biomarker of the disease

000

JCI insight @insight.jci.org · 30/08/2026

In Case You Missed It💫: Systemic sclerosis is a serious autoimmune disease with dysmotility of the esophagus as one of the most debilitating symptoms. Here, Matthew Dapas @mdapas.bsky.social et al. provide an atlas for the human esophageal epithelium in systemic sclerosis: doi.org/10.1172/jci....

010

JCI insight @insight.jci.org · 29/08/2026

Weekend read💫: A differential diagnosis for acute kidney injury: doi.org/10.1172/jci.... Chirag R. Parikh & team @kpmproject.bsky.social reveal that acute interstitial nephritis is a potentially common cause of acute kidney injury and sometimes not suspected by physicians. @the-asci.org

121

JCI insight @insight.jci.org · 28/08/2026

A salty immune system🧂: doi.org/10.1172/jci.... Rhys D.R. Evans & team show that salt balance is important for immune response regulation. Patients with inherited salt retention have increased sodium stores, dysregulated immunity, and are prone to autoimmune disease.

000

JCI insight @insight.jci.org · 28/08/2026

A new approach for kicking osteoarthritis: doi.org/10.1172/jci.... Wen Jiang @wenjiang-nano.bsky.social @mdanderson.bsky.social & team find blocking a key immune sensor, NOD2, in cartilage cells reduces joint damage in osteoarthritis mouse models. @the-asci.org

021

JCI insight @insight.jci.org · 27/08/2026

Can we eliminate HIV reservoirs? doi.org/10.1172/jci.... Maria J Buzon & team @vhir.bsky.social @uab.cat report on G-MDSC immune suppressive cells that may help HIV persist during treatment by blocking viral reactivation & suggest that these cells could be targeted through ARG1

000